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Embryonal Carcinoma

Ovarian Embryonal Carcinoma


Presentation

  • A review of the literature on germ cell testicular tumor in men sixty years old and over is also presented.[ncbi.nlm.nih.gov]
  • However, it is present as a component of almost ninety percent of mixed nonseminomatous germ cell tumours. The average age at diagnosis is 31 years, and typically presents as a testicular lump which may be painful.[en.wikipedia.org]
Epigastric Pain
  • Here we describe a 72-year-old man who remained undiagnosed for a prolonged period of time because of intractable epigastric pain.[ncbi.nlm.nih.gov]
Abnormal Behavior
  • This 29-year-old male was admitted because of abnormal behavior, disturbed consciousness, and increased intracranial pressure.[ncbi.nlm.nih.gov]
Secondary Amenorrhea
  • The case of a 12-year-old female with a history of secondary amenorrhea for 6 months is reported; her symptoms included decreased visual acuity, dizziness and postprandial vomiting over a 1-month period.[ncbi.nlm.nih.gov]
Pelvic Pain
  • A 53-year-old woman complaining of irregular menses and pelvic pain was found to have a large pelvic mass and a positive pregnancy test. Subsequent investigation revealed a large left adnexal mass, and an elevated beta-HCG and alpha-AFP.[ncbi.nlm.nih.gov]
Scrotal Mass
  • Abstract A 72-year-old Japanese man presented with a painless swollen left scrotal mass with elevated levels of serum alpha-fetoprotein and prostate specific antigen.[ncbi.nlm.nih.gov]

Workup

  • The patient elected observation after further workup showed no evidence of metastasis.A repeat ultrasound 3 months later showed interval growth and the patient underwent right radical orchiectomy.[ncbi.nlm.nih.gov]
  • Review Topic QID: 106375 5 No further workup, instruct patient to return if symptomatic M1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only ARTICLES (4) Topic COMMENTS (12) Please login[step1.medbullets.com]
Karyotype Abnormal
  • As evidences suggesting the role of karyotypic abnormalities (e.g., aneuploidy and near-tetraploidy) and stem cell in tumor development are increasing, it becomes pertinent to study karyotypically abnormal embryonal carcinoma cells.[ncbi.nlm.nih.gov]

Treatment

  • We report a rare case of advanced testicular cancer that describes the natural progression of testicular cancer without medical treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Therefore, the long-term vital prognosis can be expected in this patient.[ncbi.nlm.nih.gov]

Etiology

  • Therefore, determining the epigenetic and functional genomic landscape in GCC cell lines could provide insight into the pathophysiology and etiology of GCC and provide guidance for targeted functional experiments.[diagenode.com]
  • ETIOLOGY •Embryonal carcinoma is a NON-SEMINOMATOUS germ cell tumour characterized by primitive epithelial cells with marked pleomorphism and various histologic patterns. It may present in pure form but often is part of a mixed germ cell tumour.[slideshare.net]
  • (Etiology) The cause of Embryonal Carcinoma of the Testis is unknown.[dovemed.com]
  • About 3-10% of pure germ cell tumors are embryonal carcinomas, and embryonal carcinomas are present in more than 80% of mixed germ cell tumors. [1, 2] Etiology Genetic and environmental factors play a role in the development of germ cell tumors, [3, 4[emedicine.medscape.com]

Epidemiology

  • Epidemiological studies evidenced an increased incidence of testicular germ cell cancer after elevated pre-natal estrogen exposure but the expression of estrogen receptors in these testicular neoplasms has not been well elucidated.[ncbi.nlm.nih.gov]
  • […] cells recapitulating early stages of embryonic development Essential features Age at presentation: 30's Pure in 2% of the cases; most commonly part of mixed germ cell tumor More than 60% have metastases at presentation Multiple morphologic patterns Epidemiology[pathologyoutlines.com]
  • Epidemiology Embryonal carcinoma is one of the most common germ cell tumors. The peak incidence occurs in persons aged 20-30 years. It is extremely rare in infants.[emedicine.medscape.com]
  • Introduction Testicular tumors can be of germ cell or non-germ cell origin germ cell origin are the majority (95%) and are more commonly malignant non-germ cell origin usually benign Epidemiology incidence most common cancer in men between 15-35 years[step1.medbullets.com]
Sex distribution
Age distribution

Pathophysiology

  • Author information 1 Department of Pathophysiology, Norman Bethune Medical School, Jilin University, Changchun 130021, PR China.[ncbi.nlm.nih.gov]
  • Therefore, determining the epigenetic and functional genomic landscape in GCC cell lines could provide insight into the pathophysiology and etiology of GCC and provide guidance for targeted functional experiments.[diagenode.com]

Prevention

  • Maintaining Foxm1 expression prevents the downregulation of pluripotency-related transcription factors such as Oct4 and Nanog during P19 cell differentiation.[ncbi.nlm.nih.gov]
  • Hopefully it prevents an infection. I have a son in jr. kindergarten, so infections are always a possibility in this house. Vicfirth: I have been following your threads and I hope that you won t need to go down this road.[tc-cancer.com]
  • Removal of the testis Debulking surgery to reduce tumor size, followed by chemotherapy Clotting the vessels in the tumor (embolization) Chemotherapy Radiotherapy Undertaking treatment of underlying conditions How can Embryonal Carcinoma of the Testis be Prevented[dovemed.com]

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