Three out of 4 cases with positive receptor contnet, including the present case, responded to orchiectomy. [ncbi.nlm.nih.gov]

• Fatigue

  […] receiving FASLODEX plus abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions ( 20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue [faslodexhcp.com]

  These drugs can cause symptoms such as hot flashes, fatigue, and joint pain. On occasion, your physician can change your medication to find one that is better tolerated or work with you on strategies to manage your symptoms. [roswellpark.org]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  Fatigue A common problem in women with cancer is fatigue or a lack of energy. Many things can cause fatigue. These include anemia, depression, pain, poor nutrition, medicines, and not enough sleep. [urmc.rochester.edu]

• Noncompliance

  Furthermore, side effects and noncompliance pose another issue in achieving an optimal treatment benefit. [ncbi.nlm.nih.gov]

  A study on endocrine therapy use in elderly breast cancer patients showed noncompliance with time from diagnosis [81]. [hindawi.com]

• Nausea

  […] abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions ( 20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue, neutropenia, nausea [faslodexhcp.com]

  Tamoxifen-related adverse effects included hot flushes, skin rash, vaginal discharge, indigestion, breast pain, sleepiness, headache, vertigo, itching, hair loss, cystitis, acute thrombophlebitis, nausea, and indigestion. [cochrane.org]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  However, common side effects in this category of medications include tiredness, breast tenderness, nausea, loss of sex drive, and impotence. [oncolink.org]

• Abdominal Pain

  pain, anemia, leukopenia, decreased appetite, vomiting, and headache Indications for FASLODEX FASLODEX is an estrogen receptor antagonist indicated for the treatment of: Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)- [faslodexhcp.com]

• Dysuria

  During treatment of the above symptoms, macrohematuria, dysuria and pollakiuria occurred. Pathological examination of a transrectal needle biopsy disclosed moderately differentiated adenocarcinoma of the prostate. [ncbi.nlm.nih.gov]

• Multiple Pulmonary Nodules

  A computed tomography (CT) scan showed multiple pulmonary nodules (maximum size 48 mm) and a solitary intra-peritoneal nodule. The lung nodules were diagnosed as BML following a CT-guided needle biopsy. [ncbi.nlm.nih.gov]

• Erythrocytosis

  We recommend against starting testosterone therapy in patients with breast or prostate cancer, a palpable prostate nodule or induration or prostate-specific antigen greater than 3 ng/ml without further urological evaluation, erythrocytosis (hematocrit [ncbi.nlm.nih.gov]

Additionally, current concepts regarding the development of treatment resistance and the treatment strategies for overcoming resistance are discussed. [ncbi.nlm.nih.gov]

Multivariate analysis also showed that responding to treatment (HR 4.329, p 0.006) and low NLR (HR 3.930, p 0.008) were independent factors associated with a favorable prognosis. [ncbi.nlm.nih.gov]

[…] in the use of adjuvant endocrine therapy (AET) by race and geography, this research examined their influence on initiation and adherence to AET in female Medicare enrollees with breast cancer, diagnosed between 2007 and 2011.Using SEER (Surveillance, Epidemiology [ncbi.nlm.nih.gov]

Newman LA (2009) Epidemiology of locally advanced breast cancer Semin Radiat Oncol 19(4) 195–203 DOI: 10.1016/j.semradonc.2009.05.003 PMID: 19732683 3. [ecancer.org]

Results from a previous Surveillance, Epidemiology, and End Results (SEER) registry data analysis assessing probabilities of death from breast cancer in the presence of competing risks showed patients with metastatic disease aged 70 years or older died [hindawi.com]

[…] oncology2, Ruth E Farmer, research fellow1, Helen Strongman, research fellow1, Sara Thomas, professor1, Alexander R Lyon, clinical senior lecturer3 4, Liam Smeeth, professor1, Krishnan Bhaskaran, associate professor1 1Department of Non-Communicable Diseases Epidemiology [bmj.com]

Pathophysiology, risk factors and management of bisphosphonate-associated osteonecrosis of the jaw: is there a diverse relationship of amino- and non-aminobisphosphonates? Crit Rev Oncol Hematol 2007 ;64: 198 - 207 48. [nejm.org]

Additionally, the extended use of AIs after 5 years of tamoxifen, also proved to be efficacious in preventing late distant relapses. [ncbi.nlm.nih.gov]

A substantial portion of the benefit for extended adjuvant AI therapy was derived from prevention of second breast cancers. [jhu.pure.elsevier.com]

According to Cristofanilli, endocrine therapy is the most important therapy that is used in adjuvant prevention and management of metastatic breast cancer. [onclive.com]