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Eosinophilic Pituitary Adenoma


Presentation

  • Those of our colleagues who had presented papers at the symposium, as well as a number of others, were invited to contribute to this volume, which should serve as a presentation of the "state of the art" on all aspects of pitu itary tumors.[books.google.com]
  • Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables.[books.google.com]
  • Improve your interpretation of presenting symptoms with 39 new topics in the Differential Diagnosis section, and optimize patient care with 12 new tables in the Clinical Practice Guidelines section.[books.google.de]
  • We present a case of synchronous occurrence of a prolactinoma and somatotropinoma. Case presentation A woman presented to an outside clinic at the age of 29 because of menstrual irregularities.[edmcasereports.com]
Pathologist
  • We felt that such a book would be of value to endocrinologists, neurosurgeons, neuroradiologists, and pathologists who are involved in the investigation or care of patients with pituitary disorders.[books.google.com]
  • However, in some lesions, the pathologist may call a tumor "borderline" or "of low malignant potential." These terms are applied to a group of potentially malignant lesions that metastasize much less frequently than the carcinomas.[training.seer.cancer.gov]
  • Strong cytokeratin immunoreactivity of the neoplastic cells could be misleading to the pathologist if a metastasis is being considered.[uscapknowledgehub.org]
  • "Practical pituitary pathology: what does the pathologist need to know?" . Archives of Pathology & Laboratory Medicine . 132 (8): 1231–40. doi : 10.1043/1543-2165(2008)132[1231:PPPWDT]2.0.CO;2 (inactive 2018-09-22). PMID 18684022 .[en.wikipedia.org]
  • All surgical pathology specimens were reviewed by two endocrine pathologists.[nature.com]
Failure to Thrive
  • Fred Ferri’s popular "5 books in 1" format provides quick guidance on menorrhagia, Failure to Thrive (FTT), Cogan’s syndrome, and much more.[books.google.com]
Suggestibility
  • Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.[books.google.com]
  • Access full-color images and 65 online-only topics at Expert Consult, as well as online-only contents including EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.[books.google.com]
  • If suspicion strong, repeat studies over time Suggestive or nonspecific laboratory findings.[cushings-help.com]
  • Of the patients with apparently "silent" corticotroph adenomas, 7 individuals had symptoms that suggested Cushing's disease in retrospect while 2 patients developed symptoms at recurrence.[uscapknowledgehub.org]
Neglect
  • Abstract Acromegaly is a chronic disease not to be neglected. In addition to its metabolic abnormalities that are the consequence of excessive growth hormone secretion, neurologic sequelae can be caused by growth of the pituitary adenoma.[annals.org]

Workup

  • A careful study of hormonal workup and pre-operative imaging is necessary for synchronous pituitary adenomas to assure resection of both tumors. Summary Pituitary adenomas are usually solitary lesions.[edmcasereports.com]
  • […] adenomas show numerous enlarged mitochondria with loss of cristae and presence of electron dense tubular structures ( Brain Pathol 2012;22:443 ) Molecular / cytogenetics description No specific molecular characteristics in routine clinical diagnostic workup[pathologyoutlines.com]
  • Although ultrastructural examination still has an important role in the workup of unusual pituitary adenomas, ultrastructural examination was the only reliable way to subtype and determine the cellular origin of pituitary adenomas in the past.[nature.com]
Polyps

Treatment

  • Utilize new, clinically important molecular genetic data and updated classification schemes to help guide treatment and targeted therapy.[books.google.com]
  • Doctors want to learn whether the new treatment is safe, effective, and possibly better than the standard treatment. Clinical trials can test a new drug, a new combination of standard treatments, or new doses of standard drugs or other treatments.[cancer.net]
  • Treatment for Hyperpituitarism Treatment can consist of pituitary microsurgery to remove tumor.[healthguidance.org]
  • The team works together to research and develop individualized diagnostic and treatment plans for each patient. This coordinated, multidisciplinary approach to care is unique in the New York Metropolitan area.[columbianeurosurgery.org]
  • Top Treatment Treatment is dependent on symptoms and hormone dysfunction. Adenomas that cause vision problems secondary to compression of the optic chiasm should be surgically removed.[virtualmedstudent.com]

Prognosis

  • Prognosis Remission can be obtained in up to 90% of patients with microadenomas and in about 50% to 60% of those with macroadenomas. [ 1 ][patient.info]
  • […] with hyperthyroidism should allow prospective elucidation of the clinical, biochemical and radiological features that distinguish thyrotroph adenomas from silent subtype 3 adenomas and further clarification of whether they have differing outcomes and prognosis[nature.com]

Etiology

  • Overall, pituitary adenomas have a highly variable etiology that differs from person to person.[virtualmedstudent.com]
  • […] of somatotrophs, lactotrophs and thyrotrophs SF-1 (steroidogenic factor 1): gonadotroph cell differentiation T-PIT (T-box family member TBX19): proopiomelanocortin (POMC) lineage with differentiation of corticotrophs ( Acta Neuropathol 2017;134:521 ) Etiology[pathologyoutlines.com]

Epidemiology

  • Epidemiology [ 1 ] Pituitary tumours account for 10% to 25% of all intracranial neoplasms. Adenomas account for the largest portion of pituitary neoplasms (estimated at approximately 17%). Only a minority of adenomas are symptomatic.[patient.info]
  • Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev. 2004; 25 (1): 102-52[ DOI ][ PubMed ] 14. Otsuka F, Ogura T, Yamauchi T, Shikata K, Kageyama J, Makino H.[ijcancerprevention.com]
  • Cree Modern Pathology (2018) Epidemiology and biomarker profile of pituitary adenohypophysial tumors Ozgur Mete , Amber Cintosun , Irwin Pressman & Sylvia L.[nature.com]
Sex distribution
Age distribution

Pathophysiology

  • […] pituitary gland C75.1 Sites Majority occur in sella turcica within the adenohypophysis / anterior pituitary lobe Rare examples occur in extrasellar region on pituitary stalk Rare prolactinomas as part of ovarian teratoma ( Endocr Pathol 2014;25:321 ) Pathophysiology[pathologyoutlines.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.com]
  • , IR Iran 2 Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran 3 Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Article information Iranian Journal of Cancer Prevention[ijcancerprevention.com]
  • Sir William Osler was probably the first to describe a patient with Cushing's syndrome in 1898, but he attributed the signs and symptoms to myxedema, an error that some medical historians believe could have been prevented if an autopsy had been performed[uscapknowledgehub.org]

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