Presentation
Pronunciation[edit] (UK, US) IPA(key): /ɪˈmɛnd/ Rhymes: -ɛnd Verb[edit] emend (third-person singular simple present emends, present participle emending, simple past and past participle emended) (transitive) To correct and revise (text or a document). [en.wiktionary.org]
LAS VEGAS — Oral Emend improved gastroparesis symptoms based on commonly used gastroparesis measures in a randomized controlled trial, according to the APRON results presented at ACG 2016. [healio.com]
For job opportunities with the EMEND Project Click Here For Research opportunities with the EMEND Project Click Here For events presented by the EMEND Project Click Here [emend.ualberta.ca]
That was far from in the present study setting. [jcancer.org]
The following drug information is obtained from various newswires, published medical journal articles, and medical conference presentations. [centerwatch.com]
Entire Body System
- Weight Gain
Rare side effects (defined as less than one percent incidence) include candidiasis, staphylococcal infection, febrile neutropenia, weight gain, polydipsia, disorientation, euphoria, vivid dreams, cognitive disorder, lethargy, somnolence, conjunctivitis [ncbi.nlm.nih.gov]
Respiratoric
- Dyspnea
Injection: monitor for infusion site or hypersensitivity reactions; discontinue and treat appropriately if occur; do not reinitiate if symptoms (eg, flushing, erythema, dyspnea, hypotension, syncope) develop with first-time use. [rheumatologyadvisor.com]
Importantly, three subjects reported dyspnea after receiving fosaprepitant (observed at Table 3. Two of the three subjects who experienced dyspnea with fosaprepitant discontinued the infusion and were taken off the study. [dovepress.com]
Eyes
- Redness of Eye
Check with your doctor immediately if any of the following side effects occur: anxiousness fever low blood pressure increased sweating painful, burning urination red, itchy eyes with discharge ringing in the ears signs of infection (symptoms may include [medbroadcast.com]
Skin
- Erythema
Injection: monitor for infusion site or hypersensitivity reactions; discontinue and treat appropriately if occur; do not reinitiate if symptoms (eg, flushing, erythema, dyspnea, hypotension, syncope) develop with first-time use. [rheumatologyadvisor.com]
Neurologic
- Irritability
Pain and irritation of the throat. Inflammation of the lining of the mouth (stomatitis). Cough, sneezing. Muscle weakness and spasms. Discomfort in the chest. Skin reactions such as rash, itching, lesions, sweating. [netdoctor.co.uk]
[…] study, infusion-site reactions were reported in 2.2% of patients treated with the EMEND regimen compared to 0.6% of patients treated with the control regimen, including infusion-site pain (1.2% EMEND regimen vs 0.4% control regimen), injection-site irritation [flasco.org]
Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes. [drugs.com]
Workup
CINV refractory to all medical therapies, including aprepitant, needs further evaluation and workup for intestinal obstruction, CNS metastases, and electrolyte abnormalities.[40] Clinicians (MD, DO, NP, PA), pharmacists, and nursing staff working as an [ncbi.nlm.nih.gov]
Treatment
[…] caused by chemotherapy treatment. [centerwatch.com]
The objective of this study was to compare standard antiemetic treatment with standard treatment plus prolonged treatment with aprepitant (Emend®) until 7 days after the end of chemotherapy in patients treated with HDCT before autologous SCT. [pubmed.ncbi.nlm.nih.gov]
02/07/2019 buprenorphine (Buvidal) Full For the treatment of opioid dependence within a framework of medical, social and psychological treatment. [scottishmedicines.org.uk]
P activation of tachykinin family neurokinin 1 (NK1) receptors, which reduces the incidence of acute and delayed emesis. [1] [2] [3] Route: IV Extravasation: no information available For conciseness and simplicity, HemOnc.org currently will focus on treatment [hemonc.org]
Etiology
chlorpheniramine maleate, trimethobenzamide; Haloperidol, droperidol, tetrahydrocannabinol, or nabilone Any vomiting, retching or NCI Common Toxicity Criteria v.4.0 grade 2-4 nausea 24 hours preceding chemotherapy Ongoing vomiting from any organic etiology [clinicaltrials.gov]
Pathophysiology
“Despite recent advances in pathophysiology we still do not have any disease modifying agents, and we neither have very good symptom-related agents when it comes to taking care of patients who might have gastroparesis nor patients who have symptoms that [healio.com]
The pathophysiology of malignancy and itch has yet to be clearly elucidated; however, many mediators have been suggested to play a role. [bmccancer.biomedcentral.com]
Prevention
[…] chemotherapy including high-dose cisplatin " and "prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy." [hemonc.org]
The company markets Sustol granisetron extended release (APF530) to prevent chemotherapy-induced nausea and vomiting (CINV). The product is a long-acting formulation... [bciq.biocentury.com]
Prevention of Postoperative Nausea and Vomiting (PONV) EMEND is indicated for the prevention of postoperative nausea and vomiting [see Dosage and Administration ]. [druglib.com]
Emend for Injection is indicated in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer (HEC) chemotherapy, including high-dose cisplatin; and for prevention of nausea [europeanpharmaceuticalreview.com]
Results showed Emend, in combination with ondansetron and dexamethasone, prevented acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy including high-dose cisplatin. [centerwatch.com]