While typical presentation of EBV infection is easily diagnosed as mononucleosis syndrome in teenagers and adults, some atypical clinical presentations may be challenged. [ncbi.nlm.nih.gov]

• Fever

  METHODS: We recently had an elderly female who presented with fever, fatigue and dry cough with elevated serum transaminases and lung infiltrates. [ncbi.nlm.nih.gov]

• Fatigue

  The most controversial use of EBV serology is in chronic fatigue syndrome, a complaint predominantly (but not exclusively) of young to middle-aged women, characterized by long persistent debilitating fatigue and a panoply of usually mild somatic complaints [labcorp.com]

  In this report, we present a 19-year-old patient presented with nausea, fatigue and jaundice. Her physical examination and laboratory tests revealed the diagnosis as acute hepatitis due to EBV with cross-reacting antibodies to cytomegalovirus. [ncbi.nlm.nih.gov]

  Symptoms Symptoms of EBV infection can include fatigue fever inflamed throat swollen lymph nodes in the neck enlarged spleen swollen liver rash Many people become infected with EBV in childhood. [cdc.gov]

• Chronic Fatigue Syndrome

  The high levels of EBV antibodies in the general population, their long persistence, and the poor correlation of antibody titers with symptoms combine to make EBV serology useless in diagnosing, following, or ruling out chronic fatigue syndrome. [labcorp.com]

  Brouse as he shares his experience treating and controlling this cleaver virus from causing such debilitating consequences including chronic fatigue syndrome. [sunnysidehealthcenter.com]

  "MMPI profiles of patients with chronic fatigue syndrome". Journal of Psychosomatic Research. 40 (1): 67–74. ISSN 0022-3999. PMID 8730646. Holmøy, Trygve (2008). [me-pedia.org]

• Malaise

  The symptoms and signs of an EBV infection may include malaise, fever, muscle aches, headaches, sore throat, lymph node swelling, liver swelling, rash, and spleen swelling. [medicinenet.com]

  Infectious mononucleosis is the prototype EBV infection and is characterized by fever, sore throat, cervical and generalized lymphadenopathy, hepatosplenomegaly, and somatic complaints of fatigue and malaise. [pedsinreview.aappublications.org]

  As the condition progresses the symptoms may include: A sore throat that lasts two weeks or more Swollen lymph nodes in the neck, armpits, and groin A persistent fever (usually about 102 degrees F) Fatigue Malaise (a vague feeling of discomfort) These [healthcentral.com]

  It is perhaps the most common reason for fever of unknown origin in young children and can present with fever in isolation or in the context of lymphadenopathy, fatigue, or nonspecific malaise. [emedicine.medscape.com]

• Generalized Lymphadenopathy

  Infectious mononucleosis is the prototype EBV infection and is characterized by fever, sore throat, cervical and generalized lymphadenopathy, hepatosplenomegaly, and somatic complaints of fatigue and malaise. [pedsinreview.aappublications.org]

  Diseases in immunocompetent hosts: Infectious Mononucleosis (IM): IM is an acute, self limiting febrile illness in young adults, characterized by fever, sore throat, abdominal discomfort, pharyngitis, tonsillitis, tender generalized lymphadenopathy, palatal [msdsonline.com]

  The most common presentation is infectious mononucleosis (IM), which is an acute clinical syndrome characterized by fever, sore throat, and generalized lymphadenopathy. [journals.lww.com]

• Cervical Lymphadenopathy

  This 15-year old patient presented with B symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. [ncbi.nlm.nih.gov]

  Thus the “classic” patient with uncomplicated IM may be summarized with the following presentation; fever, pharyngitis, cervical lymphadenopathy, lymphocytosis, palatal petechiae and hepatosplenomegaly and with elevated ALAT. [bmcfampract.biomedcentral.com]

  Patients most often present with isolated cervical lymphadenopathy, which may be tender, and of several months duration. [doi.org]

  One year post-transplant, he presented with cervical lymphadenopathy concerning for recurrence of ALCL. PET/CT showing an FDG-avid lymph node prompted a biopsy. [bbmt.org]

• Rhinitis

  Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves' disease, J Clin Endocrinol Metab 1993; 77 :1667–1670 [ PubMed ] [ Google Scholar ] 6. [ncbi.nlm.nih.gov]

  In specific immunotherapy with allergen in allergic rhinitis, for example, increases in allergen-specific IgG4 levels indeed correlate with clinical responses ( 7, 23 ). [doi.org]

• Productive Cough

  A 22-year-old Caucasian woman, diagnosed with CAEBV 1.5 years earlier, was admitted to the Immunology Clinic due to a 4-week history of productive cough, fever and general weakness. [ncbi.nlm.nih.gov]

• Abdominal Pain

  Her dry cough persisted and she developed abdominal pain. [ncbi.nlm.nih.gov]

• Rectal Pain

  She had persistent rectal pain and bleeding for over a year following hemorroidectomy. A large ulcer in the distal rectum with excoriation and granular margins was noted on examination, and an initial biopsy from the lesion was inconclusive. [ncbi.nlm.nih.gov]

• Jaundice

  It results from interstitial nephritis, myositis-associated acute kidney injury, hemolytic uremic syndrome or jaundice-associated nephropathy. Copyright 2017 Elsevier B.V. All rights reserved. [ncbi.nlm.nih.gov]

• Subcutaneous Mass

  We report an EBV   PTCL in a 9-year-old child with initial symptom of subcutaneous masses without lymph node involvement. [ncbi.nlm.nih.gov]

• Excoriation

  A large ulcer in the distal rectum with excoriation and granular margins was noted on examination, and an initial biopsy from the lesion was inconclusive. [ncbi.nlm.nih.gov]

• Microscopic Hematuria

  relative bradycardia, abdominal pain, hyponatremia, hypophosphatemia, elevated ferritin levels, microscopic hematuria. Legionella titers were negative, but Legionella (serogroup 1) urinary antigen was positive. [ncbi.nlm.nih.gov]

  All healthy controls had normal UP/Cr ratio or dipstick test for protein, and none exhibited microscopic hematuria. [dx.doi.org]

Five of the patients without workup reacted after reuse of the suspected drug for infection treatment. CONCLUSION: In this study, the incidence of drug hyper-sensitivity was much lower than previously reported. [ncbi.nlm.nih.gov]

[…] before 4-5 days Serology Diagnosis of acute disease due to EBV depends mostly on testing for an immune response to the virus Immune response during acute infection may be significantly delayed, especially in children and immunocompromised hosts Extensive workup [arupconsult.com]

While it is possible to test for these antibodies as part of the EBV diagnostic workup, it is rarely necessary to do so. [labtestsonline.org.au]

• Mediastinal Mass

  This 15-year old patient presented with B symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. [ncbi.nlm.nih.gov]

• Anterior Mediastinal Mass

  This 15-year old patient presented with B symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. [ncbi.nlm.nih.gov]

• Hyponatremia

  relative bradycardia, abdominal pain, hyponatremia, hypophosphatemia, elevated ferritin levels, microscopic hematuria. Legionella titers were negative, but Legionella (serogroup 1) urinary antigen was positive. [ncbi.nlm.nih.gov]

CONCLUSION: DEP/L-DEP was a good salvage treatment. L-DEP might be a more effective first-line initial regimen than HLH-94/04 regimen for EBV-HLH. Finally, allo-HSCT is an effective radical treatment for EBV-HLH. [ncbi.nlm.nih.gov]

The prognosis of PEL is extremely poor and no optimal treatment regimen has been established. We report a case of EBV-negative PEL in a 49-year-old human immunodeficiency virus-positive man, presenting with massive bilateral pleural effusion. [ncbi.nlm.nih.gov]

Although the etiology of autism is remained unknown but it is suggested that ASD have a complex etiology, including genetic and environmental factors, which may explain the observed different behavioral disorders in these patients. [ncbi.nlm.nih.gov]

Abstract Epidemiological and serological evidence has suggested a role for Epstein-Barr virus infection in the aetiology of multiple sclerosis. [ncbi.nlm.nih.gov]

It was named after its discoverers Michael Epstein and Yvonne Barr. 2 Epidemiology The virus can be found worldwide. Humans are the sole pathogen reservoir. [flexikon.doccheck.com]

The Epstein-Barr virus (EBV) is a plausible candidate for playing a role in the pathophysiology of these diseases. Both SLE and RA are characterized by high titers of anti-EBV antibodies and impaired T-cell responses to EBV antigens. [ncbi.nlm.nih.gov]

The pathophysiology of EBV infection begin with saliva transmission and the EBV virus targeting the tonsils which is a lymphoid tissue made up of T cells and B cells. In the tonsil the EBV target B cells and tonsillar epithelial cells. [youtube.com]

Next the big challenge is to develop a vaccine that will prevent infection by the virus. We believe that a successful EBV vaccine could prevent up to 200,000 new cases of cancers per year.” [cancerresearchuk.org]

The Prevent Cancer Foundation is the only U.S. nonprofit organization solely devoted to cancer prevention and early detection. [umassmed.edu]

These topics are approached in the context of developing therapeutic and preventative strategies. [ncbi.nlm.nih.gov]