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Epidermolysis Bullosa Simplex Type Cockayne-Touraine

Weber Cockayne Syndrome


Presentation

  • In EBS, gen intermed, blisters may be present at birth or develop within the first few months of life. Involvement is more widespread than in EBS-loc, but generally milder than in EBS-gen sev.[ncbi.nlm.nih.gov]
  • Martin Carter Springer Science & Business Media, ٠٦‏/١٢‏/٢٠١٢ - 302 من الصفحات Because skin blisters are the initial manifestation of epidermolysis bullosa (EB), patients invariably present to the dermatologist for diagnosis and treatment.[books.google.com]
  • Nails are either absent or dystrophic, intraoral erosions are present. Another rare form of JEB is Inversa. Present at birth, areas involved are in inverse areas, i.e. Skin folds, axillary vaults and groin.[kissesforkatie.org]
Ectopia Lentis
  • lentis isolated Ectopia pupillae Ectopic coarctation Ectopic ossification familial type Ectopic pregnancy Ectrodactyly cardiopathy dysmorphism Ectrodactyly cleft palate syndrome Ectrodactyly diaphragmatic hernia corpus callosum Ectrodactyly dominant[bioreference.net]
  • Ectopia lentis isolated[?] Ectopia pupillae[?] Ectopic coarctation[?] Ectopic ossification familial type[?] Ectopic pregnancy Ectrodactyly cardiopathy dysmorphism[?] Ectrodactyly cleft palate syndrome[?][encyclopedia.kids.net.au]
Strabismus
  • PMID: 27384765 Diagnosis Al-Thawabieh W, Lucky AW, Wong B, Motley WW J Pediatr Ophthalmol Strabismus 2018 Aug 29;55:e26-e29. doi: 10.3928/01913913-20180806-03.[ncbi.nlm.nih.gov]
Hyperkeratosis
  • Hyperkeratosis MedGen UID: 209030 • Concept ID: C0870082 • Disease or Syndrome Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are[ncbi.nlm.nih.gov]
  • Abnormality of blood and blood-forming tissues Bruising susceptibility Abnormality of limbs Palmoplantar blistering Abnormality of the cardiovascular system Bruising susceptibility Abnormality of the integument Bruising susceptibility Hyperhidrosis Hyperkeratosis[familydiagnosis.com]
  • Epidermolytic hyperkeratosis Epidermolytic hyperkeratosis Epidermolytic hyperkeratosis epidermolytic hyperkeratosis 1[acronyms.thefreedictionary.com]
Hyperhidrosis
  • Ontology (HPO) Abnormality of blood and blood-forming tissues Bruising susceptibility Abnormality of limbs Palmoplantar blistering Abnormality of the cardiovascular system Bruising susceptibility Abnormality of the integument Bruising susceptibility Hyperhidrosis[familydiagnosis.com]
  • The keratodermia of the soles and the hyperhidrosis of the palms and soles are observed. The general condition of patients does not suffer. Dystrophic bullous epidermolysis exists from birth or begins in childhood, the disease lasts for many years.[iliveok.com]
  • Hyperhidrosis may also occur. Severe EBS usually has a generalised onset with blisters at or shortly after birth. Hands, feet and extremities tend to be involved. Palmoplantar hyperkeratosis and erosions are common, especially in Köbner EBS.[patient.info]
  • Hyperhidrosis of the palms and soles is a common association. Blisters can occasionally become secondarily infected. Postinflammatory pigmentary abnormalities occur with this variant, but milia and scarring as a rule are absent.[plasticsurgerykey.com]
  • The Weber-Cockaine subtype (EBS-WC) is characterized by mild to severe blistering and palmoplantar topography, and patients may concomitantly show hyperhidrosis.[slideplayer.com]
Keratosis
  • - Cockayne-Touraine type The list of signs and symptoms mentioned in various sources for Epidermolysis bullosa simplex, Cockayne-Touraine type includes the 10 symptoms listed below: Blisters Blisters on head Blisters on limbs Scarring Dry scaly skin Keratosis[checkorphan.org]
  • Acantholytic blisters occur in keratosis follicularis (Darier disease) as well as in pemphigus. Such blisters are a histologic rather than a clinical finding.[what-when-how.com]
Dry, Scaly Skin
  • scaly skin Keratosis pilaris Tylosis Excessive sweating Dystrophic nails Growth of excess hair Note that Epidermolysis bullosa simplex, Cockayne-Touraine type symptoms usually refers to various symptoms known to a patient, but the phrase Epidermolysis[checkorphan.org]
Plantar Hyperkeratosis
  • Keratolytics and softening agents for palmar plantar hyperkeratosis may prevent tissue thickening and cracking.[ncbi.nlm.nih.gov]
Mental Deterioration
  • deterioration Finnish type Epilepsy microcephaly skeletal dysplasia Epilepsy occipital calcifications Epilepsy progressive myoclonic type 2 Epilepsy telangiectasia Epilepsy with myoclono-astatic crisis Epilepsy, benign occipital Epilepsy, myoclonic progressive[bioreference.net]
  • Epilepsy mental deterioration Finnish type[?] Epilepsy microcephaly skeletal dysplasia[?] Epilepsy occipital calcifications[?] Epilepsy progressive myoclonic type 2[?] Epilepsy telangiectasia[?] Epilepsy with myoclono-astatic crisis[?][encyclopedia.kids.net.au]
Neglect
  • For patients, insult is thus added to injury and they feel abandoned, neglected, and frustrated.[books.google.com]

Treatment

  • More Symptoms of Epidermolysis bullosa simplex, Cockayne-Touraine type » • • • Back to: « Epidermolysis bullosa simplex Genetics of Epidermolysis bullosa simplex, Cockayne-Touraine type Treatments See also the following treatment articles: Treatments[familydiagnosis.com]
  • One way to remedy this deplorable situation is to provide clinicians with a compact source of information de tailing the principles of EB diagnosis and treatment. This text seeks to fulfill this role.[books.google.com]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[diseaseinfosearch.org]
  • Treatment - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied. Resources - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied.[checkorphan.org]
  • Interdisciplinary management and treatment The objective of treatment of EB is a quality of life as normal as possible; causal treatment of EB including gene therapy is still not available [Ferrari et al. 2006].[med-college.de]

Prognosis

  • Prognosis - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied. Treatment - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied. Resources - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied.[checkorphan.org]
  • PMID: 20849457 Prognosis Lalor L, Titeux M, Palisson F, Fuentes I, Yubero MJ, Tasanen K, Huilaja L, Has C, Tadini G, Haggstrom AN, Hovnanian A, Lucky AW Pediatr Dermatol 2019 Jan;36(1):132-138. Epub 2018 Dec 4 doi: 10.1111/pde.13722.[ncbi.nlm.nih.gov]
  • The prognosis depends on the form of dermatosis. With simple bullous epidermolysis, there is a favorable outcome, and with dystrophic and borderline forms - unfavorable, up to a lethal outcome.[iliveok.com]
  • Their prognosis mainly depends on adequate nutrition and hence on their dental status. Classification and pathogenesis of EB EB is classified by clinical, genetic and, above all, ultra-structural criteria.[med-college.de]
  • These patients generally have a favorable prognosis and a normal lifespan.[plasticsurgerykey.com]

Etiology

  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • Etiology Lalor L, Titeux M, Palisson F, Fuentes I, Yubero MJ, Tasanen K, Huilaja L, Has C, Tadini G, Haggstrom AN, Hovnanian A, Lucky AW Pediatr Dermatol 2019 Jan;36(1):132-138. Epub 2018 Dec 4 doi: 10.1111/pde.13722.[ncbi.nlm.nih.gov]
  • Drugs are more commonly the underlying etiologic agent than infection. Some of these include long-acting sulfonamides (particularly trimethoprim-sulfamethoxazole), anticonvulsants, barbiturates, and nonsteroidal anti-inflammatory drugs.[what-when-how.com]
  • Life with Epidermolysis Bullosa: Etiology, Diagnosis, and Multidisciplinary Care and Therapy Wien New York: Springer Verlag GmbH; 2009:258-277.[ojrd.biomedcentral.com]
  • This finding proved to be the basis for the eventual identification of the molecular etiology of RDEB since one year previously Lunstrom and colleagues had shown that the anchoring fibril, a basement membrane-associated structure known for many years[blog.ebinfoworld.com]

Epidemiology

  • Epidemiology Frequency United StatesThe exact prevalence of epidermolysis bullosa is unknown. Mild variants have been estimated to occur as frequently as 1 per 50,000 births.[thehealthscience.com]
  • Epidemiology Frequency United States The exact prevalence of epidermolysis bullosa is unknown. Mild variants have been estimated to occur as frequently as 1 per 50,000 births.[emedicine.medscape.com]
  • Google Scholar Fine JD: Epidemiology and the study of genetic diseases. Edited by: Grob JJ, MacKie R, Stern R, Weinstock M. Epidemiology and prevention of skin diseases London: Blackwell Science; 1996.[ojrd.biomedcentral.com]
  • A clinical, genetic and epidemiologic study. The John Hopkins Press, Baltimore Kim SK, Chang IT, Heo SJ, Keak JY (2002) Cytotoxicity of denture base resins.[studyres.com]
  • Fine JD, McGrath J, Eady RA (2000) Inherited epidermolysis bullosa comes into the new millennium: a revised classification system based on current knowledge of pathogenetic mechanisms and the clinical, laboratory, and epidemiologic findings of large,[springermedizin.de]
Sex distribution
Age distribution

Pathophysiology

  • Eponyms associated with different forms of epidermolysis bullosa include the following: Dowling-Meara Köebner Weber-Cockayne Kallin Mendes de Costa Herlitz Ogna Carmi Cockayne-Touraine Pasini Hallopeau-Siemens Shabbir Laryngoonychocutaneous (LOC) Kindler Pathophysiology[thehealthscience.com]
  • Pathophysiology In the absence of mutations of the COL7A1 gene, an autoimmune response against type VII collagen can result in an acquired form of epidermolysis bullosa called epidermolysis bullosa acquisita. [8] There exist other types of inherited epidermolysis[ipfs.io]
  • Pathophysiology [ edit ] In the absence of mutations of the COL7A1 gene, an autoimmune response against type VII collagen can result in an acquired form of epidermolysis bullosa called epidermolysis bullosa acquisita. [7] There exist other types of inherited[en.wikipedia.org]
  • As knowledge about the pathophysiology of EB has become more advanced, new variants of EB have been identified based on their specific genetic mutation. [ 1 ] Investigations [ 11 ] Skin biopsy is required.[patient.info]
  • Eponyms associated with different forms of epidermolysis bullosa include the following: Dowling-Meara Köebner Weber-Cockayne Kallin Mendes de Costa Herlitz Ogna Carmi Cockayne-Touraine Pasini Hallopeau-Siemens Shabbir Laryngoonychocutaneous (LOC) Pathophysiology[emedicine.medscape.com]

Prevention

  • Prevention - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied. Diagnosis - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied. Prognosis - Epidermolysis bullosa simplex- Cockayne-Touraine type Not supplied.[checkorphan.org]
  • Your skinHolds body fluids in, preventing dehydrationKeeps harmful microbes out, preventing infectionsHelps you feel things like heat, cold, and painKeeps your body temperature evenMakes vitamin D when the sun shines on itAnything ...[codelay.com]
  • Firm and easily torn crusts require debridement to prevent maintenance of the inflammatory process. 36 The basic principle underlying the care of patients with Herlitz JEB is to prevent blistering with meticulous skin protection and prevention of infections[scielo.br]
  • The highest priority is the prevention of de novo blister formation. Clean, sterile, nonadhesive dressings applied to the elbows, knees, shoulders, and other areas exposed to mechanical stimuli will cushion impact.[clinicaladvisor.com]
  • The skin should be left in place, functioning as a biological dressing and preventing bacterial colonization. Firm and easily torn crusts require debridement to prevent maintenance of the inflammatory process.[slideplayer.com]

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