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Endocrine Dysfunction


Presentation

  • SUMMARY: ICI use is associated with serious endocrinopathies that may have a nonspecific initial presentation.[ncbi.nlm.nih.gov]
  • Spontaneous recovery of neuro-endocrine alterations most likely presents an adaption to or dysfunction after severe illness.[ncbi.nlm.nih.gov]
  • The present report presents the cases of two female infants with PHACE syndrome, both of whom had additional congenital defects of subependymal gray matter heterotopia, craniofacial arterial anomalies, and pituitary dysfunction.[ncbi.nlm.nih.gov]
  • Serum folate and sedimentation rate may be useful screening tests for Crohn's disease in a child presenting with failure of growth.[ncbi.nlm.nih.gov]
  • We present a case of a myelolipoma in conjunction with congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency.[ncbi.nlm.nih.gov]
Galactorrhea
  • A 40-year-old Japanese woman with amenorrhea and galactorrhea for the last 2 years was referred to our department of neurosurgery for the evaluation of high prolactin levels and a tumor in the sella turcica.[ncbi.nlm.nih.gov]
  • Plasmapheresis was associated with the appearance of amenorrhea and galactorrhea; also hypertension and proliferative retinopathy developed during this therapy.[ncbi.nlm.nih.gov]
Coarctation of the Aorta
  • Abstract PHACE is an acronym to describe the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta, cardiac defects, and eye abnormalities. More than 200 cases have been reported.[ncbi.nlm.nih.gov]
Chronic Abscess
  • A chronic abscess state may be the most important factor associated with permanent hormone deficiency.[ncbi.nlm.nih.gov]

Workup

  • Abstract Evaluation for endocrine function is a pivotal part of the male infertility workup. Endocrine dysfunction may result from endogenous and exogenous sources.[ncbi.nlm.nih.gov]
  • Imaging in Endocrine Disorders is a must read and valuable reference for all professionals dealing with endocrine disorders, including internists and general practitioners who must manage the essential diagnostic workup.[karger.com]
  • Addisons disease -hypoglycemia -hypotension -dehydration -electrolyte imbalance -hyperpigmentation of skin (JFK) -sparce body hair in women -lifelong replacement therapy -steroids -DHEA for women Endocrine disorders and PT implications -refer medical workup[quizlet.com]
Alpha-Galactosidase A Deficiency
  • BACKGROUND: Fabry disease (FD) is a genetic disorder caused by lysosomal alpha-galactosidase-A deficiency and is characterized by the systemic accumulation of globotriaosylceramide.[ncbi.nlm.nih.gov]

Treatment

  • A number of "novel" adipokines and metabolic factors have been recently identified which may play a role both in the pathogenesis and the treatment of women with PCOS.[ncbi.nlm.nih.gov]
  • Although gonadal failure was likely related to intensive myeloablative treatments, thyroid, adrenal, and IGF-I impairments were late events, suggesting that immunosuppressive treatment and immune system derangement may play a role in the development of[ncbi.nlm.nih.gov]
  • Moreover, such endocrine manifestations may be the major feature at presentation, the treatment of which may significantly influence the subsequent clinical outcome.[ncbi.nlm.nih.gov]
  • It is important that those involved in leprosy management be aware of the potential endocrine changes and their treatment to address the disease in all of its aspects.[ncbi.nlm.nih.gov]
  • Those with normal growth but determined to be GH-deficient by a glucagon stimulation test will be randomized to treatment with GH vs control (no intervention; observation only).[clinicaltrials.gov]

Prognosis

  • Long-term cardiac prognosis and risk stratification in 260 adults presenting with mitochondrial diseases . Eur. Heart J. 36 , 2886–2860 (2015). 49. Ghosh, S. et al .[nature.com]

Etiology

  • A systematic multidisciplinary, multidimensional assessment of 256 impotent men showed clearly an organic etiology in 35.9 per cent, psychogenic in 38.3 per cent and mixed or uncertain in 25.8 per cent.[ncbi.nlm.nih.gov]
  • Longitudinal studies are needed to better understand the etiology and true prevalence of these disorders. 2015 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]
  • Twelve patients had morning cortisol Our data, when subdivided based on the etiology of cirrhosis, showed interesting findings. Cirrhosis patients with postviral etiology showed low IGF-1 and testosterone when compared with postalcoholic etiology.[jfmpc.com]
  • etiology is essential for the initial management and also helps in long-term prognostication of the patients.[annalsofian.org]
  • ACTH-secreting tumor -iatrogenic long term steroid therapy Cushing syndrome manifestations -musculoskeletal, integumentary, inflammatory/immune, fluid & electrolyte, metabolic, psychologic disturbances -moon face -buffalo hump -increased facial hair in women Etiologies[quizlet.com]

Epidemiology

  • Spanier , BWM , Dijkgraaf , MGW & Bruno , MJ ( 2008 ) Epidemiology, aetiology and outcome of acute and chronic pancreatitis: an update . Best Pract Res Clin Gastroenterol 22 , 45 – 63 . 8.[cambridge.org]
  • Handel AC, Miot LD2, Miot HA2 (2014) Melasma: a clinical and epidemiological review. An Bras Dermatol 89: 771-782. Martin AG, Leal-Khouri S (1992) Physiologic skin changes associated with pregnancy. Int J Dermatol 31: 375-378.[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • Diabetes in pediatric patients with Kearns-Sayre syndrome: clinical presentation of 2 cases and a review of pathophysiology . Can. J. Diabetes 38 , 225–228 (2014). 41. Yatsuga, S. et al .[nature.com]

Prevention

  • A constant eye for these symptoms and a systematic approach to diagnosis are essential for prompt initiation of therapy and prevention of significant complications.[ncbi.nlm.nih.gov]
  • Replacement of thyroid hormone prevents growth problems and mental handicap. Replacement of adrenal gland hormones can prevent serious health problems, such as shock or sudden unexpected death.[perinatalservicesbc.ca]
  • Osteoporosis can be largely prevented. Even established osteoporosis can now be treated.[endo.wustl.edu]
  • He discusses how psychological and economic factors affect stress and describes how stress can be prevented by eating a healthy diet, being physically active and having a stable sleep-wake cycle.[blogs.biomedcentral.com]
  • American Diabetes Month Diabetes Can Affect Your Oral Health Diabetes Can be Identified in Dental Office Diabetes: What You Need to Know Glucose, Diabetes and Oral Health Good Oral Hygiene Essential for Diabetics Diabetes Prevent Diabetes Problems, Keep[colgate.com]

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