Presentation
CONCLUSION: The present study represents the larger series of uterine carcinosarcoma studied in Portugal and reflects the clinical presentation, histopathological characteristics and stage at diagnosis and confirms the aggressiveness of this rare tumor [ncbi.nlm.nih.gov]
Whilst often presented as polar causations, in reality, the balance between the placental and maternal component is likely to vary across the spectrum of gestational age at clinical presentation. [isshp.org]
The condition appears to be present in a developing fetus, but estrogen levels during puberty are thought to trigger the symptoms. Symptoms are generally present during the reproductive years. [medicalnewstoday.com]
Establishing the source of bleeding is an essential first step when assessing women* who present with per vaginum (PV) bleeding. [bpac.org.nz]
Workup
A workup for endometrial disease may be prompted by abnormal uterine bleeding, or the presence of atypical glandular cells on a pap smear.[6] Treatment[edit] Treatment of endometrial hyperplasia is individualized, and may include hormonal therapy, such [en.wikipedia.org]
Precautions Failed medical treatment requires further workup. Consider DVT prophylaxis when treating with high-dose estrogens (2)[C]. [unboundmedicine.com]
An accurate preoperative workup (anamnesis, clinical examination, and imaging information; cystoscopy) is essential for planning a correct laparoscopic approach. [frontiersin.org]
Treatment
The SIGEED addresses all aspects of these disorders: pathogenesis (endometrial biology), epidemiology, diagnosis, medical and surgical* treatment, quality of life and social consequences of the disease, and complementary approaches to treatment. (*)endometriosis [eshre.eu]
Remember, all treatments—including medicine, surgery, other types of treatments, and even a decision to wait or not be treated—have risks and benefits. Be sure to ask your doctor about the risks and benefits of each treatment option you are offered. [archive.ahrq.gov]
For example, hormonal treatment (instead of surgical treatment) of endometrial cancer may better preserve fertility. With conservative surgical treatment, women post-endometrial cancer treatment can have problems with a thin endometrium. [verywellfamily.com]
If your BMI is over 35, it is more likely that progesterone treatment will not work well unless you also lose weight. You should discuss with your doctor which type of progesterone treatment is best for you. [verywellhealth.com]
Prognosis
Young women with endometrial carcinoma are considered to have a favorable prognosis with early stage, well differentiated lesions. In this report we present young patient with advanced stage endometrial adenocarcinoma who had poor prognosis. [atif.sobiad.com]
These are associated with either endogenous or exogenous unopposed estrogen exposure and usually consist of a low-grade or well-differentiated tumor with a favorable prognosis. [accessmedicine.mhmedical.com]
Management and prognosis of endometrioid borderline tumors of the ovary. Surg Oncol. 2012;21:178–84. 7. Bell KA, Kurman RJ. [ovarianresearch.biomedcentral.com]
Bergman L, Beelen ML, Gallee MP, Hollema H, Benraadt J, van Leeuwen FE (2000) Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. [link.springer.com]
Answer all questions, especially those related to cancer and fertility. https://www.acog.org/Patients https://www.uptodate.com (patient education) Prognosis Varies with pathophysiologic process Most anovulatory cycles can be treated with medical therapy [unboundmedicine.com]
Etiology
Differential Diagnosis See “Etiology and Pathophysiology.” [unboundmedicine.com]
Secondary amenorrhea Definition: absence of menses for more than 3 months (in women with previously regular cycles) or 6 months (in women with previously irregular cycles) Etiology Pregnancy → most common cause of secondary amenorrhea Ovarian disorders [amboss.com]
Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications. Gynecol Obstet Invest. 2008; 66: 257–267. 26. Miravet- Valenciano JA, Rincon- Bertolin A, Vilella F, Simon C. [monz.pl]
The etiology of adenomyosis is currently unknown. [nature.com]
Its etiology and pathogenesis are controversial but it is believed to involve multiple, genetic, environmental, immunological, angiogenic, endocrine, and even embryonic processes (1, 2). [frontiersin.org]
Epidemiology
The SIGEED addresses all aspects of these disorders: pathogenesis (endometrial biology), epidemiology, diagnosis, medical and surgical* treatment, quality of life and social consequences of the disease, and complementary approaches to treatment. (*)endometriosis [eshre.eu]
Uniform histopathologic and imaging criteria are needed in order to standardize the diagnosis and to have reliable epidemiological figures. Lay Summary Scientists, Drs. [endonews.com]
Epidemiology 2005;16(4):500-7. Buis CC, et al. Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis. Hum Reprod 2013;28(12):3358-69 Cottreau CM, et al. [endometriosis.org]
The association between endometriosis and gynecological cancers and breast cancer: A review of epidemiological data. Gynecologic Oncology, 123, 157-163. This content is provided by the Office on Women's Health. [womenshealth.gov]
Commonly associated with anovulation Epidemiology Adolescent and perimenopausal women are affected most often. Incidence 5% of reproductive-aged women will see a doctor in any given year for AUB. [unboundmedicine.com]
Pathophysiology
[…] maximise public and European government awareness of endometriosis and endometrial disorders Mission statement The SIGEED combines a basic and a clinical focus on research and training related to endometriosis and endometrial disorders (e.g. endometrial pathophysiology [eshre.eu]
Differential Diagnosis See “Etiology and Pathophysiology.” [unboundmedicine.com]
Burton, FMedSci Director of Centre for Trophoblast Research University of Cambridge Pre-eclampsia is a syndrome defined by unique diagnostic criteria laid down by the ISSHP, but is just one of a number of complications of pregnancy that share a common pathophysiology [isshp.org]
Role of nuclear progesterone receptor isoforms in uterine pathophysiology. Hum. Reprod. Update 21, 155–173 (2015). 29. Wu, Y., Strawn, E., Basir, Z., Halverson, G. & Guo, S.-W. [nature.com]
Prevention
Endometriosis cannot be prevented. The fact that this disorder is poorly understood is a contributing factor, though long-term treatment with birth-control hormones has often been shown to help prevent the condition from getting worse. [leading-medicine-guide.com]
(Treatment is discussed in Can endometrial cancer be prevented?) [cancer.org]
Can endometrial hyperplasia be prevented or avoided? You are more likely to have endometrial hyperplasia if you have gone through menopause. This is because your body’s hormones and menstrual cycles change. [familydoctor.org]
[…] of Endometrial Hyperplasia Although endometrial hyperplasia cannot be prevented, women should have regular pelvic examinations once they reach age 18 or become sexually active, to aid in early detection and treatment of any abnormalities. [healthcommunities.com]
Learn more from CDC’s Act Against AIDS campaign including how HIV is spread, and how to prevent HIV. [cdc.gov]