Patients present with one, or usually more of the following signs and symptoms: pelvic pain, lower abdominal and/or back pain [8], dysmenorrhea, dyspareunia, dyschezia, heavy bleeding during and between periods, irregular menstruation and urinary frequency. They may also complain of nausea, bloating and pain during or after exercise. Sometimes the presentation may appear similar to be that of a genito-reproductive tract tumor, in which case a detailed work up can help differentiate the disease from cancer.

• Pain

  However, when women do experience signs and symptoms of endometriosis they may include: Pelvic pain that may worsen during menstruation Painful intercourse Painful bowel movements or urination Infertility Pelvic pain during menstruation or ovulation can [medicinenet.com]

  Symptoms may include abdominal pain, heavy periods, and infertility. Treatment options include pain relievers, hormones, and surgery. [webmd.com]

  Infertility Miscarriage(s) Painful ovulation Uterosacral/Presacral Nerve Endometriosis Backache Leg pain Painful Intercourse Cul-de-sac ("Pouch of Douglas") Endometriosis Dyspareunia (pain during intercourse) Gastrointestinal symptoms Pain after intercourse [endo-resolved.com]

  […] lower back pains linked to the pelvis chronic pelvic pain – typically accompanied by lower back pain or abdominal pain dyspareunia – painful sexual intercourse dysuria – urinary urgency, frequency, and sometimes painful voiding [14] mittelschmerz – pain [en.wikipedia.org]

• Infertility

  Endometriosis is more common in women who are experiencing infertility than in fertile women, but the condition does not necessarily cause infertility. Most women with endometriosis have no symptoms. [medicinenet.com]

  Symptoms may include abdominal pain, heavy periods, and infertility. Treatment options include pain relievers, hormones, and surgery. [webmd.com]

  General Inflammation The possible role of general body inflammation and infertility is the subject of ongoing research. Increased inflammation in the body does seem to be correlated with infertility. [verywell.com]

  Treatments for endometriosis, as medical treatment, non-pharmacological treatment as well as surgery, are discussed for both relief of painful symptoms and for infertility due to endometriosis. [eshre.eu]

• Fatigue

  Fatigue Fatigue and Endometriosis seem to go hand in hand. No-one knows what causes the acute fatigue that women suffer, and is not often recognized as a symptom. [endo-resolved.com]

  It may also lead to infertility, fatigue and bowel and bladder problems. Around 1.5 million women in the UK are currently living with the condition. Endometriosis can affect all women and girls of a childbearing age, regardless of race or ethnicity. [endometriosis-uk.org]

  These include allergies, asthma, and some chemical sensitivities, some autoimmune diseases, chronic fatigue syndrome, and ovarian and breast cancer. [medicalnewstoday.com]

  Commonly they include painful, heavy or irregular periods, pain during or after sex, infertility, painful or bloody bowel movements, pelvic pain, and fatigue. [endometriosisnews.com]

• Inguinal Pain

  Such symptoms may include the following: Dysmenorrhea Heavy or irregular bleeding Pelvic pain Lower abdominal or back pain [2] Dyspareunia Dyschezia (pain on defecation) often with cycles of diarrhea and constipation Bloating, nausea, and vomiting Inguinal [emedicine.medscape.com]

  […] or back pain [2] Dyspareunia Dyschezia (pain on defecation) - Often with cycles of diarrhea and constipation Bloating, nausea, and vomiting Inguinal pain Pain on micturition and/or urinary frequency Pain during exercise Patients with endometriosis do [emedicine.com]

• Perineal Pain

  Pelvic and perineal pain Micrograph showing endometriosis (H&E stain), a common cause of chronic pelvic pain in women. Pelvic pain is pain in the area of the pelvis. Acute pain is more common than chronic pain. [en.wikipedia.org]

• Abdominal Pain

  Symptoms may include abdominal pain, heavy periods, and infertility. Treatment options include pain relievers, hormones, and surgery. [webmd.com]

  This was associated with cyclical lower abdominal pains, abdominal swelling, and weight loss. Examination revealed hyperactive bowel sounds with scant fecal matter on rectal examination. [ncbi.nlm.nih.gov]

  Symptoms of Endometriosis Endometriosis Symptoms Pain, including pelvic or lower abdominal pain and pain with menses, is the most common symptom of endometriosis. Women may also have pain with intercourse. [obgyn.ucla.edu]

• Constipation

  This case report is that of a 42-year-old female who presented with a 6-month history of change in bowel habits in favor of increasing constipation. This was associated with cyclical lower abdominal pains, abdominal swelling, and weight loss. [ncbi.nlm.nih.gov]

  […] during periods: severe menstrual cramping, lower back or abdominal pain, painful bowel movements or painful urination Pain during or after sex Excessive bleeding: heavy periods or bleeding or spotting between periods Gastrointestinal symptoms: diarrhea, constipation [health.ucsd.edu]

  The main Gastro-intestinal signs are: Nausea Diarrhoea Blood in stool Bloating Vomiting Rectal pain Rectal bleeding Tailbone pain Abdominal cramping Constipation Sharp gas pains Painful bowel movements For more information on Intestinal endometriosis [endo-resolved.com]

• Nausea

  […] menstrual cramping, lower back or abdominal pain, painful bowel movements or painful urination Pain during or after sex Excessive bleeding: heavy periods or bleeding or spotting between periods Gastrointestinal symptoms: diarrhea, constipation, bloating, or nausea [health.ucsd.edu]

  They may also complain of nausea, bloating and pain during or after exercise. [symptoma.com]

  Clinical case: A 28-year-old female patient with abdominal pain in the right iliac fossa and pelvic cavity, fever and nausea, exploratory laparotomy is performed with the discovery of sigmoid perforation of the colon, requiring resection of the lesion [medigraphic.com]

  Common symptoms may include: Pelvic pain and cramping before and during periods Lower back and stomach pain during periods Excessive bleeding during periods Pelvic pain during intercourse Fatigue Diarrhea Constipation Nausea Infertility These symptoms [ucsfhealth.org]

  The symptoms of endometriosis include: painful periods pain with sex pelvic pain ovulation pain pain in the lower back and thighs bowel symptoms – pain using your bowel bladder symptoms – pain when passing urine reduced fertility nausea and lethargy premenstrual [betterhealth.vic.gov.au]

• Dyschezia

  Even the common mild forms of endometriosis can strongly affect quality of life due to dysmenorrhea, dyspareunia, dyschezia, or subfertility. [ncbi.nlm.nih.gov]

• Pelvic Mass

  Following removal of the pelvic masses with laparotomy, the histological exam revealed an endometriosis. [ncbi.nlm.nih.gov]

  A fetal pelvic mass was diagnosed at 35 weeks’ gestation and removed on day of life 2, revealing endometriosis. [fertstertdialog.com]

  […] et al. (1991) 201 Various No (stage: frequency of pain symptoms) Marana et al. (1991) 206 Infertility, pain, pelvic mass No (stage, type and site of lesions: severity of pain) Ripps and Martin (1991) 59 Infertility, pain, pelvic mass Yes (deep lesions [dx.doi.org]

• Back Pain

  Therefore symptoms of endometriosis include severe reoccurring pain in the pelvic area as well as lower back and abdominal pain. [ncbi.nlm.nih.gov]

• Low Back Pain

  It can cause dyspareunia, dysmenorrhea, low back pain and infertility. A definitive diagnosis can be made only by means of laparoscopy. [ncbi.nlm.nih.gov]

  […] menstrual bleeding, infertility, abdominal bloating, diarrhea or constipation, low back pain, and/or fatigue. [medicine.umich.edu]

  Pain with bowel movements. Long-term pelvic or low back pain that may occur at any time and last for 6 months or more. [nlm.nih.gov]

• Leg Pain

  Ultimately, once diagnosed with endometriosis of the retroperitoneal spinal and neural elements, her back and leg pain responded completely to hormonal therapy and then to a hysterectomy and a bilateral salpingo-oophorectomy. [ncbi.nlm.nih.gov]

  ' or bleeding between periods Symptoms of irritable bowel (diarrhoea, constipation, bloating - particularly during your period) Back pain Pain during or after sex Irregular periods Pain when passing urine Leg pain Pelvic pain Loss of 'old' or 'dark blood [endometriosis-uk.org]

  Subfertility/infertility, excruciating pain during sexual intercourse, silent kidney loss, searing lower back, hip and leg pain, and severe bowel and bladder dysfunction are among other symptoms experienced by women with endometriosis. [nezhat.org]

  Lower back pain or leg pain, especially around the time of menses. Fatigue Infertility Testing Endometriosis can only be diagnosed through laparoscopy and confirmation of the disease can be achieved through pathological biopsy. [resolve.org]

• Pelvic-Girdle Pain

  Susannah provides assessment and treatment for pelvic pain conditions such as pelvic floor dysfunction, pelvic girdle pain, vulvar and vaginal pain, bladder and bowel dysfunction, and chronic pelvic pain and endometriosis. [bcwomens.ca]

  (also known as visceral pain) pelvic girdle pain (SPD or DSP) Pudendal nerve entrapment Gynecologic Dysmenorrhea—pain during the menstrual period Endometriosis—pain caused by uterine tissue that is outside the uterus. [en.wikipedia.org]

• Pelvic Pain

  However, when women do experience signs and symptoms of endometriosis they may include: Pelvic pain that may worsen during menstruation Painful intercourse Painful bowel movements or urination Infertility Pelvic pain during menstruation or ovulation can [medicinenet.com]

  Susannah provides assessment and treatment for pelvic pain conditions such as pelvic floor dysfunction, pelvic girdle pain, vulvar and vaginal pain, bladder and bowel dysfunction, and chronic pelvic pain and endometriosis. [bcwomens.ca]

  […] because it is a common cause of pain and dysmenorrhoea, affecting 45–70% of those with chronic pelvic pain ( Propst and Laufer, 1999 ). [humrep.oxfordjournals.org]

  A 32-year-old woman consulted for an evaluation of pelvic pain following intrauterine insemination (IUI). [ncbi.nlm.nih.gov]

• Dysmenorrhea

  Even the common mild forms of endometriosis can strongly affect quality of life due to dysmenorrhea, dyspareunia, dyschezia, or subfertility. [ncbi.nlm.nih.gov]

  Decreasing dyspareunia and dysmenorrhea in women with endometriosis via a manual physical therapy: Results from two independent studies Journal of Endometriosis 2011; 3(4): 188 - 196 Article Type: ORIGINAL ARTICLE DOI:10.5301/JE.2012.9088 Authors Belinda [web.archive.org]

• Dyspareunia

  […] on the Mankoski Pain Scale for analyzing the effect on dysmenorrhea and dyspareunia (n=18), respectively. [web.archive.org]

  Even the common mild forms of endometriosis can strongly affect quality of life due to dysmenorrhea, dyspareunia, dyschezia, or subfertility. [ncbi.nlm.nih.gov]

  Assessment of deep dyspareunia was not available or not reliable in 309 cases. [dx.doi.org]

  Dyspareunia (painful sexual intercourse) Dyspareunia is a common problem with this disease. Pain may be felt during intercourse as well as up to 48 hours after sexual activity. [endo-resolved.com]

• Adnexal Mass

  A set of 38 patients with surgically evaluated adnexal masses, but no hydrosalpinx, were randomly chosen as control subjects. [dx.doi.org]

  Oral CHM may have a better overall treatment effect than danazol; it may be more effective in relieving dysmenorrhoea and shrinking adnexal masses when used in conjunction with a CHM enema. [ncbi.nlm.nih.gov]

• Dysuria

  Bladder involvement, causing dysuria and hematuria, occurs in a very small number of endometriosis patients. The patient presented at age 12 years with dysuria and pelvic pain. Laparoscopy revealed stage I endometriosis. [ncbi.nlm.nih.gov]

  Symptoms can include severe pain, dysmenorrhea, dyspareunia, dysuria, infertility, and fatigue. The pathogenesis is unclear. Hormonal therapy controls symptoms in some women; others require surgery, which may not be effective. [nejm.org]

Work up includes a detailed history, physical examination and tests.

Laboratory tests

• Complete blood count
• Urinalysis
• Blood cultures (to rule out STDs)
• Serum cancer antigen test (Ca-125)
• Antibody testing against Thomsen-Friedenreich (T) antigen (Gal beta1-3GalNAc) bearing proteins

Imaging 

The following imaging studies may be performed:

• Transvaginal ultrasound
• Endorectal ultrasound
• CT scan and MRI

Other tests

• Biopsy
• Pelvic laparoscopy (It is the primary modality for assessing and diagnosing endometriosis).

Test results

Diagnosis is based on physical findings and test results. Imaging studies in particular play an important role in disease identification.

• Hypoglycemia

  […] disease distorted pelvic anatomy and adhesions contribute to impaired fertilisation.[19] Other[edit] Other symptoms include diarrhea or constipation, chronic fatigue, nausea and vomiting, headaches, low-grade fevers, heavy and/or irregular periods, and hypoglycemia [en.wikipedia.org]

• Ovarian Mass

  Diagnosis of ovarian masses. J Reprod Med 1990 ; 35:491-495. Medline, Google Scholar 10 Bourne T, Campbell S, Steer C, Whitehead M, Collins W. Transvaginal colour flow imaging: a possible new screening technique for ovarian cancer. [dx.doi.org]

  We at the Institute, however, council women that if their ovarian masses prove benign, radical surgery would be unnecessary. Often times, during surgery, we find the presence of an endometrioma (Endometriosis of the ovary). [alternativesurgery.com]

  Guerriero S, Mais V, Ajossa S: The role of endovaginal ultrasound in differentiating endometriomas from other ovarian cysts. Clin Exp Obstet Gynecol 1995; 22(1): 20-2 [Medline]. Jeong YY, Outwater EK, Kang HK: Imaging evaluation of ovarian masses. [web.archive.org]

• Leukocytosis

  Laboratory analysis may reveal leukocytosis and anemia, both from the underlying disease and enterolith related pressure on the intestinal mucosa. Elevated C-reactive protein and erythrocyte sedimentation rate may be present. [ncbi.nlm.nih.gov]

Conservative management

It includes the use of analgesics to relieve pelvic and abdominal pain and the use of hormone therapy like the use of Danazol or progesterone. Oral contraceptives have proved to be effective in slowing disease progression. In many women, menopause (natural or surgical) will abate the process [9].

Surgical intervention

If the disease cannot be satisfactorily managed conservatively, it may be treated surgically. Surgical intervention is of two types. The first is called conservative or semi conservative surgical intervention in which reproductive organs are spared. The second type, called radical surgery, involves a total hysterectomy and bilateral oophorectomy as well as adhesiolysis. This type is usually only performed in women past the child bearing age or in women with very serious, grade IV endometriosis.

It is a progressive disease with a high rate of recurrence even after treatment. However, endometriosis has been found to resolve spontaneously in one third of women who are not actively treated [7]. Prognosis depends upon the stage of the disease. It has 4 stages.

• Stage I: Only superficial lesions and adhesions are present.
• Stage II: Some superficial as well as deep lesions are present
• Stage III: Presence of superficial and deep lesions as well as presence of endometriomas in the ovaries
• Stage IV: All the above findings plus large endometriomas and extensive adhesions.

The exact cause of endometriosis is unknown. Several factors have been implicated in its development. The two main theories; metastatic and metaplastic theories have been explained in a later section. Humoral antibodies to endometrial tissue have also been found in sera of women with endometriosis [2]. Some women may also be genetically predisposed to this condition. Overall it is thought to be a collection of several factors, not just one, that ultimately cause this disease. As for why some women may be prone to this disease as opposed to those who are not, studies reveal that it varies on individual-based responses.

Incidence

Endometriosis is not a common occurrence. Approximately, endometriosis occurs in roughly 4–10% of women [3]. It has a prevalence of 7-10% in the United States.

Age

It is principally a disease of women in their active reproductive life. So it is common in women aged between mid-twenties and early-forties.

Race

There does not appear to be any predilection to a particular race or ethnicity.

The most common site of ectopic endometrial tissue is the ovary. The next most common sites, in decreasing order of frequency are: Uterine ligaments, rectovaginal septum, cul de sac, pelvic peritoneum, large and small bowel, appendix, cervical mucosa, vagina, fallopian tubes and laparotomy scars. Two major theories for the development of endometriosis have been proposed [4], they are:

• Metastatic theory

According to this theory, there is lymphatic or hematogenous ‘metastasis’ of endometrial tissue to abnormal locations. Retrograde menstruation may be the cause of peritoneal endometriosis, for example.

• Metaplastic theory

According to this theory, endometrial tissue may itself arise directly from coelomic epithelium at extrauterine sites. This coelomic epithelium is from which the mullerian ducts and ultimately the endometrium itself originates during embryonic development. Under the influence of factors that are still unclear, there may be abnormal production of endometrial gland and stromal cells in sites other than the uterus.

Specific abnormalities that distinguish normal endometrium from endometriotic tissue are highlighted below [5].

1. Profound activation of inflammatory cascade, characterized by high levels of prostaglandin E2, IL-1B, IL-6 and TNF. 
2. Marked upregulation of estrogen production mainly due to high levels of the key steroidogenic enzyme aromatase [6].

Endometriosis may be prevented or at least slowed by use of birth control pills [10]. Birth control pills act to decrease the production of hormones by the body which are necessary to support the endometrial tissue’s growth and division.

Endometriosis is defined as ectopic production or occurrence of endometrial tissue in extrauterine sites [1]. Endometrium is the innermost layer lining the uterus. Due to some reasons, as discussed in detail in later sections, this tissue may occur abnormally in extrauterine sites. Commonly, the ectopic tissue consists of both the endometrial glands and the stroma. It may occur anywhere in the body but typically remains within the abdominal and pelvic cavities. It may be confused with cancer so a thorough knowledge of the disease and its manifestation is imperative for proper diagnosis and treatment.

Definition

Endometriosis can be defined as abnormal presence of endometrial tissue (cells of the inner lining of the uterus), outside of the uterus. For example, endometrial tissue may abnormally occur in the ovaries, uterine ligaments, fallopian tubes, peritoneum, as well as other sites.

Cause

There is no known specific cause of endometriosis. It may be genetic or due to some immune dysfunction or it may simply be due to displacement and/or abnormal growth of uterine tissue in sites other than the uterus.

Symptoms

It may be asymptomatic but in symptomatic patients, it presents with painful menstruation, pelvic pain and in severe cases, infertility. Other symptoms include pain during urination or defecation, heavy menstrual bleeding, mid-cycle bleeding, nausea and vomiting and lower back pain.

Treatment

Treatment involves the use of contraceptive pills and painkillers. Surgical intervention may be needed in severe cases.

1. Shepard MK, Mancini MC, Campbell GD Jr, George R. Right-sided hemothorax and recurrent abdominal pain in a 34-year-old woman. Chest. Apr 1993;103(4):1239-40.
2. Kennedy S, Bergqvist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. Oct 2005;20(10):2698-704.
3. Markham SM, Carpenter SE, Rock JA. Extrapelvic endometriosis. Obstet Gynecol Clin North Am. Mar 1989;16(1):193-219.
4. Kruitwagen RF, Poels LG, Willemsen WN, de Ronde IJ, Jap PH, Rolland R. Endometrial epithelial cells in peritoneal fluid during the early follicular phase. Fertil Steril. Feb 1991;55(2):297-303.
5. Mathur S, Peress MR, Williamson HO, Youmans CD, Maney SA, Garvin AJ, et al. Autoimmunity to endometrium and ovary in endometriosis. Clin Exp Immunol. Nov 1982;50(2):259-66.
6. Ailawadi RK, Jobanputra S, Kataria M, Gurates B, Bulun SE. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. Fertil Steril. Feb 2004;81(2):290-6.
7. Ferrero S, Esposito F, Abbamonte LH, Anserini P, Remorgida V, Ragni N. Quality of sex life in women with endometriosis and deep dyspareunia. Fertil Steril. Mar 2005;83(3):573-9.
8. Barbati A, Cosmi EV, Spaziani R, Ventura R, Montanino G. Serum and peritoneal fluid CA-125 levels in patients with endometriosis. Fertil Steril. Mar 1994;61(3):438-42.
9. Guzick DS, Huang LS, Broadman BA, Nealon M, Hornstein MD. Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain. Fertil Steril. Apr 2011;95(5):1568-73.
10. Dmowski WP, Kapetanakis E, Scommegna A. Variable effects of danazol on endometriosis at 4 low-dose levels. Obstet Gynecol. Apr 1982;59(4):408-15.