As the World Health Organization (WHO) had declared the eradication of smallpox in 1979 after successful global immunization, the use of vaccinia virus in the prophylaxis of humans was not carried out until the beginning of the 21st century, when smallpox was considered to be a possible biological weapon [1] [2]. Consequently, the United States and several other countries have reintroduced vaccination of military personnel and certain at-risk individuals, which led to reports of various complications and adverse reactions, one of them being eczema vaccinatum [1] [2] [3] [4]. Although seen only in a handful of cases, patients develop eczema vaccinatum shortly after vaccination or after direct contact with recently vaccinated individuals [1] [2] [3] [5] [7]. Studies have confirmed that the main predisposing factor (and a contraindication) for this cutaneous disorder is the presence of atopic dermatitis (or some other type of dermatitis) [1] [2] [4] [5] [6]. The abrupt onset of vesicles, pustules, and erosions in same stages approximately 3-14 days after being in contact with the vaccinia virus is the hallmark of eczema vaccinatum [2]. Lesions that are seen on the skin are commonly superinfected (predominantly by Staphylococcus aureus), while corneal lesions may also develop, potentially leading to corneal ulceration and even blindness [2]. Furthermore, fever, lymphadenopathy, and malaise can accompany skin lesions [2]. In addition to cutaneous and ocular disorders, life-threatening subglottic edema is a possible complication [2], implying that early recognition is vital.

• Fever

  The appearance of vesicles and pustules, as well as systemic symptoms such as fever and malaise, constitute the clinical presentation. Clinical and microbiological studies are needed to make the diagnosis. [symptoma.com]

  Princeton's WordNet (0.00 / 0 votes) Rate this definition: eczema vaccinatum, Kaposi's varicelliform eruption (noun) a now rare complication of vaccinia superimposed on atopic dermatitis with high fever and generalized vesicles and papulovesicles Freebase [definitions.net]

  Vaccinatum 2 3 4 5 Progressive Vaccinia 6 7 Enlarged Site vs PV Large Reaction Differentiation 8 Enlarged Site vs PV Large Reaction Differentiation 9 Progressive Vaccinia 10 Post-Vaccinial Encephalitis Diagnosis Cerebral or cerebellar dysfunction Headache Fever [slideplayer.com]

  Persons suffering from childhood eczema may develop another allergic condition later, most often hay fever or asthma. Cause and Treatment. Eczema is sometimes caused by an allergic sensitivity to foods such as milk, fish, or eggs. [medical-dictionary.thefreedictionary.com]

• Vietnamese

  Русский (Russian) ಕನ್ನಡ (Kannada) 한국어 (Korean) עברית (Hebrew) Український (Ukrainian) اردو (Urdu) Magyar (Hungarian) मानक हिन्दी (Hindi) Indonesia (Indonesian) Italiano (Italian) தமிழ் (Tamil) Türkçe (Turkish) తెలుగు (Telugu) ภาษาไทย (Thai) Tiếng Việt (Vietnamese [definitions.net]

• Skin Rash

  Eczema vaccinatum is a serious, potentially life-threatening skin rash caused by widespread dissemination of vaccinia virus with an ensuing infection of the skin. [sciencephoto.com]

  It's characterized by serious local or disseminated, umbilicated, vesicular, crusting skin rashes in the face, neck, chest, abdomen, upper limbs and hands, caused by widespread infection of the... (36 of 889 words, 1 image) en.wikipedia.org/wiki/Eczema [memidex.com]

  It is characterized by serious local or disseminated, umbilicated, vesicular, crusting skin rashes in the face, neck, chest, abdomen, upper limbs and hands, caused by widespread infection of the skin in people with previous diagnosed skin conditions such [en.wikipedia.org]

• Excoriation

  B) Detail of the excoriated papules and crusts on the back. This suggests that healthy junctional complexes may be a key deterrent to the spread of HSV-1 from one keratinocyte to another. [optimization-nation.com]

  Pruritus/excoriation and application of topical corticosteroids can contribute to the spread of infection. Viremia and/or bacterial superinfection leading to bacteremia can lead to septic shock and even death. [clinicaladvisor.com]

• Angioedema

  Adverse reaction to cytokines · Bromoderma · Halogenoderma · Iododerma · Red man syndrome · Methotrexate-induced papular eruption unspecified agent: Acute generalized exanthematous pustulosis · Bullous drug reaction · Drug-induced acne · Drug-induced angioedema [dictionnaire.sensagent.leparisien.fr]

• Rabies

  Author information 1 Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. [email protected] Abstract On March 3, 2007, a 2-year-old boy was hospitalized with eczema [ncbi.nlm.nih.gov]

  Med Ctr, Infect Control Program, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Dermatol Sect, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Dept Pathol, Chicago, IL 60637 USA Chicago Dept Publ Hlth, Chicago, IL USA Ctr Dis Control & Prevent, Poxvirus & Rabies [accessdata.fda.gov]

  Inger Damon, chief of the CDC's poxvirus and rabies branch. Damon has been involved in the daily conference calls on the boy's treatment. [articles.chicagotribune.com]

  Specimens (swabs, lesion biopsy tissue, and/or sera) can also be sent to the Centers for Disease Control (CDC) Poxvirus and Rabies Branch for vaccinia species confirmation, culture and serologic response (which are important in heralding patient recovery [clinicaladvisor.com]

Given the rare occurrence of eczema vaccinatum in clinical practice, the diagnosis may not be easy. For this reason, physicians must obtain a thorough patient history that will assess the course and progression of symptoms, the presence of preexisting skin diseases, and if family members or close relatives/friends (or the patient him/herself) have been recently vaccinated for smallpox. As military personnel are predominantly mentioned in the reports [1] [2] [4], the patient's occupation (or their parents') should be evaluated. A detailed physical examination is equally important, as the abrupt onset of typical lesions has a very narrow differential diagnosis. Microbiological studies, however, are necessary to confirm eczema vaccinatum. Molecular methods that detect viral genetic material - polymerase chain reaction (PCR) are recommended tests for identifying vaccinia virus in skin biopsy samples, swabs from the lesions or from the skin of an open vesicle [1] [2]. Moreover, the specific finding of Guarnieri bodies (intracytoplasmic inclusions) on histological examination is useful in making the diagnosis [2]. Thus, a microbiological investigation should be initiated as soon as clinical suspicion is raised.

And Prevention Of Eczema Vaccinatum In Atopic Atopic Dermatitis Treatment Pictures Home Remedies Causes Generalized Vaccinia Progressive Vaccinia And Eczema Vaccinatum Smallpox Vaccination And Adverse Reactions Induction Treatment And Prevention Of Eczema [eczema-prevent.blogspot.com]

[…] the treatment of orthopoxvirus infection. [ncbi.nlm.nih.gov]

Early treatment can greatly improve the prognosis, as well as limit permanent skin damage. Related wiseGEEK Articles [wisegeek.com]

While it is a well known entity to the specially trained dermatologist and pediatrician, the average physician's knowledge of this disease is not commensurate with the importance of his potential rôle in its causation or with the relatively serious prognosis [annals.org]

The etiology is unknown, though the familial tendency is well documented. [nejm.org]

Professional Edition Eczema Symptoms And Diagnosis Everyday Health Dermatitis Wikipedia Atopic Dermatitis Practice Essentials Background Pathophysiology Eczema Symptoms And Diagnosis Everyday Health Kaposi Varicelliform Eruption Background Pathophysiology Etiology [eczema-prevent.blogspot.com]

Dilated cardiomyopathy and cardiac ischemia Dilated cardiomyopathy and cardiac ischemia have been noted in temporal association to smallpox vaccination, but have not been demonstrated to be linked etiologically. [cdc.gov]

Author Affiliations * Instructor in epidemiology, Harvard School of Public Health; district health officer, Massachusetts Department of Public Health. [nejm.org]

In each of these chapters, a short discussion of the epidemiology of the disease and the history of immun isation against it is followed by a description of the vaccine, its efficacy, contraindications to its use and future developments. [books.google.ro]

The epidemiology of atopic dermatitis. Clin Dermatol. 2003;21(2):109–115. doi:10.1016/S0738-081X(02)00360-7 [CrossRef] Horii K, Simon S, Liu D, Sharma V. [healio.com]

[…] auto-inoculation of mucous membranes or abraded skin, benign rash, secondary infections; complications are serious for those with eczema or who are immunocompromised; death is most often the result of postvaccinial encephalitis or progressive vaccinia EPIDEMIOLOGY [msdsonline.com]

Eczema Symptoms And Diagnosis Everyday Health Kaposi Varicelliform Eruption Background Pathophysiology Etiology Complicacoes Decorrentes Da Vacinacao Antivariolica A Eczema Rostrum Smallpox Vaccination Risk Considerations For Patients With Eczema Vaccinatum [eczema-prevent.blogspot.com]

Despite much current research interest, the pathophysiology of these disorders and their optimum treatment remain uncertain. [books.google.ro]

Two pathophysiologic mechanisms have been proposed to explain the increased propensity of persons with AD to develop bacterial and viiral infections. [grantome.com]

Of Eczema Vaccinatum In Atopic Atopic Dermatitis Treatment Pictures Home Remedies Causes Generalized Vaccinia Progressive Vaccinia And Eczema Vaccinatum Smallpox Vaccination And Adverse Reactions Induction Treatment And Prevention Of Eczema Vaccinatum [eczema-prevent.blogspot.com]

WASHINGTON (Reuters) - A two-year-old boy who developed a serious reaction to his father’s smallpox vaccination has recovered but disease detectives found infectious virus all over his house, the Centers for Disease Control and Prevention reported on [reuters.com]

Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization [books.google.ro]

This image was created in 08/2003 and provided by the Centers for Disease Control and Prevention/Allen W. Mathies, MD, John Leedom, MD/ California Emergency Preparedness Office (Calif/EPO), Immunization Branch. [imageenvision.com]

Centers for Disease Control and Prevention Fact Sheet. Vaccine Reaction Images. CDC. Eczema vaccinatum. About. [en.wikipedia.org]

1. Vora S, Damon I, Fulginiti V, et al. Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis. 2008;46(10):1555-1561.
2. Jen M, Chang MW. Eczema herpeticum and eczema vaccinatum in children. Pediatr Ann. 2010;39(10):658-664.
3. Moses AE, Cohen-Poradosu R. Images in clinical medicine. Eczema vaccinatum--a timely reminder. N Engl J Med. 2002;346(17):1287.
4. Reed JL, Scott DE, Bray M. Eczema vaccinatum. Clin Infect Dis. 2012;54(6):832-840.
5. Vellozzi C, Lane JM, Averhoff F, et al. Generalized vaccinia, progressive vaccinia, and eczema vaccinatum are rare following smallpox (vaccinia) vaccination: United States surveillance, 2003. Clin Infect Dis. 2005;41(5):689-697.
6. Cono J, Casey C, Bell D. Smallpox vaccination and adverse reactions. Guidance for clinicians. MMWR Recomm Rep. 2003;52(RR-4):1–28.
7. Herderson DA. Smallpox vaccination: a review, part II: adverse events, Clin Infect Dis. 2003;37:251-271.