Symptoma

Efavirenz Toxicity

We present the case of an HIV-infected patient with cirrhosis in whom severe neuropsychiatric signs and symptoms developed in the setting of a significantly elevated plasma efavirenz level. [ncbi.nlm.nih.gov]

Weiner, Bernard Gonik, Caroline Crowther, and Stephen Robson present an evidence-based approach to the available management options, equipping you with the most appropriate strategy for each patient. [books.google.de]

Session Title: HOST AND VIRAL BIOMARKERS Presenter Institution: University of Pennsylvania Perelman School of Medicine [croiconference.org]

Lee Research Group, University of Toronto, Canada, for providing the necessary facilities to develop the present research. This research was supported by Technology Support Foundation of Pernambuco—FACEPE. [link.springer.com]

Case presentation Four black African children, between the ages of 4 and 8 years presenting between 1 and 20 months post-efavirenz initiation, are described. [bmcinfectdis.biomedcentral.com]

  • Candidiasis

    Pappas PG, Rex JH, Sobel JD et al (2004) Guidelines for treatment of candidiasis. Clin Infect Dis 38(15):161–189 PubMed CrossRef Google Scholar 22. [link.springer.com]

    Maraviroc is associated with bronchitis, nasopharyngitis, and esophageal candidiasis. Adverse effects of raltegravir are comparable to those experienced with placebo, with the exception of increased risk of myopathy and rhabdomyolysis. [aafp.org]

  • Sepsis

    Müller E (2006) Antibiotika bei Sepsis und Multiorganversagen. Intensivmed 43:94–102 CrossRef Google Scholar 20. [link.springer.com]

  • Macula

    The case report notes ‘ophthalmoscopy showed an area of retinal opacification occupying most of his macula in both eyes’. The authors have attributed this visual loss to Efavirenz. [nature.com]

  • Cognitive Impairment

    AREAS COVERED: The authors conducted a systematic review using the PubMed database, references cited by other articles and conference web sites to determine if there is evidence that efavirenz may contribute to cognitive impairment by damaging nerve cells [ncbi.nlm.nih.gov]

    Drug toxicities could be a major contributing factor to cognitive impairment in patients with HIV.” [hopkinsmedicine.org]

    The scientists hypothesize, but did not conduct the studies necessary to prove, that this may contribute to cognitive impairment in people living with HIV. [poz.com]

  • Sleep Disturbance

    disturbance, somnolence, vivid dreams and others. [croiconference.org]

    The increased potential for sleep disturbances and impaired concentration during periods of rapid brain development should cause prescribers to carefully monitor mental and physical development among young patients on efavirenz. [dovepress.com]

Proteinuria : Although proteinuria is not specific for proximal tubular dysfunction it should also be included in the workup. [hivwebstudy.org]

Dolutegravir is within a novel class of antiretroviral agents licensed in the UK for the treatment of HIV. [clinicaltrials.gov]

The HIV treatment community has been caught largely unaware of this emerging dilemma. [books.google.de]

Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter [books.google.com]

In a large primary and tertiary referral centre in London (Chelsea and Westminster Hospital), 683 patients have received Efavirenz since December 2000 as part of their HIV treatment. [nature.com]

Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996 ;272: 1167 - 1170 [Erratum, Science 1997;275:14.] 35. Panel on Clinical Practices for Treatment of HIV Infection, Department of Health and Human Services (DHHS). [nejm.org]

Its etiology and natural history are still under debate. [dovepress.com]

The etiology is unclear (Review: Wilde 2000). During clinical trials with tipranavir/r, the manufacturer received 14 reports of intracranial hemorrhage, among them 8 fatal cases, in 13 out of 6,840 HIV-1 infected individuals. [hivbook.com]

HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. [books.google.de]

Página 259 - Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. [books.google.es]

Kullberg BJ, Oude Lashof AML (2002) Epidemiology of opportunistic invasive mycoses. Eur J Med Res 7:183–191 PubMed Google Scholar 17. [link.springer.com]

GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011 Apr;64(4):380-2. doi: 10.1016/j.jclinepi.2010.09.011. Epub 2010 Dec 24. [hivinsite.ucsf.edu]

Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa, 2 School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, South Africa, 3 Health Economics and Epidemiology [panafrican-med-journal.com]

Task Force on Community Preventive Services. Data collection instrument and procedure for systematic reviews in the Guide to Community Preventive Services. [imic.or.jp]

Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. ‎ Seite 470 - Slone D. Siskind V. [books.google.de]

Breastfeeding / Human Immunodeficiency Virus (HIV) Infections / Pregnancy 1 4 Active Not Recruiting Prevention Human Immunodeficiency Virus (HIV) Infections 1 4 Active Not Recruiting Prevention Infection, Human Immunodeficiency Virus I 1 4 Active Not [drugbank.ca]

Lallemant M, Gonzague Jourdain G, Sophie Le Coeur S, et al. (2004) Single-Dose Perinatal Nevirapine plus Standard Zidovudine to Prevent Mother-to-Child Transmission of HIV-1 in Thailand. [ja.wikipedia.org]

one of the study’s other authors, has found a way to modify the drug to prevent it from metabolizing into 8-hydroxyefavirenz while maintaining its effectiveness as a tool to suppress the HIV virus. [hopkinsmedicine.org]