Presentation
Three cases of endocardial fibroelastosis with vectorcardiographic findings suggestive of an anterior myocardial infarct are presented. [ncbi.nlm.nih.gov]
Entire Body System
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Congestive Heart Failure
Endocardial fibroelastosis is an important cause of congestive heart failure and death in infancy and early childhood. When present, it is commonly associated with non immune hydrops fetalis. [ncbi.nlm.nih.gov]
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Death in Infancy
Endocardial fibroelastosis is an important cause of congestive heart failure and death in infancy and early childhood. When present, it is commonly associated with non immune hydrops fetalis. [ncbi.nlm.nih.gov]
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Cerebral Palsy
Postoperative observation showed the infant developed normally except for moderate cerebral palsy. (Texas Heart Institute Journal 1990;17:122-5) Full text Full text is available as a scanned copy of the original print version. [ncbi.nlm.nih.gov]
Gastrointestinal
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Failure to Thrive
Symptoms - Endocardial fibroelastosis Breathlessness Cough Wheezing Feeding difficulty Excessive sweating Failure to thrive Recurrent chest infections (20%) Causes - Endocardial fibroelastosis EFE has two distinct genetic forms, each having a different [checkorphan.org]
Cardiovascular
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Heart Disease
The EFE heart disease group had both fewer B cells (0.18 vs. 0.44 cells/mm(2); p 0.08) and T cells (0.29 vs. 0.80 cells/mm(2); p 0.04) than the control group. [ncbi.nlm.nih.gov]
A comprehensive and exhaustive reference of fundamental and clinical aspects of heart disease in infancy and childhood. [books.google.de]
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Gallop Rhythm
rhythm, persistent jugular venous distention, systemic hypotension, peripheral vascular disease Laboratory findings Hyponatremia, persistently elevated B-type natriuretic peptide and A-type natriuretic peptide levels, elevated norepinephrine and renin [clevelandclinicmeded.com]
Workup
Today, if a patient presented with myocarditis ( pdf on endocarditis and myocarditis), a complete workup would be done. First, the doctor would do a physical exam, then an electrocardiogram and blood work. [theancestorfiles.blogspot.com]
P Wave
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P Mitrale
The ECG showed sinus rhythm, P mitrale, deep S waves in V3 and pronounced R waves in V4, profound ST depression and deep T wave inversion in V3-6, without criteria for LVH (Fig 2A). [escardio.org]
Other Pathologies
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Myocardial Fibrosis
Observations that favor a viral etiology include a clinical presentation similar to that of chronic myocarditis, findings of myocarditis or myocardial fibrosis in affected patients, a higher incidence following epidemics of coxsackievirus B infection, [chdbabies.com]
The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]
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Hepatic Necrosis
Hepatic necrosis was notable in 3 patients (patients 1, 3, and 21 in Table 2 ), while cerebral infarction (patient 7, Table 2 ) and renal infarction (patient 25, Table 2 ) occurred in 1 child each. [doi.org]
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Lymphocytic Infiltrate
Additionally, there was a mixture of myocardial fibers with a marked "wavy" appearance and a scattering of mild interstitial lymphocytic infiltration. [ncbi.nlm.nih.gov]
Treatment
The prognosis mainly depends on the early and accurate diagnosis and treatment. However, without a typical and specific clinical manifestation in early stage, ALCAPA has a higher rate of false initial diagnosis. [ncbi.nlm.nih.gov]
Prognosis
Middle-term prognosis of isolated autoantibody-associated EFE may be better than previously reported, although the longterm prognosis remains unknown. We hypothesize that a fetal insult can lead to DCM. [ncbi.nlm.nih.gov]
Etiology
We propose that the presence of these particles in this case in association with the other morphological alterations in support for the viral etiology of EFE. [ncbi.nlm.nih.gov]
Epidemiology
OBJECTIVES: To analyze the epidemiologic, clinical and anatomopathological aspects of primary EFE. [scielo.br]
An epidemiologic assessment of primary endocardial fibroelastosis. Am J Cardiol. 1966 Dec. 18(6):859-66. [Medline]. Nield LE, Silverman ED, Smallhorn JF, et al. [emedicine.medscape.com]
Recent advances in the epidemiology, diagnosis and treatment of endomyocardial fibrosis in Africa. Heart. 2013;99:1481-7. Mavrogeni S, Sfikakis PP, Gialafos E, et al. [escardio.org]
Pathophysiology
We also discuss the pathophysiology of this association and related literature. [ncbi.nlm.nih.gov]
Grasp the full scope of the pathophysiology of CHD with well-organized, expert guidance. Quickly search the contents online, download images in JPG or PPT format, and view 70 echocardiogram videos at expertconsult.com. [books.google.de]
However, a recently published study has highlighted that 25% of children who were transplanted for dilated cardiomyopathy demonstrated significant endocardial fibroelastosis on histopathology of the explanted hearts. [2] Pathophysiology Endocardial fibroelastosis [emedicine.medscape.com]
Prevention
The contracted form of primary fibroelastosis in the fetus must have followed an insult that prevented any further increase in the size of the left ventricular cavity. [ncbi.nlm.nih.gov]
There is also some evidence that viral infection may play a role as a cause or trigger Prevention - Endocardial fibroelastosis Not supplied. [checkorphan.org]
Take good care of your teeth and gums to prevent infections. Make regular visits to your dentist. Take antibiotics before you have any medical work that may cause bleeding, like dental work and most surgeries. [webmd.com]
[…] that the enlarged heart and heart failure was caused by a viral infection or a viral infection in conjunction with a congenital heart defect, the vaccine development was too late to save her life, but Hilleman's "measles vaccine alone is estimated to prevent [theancestorfiles.blogspot.com]
Treatment of CHB Curative treatment of CHB and prophylactic treatment to prevent the recurrence of CHB are two major issues. [arthritis-research.biomedcentral.com]