Classically, lesions present as symmetric red to purple plaques, papules, and nodules overlying joints. First-line therapy is dapsone. We present a case of EED with widespread lesions involving the hands, extensor arms and legs, and trunk. [ncbi.nlm.nih.gov]

• Pseudotumor

  This case is noteworthy clinically due to its location and its histopathological presentation that comprises a wide differential diagnosis, including inflammatory pseudotumor, dermatofibrosarcoma protuberans, superficial nodular fasciitis, hyalinized [ncbi.nlm.nih.gov]

  Because of transitions between EED or GF-like areas and those of patterned sclerosis with plasma cell-rich infiltrates, we believe that some "inflammatory pseudotumors" of the skin, and perhaps of other sites could be the result of localized vasculitis [geocities.ws]

• Disability

  We report a patient with unusually widespread and disabling EED that had been unresponsive to corticosteroids and antibiotics, but resolved on dapsone. [ncbi.nlm.nih.gov]

• Papule

  Asymptomatic papules and plaques measuring from 0.7 to 9.0 cm were seen over the interphalangeal joints, elbows, knees, and ankles. [ncbi.nlm.nih.gov]

  […] scattered erythematous papules with central hemorrhagic crusting of the left flank (C). [mdedge.com]

  Figure 165-2 Multiple erythematous scaly papules coalescing into plaques on extensor elbow. Figure 165-3 Crusted brown and violaceous papules over knee and anterior thigh. [plasticsurgerykey.com]

• Pruritus

  678 206 Pruritus ani 686 207 Pruritus vulvae 688 208 Pseudofolliculitis barbae 691 209 Pseudoxanthoma elasticum 695 210 Psoriasis 697 211 Psychogenic excoriation 708 212 Pyoderma gangrenosum 711 213 Pyogenic granuloma 716 214 Radiation dermatitis 719 [books.google.de]

  […] herpetiformis Inflammatory Dermatitis and eczema Atopic dermatitis · Seborrhoeic dermatitis ( Dandruff, Cradle cap ) · Contact dermatitis ( Diaper rash, Urushiol-induced contact dermatitis ) · Erythroderma · Lichen simplex chronicus / Prurigo nodularis · Itch ( Pruritus [wikidoc.org]

  […] either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease; often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus [icd9data.com]

  Under this therapy regime, she achieved only a partial remission of the skin lesions and pruritus remained unresolved. In 2015 the patient presented with a severe relapse of the EED despite continuous treatment. [gavinpublishers.com]

• Skin Rash

  However she developed a hypersensitivity syndrome compatible with DRESS with fever, skin rash and acute hepatitis confirmed in vitro by the presence of circulating dapsone- specific T cells. [ncbi.nlm.nih.gov]

  Since then she had had intermittent episodes of arthritis with significant morning stiffness and skin rashes mainly over the extensor aspects. [edoj.org.eg]

  Showing of 8 | 80%-99% of people have these symptoms Arthralgia Joint pain 0002829 Skin rash 0000988 Vasculitis in the skin 0200029 30%-79% of people have these symptoms Abnormal blistering of the skin Blistering, generalized Blisters [ more ] 0008066 [rarediseases.info.nih.gov]

• Subcutaneous Mass

  One, whose histology resembled GF, had a large multinodular dermal and subcutaneous mass that persisted despite attempted resection. [ncbi.nlm.nih.gov]

An extensive workup was positive for underlying hepatitis B infection. Our case represents the clinicopathologic spectrum that EED can present and emphasizes the importance of searching for an underlying etiology. [ncbi.nlm.nih.gov]

This workup should include complete blood counts, urine analysis, and age appropriate cancer screening. CT scan of the chest, abdomen, and pelvis must also be considered if other tests are not diagnostic. [ozarkderm.com]

An additional infectious workup was negative for hepatitis C, streptococcus, syphilis, tuberculosis, and HIV. [mdedge.com]

Treatment of these lesions is notoriously difficult. Dapsone is used as the mainstay of treatment, however other options exist. We have highlighted different treatment options and suggested a treatment algorithm. [ncbi.nlm.nih.gov]

Response to this treatment was highly encouraging. Peripheral blood cell counts showed abnormal results at the beginning of treatment (Hb 11,9 g/dl) (normal 12,0-16,0 g/dl). [gavinpublishers.com]

Treatment: Treatment of EED is difficult because this disorder runs a chronic and recurrent course. Treatment of the underlying cause or infection should result in improvement of EED. [medigoo.com]

What is the Prognosis of Erythema Elevatum Diutinum? (Outcomes/Resolutions) The prognosis of Erythema Elevatum Diutinum is dependent upon the associated disorder/condition, severity of the symptoms, and the complications it presents. [dovemed.com]

Prognosis Although EED is a chronic condition, it is usually sensitive to treatment and the prognosis is good. The documents contained in this web site are presented for information purposes only. [orpha.net]

It has many histological mimics and is often associated with a variety of underlying systemic diseases, when these are present the management and prognosis dictates the course of the EED. [ncbi.nlm.nih.gov]

Introduction Define/describe the condition Anatomy Describe the pertinent anatomy Pathogenesis Describe the biomechanics/biologic basis of the disorder or the mechanism of injury Natural History Describe the natural history, epidemiology and prognosis [orthopaedicsone.com]

Erythema elevatum diutinum is a rare chronic inflammatory skin disease of unknown etiology with a histopathology of a leukocytoclastic vasculitis. [ncbi.nlm.nih.gov]

Summary Epidemiology It is very rare, although the exact prevalence is unknown. Clinical description The disease manifests as chronic, red to purple papules, located mainly on the dorsal aspect of the main joints (knees, elbows, hands and feet). [orpha.net]

Introduction Define/describe the condition Anatomy Describe the pertinent anatomy Pathogenesis Describe the biomechanics/biologic basis of the disorder or the mechanism of injury Natural History Describe the natural history, epidemiology and prognosis [orthopaedicsone.com]

Epidemiology The incidence of EED is unknown; however, it appears to be a rare disease. There is no significant mortality associated with EED. It presents predominantly in males, in the fourth to sixth decade of life. [plasticsurgerykey.com]

This leads to repetitive damage to the vessels and ultimately develops into fibrosis. [3][2][1] Epidemiology EED is rare, with descriptions of only several hundred cases in the literature. [ncbi.nlm.nih.gov]

Erythema elevatum diutinum has also been reported after the administration of erythropoietin. [14] Epidemiology Frequency Erythema elevatum diutinum is a rare disease. [emedicine.com]

CONCLUSIONS: The ANCAs, particularly of IgA class, may prove to be a helpful paraclinical marker in erythema elevatum diutinum and an interesting perspective for understanding the pathophysiology of the disease. [ncbi.nlm.nih.gov]

Pathophysiology The pathophysiology of erythema elevatum diutinum is not well understood. According to Gibson and Su, [5] the lesions are thought to be caused by the deposition of immune complexes in small blood vessels. [emedicine.com]

Newly formed vessels in granulation tissue may be more susceptible to damage by immune complexes, and the early formation of granulation tissue in EED may prevent an early resolution of vasculitis. [journals.lww.com]

Erythema Prevention lies in what ultimately causes your erythema. [sunsaferx.com]

ABSTRACT: Objectives: The time that drugs for moderate-to-severe psoriasis take to... more The Role of Topical Retinoids in Prevention and Treatment of Atrophic Acne .... ABSTRACT: Atrophic acne scarring is a frequent occurrence among acne patients. [jddonline.com]

Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [jamanetwork.com]