(B) Nuclear debris and eosinophilic-degenerated elastic fibers present in multiple channel lumens (H&E, ×400). [ncbi.nlm.nih.gov]

It presents as a group of small reddish bumps. [dermnetnz.org]

These lesions were present on her neck, in her axillary skin folds, antecubital fossa and groin. She had associated skin laxity (figures 1 and 2). [casereports.bmj.com]

• Kinky Hair

  Determination of apoceruloplasmin by radioimmunoassay in nutritional copper deficiency, Menkes' kinky hair syndrome, Wilson's disease, and umbilical cord blood. Pediatr Re. 1974;8:821-4. [PubMed] 13. Nimni ME. Penicillamine and collagen metabolism. [escholarship.org]

Progress logically from the histologic pattern, through the appropriate workup, around the pitfalls, to the best diagnosis. [books.google.de]

However, no 'gold standard' therapy exists among these treatment modalities. [ncbi.nlm.nih.gov]

Elastosis perforans serpiginosa: treatment with liquid nitrogen. Int J Dermatol. 1990 Nov. 29(9):655-6. [QxMD MEDLINE Link]. Humphrey S, Hemmati I, Randhawa R, Crawford RI, Hong CH. [emedicine.medscape.com]

Treatment Options Treatment options are listed in Table I. A consistently effective treatment for EPS is not currently available. [dermatologyadvisor.com]

(Outcomes/Resolutions) The prognosis of Elastosis Perforans Serpiginosa depends upon the severity of the condition; mild cases (idiopathic and reactive forms) have better prognosis than severe ones It is also dependent upon the underlying health condition [dovemed.com]

▪ PROGNOSIS, CLINICAL COURSE, AND TREATMENT The perforating disorders are difficult to treat. Their prognosis is tied to the underlying diseases, so treatment of the underlying cause can be effective. [dermaamin.com]

Prognosis - Ehlers-Danlos syndrome - general Treatment - Ehlers-Danlos syndrome - general Resources - Ehlers-Danlos syndrome - general [checkorphan.org]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

The etiology, pathophysiology, natural history, and treatment options for DPA-induced EPS are reviewed, and the authors suggest this method of treatment to be effective and safe for patients of DPA-induced EPS refractory to conventional therapy. [ncbi.nlm.nih.gov]

Etiology Elastic fibers are perceived by the skin to be abnormal and become the primary objects of an inflammatory attack. They may be abnormal as a result of genetic influence or penicillamine. [emedicine.medscape.com]

There are three distinct etiologies of EPS: Idiopathic EPS - likely a genetic predisposition and the exact cause remains unknown. Approximately 60-70% of EPS cases fall in this category. [aocd.org]

HISTORY ETIOLOGY AND PATHOGENESIS D- penicillamine appears to be a clear trigger for EPS. [dermaamin.com]

You might also be interested in Dermatology Occurrence/Epidemiology This section has been translated automatically. m>w Manifestation This section has been translated automatically. The first symptoms can already appear in childhood. [altmeyers.org]

Epidemiology Either idiopathic, drug induced (D-penicillamine), or associated with other inherited disorders (Down syndrome, Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, Rothmund-Thomson syndrome) Diagrams / tables Images hosted on [pathologyoutlines.com]

Epidemiology Frequency Elastosis perforans serpiginosa is a rare condition. No geographic preferences are apparent for elastosis perforans serpiginosa. Race No racial differences have been reported for elastosis perforans serpiginosa. [emedicine.medscape.com]

[…] between EPS and Down's syndrome is unknown; however, factors present in this syndrome such as premature skin aging, joint hyperelasticity and acrocyanosis may suggest an underlying connective tissue disorder. 1,2 table 1 illustrates some clinical and epidemiological [scielo.br]

The pathophysiology of OI involves mutations in genes encoding α-chains of type I collagen, the main component of the dermis. [jhu.pure.elsevier.com]

The etiology, pathophysiology, natural history, and treatment options for DPA-induced EPS are reviewed, and the authors suggest this method of treatment to be effective and safe for patients of DPA-induced EPS refractory to conventional therapy. [ncbi.nlm.nih.gov]

The pathophysiology is not well understood. [renalfellow.blogspot.com]

There are a few reports of its familial occurrence. [2] The pathophysiology of d-penicillamine induced EPS is due to not only a decrease in the rate of synthesis of elastic fibers in papillary dermis but also over-proliferative state of elastic fibers [e-ijd.org]

Pathophysiology Elastosis perforans serpiginosa (EPS) may be a form of granulomatous inflammation that displays an unusual method for removing elastic tissue from the area of involvement. [emedicine.medscape.com]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

Key words: Ehlers-Danlos syndrome, elastosis perforans serpiginosa Advertisement American Journal of Preventive Medicine and Public Health SUBMIT YOUR ARTICLE NOW [scopemed.org]

The patient should avoid sun exposure to prevent recurrence. elastosis perforans serpiginosa See: perforating disorder [medical-dictionary.thefreedictionary.com]

An early and lifelong therapy with chelators (penicillamine, trientine) or zinc is necessary to prevent disease evolution. [journals.lww.com]