Patients suffering from endogenous depression may conceal psychiatric symptoms and may address a general physician instead of a psychiatrist with somatic complaints [1] [2] [3] like headaches, muscle aches, numbness or abdominal distress, for fear of being diagnosed with a mental illness, that would cast a stigma on them. They may also genuinely believe physical symptoms are the cause of their low mood and dysphoria, not the other way around [4] [5] [6]. Aside from the symptoms enumerated above, affected individuals exhibit anhedonia, irritability, persistent sadness or sense of worthlessness, asthenia, isolation, eating disorders leading to weight changes, lack of motivation, insomnia, and difficulty in concentrating and memorizing new information. Disinterest in sexual activities is also noticed. Patients may find it difficult to impose their opinion, express strong feelings and cope with casual activities. They are often insecure and feel helpless. Perceived quality of life decreases, for the individual and his or her caregivers. Agitation or lethargy or swings between these two states are also frequently encountered. In more advanced stages, hallucinations and suicidal ideation arise, in parallel with social isolation. Patients may also provoke self-injury. Depression may also be a symptom of other psychiatric diseases, such as schizophrenia. When associated with psychosis, depression may also signalize bipolar affective disorder, substance abuse or organic brain syndrome. The prognosis of associated illnesses is two times worse in a depressed patient.

Symptoms may vary among age groups. Even preschool children may be affected [7] [8]. Children of all ages more often present with irritability or decline in school grades or even marasmus [9], whereas elders more often have confusion and somatic signs as dominant findings.

• Fatigue

  Fatigue Depression can seriously take it out of you. “Depressed peoples’ bodies act as though they are under constant stress, which can lead to inflammation, which in turn can contribute to feelings of fatigue,” Forand says. [livestrong.com]

  The person may experience fatigue and a lack of energy, not wanting to do the things they'd normally find enjoyable. People with endogenous depression may have trouble concentrating and suffer from unpredictable mood swings. [study.com]

  The person could appear anxious, have a change in sleeping patterns, a change in eating habits, show fatigue, have low self-esteem and even sudden mood changes. [depressivedisorder.blogspot.com]

  Afflicted with ailment you have symptoms of severe fatigue, even if you do nothing. Fatigue is based on the lack of will to perform any action. The man himself (even without a good reason) is blamed for all sins, defects and defects. [scopeheal.com]

• Family History of Depression

  Thus a family history of depression and a poor marriage before the onset of depression are associated with both non-endogenous and endogenous depression but unemployment, separation for one year or more from a parent before 17 years of age, and having [ncbi.nlm.nih.gov]

  A significant association was found between positive DST results and a positive family history of depression. These results support other evidence for use of a positive DST result as an external validating criterion for ED. [deepblue.lib.umich.edu]

  Patients with endogenous depression often are more likely to have a positive family history of disorders and fewer psychosocial and environmental factors that cause their symptoms. [youtube.com]

  People who have a family history of depression and/or bad personal relationships are at risk for endogenous depression. Also, people are more likely to have a history of disorders that run in the family. [blog.cognifit.com]

• Weight Loss

  The apparently complex influence of weight loss on prolactin response to serotonergic challenge remains to be clarified as well as the role played by the bioavailability of the challenge drug and its metabolite. [ncbi.nlm.nih.gov]

  It is generally accepted that endogenous depression includes marked vegetative changes, such as loss of appetite, loss of weight, loss of sleep, psychomotor retardation or agitation, marked guilt, and loss of pleasure. [link.springer.com]

  […] of interest in daily activities; physical Sx–weight loss, insomnia, reduced libido; in ED, there may be an ↑ 'threshold' to stressful life events that requires little external input to initiate recurrence. [medical-dictionary.thefreedictionary.com]

  Psychiatrya severe form of depression usually characterized by insomnia, weight loss, and inability to experience pleasure, thought to be of internal origin and not influenced by external events. [wordreference.com]

• Crying

  Antidepressants can get an endogenous patient into a fit of rage (I destroyed my bedroom while on medication) and CBT increased the apathy/crying cycle. [wisegeek.com]

  They increasingly sleep later, have difficulty waking up, cry for unknown reasons, and complain of physical ailments like headaches. [sites.google.com]

  Depression in children can have the same effects as in adults: The child will seem sad, will cry and mope, lose his appetite and sleep badly. [psychcentral.com]

  When they confront loss, women are more reinforced for passivity and crying, while men are more reinforced for anger or indifference (Weissman and Paykel, 1974). [social-anxiety-treatment-cure.weebly.com]

• Weight Gain

  Anticholinergic effects, weight gain and orthostatic hypotension were more frequent in the clomipramine group. No biological treatment-related changes were observed. [ncbi.nlm.nih.gov]

  TCAs may cause drowsiness, dizziness, and weight gain. Carefully read the information provided by the pharmacy and speak to your doctor if you have any concerns. [healthline.com]

• Dyspnea

  […] include the following: Odynophagia, dysphagia Nausea, vomiting, abdominal pain Hematemesis, hematochezia, melena Bowel obstruction Pulmonary lesions may be an asymptomatic radiographic finding, but signs and symptoms can include the following: Cough Dyspnea [emedicine.medscape.com]

• Overeating

  The results clearly favour moclobemide over tranylcypromine for both efficacy and tolerance in the treatment of endogenous depression. [ncbi.nlm.nih.gov]

  A recent study of 120 people with atypical depression revealed that are over 75% responded to the antidepressant drug nardil (phenelzine). [sites.google.com]

• Loss of Appetite

  It is generally accepted that endogenous depression includes marked vegetative changes, such as loss of appetite, loss of weight, loss of sleep, psychomotor retardation or agitation, marked guilt, and loss of pleasure. [link.springer.com]

  Symptoms of Endogenous Depression Patients who have been diagnosed with Endogenous Depression will often have many of these symptoms: Low mood Hallucinations Loss of appetite or change in eating habits Inability to experience pleasure Insomnia or difficulty [embracingdepression.org]

  […] or staying asleep social isolation thoughts of suicide headaches muscle aches loss of appetite or overeating Your primary care provider or mental health professional can diagnose MDD. [healthline.com]

• Constipation

  In the zimeldine group, increased sweating and headache were more pronounced, while the amitriptyline patients more often reported dry mouth and constipation. Body weight was not significantly changed by either treatment. [ncbi.nlm.nih.gov]

  The most common effects are: Guilt due to an imaginary wrongdoing Constipation Severe anxiety Misery Loss of libido Insomnia Lack of drive to move Suicidal thoughts Loss of appetite Prognosis of endogenous depression Overall, the prognosis is good with [blog.cognifit.com]

• Abdominal Pain

  Lesions are often asymptomatic and clinically indolent, but signs and symptoms can include the following: Odynophagia, dysphagia Nausea, vomiting, abdominal pain Hematemesis, hematochezia, melena Bowel obstruction Pulmonary lesions may be an asymptomatic [emedicine.medscape.com]

• Low Self-Esteem

  Along with the speech and mental retardation, such people is exacerbated by a sense of guilt, of remorse in combination with low self-esteem. [healthrxmeds.com]

  Personality You may be more vulnerable to depression if you have certain personality traits, such as low self-esteem or being overly self-critical. [nhs.uk]

  Other symptoms include anxiety, hopelessness and despair, self-doubt, low self-esteem, poor concentration, loss of interest, aches and pains, and inability to sleep. It is important that the person seeks help for their depression. [irishhealth.com]

• Anhedonia

  Endogenous depression is characterized by feelings of guilt and worthlessness and anhedonia. Anhedonia is the inability to derive pleasure from once pleasurable activities such as exercise, hobbies, or sex. [7cups.com]

  The "anhedonia hypothesis" of depression from DSM-IV permits the inclusion of the non-core group of depression into major depressive disorder, because patients with the endogenous type suffer not only from a loss of pleasure but also from a loss of sadness [ncbi.nlm.nih.gov]

  Many depression patients exhibit anhedonia, for example, but many others don’t. [theatlantic.com]

• Mood Swings

  People with endogenous depression may have trouble concentrating and suffer from unpredictable mood swings. Often, they will isolate themselves and not want to spend a lot of time with family or friends. [study.com]

  Possible options for the daily mood swings, which are particularly clearly seen after the morning awakening. Slow thinking This condition is not controlled by a person, and is not dependent on its whims. [healthrxmeds.com]

  However, without an actual disease present, this neurotic thinking often results in severe anxiety, sleep disturbance, and mood swings which may hinder social relationships. [youtube.com]

  A severe head injury can trigger mood swings and emotional problems. Some people may have an underactive thyroid (hypothyroidism) resulting from problems with their immune system. [nhs.uk]

  swings which may hinder social relationships. [en.wikipedia.org]

• Psychomotor Retardation

  Keywords Psychomotor Retardation Depressive Illness Global Rating Scale Research Diagnostic Criterion Placebo Response Rate These keywords were added by machine and not by the authors. [link.springer.com]

  To obtain more reliable measures the scores for the various symptoms were added together to form a total score, which was then divided into a depression score and a retardation score, presumably measuring mainly depressive mood and psychomotor retardation [ncbi.nlm.nih.gov]

  It is often identified with a specific symptom complex—psychomotor retardation, early morning awakening, weight loss, excessive guilt, and lack of reactivity to the environment—that is roughly equivalent to the symptoms of major depressive disorder. neurotic [medical-dictionary.thefreedictionary.com]

  Psychomotor retardation in depression: Biological underpinnings, measurement, and treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 35, Issue. 2, p. 395. CrossRef Google Scholar Seongyu KO 강준 and Young-gun Ko 2012. [cambridge.org]

• Feeling of Worthlessness

  Self-destructive behavior is a manifestation of the patient's feeling of worthlessness and loss of self esteem. [medical-dictionary.thefreedictionary.com]

  […] of worthlessness Each patient will have a different set of symptoms with different severity level for each, but if an individual has had several of these symptoms for an extended period of time – usually two weeks or longer – they may be suffering from [embracingdepression.org]

  For example, a person may feel persistently sad after the death of a loved one or struggle with guilt and feelings of worthlessness after losing their job. [verywellmind.com]

  Impact on Feelings: Person starts having a feeling of worthlessness. It may show irritability with time. Intolerable mood swings with temper outburst conditions. Great decay in motivation level. Person may feel tired all the time. [std-gov.org]

• Insomnia

  Some of the typical characteristic features of depression endogenous include insomnia, sleeplessness, depleting energy levels, inability to focus or poor concentration levels, problems remembering and memorizing, and lack of interest in any form of physical [all-on-depression-help.com]

  Psychiatrya severe form of depression usually characterized by insomnia, weight loss, and inability to experience pleasure, thought to be of internal origin and not influenced by external events. [wordreference.com]

  If the patient has been suffering from depression related insomnia, the addition of antidepressants can assist them in getting a full nights rest. Further treatment often entails Cognitive Behavior Therapy. [embracingdepression.org]

  Aside from the symptoms enumerated above, affected individuals exhibit anhedonia, irritability, persistent sadness or sense of worthlessness, asthenia, isolation, eating disorders leading to weight changes, lack of motivation, insomnia, and difficulty [symptoma.com]

• Sleep Disturbance

  Overall, there was little support for the prediction of a difference in short- or long-term outcome between patients with and without EEG sleep disturbances. [ncbi.nlm.nih.gov]

  However, without an actual disease present, this neurotic thinking often results in severe anxiety, sleep disturbance, and mood swings which may hinder social relationships. [youtube.com]

  disturbance, and mood swings which may hinder social relationships. [en.wikipedia.org]

  These same people often experience sleep disturbances, which can exacerbate feelings of fatigue and grogginess. [livestrong.com]

• Apathy

  Antidepressants can get an endogenous patient into a fit of rage (I destroyed my bedroom while on medication) and CBT increased the apathy/crying cycle. [wisegeek.com]

  Aggression is easier and quicker to be observed than apathy; therefore endogenous depression is a more complicated type of depression. [treat-depression.com]

  Impact on your Thoughts: Lack of concentration Forgetfulness Inability to make spontaneous decisions Pessimistic attitude Guilt Self pity Thoughts of self destruction Impact on your Behavior: Apathy Cry often Prefer to stay away from social situations [depressivedisorder.blogspot.com]

  By underestimating their development, the person in the subconscious has ridiculous thoughts about its uselessness in this world, as well as a strong apathy, a sense of oppression and uselessness. [scopeheal.com]

• Neglect

  Therefore, the idea of Verstehen (Jaspers, K) becomes essential, but has been neglected in academic journals in English-speaking countries. [ncbi.nlm.nih.gov]

  Simple things start to require real effort or just get neglected. [dnet.org.au]

• Amnesia

  This condition is called retrograde amnesia. You may also have trouble recalling events that occurred during the weeks of your treatment. For most people, these memory problems usually improve within a couple of months after treatment ends. [mayoclinic.org]

There is no specific physical trait that helps diagnose endogenous depression aside from the fact that the physician may notice decreased hygiene, decreased movement and reactivity or agitation. However, infection, hypothyroidism, Cushing's syndrome, Addison's disease, hypopituitarism and a number of tumors and neurologic organic disorders may cause endogenous depression and must be eliminated by physical examination and laboratory workup. Blood tests should include a complete blood cell count, blood alcohol and vitamin B12 levels, toxicology screening, thyroid-stimulating hormone levels, liver, and kidney function tests. Dexamethasone suppression test and cosyntropin stimulation test can overrule Cushing's syndrome and Addison's disease.

When a neurologic substrate is suspected based on the presence of neurologic deficits, imaging modalities such as computer tomography, magnetic resonance imaging, positron emission tomography and single-photon emission computed tomography scanning may prove useful; the latter demonstrating regional perfusion deficits in affected patients [10] [11].

Several depression tests exist. Some are based on patient's understanding of depression [12], some describe and inquire about symptoms [13]. Depression scales, such as Zung self-rating depression scale, geriatric depression scale, patient health questionnaire, Beck depression inventory, center for epidemiologic studies-depression scale or Hamilton depression rating scale should be used. They are self-applied or the last one should be carried out in a clinical setting.

The rating was performed before treatment, one week after the fourth treatment (a treatment pause was then made) and one week after the completed series. [ncbi.nlm.nih.gov]

The Incidence and Prognosis of Endogenous Depression Articles Br Med J 1956 ; 1 doi: https://doi.org/10.1136/bmj.1.4980.1392 (Published 16 June 1956) Cite this as: Br Med J 1956;1:1392 Article Related content Metrics Responses Peer review This is a PDF-only [doi.org]

Endogenous Depression information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis. [omicsonline.org]

"The Incidence and Prognosis of Endogenous Depression". British Medical Journal. 1 (4980): 1392–1397. doi:10.1136/bmj.1.4980.1392. ISSN 0007-1447. PMC 1979411. PMID 13316166. ^ a b c Watts, C.A.H. (April 1968). [en.wikipedia.org]

The prognosis of associated illnesses is two times worse in a depressed patient. Symptoms may vary among age groups. Even preschool children may be affected. [symptoma.com]

The patients were referred to the three treatments at random and the groups may be regarded as having a similar prognosis (Table 2-5, 7). [ncbi.nlm.nih.gov]

The classification and diagnosis of depressive disorders are based on the symptoms, etiology and the course of the disease. Therefore we aim at a three-dimensional scheme of classification that takes into account all these variables. [ncbi.nlm.nih.gov]

However, this pluralistic understanding has been threatened by a recent diagnostic approach represented by the DSM-5, which have adopted a phenomenological understanding rather than an etiological perspective. [dbpia.co.kr]

This theory, as it was promoted at the time, not only made the distinction between endogenous and exogenous depression based on symptoms (ie, did they or did they not have vegetative symptoms of depression), but also by assumed etiology. [medscape.com]

Depression scales, such as Zung self-rating depression scale, geriatric depression scale, patient health questionnaire, Beck depression inventory, center for epidemiologic studies-depression scale or Hamilton depression rating scale should be used. [symptoma.com]

Epidemiology of classic Kaposi's sarcoma, with special reference to mediterranean population. Tumori. 1995 Sep-Oct. 81(5):308-14. [Medline]. Sarid R, Olsen SJ, Moore PS. [medscape.com]

Conclusions These data suggest clinical overlap between epidemiological variants. [infectagentscancer.biomedcentral.com]

The epidemiology of KS has changed dramatically from 1872, when it was first described as a rare disease in Eastern European men. [emedicine.medscape.com]

Journal of Clinical Epidemiology, Vol. 53, Issue. 4, p. 351. CrossRef Google Scholar 2000. Men and Depression. p. 177. CrossRef Google Scholar Zieba, Andrzej Dudek, Dominika and Jawor, Mirosława 1997. [doi.org]

[…] armed with new knowledge from various studies about dietary manipulation, blood and CSF level monitoring, and other sophisticated methodology -- that the deficit model of neurotransmitters is considerably more simplistic than whatever the reality of the pathophysiology [medscape.com]

Ultimately, biological assessments of both epidemiological variants are required to establish the precise pathophysiological mechanisms driving the distinct clinical features that have been observed. [infectagentscancer.biomedcentral.com]

The authors say 'This study investigated mitochondrial respiration in peripheral blood mononuclear cells (PBMCs), an established model to investigate the pathophysiology of depression.' which seems to me a pretty silly comment. [forums.phoenixrising.me]

Pathophysiology The discovery of Kaposi sarcoma human herpes virus (KSHV) in 1994 led to rapid progress in understanding the disease’s pathophysiology. [emedicine.medscape.com]

How does it affect our brains and what are some tips to help prevent it? In this article, you will find a full guide to everything you need to know about endogenous depression, including tips on how to prevent it. [blog.cognifit.com]

Over time, scientists have discovered that these three nutrients can prevent depression or reduce symptoms if they are taken together. Future bouts of depression may be able to be prevented by adopting a healthy lifestyle. [embracingdepression.org]

As preventative measures, pharmaceuticals such as SSRI's and antidepressants may also be utilized to avoid further development or progression to Major Depressive Disorder. [youtube.com]

If you think someone is considering suicide, get help from a crisis or suicide prevention hotline. Try the National Suicide Prevention Lifeline at 800-273-8255. [healthline.com]

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