Chronic lymphedema, either congenital or secondary to infection, surgery, radiation, neoplastic obstruction, obesity, portal hypertension, or chronic congestive heart failure, plays a pivotal role in the pathogenesis. [ncbi.nlm.nih.gov]

Elephantiasis Nostras Verrucosa (ENV) is a rare form of pretibial myxedema, which is nearly always associated with Graves' disease. A case is presented here of Graves' disease who had elephantiasis variety of pre-tibial myxedema (PTM). [ncbi.nlm.nih.gov]

A notable sufferer of Proteus syndrome was the so-called Elephant Man.Other causes may include: Repeated streptococcal infection Lymphadenectomy Hereditary birth defects Pretibial myxedema "Lymphatic filariasis". World Health Organization. [en.wikipedia.org]

We present the case of a 51-year-old woman who had progressively developed an enormous pediculated abdominal mass hanging down her knees. The skin was thickened, hyperpigmented, and fissured. She had a history of multiple abdominal cellulites. [ncbi.nlm.nih.gov]

Chronic lymphedema, either congenital or secondary to infection, surgery, radiation, neoplastic obstruction, obesity, portal hypertension, or chronic congestive heart failure, plays a pivotal role in the pathogenesis. [ncbi.nlm.nih.gov]

American man presented with a medical history of morbid obesity (weighing more than 550 lb), benign prostatic hyperplasia, hyperlipidemia, gynecomastia, atrial fibrillation, hypertension, chronic obstructive pulmonary disease, psoriasis, sleep apnea, and cardiomegaly [ncbi.nlm.nih.gov]

It has been reported that maintaining a seated posture obstructs both lymphoducts and veins because of bending the groin, decreases their return flow by inducing muscular atrophy, and causes subcutaneous edema in the lower limbs. [ncbi.nlm.nih.gov]

RESULTS: Over a total of 511 patients, lymphedema resulted from trauma (40.7%), chronic venous insufficiency (12.5%), deep mycoses (10.8%), lymphatic filariasis (9.2%), elephantiasis nostras verrucosa (7.0%), tropical ulcer (6.3%), leprosy (4.9%), recurrent [ncbi.nlm.nih.gov]

There is no standard treatment for this rare cutaneous manifestation. This article describes debridement that is helpful when performed in addition to physiotherapy. [ncbi.nlm.nih.gov]

Edema of the limbs is graded on the severity of the edema Grade I – Pitting (after pressing the edematous limb with the finger tip for 30 seconds, the fluid gets displaced into the surrounding tissue and leaves a ‘depression’ in the skin) edema which [pediatriconcall.com]

Chronic mental distress and disability can result as it interferes with daily/routine activities of the affected individual. [ncbi.nlm.nih.gov]

Definitions of elephantiasis 1 n hypertrophy of certain body parts (usually legs and scrotum); the end state of the disease filariasis Types: elephantiasis neuromatosa hypertrophy of a limb chyloderma, elephantiasis scroti swelling of the scrotum resulting [vocabulary.com]

People with the disease can suffer from lymphedema and elephantiasis and in men, swelling of the scrotum, called hydrocele. Lymphatic filariasis is a leading cause of permanent disability worldwide. [cdc.gov]

In men, elephantiasis can also result in the swelling of the scrotum (hydrocele). Elephantiasis affects the poorest communities, preventing individuals from living a productive working and social life, further trapping them in the cycle of poverty. [unitingtocombatntds.org]

In men, lymphedema of the genitalia usually involves swelling of the scrotum, often to the size of a watermelon making it very painful and difficult to walk. In women, the condition may present swelling in one or both breasts. [end.org]

Elephantiasis causes swelling of the scrotum, legs, or breasts. Elephantiasis is considered a neglected tropical disease (NTD). It’s more common in tropical and subtropical areas of the world, including Africa and Southeast Asia. [healthline.com]

Lymphogranuloma venereum (LGV) is a sexually transmitted disease of the lymph channels caused by Chlamydia trachomatis. Esthiomene, a rare late manifestation of LGV, is a primary infection affecting the lymphatics of scrotum, penis, or vulva. [ncbi.nlm.nih.gov]

Other infections such as chlamydia, herpes and syphilis are known to increase susceptibility to HIV. [ndtv.com]

Other types of elephantiasis are genital elephantiasis caused by a sexually transmitted organism of Chlamydia group. The disease is called as Lymphogranuloma Venereum. [pediatriconcall.com]

Another bacterium called Chlamydia trachomatis can also cause obstruction of lymphatic system leading to swelling of genitals. In rare cases elephantiasis can also be caused by podoconiosis disorder. [diseasespictures.com]

Lymphogranuloma venereum (LGV) is a sexually transmitted disease of the lymph channels caused by Chlamydia trachomatis. Esthiomene, a rare late manifestation of LGV, is a primary infection affecting the lymphatics of scrotum, penis, or vulva. [ncbi.nlm.nih.gov]

Another bacterium called Chlamydia trachomatis can also cause obstruction of lymphatic system leading to swelling of genitals. In rare cases elephantiasis can also be caused by podoconiosis disorder. [diseasespictures.com]

Chlamydia trachomatis serovar L1-L3 causes the lymphogranuloma venereum. It damages the lympathic system causing lymphatic obstruction in the genitals. When the obstruction is chronic in nature, eventually genital elephantiasis may be caused. [xpertdox.com]

The bacterium that results in LGV, Chlamydia trachomatis serovar L1-L3, damages the lympathic system resulting in lymphatic obstruction in the genitals. Chronic obstruction eventually results in genital elephantiasis. [rarediseases.org]

We identified 24 cases of localized lymphedema presenting as solitary large polyps (11), solid or papillomatous plaques (7), pendulous swellings (4), or tumors mimicking sarcoma (2). [ncbi.nlm.nih.gov]

Filariasis is a helminthic infection caused by tissue nematodes. It is estimated that at least 120 million people are infected worldwide and another 1 billion are "at risk" of infection. [ncbi.nlm.nih.gov]