Presentation
Children should be isolated at home until the rash, if present, has gone, all blisters have dried up and any fever has settled. [health.nsw.gov.au]
Testing Guidelines for Patients with AFP/AFM or Other Acute Neurological Presentations of Possible Viral Cause Persons of any age presenting with AFM, or any child less than 15 years of age with AFP should have laboratory investigations to detect a viral [publichealthontario.ca]
This demonstrates that the amount of virus present in these tissues is low and needs further amplification in order to be detected. [diabetes.diabetesjournals.org]
To identify evidence of any past viral infections in AFM patients, the researchers adapted a method developed by Elledge that uses bacteriophages to collect antibodies present in a sample, in this case, the patients’ spinal fluid. [the-scientist.com]
Most enterovirus infections are asymptomatic or present with mild cold-like symptoms. Though, due to the multitude of enterovirus species the clinical presentation in severe symptomatic diseases is of broad variety. [clinical.r-biopharm.com]
Cardiovascular
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Tachycardia
Signs of complicated EV71 infections include the following: Myoclonic jerks, particularly in sleep Urinary retention Ataxia, weakness, or any focal neurological signs Hypertension and/or bradycardia Severe, unexplained or persistent tachycardia or poor [health.nsw.gov.au]
Skin
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Eczema
"Eczema coxsackium" and unusual cutaneous findings in an enterovirus outbreak. Pediatrics. 2013 Jul. 132(1):e149-57. [Medline]. Begier EM, Oberste MS, Landry ML, et al. [emedicine.medscape.com]
Neurologic
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Lethargy
Usually, several days after birth, the neonate suddenly develops a syndrome resembling sepsis with fever, lethargy, disseminated intravascular coagulation, bleeding, and multiple organ (including heart) failure. [msdmanuals.com]
[…] be heard when the doctor examines the chest with a stethoscope Hand, foot, and mouth disease ( HFMD ): small nodules and blisters that are tender and appear gray that occur on the hands, feet, and in the oral cavity Encephalitis : Symptoms range from lethargy [medicinenet.com]
coma, and movement disorders early in the course [6] Encephalitis – Manifestations range from lethargy, drowsiness, and personality change to seizures, paresis, coma, motor seizures, hemichorea, and acute cerebellar ataxia [7] Herpangina – Punctate [emedicine.medscape.com]
Workup
If included earlier in the diagnostic workup, the value of a positive EV-PCR result may increase, especially in reducing unnecessary diagnostic tests. [jamanetwork.com]
[…] affected; yield is increased if multiple sites are sampled Polymerase chain reaction (PCR) – Provides rapid results; the best diagnostic test for use in CSF In myopericarditis, chest radiography, echocardiography, and ECG can be used for diagnosis See Workup [emedicine.medscape.com]
Treatment
Diagnosis and Treatment Although a laboratory test can detect enterovirus, most diagnoses are made on the basis of symptoms. Treatment for enterovirus means managing the symptoms until the infection clears. [intermountainhealthcare.org]
Treatment There are no specific treatments or antiviral medications for people with illness caused by EV-D68. If symptoms become severe enough, infected people may need to be hospitalised. [health.govt.nz]
Management and treatment There is no specific curative treatment for EV maternal or congenital infection. Prognosis Prognosis of mild congenital EV infections is quite good if reanimation procedures are available. [orpha.net]
Learn about non-polio enterovirus infections, their causes, symptoms, risks, treatment and prevention. Also find information on surveillance and for health professionals. [canada.ca]
There is no specific treatment for non-polio enterovirus infection. [dchealth.dc.gov]
Prognosis
Prognosis Prognosis of mild congenital EV infections is quite good if reanimation procedures are available. Prognosis of severe congenital EV infections is poor and the disease has been reported to be fatal. [orpha.net]
In most cases, the prognosis (outcomes) of enterovirus infections is good with no complications; however, the prognosis worsens as the severity of infection increases and when complications develop. [medicinenet.com]
Etiology
“While continued vigilance for other possible etiologies of AFM is warranted, together, our combined [results support] the notion that EV infection likely underlies the majority of AFM cases tested in this study,” the authors write in their paper, which [the-scientist.com]
While a lot of work still remains to fully determine the etiological agents that cause acute flaccid myelitis/paralysis, JCVI scientists continue to characterize EV-D68 pathogenesis and its disease phenotype. [jcvi.org]
Etiology Coxsackie A, B, ECHO viruses, and numbered EVs are believed to cross the placenta and cause fetal disease. [orpha.net]
Acute Neurologic Illness with Focal Limb Weakness of Unknown Etiology in Children : More information is available at the following resources: www.cdc.gov [dchealth.dc.gov]
Etiology: The nonpolio Enteroviruses are positive strand RNA viruses. [meddean.luc.edu]
Epidemiology
Here, we review the features of this virus and related viruses, the clinical syndromes this virus causes, the epidemiology of the recent outbreak, and its diagnosis and treatment. [mdedge.com]
This special issue, published in Journal of Biomedical Science, presents reviews and primary research papers on EV71 that cover several topics: a clinical guideline on management of children with HFMD, epidemiology of EV71 in Thailand, the cell and tissue [biomedcentral.com]
Epidemiology: Transmission Enterovirus infections are common and are spread by fecaloral and respiratory routes and from mother to infant in the peripartum period. [meddean.luc.edu]
Tengelsen, PhD, DVM - Epidemiology [healthy.kaiserpermanente.org]
Summary Epidemiology The prevalence of congenital EV infection is still unknown. EV infections are underdiagnosed in the mother (mainly because of frequent subclinical infections) and hence may be far more frequent than supposed. [orpha.net]
Pathophysiology
Useful For Suggests clinical disorders or settings where the test may be helpful Aids in diagnosing enterovirus infections Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Enteroviruses [mayocliniclabs.com]
Pathophysiology Enteroviruses are transmitted predominantly via the fecal-oral route. [emedicine.medscape.com]
Prevention
Centers for Disease Control and Prevention. . Accessed July 20, 2017. Non-polio enterovirus. Centers for Disease Control and Prevention. . Accessed July 20, 2017. Enterovirus D68 for health care professionals. [mayoclinic.org]
Prevention Learn how non-polio enterovirus infections can be prevented. Surveillance Discover how non-polio enterovirus infections are monitored. Report a problem or mistake on this page Thank you for your help! You will not receive a reply. [canada.ca]
Prevention Vaccine to prevent EV71 infection is not available in Hong Kong at the moment. Good personal and environmental hygiene are the mainstay of prevention. 1. [chp.gov.hk]
There are no vaccines for preventing EV-D68 infection. [health.govt.nz]
Also, see a graphic that shows these prevention steps. [solutionsdesignedforhealthcare.com]