A review of the literature on EATL is also presented. [ncbi.nlm.nih.gov]

The majority of EATLs present as large cell lymphoma CD[Formula: See Text] [Formula: See Text], CD[Formula: See Text] [Formula: See Text], CD[Formula: See Text] [Formula: See Text]; however, they also present as small cell lymphoma CD[Formula: See Text [doi.org]

• Fatigue

  ICD-9 Codes Corresponding ICD-10 Codes C84.5 Other and unspecified T-cell lymphomas Corresponding ICD-10-CM Codes (U.S. only) C86.2 Enteropathy-type (intestinal) T-cell lymphoma (effective October 01, 2015) Signs and Symptoms Drenching night sweats Fatigue [seer.cancer.gov]

  It may include the following modalities: Chemotherapy: This approach uses a combination of drugs to kill the cancerous cells and can be used in patients, for all stages of the tumor There can be severe side effects including fatigue, nausea, hair loss [dovemed.com]

  Unlike EATL, it often occurs in celiac disease patients who, while otherwise well-maintained on a gluten-free diet, have vague gastrointestinal symptoms such as fatigue, malaise, and weight loss. [en.wikipedia.org]

  In addition, if you ever develop any symptoms of non-Hodgkin lymphoma (which can include swollen lymph nodes, fatigue, unexplained weight loss, fever and night sweats), you should talk to your doctor immediately, and make sure she knows the connection [verywell.com]

• Fishing

  The 9q34.3 gain was the most frequent change confirmed by FISH irrespective of the cell origin of αβ-T-cells and γδ-T-cells. [ncbi.nlm.nih.gov]

  […] pathological state, 054674, 分子遺伝現象, ﾌﾞﾝｼｲﾃﾞﾝｹﾞﾝｼｮｳ, molecular genetic phenomenon, 045542, 免疫染色, ﾒﾝｴｷｾﾝｼｮｸ, immunostaining, 059301, 小腸, ｼｮｳﾁｮｳ, small intestine, 011347, 染色体, ｾﾝｼｮｸﾀｲ, chromosome, 010883, ヒト白血球抗原, ﾋﾄﾊｯｹｯｷｭｳｺｳｹﾞﾝ, human leucocyte antigen, 039582, FISH [togodb.biosciencedbc.jp]

  FISH labelling was performed using the Histology FISH Accessory Kit (Dako) according to the manufacturer’s protocol, with minor modifications. [nature.com]

  Cytogenetics Molecular Extra copies of chromosome 9q centered around the 9q33-34 region was detected by CGH and FISH studies (Zettl et al., 2002). 9p deletion with p16 loss was found in 18% of the cases, and loss of heterozygosity at 9p21 with loss of [atlasgeneticsoncology.org]

  Molecular genetic studies by FISH technique were negative for ALK-1 gene rearrangement. PCR study showed clonal population T-cell receptor (gamma) gene rearrangement [Figure 2] d. [indianjcancer.com]

• Painless Jaundice

  We report a patient with a 13-year history of celiac sprue presenting with painless jaundice and a Courvoisier gallbladder. [ncbi.nlm.nih.gov]

• Leg Edema

  On presentation, he was extremely emaciated with superficial lymph node swelling, ascitic signs, and leg edema. Histological image of a biopsied mesenteric lymph node demonstrated diffuse infiltration of large abnormal T cells. [ncbi.nlm.nih.gov]

• Abdominal Pain

  A 64-year-old woman was referred with a short history of abdominal pain, anorexia and weight loss. Investigations revealed a probable enteropathy associated T-cell lymphoma (EATL). [ncbi.nlm.nih.gov]

• Severe Abdominal Pain

  She was admitted because of sudden onset of severe abdominal pain. [ncbi.nlm.nih.gov]

  Later that evening, patient developed severe abdominal pain, which did not respond to the usual symptomatic treatment. He now developed peritoneal signs and rapidly evolved into sepsis with hypotension, azotemia, and acidosis. [jmedscindmc.com]

The suspicion of EATL should lead to an extensive diagnostic workup in which magnetic resonance enteroclysis, positron emission tomography scan, and histologic identification of lesions represent the best options. [ncbi.nlm.nih.gov]

Some patients with no history of coeliac disease present with symptoms and/or signs of a small intestinal lymphoma but on diagnostic workup are found to have coeliac disease. [en.wikipedia.org]

• Pleural Mass

  A case of enteropathy associated T cell lymphoma (EATCL) is described, which was diagnosed by biopsy of a lymphomatous pleural mass. [ncbi.nlm.nih.gov]

• Ovarian Mass

  We report a case of EATL in a 49-year-old female presenting as bilateral ovarian masses. The morphology and immunophenotypic features were compatible with monomorphic variant of EATL. [ncbi.nlm.nih.gov]

• Gastric Lesion

  The gastric EATL should be distinguished from other gastric lesions, such as peptic ulcer, poorly-differentiated adenocarcinoma and other types of lymphoma. The virtual slide(s) for this article can be found here: . [ncbi.nlm.nih.gov]

  The gastric EATL should be distinguished from other gastric lesions, such as peptic ulcer, poorly-differentiated adenocarcinoma and other types of lymphoma. [diagnosticpathology.biomedcentral.com]

• Multiple Ulcerations

  ulcerated mucosal masses, also single / multiple ulcers or large exophytic mass Gross images Images hosted on other servers: Well defined mural mass Resected small intestine with multiple patchy segmented lesions Microscopic (histologic) description [pathologyoutlines.com]

  EATL usually affects the jejunum and grossly (visible to the eye) appears as multiple ulcers causing circumferential thickening of affected bowel wall without the formation of definite tumor masses most commonly in the proximal small bowel. [glutenfreeworks.com]

  They present as single or multiple ulcers, plaques, or strictures. Large polypoidal masses as seen in B-cell lymphoma is unusual. [indianjcancer.com]

There are no standardized treatment protocols, and the optimal therapy for EATL remains unclear. The primary step of treatment consists of local debulking, preferably as early as possible after EATL diagnosis. [ncbi.nlm.nih.gov]

High-dose chemotherapy with autotransplantion seems to only improve the prognosis in localised forms. Allogeneic bone marrow transplantation was not evaluated. [ncbi.nlm.nih.gov]

Inflammatory bowel disease, celiac disease, immunosuppression, and infectious etiologies, such as Epstein-Barr and human T-lymphotropic viruses, have been reported as risk factors, but no direct causal link has been established. [ncbi.nlm.nih.gov]

Source: Aliment Pharmacol Ther. 2010 Dec;32(11-12):1392-7. celiac disease celiac disease etiology lymphocytic duodenosis prospective study Read more... 1 comment 10,080 views [celiac.com]

Higher frequency in areas with high prevalence of celiac disease (northern Europe) Monomorphic variant (type II EATL): 10% - 20% of cases of EATL, broader geographic distribution and sporadic occurrence in areas where celiac disease is rare (Asia) Etiology [pathologyoutlines.com]

The etiology of indolent small intestinal CD4 T-cell lymphomas is unclear. Persistent antigenic stimulation as a consequence of an immune-mediated or infectious disorder is a possibility. [journals.plos.org]

The epidemiology, presentation, diagnosis, management and prognosis of this rare condition are discussed. [ncbi.nlm.nih.gov]

Consecutive pathophysiological and immunohistochemical analyses confirmed the diagnosis of EATCL: CD45RO , CD43 , CD3 . The revision of renal pathophysiology substantiated the diagnosis. [ncbi.nlm.nih.gov]

Pathophysiology Type 1 Arises in a background of celiac disease. [cancertherapyadvisor.com]

Declarations Authors’ Affiliations (1) Department of Pathologym, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China (2) Institute of Pathology and Pathophysiology, China Medical University [diagnosticpathology.biomedcentral.com]

Moreover, the high incidence of severe postsurgical complications and the poor nutritional and immunological conditions lead to progressive deterioration of these patients, preventing the use of an adequate and effective treatment. [ncbi.nlm.nih.gov]

There is no satisfactory treatment for EATL, the only possibility of preventing EATL development in RCD being autologous bone marrow transplantation. [doi.org]