Three out of 4 cases with positive receptor contnet, including the present case, responded to orchiectomy. [ncbi.nlm.nih.gov]

Presented June 5, 2016. 2. [ascopost.com]

• Fatigue

  […] receiving FASLODEX plus abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue [faslodexhcp.com]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  Fatigue A common problem in women with cancer is fatigue or a lack of energy. Many things can cause fatigue. These include anemia, depression, pain, poor nutrition, medicines, and not enough sleep. [urmc.rochester.edu]

  Other problems for women may include: Vaginal dryness or itching Irregular periods Headache Nausea and vomiting Skin rash Fatigue Water retention and weight gain The side effects may be similar to menopause, but tamoxifen doesn’t trigger menopause. [webmd.com]

  These drugs can cause symptoms such as hot flashes, fatigue, and joint pain. On occasion, your physician can change your medication to find one that is better tolerated or work with you on strategies to manage your symptoms. [roswellpark.org]

• Painful Cough

  nausea, bone pain, arthralgia, headache, back pain, fatigue, pain in extremity, hot flash, myalgia, vomiting, anorexia, diarrhea, asthenia, musculoskeletal pain, cough, dyspnea, and constipation Increased hepatic enzymes (ALT, AST, ALP) occurred in [faslodexhcp.com]

• Nausea

  […] abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue, neutropenia, nausea [faslodexhcp.com]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  However, common side effects in this category of medications include tiredness, breast tenderness, nausea, loss of sex drive, and impotence. [oncolink.org]

  For men, tamoxifen can cause: Headache Nausea and vomiting Skin rash Sexual side effects like erectile dysfunction or a lower sex drive Are There Risks to Taking Tamoxifen? Yes. The risks include: Fertility. [webmd.com]

  Tamoxifen-related adverse effects included hot flushes, skin rash, vaginal discharge, indigestion, breast pain, sleepiness, headache, vertigo, itching, hair loss, cystitis, acute thrombophlebitis, nausea, and indigestion. [cochrane.org]

• Abdominal Pain

  nausea, bone pain, arthralgia, headache, back pain, fatigue, pain in extremity, hot flash, myalgia, vomiting, anorexia, diarrhea, asthenia, musculoskeletal pain, cough, dyspnea, and constipation Increased hepatic enzymes (ALT, AST, ALP) occurred in [faslodexhcp.com]

• Multiple Pulmonary Nodules

  A computed tomography (CT) scan showed multiple pulmonary nodules (maximum size 48 mm) and a solitary intra-peritoneal nodule. The lung nodules were diagnosed as BML following a CT-guided needle biopsy. [ncbi.nlm.nih.gov]

• Torsades De Pointes

  QT-interval prolongation was also observed in patients in the placebo group who received tamoxifen.17 No instances of symptomatic arrhythmias or torsades de pointes have been observed in this trial. [nejm.org]

Additionally, current concepts regarding the development of treatment resistance and the treatment strategies for overcoming resistance are discussed. [ncbi.nlm.nih.gov]

Multivariate analysis also showed that responding to treatment (HR=4.329, p=0.006) and low NLR (HR=3.930, p=0.008) were independent factors associated with a favorable prognosis. [ncbi.nlm.nih.gov]

[…] in the use of adjuvant endocrine therapy (AET) by race and geography, this research examined their influence on initiation and adherence to AET in female Medicare enrollees with breast cancer, diagnosed between 2007 and 2011.Using SEER (Surveillance, Epidemiology [ncbi.nlm.nih.gov]

Newman LA (2009) Epidemiology of locally advanced breast cancer Semin Radiat Oncol 19 (4) 195–203 DOI: 10.1016/j.semradonc.2009.05.003 PMID: 19732683 3. [ecancer.org]

Results from a previous Surveillance, Epidemiology, and End Results (SEER) registry data analysis assessing probabilities of death from breast cancer in the presence of competing risks showed patients with metastatic disease aged 70 years or older died [hindawi.com]

University, Montreal, QC, Canada 2 Department of Surgery, McGill University, Montreal, QC, Canada 3 Department of Oncology, McGill University, Montreal, QC, Canada 4 Breast Clinic, McGill University Health Centre, Montreal, QC, Canada 5 Department of Epidemiology [researchprotocols.org]

Pathophysiology, risk factors and management of bisphosphonate-associated osteonecrosis of the jaw: is there a diverse relationship of amino- and non-aminobisphosphonates? Crit Rev Oncol Hematol 2007 ;64: 198 - 207 48. [nejm.org]

Additionally, the extended use of AIs after 5 years of tamoxifen, also proved to be efficacious in preventing late distant relapses. [ncbi.nlm.nih.gov]

A substantial portion of the benefit for extended adjuvant AI therapy was derived from prevention of second breast cancers. [jhu.pure.elsevier.com]

According to Cristofanilli, endocrine therapy is the most important therapy that is used in adjuvant prevention and management of metastatic breast cancer. [onclive.com]

It may also be used to prevent cancer from returning after surgery or radiation (adjuvant therapy). In some women who have a high risk of getting breast cancer, hormonal therapy is used to prevent cancer from developing. [urmc.rochester.edu]

Can Other Drugs Prevent Breast Cancer? Another drug, raloxifene (Evista), which prevents the bone-thinning disease osteoporosis, is similar to tamoxifen. [webmd.com]