Three out of 4 cases with positive receptor contnet, including the present case, responded to orchiectomy. [ncbi.nlm.nih.gov]

presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in 2013, support the use of 10 rather than 5 years of treatment. [hematologyandoncology.net]

• Fatigue

  […] receiving FASLODEX plus abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue [faslodexhcp.com]

  Other problems for women may include: Vaginal dryness or itching Irregular periods Headache Nausea and vomiting Skin rash Fatigue Water retention and weight gain The side effects may be similar to menopause, but tamoxifen doesn’t trigger menopause. [webmd.com]

  Fatigue A common problem in women with cancer is fatigue or a lack of energy. Many things can cause fatigue. These include anemia, depression, pain, poor nutrition, medicines, and not enough sleep. [urmc.rochester.edu]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

• Surgical Procedure

  The Latest Procedures and Treatments We have pioneered surgical techniques and procedures that improved the lives of our patients. [pennmedicine.org]

• Nausea

  However, common side effects in this category of medications include tiredness, breast tenderness, nausea, loss of sex drive, and impotence. [oncolink.org]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  […] abemaciclib were neutropenia, diarrhea, leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue, neutropenia, nausea [faslodexhcp.com]

  For men, tamoxifen can cause: Headache Nausea and vomiting Skin rash Sexual side effects like erectile dysfunction or a lower sex drive Are There Risks to Taking Tamoxifen? Yes. The risks include: Fertility. [webmd.com]

  Tamoxifen-related adverse effects included hot flushes, skin rash, vaginal discharge, indigestion, breast pain, sleepiness, headache, vertigo, itching, hair loss, cystitis, acute thrombophlebitis, nausea, and indigestion. [cochrane.org]

• Diarrhea

  leukopenia, anemia, and infections The most common adverse reactions (≥20%) of any grade reported in patients receiving FASLODEX 500 mg plus abemaciclib 150 mg twice daily were diarrhea, fatigue, neutropenia, nausea, infections, abdominal pain, anemia [faslodexhcp.com]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  Diarrhea Diarrhea is a less common side effect of hormone therapy. Dietary measures can help ease symptoms. Measures include eating a bland diet and staying away from foods such as dairy products and spicy foods. [urmc.rochester.edu]

• Vomiting

  […] estradiol levels Adverse Reactions The most common adverse reactions occurring in ≥5% of patients receiving FASLODEX 500 mg were injection site pain, nausea, bone pain, arthralgia, headache, back pain, fatigue, pain in extremity, hot flash, myalgia, vomiting [faslodexhcp.com]

  For men, tamoxifen can cause: Headache Nausea and vomiting Skin rash Sexual side effects like erectile dysfunction or a lower sex drive Are There Risks to Taking Tamoxifen? Yes. The risks include: Fertility. [webmd.com]

  Frequently reported adverse events in the dovitinib (diarrhea, nausea, vomiting, asthenia, and headache) and placebo (diarrhea, fatigue, nausea, and asthenia) arms were mostly low grade. [ncbi.nlm.nih.gov]

  […] risk of blood clots, especially in the lungs and legs stroke cataracts endometrial cancer and uterine sarcoma bone loss in premenopausal women, but no increased risk of fracture mood swings, depression, and loss of libido in men: headaches, nausea, vomiting [cancer.gov]

  Your healthcare provider may advise antinausea or antianxiety medicines that prevent or treat nausea or vomiting. If you get dehydrated, you may need IV fluids. Diarrhea Diarrhea is a less common side effect of hormone therapy. [urmc.rochester.edu]

• Abdominal Pain

  nausea, bone pain, arthralgia, headache, back pain, fatigue, pain in extremity, hot flash, myalgia, vomiting, anorexia, diarrhea, asthenia, musculoskeletal pain, cough, dyspnea, and constipation Increased hepatic enzymes (ALT, AST, ALP) occurred in [faslodexhcp.com]

• Osteoporosis

  Bone modifying agents such as bisphosphonates were initially used to reduce osteoporosis and fractures in AI-treated patients and patients with bone metastases. [endocrinology.org]

  As preventive agents, raloxifene and tamoxifene are equivalent, while raloxifene has more potent antiresorptive effects in postmenopausal osteoporosis. [ncbi.nlm.nih.gov]

  In addition, your healthcare provider may recommend taking steps to decrease the risk or severity of osteoporosis. [oncolink.org]

  Osteoporosis Osteoporosis is a disorder in which bones become porous and break more easily. Women who have gone through menopause have a higher risk for bone loss. [urmc.rochester.edu]

  However, bone-related adverse effects (i.e., osteoporosis, fracture) and a trend toward an increased risk of arterial thrombotic events were more common in the treatment groups. [uspharmacist.com]

• Irritability

  […] cancer developing in other breast tissue Slow or stop the growth of cancer that has spread Reduce the size of a tumor prior to surgery Risks Side effects of hormone therapy for breast cancer include: Hot flashes Vaginal discharge Vaginal dryness or irritation [mayoclinic.org]

  Vaginal dryness or irritation Lowered oestrogen levels cause the tissues of the vagina to become thin, dry and less elastic. The vagina becomes slightly shorter and narrower. (These changes also happen with menopause.) [breastcancerfoundation.org.nz]

Additionally, current concepts regarding the development of treatment resistance and the treatment strategies for overcoming resistance are discussed. [ncbi.nlm.nih.gov]

A need to define how to select the patients who will benefit most from these therapies, the optimal duration of treatment, the best method to evaluate the treatment response achieved, the existence of predictive factors for response, or the superiority [journals.lww.com]

The BIG 1–98 trial was the only trial that directly compared the sequential treatment of AI followed by TAM [1,540], the reverse sequence [1,548], and upfront treatment of AI [1,546] or TAM [1,548] in the four-arm option. [cco.amegroups.com]

Multivariate analysis also showed that responding to treatment (HR=4.329, p=0.006) and low NLR (HR=3.930, p=0.008) were independent factors associated with a favorable prognosis. [ncbi.nlm.nih.gov]

[…] in the use of adjuvant endocrine therapy (AET) by race and geography, this research examined their influence on initiation and adherence to AET in female Medicare enrollees with breast cancer, diagnosed between 2007 and 2011.Using SEER (Surveillance, Epidemiology [ncbi.nlm.nih.gov]

The nation-wide epidemiological study is an effective way to gain a better understanding of the treatment pattern of HR+ ABC patients. [frontiersin.org]

Newman LA (2009) Epidemiology of locally advanced breast cancer Semin Radiat Oncol 19(4) 195–203 DOI: 10.1016/j.semradonc.2009.05.003 PMID: 19732683 3. [ecancer.org]

Results from a previous Surveillance, Epidemiology, and End Results (SEER) registry data analysis assessing probabilities of death from breast cancer in the presence of competing risks showed patients with metastatic disease aged 70 years or older died [hindawi.com]

Pathophysiology, risk factors and management of bisphosphonate-associated osteonecrosis of the jaw: is there a diverse relationship of amino- and non-aminobisphosphonates? Crit Rev Oncol Hematol 2007 ;64: 198 - 207 48. [nejm.org]

Additionally, the extended use of AIs after 5 years of tamoxifen, also proved to be efficacious in preventing late distant relapses. [ncbi.nlm.nih.gov]

A substantial portion of the benefit for extended adjuvant AI therapy was derived from prevention of second breast cancers. [jhu.pure.elsevier.com]

Can Other Drugs Prevent Breast Cancer? Another drug, raloxifene (Evista), which prevents the bone-thinning disease osteoporosis, is similar to tamoxifen. [webmd.com]

It may also be used to prevent cancer from returning after surgery or radiation (adjuvant therapy). In some women who have a high risk of getting breast cancer, hormonal therapy is used to prevent cancer from developing. [urmc.rochester.edu]

Can hormone therapy be used to prevent breast cancer? Yes. [cancer.gov]