PMID: 27384765 Diagnosis Al-Thawabieh W, Lucky AW, Wong B, Motley WW J Pediatr Ophthalmol Strabismus 2018 Aug 29;55:e26-e29. doi: 10.3928/01913913-20180806-03. [ncbi.nlm.nih.gov]

Hyperkeratosis MedGen UID: 209030 • Concept ID: C0870082 • Disease or Syndrome Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are [ncbi.nlm.nih.gov]

Abnormality of blood and blood-forming tissues Bruising susceptibility Abnormality of limbs Palmoplantar blistering Abnormality of the cardiovascular system Bruising susceptibility Abnormality of the integument Bruising susceptibility Hyperhidrosis Hyperkeratosis [familydiagnosis.com]

Epidermolytic hyperkeratosis Epidermolytic hyperkeratosis Epidermolytic hyperkeratosis epidermolytic hyperkeratosis 1 [acronyms.thefreedictionary.com]

Ontology (HPO) Abnormality of blood and blood-forming tissues Bruising susceptibility Abnormality of limbs Palmoplantar blistering Abnormality of the cardiovascular system Bruising susceptibility Abnormality of the integument Bruising susceptibility Hyperhidrosis [familydiagnosis.com]

The keratodermia of the soles and the hyperhidrosis of the palms and soles are observed. The general condition of patients does not suffer. Dystrophic bullous epidermolysis exists from birth or begins in childhood, the disease lasts for many years. [iliveok.com]

Hyperhidrosis may also occur. Severe EBS usually has a generalised onset with blisters at or shortly after birth. Hands, feet and extremities tend to be involved. Palmoplantar hyperkeratosis and erosions are common, especially in Köbner EBS. [patient.info]

Hyperhidrosis of the palms and soles is a common association. Blisters can occasionally become secondarily infected. Postinflammatory pigmentary abnormalities occur with this variant, but milia and scarring as a rule are absent. [plasticsurgerykey.com]

The Weber-Cockaine subtype (EBS-WC) is characterized by mild to severe blistering and palmoplantar topography, and patients may concomitantly show hyperhidrosis. [slideplayer.com]

Cockayne-Touraine type The list of signs and symptoms mentioned in various sources for Epidermolysis bullosa simplex, Cockayne-Touraine type includes the 10 symptoms listed below: Blisters Blisters on head Blisters on limbs Scarring Dry scaly skin Keratosis [checkorphan.org]

Acantholytic blisters occur in keratosis follicularis (Darier disease) as well as in pemphigus. Such blisters are a histologic rather than a clinical finding. [what-when-how.com]

scaly skin Keratosis pilaris Tylosis Excessive sweating Dystrophic nails Growth of excess hair Note that Epidermolysis bullosa simplex, Cockayne-Touraine type symptoms usually refers to various symptoms known to a patient, but the phrase Epidermolysis [checkorphan.org]

Keratolytics and softening agents for palmar plantar hyperkeratosis may prevent tissue thickening and cracking. [ncbi.nlm.nih.gov]

For patients, insult is thus added to injury and they feel abandoned, neglected, and frustrated. [books.google.com]