Case presentation A four month infant was admitted to the emergency department for an episode of melena. [ijponline.biomedcentral.com]

A case of eosinophilic gastritis that presented with a gastric mass and simulated a malignancy is described. The patient underwent a gastric resection, developed a recurrence and then had a spontaneous remission. [ncbi.nlm.nih.gov]

There are some limitations to the estimates presented. [journals.lww.com]

• Non-Cardiac Chest Pain

  Cardiac Chest Pain (NCCP) Terminated NCT02825342 Phase 4 Citalopram 8 Effect of Swallowed Fluticasone Propionate on Eosinophilic Esophagitis; A Prospective, Randomized, Placebo-Controlled Trial Completed NCT00266578 Phase 3 Fluticasone Propionate 9 An [malacards.org]

• Vomiting

  A 3-year-old girl presented with multiple episodes of vomiting, fever, and hematemesis for the past 2 months. Except for hemoglobin, her rests of the laboratory tests were unremarkable. [ncbi.nlm.nih.gov]

  Case: An 8-year-old boy presented to our clinic with a 6-month history of intermittent vomiting. Other than vomiting episodes once or twice a month, he had no other GI symptoms. [pediatrics.or.kr]

  Herein we report the case of a 65-year-old North Korean defector who presented with nausea and vomiting for 1 year. [kci.go.kr]

  I recently discovered that peanuts in any amount also result in nausea and stomach pain, though that episode never escalated to vomiting. [inspire.com]

  EG presents with recurrent nausea, vomiting, and abdominal pain. EG is diagnosed by endoscopy and biopsy of the esophagus, stomach, and small intestine. Food allergy may play a role in EG. [flatironallergy.com]

• Abdominal Pain

  Our case demonstrates that patients with uncharacteristic abdominal pain who are unresponsive to conventional treatment, rare illnesses like eosinophilic gastritis should be considered. [ncbi.nlm.nih.gov]

  Clinical: Abdominal pain.[1] May mimic a gastric tumour.[2] Gross +/-Snakeskin appearance. DDx: Portal hypertensive gastropathy. [librepathology.org]

  The patient’s abdominal pain and recent weight loss prompted his admission for serial abdominal examinations and urgent investigation. An abdominal sonogram was normal. [emj.bmj.com]

  Common symptoms of EoE include: Heartburn (does not respond to usual medications) Difficulty Swallowing Nausea/Vomiting Food Regurgitation Food Impaction Abdominal Pain Chest Pain In children with EoE, additional findings may include: Poor Weight Gain [flatironallergy.com]

• Nausea

  Herein we report the case of a 65-year-old North Korean defector who presented with nausea and vomiting for 1 year. [kci.go.kr]

  I recently discovered that peanuts in any amount also result in nausea and stomach pain, though that episode never escalated to vomiting. [inspire.com]

  EG presents with recurrent nausea, vomiting, and abdominal pain. EG is diagnosed by endoscopy and biopsy of the esophagus, stomach, and small intestine. Food allergy may play a role in EG. [flatironallergy.com]

  After an initial dose of steroids, she clinically improved significantly, her abdominal pain, nausea and vomiting improved, and she tolerated her diet. [karger.com]

  Muscular EGE is often associated with hypertrophy and hyperplasia of the muscular layers, leading to symptoms of intestinal stenosis/obstruction (e.g. vomiting, nausea). [orpha.net]

• Gastropathy

  DDx: Portal hypertensive gastropathy. Microscopic Features: Abundant eosinophils -- >=127 eosinophils/mm2.[3] 30 eosinophils/HPF, if the field diameter of 1 HPF is 0.55 mm. Notes: Normal range:[3] <38 eosinophils/mm2. Typically ~16 eosinophils/mm2. [librepathology.org]

  Abdul-Ghani, Rima Feldman, Moshe Shai, Jacob Varkel Dept. of Medicine C, Western Galilee Hospital, Naharia Atrophic gastritis is an autoimmune gastropathy in which there is destruction of gastric parietal cells. [ima.org.il]

  […] updated Sydney system specifically stated that intraepithelial eosinophils must always be viewed as abnormal. 10 Increased numbers of eosinophils in the lamina propria have been reported after eradication therapy for Helicobacter pylori, 11 in reactive gastropathy [nature.com]

• Early Satiety

  In individuals with EG/EGE eosinophils, a type of white blood cell, gain access to the lining of the gastrointestinal tract and may produce symptoms such as trouble swallowing, nausea, vomiting, abdominal pain, early satiety, diarrhea, weight loss, chest [rarediseasesnetwork.org]

  The patient had initially presented 7 years earlier, with complaints of early satiety, epigastric pain, heartburn, and indigestion; all symptoms were worse following meals. He had reported no nausea, vomiting, hematemesis, or melena. [consultant360.com]

  The most common symptoms are abdominal pain, vomiting/ nausea, early satiety and diarrhea. [omicsonline.org]

  Symptoms include, but are not limited to, the following: abdominal pain (EG, EE, ED) anorexia (EG, EE) asthma (EE) bloating (EG, ED, EC) cramps (EG, EC, ED) feeling full before finishing a meal (early satiety) (EG) milk/formula regurgitation (EG, EE) [healthofchildren.com]

On initial workup, the diagnosis was missed. However the diagnosis was established after subsequent work up in Gastroenterology clinic. [ncbi.nlm.nih.gov]

Secondary (reactive) eosinophilic gastritis caused by cerebral sparganosis was suspected after a workup that included brain magnetic resonance imaging, cerebrospinal fluid tapping, and gastric mucosal biopsy. [kci.go.kr]

Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. [books.google.com]

• Eosinophils Increased

  The increased number of eosinophils can damage the heart, lungs, liver, skin, and nervous system. [msdmanuals.com]

  When triggered by allergies, infection, or cancer, eosinophils increase in number and become active. In the short-term, this response is important and effective in ridding the body of intruders. [badgut.org]

  As eosinophils normally increase in response to parasites, this would likely not be an effective therapy for eosinophilic gastrointestinal disorders (EGIDs). [cincinnatichildrens.org]

  Eosinophilia —An abnormal increase in the number of eosinophils, a type of white blood cell. [healthofchildren.com]

• Paragonimus Westermani

  Analysis of parasite-specific-antibody positive patients for clonorchis sinensis, paragonimus westermani, cysticercus and sparganum using ELISA. Korean J Lab Med 2003;23:126–131. 10. Gonzenbach RR, Kong Y, Beck B, Buck A, Weller M, Semmler A. [ekjm.org]

  The serological test for Toxocara antibodies (IgG) was positive, whereas those for Echinococcus, Paragonimus westermani, Sparganumi, and Trichinella antibodies were negative. [ncbi.nlm.nih.gov]

One of the main treatments is to eliminate the foods that are causing the reaction. Diagnosis, treatment and understanding of eosinophilic esophagitis (EoE), the most common EGID, has improved greatly in the last decade. [blog.cincinnatichildrens.org]

Our case demonstrates that patients with uncharacteristic abdominal pain who are unresponsive to conventional treatment, rare illnesses like eosinophilic gastritis should be considered. [ncbi.nlm.nih.gov]

1 A Randomized, Double-blind, Placebo-controlled Study of the Use of Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Completed NCT02371941 Phase 4 oral cromolyn sodium;Placebo 2 Budesonide Versus Fluticasone for Treatment of Eosinophilic [malacards.org]

Prognosis With treatment, prognosis is good with full resolution of symptoms in spite of a possible relapsing course. [orpha.net]

LM DDx chronic gastritis, Helicobacter gastritis, Crohn's disease - see inflammatory bowel disease and the stomach, eosinophilic myeloproliferative neoplasm, eosinophilic gastroenteritis Site stomach Symptoms +/-abdominal pain Prevalence very rare Prognosis [librepathology.org]

Treatment: Avoid known food allergens or triggers Systemic Steroids (prednisone) Elemental diet (avoid all food protein and obtain all nutrition from a special formula) Iron supplementation if iron deficient Prognosis: Depends on response to treatment [apfed.org]

Prognosis : reasonable. Pathogenesis Etiology Unknown. Immune-mediated disease associated with dietary factors or parasites. Pathophysiology Eosinophilic infiltration, usually in mucosa but can affect other layers of stomach. [vetstream.com]

The disease is highly responsive to dietary restriction therapies in children, implicating an allergic etiology. Associated EoE is more resistant to therapy. [ncbi.nlm.nih.gov]

However, etiological emphasis is given to an allergic reaction. Other etiologies suggested are chronic inflammation and foreign body reaction. [ijpmonline.org]

기타언어초록 Eosinophilic gastroenteritis is a rare clinicopathologic entity of unknown etiology with a variety of digestive symptoms. The pathogenesis is poorly understood. [newnonmun.com]

Synopsis eosinophilic infiltrate of the gastric chorion eosinophils in gastric surface epithelium and gastric glandular epithelium Etiology isolated eosinophilic gastritis associated eosinophilic gastritis eosinophilic gastrointestinal disorders eosinophilic [humpath.com]

[…] isolated, part of spectrum of eosinophilic gastroenteritis or associated with peripheral eosinophilia or reflux esophagitis Patients may have enhanced production of cytokines against both food and environmental allergens ( Dig Dis Sci 2006;51:1934 ) Epidemiology [pathologyoutlines.com]

Epidemiology Available data about the epidemiology of EGE are limited. Although it can affect all ages, the majority of cases occur in adults in the third to the fifth decades of life. [flipper.diff.org]

Summary Epidemiology Prevalence and incidence are unknown. To date, more than 280 cases have been reported, mainly in Caucasians and with a slight male preponderance. [orpha.net]

Aim of the study: This review focuses on the epidemiology, pathophysiology, clinical features and treatment of primary eosinophilic gastrointestinal disorders with particular attention to primary eosinophilic gastroenteritis. [italjmed.org]

However, little is known about the relationship between precise endoscopic findings and the pathophysiological process responsible for EG. [ncbi.nlm.nih.gov]

Pathophysiology Eosinophilic infiltration, usually in mucosa but can affect other layers of stomach. Damage to gastric mucosal barrier may → ulceration. Thickening/granuloma in pyloric region → mechanical outflow obstruction (rare). [vetstream.com]

[…] may present with dysphagia, food impaction, abdominal pain, nausea, vomiting, or diarrhea depending on the site of involvement in severely affected children it may result in growth retardation chronic inflammatory disorder of GI wall of undetermined pathophysiology [radiopaedia.org]

CURED provides grants support to new and established investigators performing clinical research in any area that is relevant to the etiology or pathophysiology of eosinophilic esophagitis, eosinophilic gastroenteritis, eosinophilic colitis and other eosinophilic [curedfoundation.org]

Prevention There are no current steps to prevent EG because the cause is not clear. References Eosinophilic gastritis. National Organization for Rare Disorders (NORD) website. [lahey.org]

MAINTENANCE AND RELAPSE PREVENTION Although the cessation attempt is relatively straightforward when patients are motivated to quit, data suggest that maintenance strategies and relapse prevention techniques must be considered from the start. [consultant360.com]

The goals in the treatment of EoE are relief of symptoms and prevention of complications. [flatironallergy.com]

Therefore, preventing mite or tick bites is the best way to prevent the diseases. [kiss.kstudy.com]

Currently, no preventative measures are available for Eosinophilic Gastroenteritis Early detection and treatment of the disease are important to prevent the symptoms from becoming too severe/adverse What is the Prognosis of Eosinophilic Gastroenteritis [dovemed.com]