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Eosinophilic Gastritis


Presentation

  • We report a 41-year-old man who presented with features of gastric outlet obstruction due to a submucosal lesion in the distal end of the stomach. Distal gastrectomy with Billroth II reconstruction was done.[ncbi.nlm.nih.gov]
Splenectomy
  • Her past medical history included idiopathic thrombocytopenic purpura, splenectomy at the age of 11 years, hyperlipidaemia, hypertension, diabetes mellitus type II, and depression.[ncbi.nlm.nih.gov]
Burning Pain
  • Case Report A 42-year-old man presented with a 2-month history of epigastric burning pain and occasional postprandial vomiting. There was no history of nonsteroidal anti-inflammatory drug (NSAID) ingestion.[jdeonline.in]
Vomiting
  • A 3-year-old girl presented with multiple episodes of vomiting, fever, and hematemesis for the past 2 months. Except for hemoglobin, her rests of the laboratory tests were unremarkable.[ncbi.nlm.nih.gov]
  • I recently discovered that peanuts in any amount also result in nausea and stomach pain, though that episode never escalated to vomiting.[inspire.com]
  • Definition / general Usually children or young adults with vomiting, diarrhea, protein losing enteropathy, food sensitivity, growth failure Also allergic history, anemia, blood eosinophilia, increased serum IgE Stomach most common site, but primary eosinophilic[pathologyoutlines.com]
  • A 22-year old man presented with abdominal pain and vomiting. Endoscopic gastric biopsy revealed eosinophilic infiltration, and the serum level of Interleukin (IL)-5 was increased. Gastric emptying was moderately delayed in this patient.[e-ce.org]
  • Symptoms: Vomiting, nausea Difficulty feeding and/or gaining weight Poor growth Abdominal pain Anemia (low blood counts) Fatigue Associated Diseases: Environmental and/or food allergies in some May occur in conjunction with other EGIDs Causes: Unknown[apfed.org]
Abdominal Pain
  • Our case demonstrates that patients with uncharacteristic abdominal pain who are unresponsive to conventional treatment, rare illnesses like eosinophilic gastritis should be considered.[ncbi.nlm.nih.gov]
  • A 63-year old male was admitted to our hospital with complaints of abdominal pain and constipation. Physical examination revealed a distended abdomen with diffuse tenderness. Ultrasound showed free fluid in peritoneal cavity.[ijcbr.com]
  • A 22-year old man presented with abdominal pain and vomiting. Endoscopic gastric biopsy revealed eosinophilic infiltration, and the serum level of Interleukin (IL)-5 was increased. Gastric emptying was moderately delayed in this patient.[e-ce.org]
  • Symptoms: Vomiting, nausea Difficulty feeding and/or gaining weight Poor growth Abdominal pain Anemia (low blood counts) Fatigue Associated Diseases: Environmental and/or food allergies in some May occur in conjunction with other EGIDs Causes: Unknown[apfed.org]
Nausea
  • I recently discovered that peanuts in any amount also result in nausea and stomach pain, though that episode never escalated to vomiting.[inspire.com]
  • Symptoms: Vomiting, nausea Difficulty feeding and/or gaining weight Poor growth Abdominal pain Anemia (low blood counts) Fatigue Associated Diseases: Environmental and/or food allergies in some May occur in conjunction with other EGIDs Causes: Unknown[apfed.org]
  • A 44 year old woman presented with a two month history of vomiting, nausea, and crampy abdominal pain.[ncbi.nlm.nih.gov]
  • This inflammation leads to injury of the stomach and patients often present with abdominal pain, nausea, vomiting, weight loss and / or poor growth.[seedcenteratl.org]
  • He reported that he was unable to retain the pills, owing to nausea and vomiting.[consultant360.com]
Early Satiety
  • The patient had initially presented 7 years earlier, with complaints of early satiety, epigastric pain, heartburn, and indigestion; all symptoms were worse following meals. He had reported no nausea, vomiting, hematemesis, or melena.[consultant360.com]
  • In individuals with EG/EGE eosinophils, a type of white blood cell, gain access to the lining of the gastrointestinal tract and may produce symptoms such as trouble swallowing, nausea, vomiting, abdominal pain, early satiety, diarrhea, weight loss, chest[rarediseasesnetwork.org]
  • The most common symptoms are abdominal pain , vomiting/ nausea , early satiety and diarrhea.[omicsonline.org]
  • Symptoms include, but are not limited to, the following: abdominal pain (EG, EE, ED) anorexia (EG, EE) asthma (EE) bloating (EG, ED, EC) cramps (EG, EC, ED) feeling full before finishing a meal (early satiety) (EG) milk/formula regurgitation (EG, EE)[healthofchildren.com]
Gastropathy
  • […] updated Sydney system specifically stated that intraepithelial eosinophils must always be viewed as abnormal. 10 Increased numbers of eosinophils in the lamina propria have been reported after eradication therapy for Helicobacter pylori , 11 in reactive gastropathy[nature.com]
Addictive Behavior
  • Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors . New York, NY: Guilford; 1985. Task Force 5. Interventions to prevent relapse. Health Psychol . 1986;5(suppl):53-68. Venters MH, Solberg LI, Kottke TE, et al.[consultant360.com]

Workup

  • On initial workup, the diagnosis was missed. However the diagnosis was established after subsequent work up in Gastroenterology clinic.[ncbi.nlm.nih.gov]
  • Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate.[books.google.com]
Pulmonary Infiltrate
  • Meloxicam-induced pulmonary infiltrates with eosinophilia: a case report . Rheumatology (Oxford) 2003; 42 :1112–1113. 27. Yan BM , Shaffer EA . Primary eosinophilic disorders of the gastrointestinal tract . Gut 2009; 58 :721–732.[nature.com]
Eosinophils Increased
  • Hypereosinophilic syndrome is an uncommon disorder in which the number of eosinophils increases to more than 1,500 cells per microliter of blood for more than 6 months without an obvious cause. Some people have a rare chromosome disorder.[msdmanuals.com]
  • When triggered by allergies, infection, or cancer, eosinophils increase in number and become active. In the short-term, this response is important and effective in ridding the body of intruders.[badgut.org]
  • Eosinophils increase in response to parasitic infections and allergic reactions. Eosinophilia —An abnormal increase in the number of eosinophils, a type of white blood cell.[healthofchildren.com]

Treatment

  • In a 32-year-old woman with an ulcer that had persisted for more than 13 months despite treatment with the H2 blocker ranitidine, the latter was replaced by the H K( )-ATPase inhibitor omeprazole.[ncbi.nlm.nih.gov]
  • One of the main treatments is to eliminate the foods that are causing the reaction. Diagnosis, treatment and understanding of eosinophilic esophagitis (EoE), the most common EGID, has improved greatly in the last decade.[blog.cincinnatichildrens.org]

Prognosis

  • Treatment: Avoid known food allergens or triggers Systemic Steroids (prednisone) Elemental diet (avoid all food protein and obtain all nutrition from a special formula) Iron supplementation if iron deficient Prognosis: Depends on response to treatment[apfed.org]
  • Prognosis : reasonable. Pathogenesis Etiology Unknown. Immune-mediated disease associated with dietary factors or parasites. Pathophysiology Eosinophilic infiltration, usually in mucosa but can affect other layers of stomach.[vetstream.com]
  • Prognosis With treatment, prognosis is good with full resolution of symptoms in spite of a possible relapsing course.[orpha.net]
  • […] nodularity particularly in gastric antrum, without submucosal edema when chronic, the antrum is narrowed with a nodular " cobblestone " mucosal appearance CT CT features are non-specific and may show GI wall thickening and submucosal edema Treatment and prognosis[radiopaedia.org]
  • (Outcomes/Resolutions) Severe malabsorption and malnutrition can occur, if Eosinophilic Gastroenteritis is untreated With prompt diagnosis and management of the condition, the long-term prognosis of the disorder is favorable Reviewed and Approved by a[dovemed.com]

Etiology

  • The disease is highly responsive to dietary restriction therapies in children, implicating an allergic etiology. Associated EoE is more resistant to therapy.[ncbi.nlm.nih.gov]
  • Pathogenesis Etiology Unknown. Immune-mediated disease associated with dietary factors or parasites. Pathophysiology Eosinophilic infiltration, usually in mucosa but can affect other layers of stomach.[vetstream.com]
  • Synopsis eosinophilic infiltrate of the gastric chorion eosinophils in gastric surface epithelium and gastric glandular epithelium Etiology isolated eosinophilic gastritis associated eosinophilic gastritis eosinophilic gastrointestinal disorders eosinophilic[humpath.com]
  • Neurological and mental state Usually normal, depending on etiology.[epilepsy.com]

Epidemiology

  • Epidemiology Available data about the epidemiology of EGE are limited. Although it can affect all ages, the majority of cases occur in adults in the third to the fifth decades of life.[flipper.diff.org]
  • […] isolated, part of spectrum of eosinophilic gastroenteritis or associated with peripheral eosinophilia or reflux esophagitis Patients may have enhanced production of cytokines against both food and environmental allergens ( Dig Dis Sci 2006;51:1934 ) Epidemiology[pathologyoutlines.com]
  • Aim of the study: This review focuses on the epidemiology, pathophysiology, clinical features and treatment of primary eosinophilic gastrointestinal disorders with particular attention to primary eosinophilic gastroenteritis.[italjmed.org]
  • Summary Epidemiology Prevalence and incidence are unknown. To date, more than 280 cases have been reported, mainly in Caucasians and with a slight male preponderance.[orpha.net]
  • [ edit ] Epidemiology may differ between studies, as number of cases are small, with approximately 300 EG cases reported in published literature.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • However, little is known about the relationship between precise endoscopic findings and the pathophysiological process responsible for EG.[ncbi.nlm.nih.gov]
  • Pathophysiology Eosinophilic infiltration, usually in mucosa but can affect other layers of stomach. Damage to gastric mucosal barrier may ulceration. Thickening/granuloma in pyloric region mechanical outflow obstruction (rare). Timecourse Months.[vetstream.com]
  • […] may present with dysphagia, food impaction, abdominal pain, nausea, vomiting, or diarrhea depending on the site of involvement in severely affected children it may result in growth retardation chronic inflammatory disorder of GI wall of undetermined pathophysiology[radiopaedia.org]
  • CURED provides grants support to new and established investigators performing clinical research in any area that is relevant to the etiology or pathophysiology of eosinophilic esophagitis, eosinophilic gastroenteritis, eosinophilic colitis and other eosinophilic[curedfoundation.org]

Prevention

  • MAINTENANCE AND RELAPSE PREVENTION Although the cessation attempt is relatively straightforward when patients are motivated to quit, data suggest that maintenance strategies and relapse prevention techniques must be considered from the start.[consultant360.com]
  • Currently, no preventative measures are available for Eosinophilic Gastroenteritis Early detection and treatment of the disease are important to prevent the symptoms from becoming too severe/adverse What is the Prognosis of Eosinophilic Gastroenteritis[dovemed.com]
  • The goals in the treatment of EoE are relief of symptoms and prevention of complications.[flatironallergy.com]
  • To help prevent anaphylactic shock, we carry around an Epi Pen, a drastic measure that will help to open his airways in the case that he has a reaction after eating something He has been on medications, but none seem to be working well enough right now[globalgenes.org]

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