Three out of 4 cases with positive receptor contnet, including the present case, responded to orchiectomy. [ncbi.nlm.nih.gov]

Presented June 5, 2016. 2. [ascopost.com]

• Fatigue

  […] receiving FASLODEX plus abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue [faslodexhcp.com]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  Fatigue A common problem in women with cancer is fatigue or a lack of energy. Many things can cause fatigue. These include anemia, depression, pain, poor nutrition, medicines, and not enough sleep. [urmc.rochester.edu]

  Other problems for women may include: Vaginal dryness or itching Irregular periods Headache Nausea and vomiting Skin rash Fatigue Water retention and weight gain The side effects may be similar to menopause, but tamoxifen doesn’t trigger menopause. [webmd.com]

  These drugs can cause symptoms such as hot flashes, fatigue, and joint pain. On occasion, your physician can change your medication to find one that is better tolerated or work with you on strategies to manage your symptoms. [roswellpark.org]

• Nausea

  […] abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue, neutropenia, nausea [faslodexhcp.com]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  However, common side effects in this category of medications include tiredness, breast tenderness, nausea, loss of sex drive, and impotence. [oncolink.org]

  For men, tamoxifen can cause: Headache Nausea and vomiting Skin rash Sexual side effects like erectile dysfunction or a lower sex drive Are There Risks to Taking Tamoxifen? Yes. The risks include: Fertility. [webmd.com]

  Tamoxifen-related adverse effects included hot flushes, skin rash, vaginal discharge, indigestion, breast pain, sleepiness, headache, vertigo, itching, hair loss, cystitis, acute thrombophlebitis, nausea, and indigestion. [cochrane.org]

• Abdominal Pain

  nausea, bone pain, arthralgia, headache, back pain, fatigue, pain in extremity, hot flash, myalgia, vomiting, anorexia, diarrhea, asthenia, musculoskeletal pain, cough, dyspnea, and constipation Increased hepatic enzymes (ALT, AST, ALP) occurred in [faslodexhcp.com]

These studies provide a solid evidence base to aim for 10 years of treatment. The only study to date that explored longer durations of treatment was the MA.17R trial,3 in which 70% patients received treatment beyond 10 years of therapy. [ascopubs.org]

Hormone therapy is also a treatment option for ER-positive breast cancer that has come back in the breast, chest wall, or nearby lymph nodes after treatment (also called a locoregional recurrence). [cancer.gov]

These patients were divided into two groups: those whose first treatment after ABC diagnosis was ET and those whose first treatment included CT. [frontiersin.org]

But the muscle and joint pain has led some women to stop treatment. If this happens, most doctors recommend using tamoxifen to complete 5 to 10 years of hormone treatment. [cancer.org]

Additionally, current concepts regarding the development of treatment resistance and the treatment strategies for overcoming resistance are discussed. [ncbi.nlm.nih.gov]

Multivariate analysis also showed that responding to treatment (HR=4.329, p=0.006) and low NLR (HR=3.930, p=0.008) were independent factors associated with a favorable prognosis. [ncbi.nlm.nih.gov]

Even for women with the best prognosis, the risks were appreciable. [nejm.org]

[…] in the use of adjuvant endocrine therapy (AET) by race and geography, this research examined their influence on initiation and adherence to AET in female Medicare enrollees with breast cancer, diagnosed between 2007 and 2011.Using SEER (Surveillance, Epidemiology [ncbi.nlm.nih.gov]

The nation-wide epidemiological study is an effective way to gain a better understanding of the treatment pattern of HR+ ABC patients. [frontiersin.org]

Newman LA (2009) Epidemiology of locally advanced breast cancer Semin Radiat Oncol 19 (4) 195–203 DOI: 10.1016/j.semradonc.2009.05.003 PMID: 19732683 3. [ecancer.org]

Senkus E, Kyriakides S, Ohno S, et al Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up incidence and epidemiology.  2015;26 Suppl 5:v8-30. doi:10.1093/annonc/mdv298 28. [jamanetwork.com]

Pathophysiology, risk factors and management of bisphosphonate-associated osteonecrosis of the jaw: is there a diverse relationship of amino- and non-aminobisphosphonates? Crit Rev Oncol Hematol 2007 ;64: 198 - 207 48. [nejm.org]

Additionally, the extended use of AIs after 5 years of tamoxifen, also proved to be efficacious in preventing late distant relapses. [ncbi.nlm.nih.gov]

Can hormone therapy be used to prevent breast cancer? Yes. [cancer.gov]

A substantial portion of the benefit for extended adjuvant AI therapy was derived from prevention of second breast cancers. [jhu.pure.elsevier.com]

As such, the recommendations on extended adjuvant AI therapy are based on benefits that include prevention of distant recurrence and prevention of second breast cancers. Literature review and analysis. [ascopubs.org]

According to Cristofanilli, endocrine therapy is the most important therapy that is used in adjuvant prevention and management of metastatic breast cancer. [onclive.com]