Presentation
Figure 1 Histopathological findings of lymph node at the initial presentation. [diagnosticpathology.biomedcentral.com]
We present a lung transplant recipient with a history of acute rejection and Epstein Barr virus-associated posttransplantation malignant non-Hodgkin's lymphoma. [ncbi.nlm.nih.gov]
In rare circumstance when EBV-positive RS-like cells are present in a T-cell-rich infiltrate, the distinction may be challenging [ 1 ]. [omicsonline.org]
We herein present a fulminant fatal case in an elderly female with an unusual presentation of abdominal compartment syndrome (ACS), and review recent advances in diagnosing adult HLH. [hrjournal.net]
The mean age at presentation with primary testicular disease (stage IE) is 44 years (range: 30-66 years) [2]. Most of the patients are Asian. [latunisiemedicale.com]
Entire Body System
- Infertility
Some chemotherapy agents can cause infertility in both men and women. There can be permanent damage to the testicles and ovaries, harming their ability to produce sperms or ova. In men, sperm banking can be considered before initiating therapy. [dovemed.com]
Skin
- Skin Lesion
The skin biopsies were performed in the skin lesion located at the left upper arm. [diagnosticpathology.biomedcentral.com]
Keratosis : a skin lesion that may be rough or scaly in appearance. Lichenoid eruptions : a skin condition where there is damage to the lower epidermis along with a focused chronic inflammation between the epidermal and dermal layers of skin. [thebody.com]
Severe HV-type tends to exhibit more extensive skin lesions and systemic manifestations of fever, hepatomegaly, serologic abnormalities, and peripheral NK lymphocytosis. [jpatholtm.org]
Face, Head & Neck
Neurologic
- Meningism
Due to this, individuals are more vulnerable to infections; there is an increased risk of developing serious complications from such infections If the condition spreads to the brain and central nervous system, it can give rise to: Inflammation of the meninges [dovemed.com]
Meninges are involved in 25–35% of AIDS-related PCNSL cases. EBV studies (in situ hybridization for EBER in tumor cells and PCR for EBV DNA in CSF), flow cytometry and immunoglobulin heavy-chain PCR are all diagnostically useful [ 4, 5, 45 ]. [karger.com]
Workup
Infectious Mononucleosis Workup. Medscape. Available online at http://emedicine.medscape.com/article/222040-workup. Accessed June 13, 2016. (Aug 2004) Hess, R. [labtestsonline.it]
Treatment
Treatment with ECP, with its beneficial effects on both, rejection after organ transplantation and malignant lymphoma, may be a particularly valuable approach for the treatment of PTLD in patients after lung transplantation, with its increased risk for [ncbi.nlm.nih.gov]
Because of the progression of the disease, treatment with standard doses of cladribine was initiated in June 1994 and repeated in August 1994. The patient had a remarkable response, with alleviation. .. Ruben Niesvizky, M.D. Andrew X. [nejm.org]
Treatment : The type of treatment will depend on the type of lymphoma, how aggressive it is, and other clinical details, such as the patient's age, general health, and the number and types of prior treatments. Also see Treatment Decisions Resources [lymphomation.org]
Magrath DSc (Med), FRCP, FRCPath President, International Network for Cancer Treatment and Research, Adjunct Professor of Pediatrics, Uniformed Services University of the Health Sciences, International Network for Cancer Treatment and Research, Brussels [books.google.com]
However, its acute development after conventional chemotherapy as treatment for another malignancy is a rare finding. [bloodjournal.org]
Prognosis
[…] generally have poorer prognosis than younger individuals The size of the tumor: Individuals with small-sized tumors fare better than those with large-sized tumors Individuals with bulky disease have a poorer prognosis Involvement of vital organs may [dovemed.com]
Extra-nodal NK/T-cell lymphoma should be distinguished from peripheral T-cell lymphoma since it is associated with poorer prognosis compared with peripheral T-cell. [latunisiemedicale.com]
Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA. Lancet 1990 ; 335 : 1171 –4. [jcp.bmj.com]
Cell Transformation, Viral/genetics Epstein-Barr Virus Infections/complications* Herpesvirus 4, Human/physiology* Humans Lymphoma, B-Cell/complications Lymphoma, B-Cell/diagnosis* Lymphoma, B-Cell/etiology* Lymphoma, B-Cell/virology Models, Biological Prognosis [ncbi.nlm.nih.gov]
Prognosis of EBV status in the young group We carried out survival analysis in the young group. [nature.com]
Etiology
[…] physiology B-Lymphocytes/metabolism B-Lymphocytes/pathology Cell Transformation, Viral/genetics Epstein-Barr Virus Infections/complications* Herpesvirus 4, Human/physiology* Humans Lymphoma, B-Cell/complications Lymphoma, B-Cell/diagnosis* Lymphoma, B-Cell/etiology [ncbi.nlm.nih.gov]
The virus may be a prime etiologic agent, a cocarcinogen, or just an innocent passenger. [anmjournal.com]
This DNA virus of the herpes group, which came to be known as EBV, has been implicated as the etiologic agent for Burkitt's lymphoma. [jcda.ca]
Introduction Early clues that the Epstein-Barr virus (EBV) may play a role in the etiology of Hodgkin lymphoma came from seroepidemiologic case-control studies showing that Hodgkin lymphoma cases had altered antibody titers against the EBV viral capsid [bloodjournal.org]
The exact etiology remains unknown. A widely accepted explanation is cytokine storm due to an overactive but ineffective immune reaction. HLH is classified into primary and secondary forms according to the World Health Organization classification. [hrjournal.net]
Epidemiology
Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt’s lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region, Claudete Esteves Klumb, Fabricio E. Felisbino, Deisy M. [haematologica.org]
Over the past 40 years there has been great progress towards understanding the biology and epidemiology of Epstein-Barr virus, which conclusively show that these early ideas were overly simplistic. [ncbi.nlm.nih.gov]
Moreover, its epidemiological behavior is similar to that of HL. [scielo.org.mx]
Epidemiologic patterns of Hodgkins disease. Int J Cancer, v. 8, p. 192-201, 1971. [ Links ] 8. DELSOL, G. et al. [scielo.br]
However, changes in economic status may have changed both the age of initial infection and the incidence of infectious mononucleosis since the large epidemiologic studies were completed. [emedicine.medscape.com]
Pathophysiology
"Alice in Wonderland Syndrome: A Clinical and Pathophysiological Review". BioMed Research International. 2016 : 1–10. doi : 10.1155/2016/8243145. PMC 5223006. PMID 28116304. ^ Nussinovitch M, Prais D, Volovitz B, Shapiro R, Amir J (September 2003). [en.wikipedia.org]
These entities often pose diagnostic challenges, both clinically and pathologically, and it is important to understand their unique pathophysiology for correct diagnoses and optimal management. [jpatholtm.org]
Sullivan R, Pantanowitz L, Casper C, Stebbing J, Dezube B: Epidemiology, pathophysiology and treatment of Kaposi sarcoma- associated herpes-virus disease: Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. [karger.com]
Prevention
[…] doi: 10.1097/COH.0000000000000333 PREVENTION AND CARE STRATEGIES Abstract Author Information Authors Article Metrics Metrics The present review summarizes the association of the different histotypes of Epstein–Barr virus (EBV)-associated lymphomas with [journals.lww.com]
(Jan 2014) Centers for Disease Control and Prevention. Epstein-Barr Virus and Infectious Mononucleosis. Available online at http://www.cdc.gov/epstein-barr/laboratory-testing.html. Accessed June 11, 2016. (Oct 2015) Cunha, B.A., et al. [labtestsonline.it]
How can Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders be Prevented? Presently, the cause of Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders is unknown and there are no known methods to prevent their occurrence. [dovemed.com]
After any sort of organ transplantation, those receiving the transplant have to be given drugs that prevent an immune response to foreign material. [verywell.com]
For example: People who receive organ transplants are treated with drugs that suppress their immune system to prevent it from attacking the new organ. These people have a higher risk of developing NHL. [cancer.org]