Splenomegaly is the rule, and in large family studies, palpable spleens have been detected in more than 75% of affected members. No apparent correlation has been shown between spleen size and disease severity, but it may exist. [oncohemakey.com]

Anemia, Hemolytic, Congenital/blood* Anemia, Hemolytic, Congenital/complications Anemia, Hemolytic, Congenital/surgery Elliptocytosis, Hereditary/blood* Elliptocytosis, Hereditary/complications Elliptocytosis, Hereditary/surgery Erythrocyte Membrane/ [ncbi.nlm.nih.gov]

Congenital hemolytic anemia with high-sodium, low-potassium red cells. New Engl. J. Med. 280, 909 (1969) PubMed Google Scholar 18. [link.springer.com]

Four new chapters cover anemias unique to the newborn period, pathology of LHC and other histiocytic disorders, tumors of the spleen, and pathology and classification of myeloproliferative disorders and mast cell disease. [books.google.com]

anemia associated with ulcerative colitis Hemolytic anemia, hereditary Hemolytic anemia, lymphoproliferative disease Hemolytic anemia, with ulcerative colitis Hereditary hemolytic anemia Clinical Information A congenital hemolytic anemia caused by defects [icd10data.com]

Membrane Potential 223 Active Transport 224 Properties of the Na K Pump 225 7 Transport Modes of the Na K Pump 227 Ion Selectivity of the Na K Pump 228 Ouabain and the Na K Pump 229 References 231 General Principles MICHAEL J JACKSON 1 Introduction 235 Weak [books.google.com]

The principal defect in the erythrocyte is a mechanical weakness caused by abnormalities in the proteins involved in the membrane skeleton, including α-spectrin, β-spectrin, protein 4.1, and glycophorin C. [mhmedical.com]

Membrane protein-protein and protein-lipid interactions are often divided into two categories: (1) vertical interactions, which are perpendicular to the plane of the membrane and involve spectrin-ankyrin-band 3-protein 4.2 interactions and weak interactions [oncohemakey.com]

The text continues its tradition of correlating basic science with the clinical practice of hematology and is organized to help physicians find clinical answers quickly and easily. [books.google.com]

Trans Assoc Am Physicians 1988 ; 101: 149 –54. 31. Winkelmann JC, Chang J-G, Tse WT, Scarpa AL, Marchesi VT, Forget BG.. Full-length sequence of the cDNA for human erythroid β-spectrin. J Biol Chem 1990 ; 265: 11827 –32. 32. [nejm.org]

– If present, family history of anemia and/orsplenectomy.– Immune spherocytosis  positive directCoombs test. 15. Hereditary SpherocytosisDiagnosis– Splenomegaly can also be seenCirrhosis.Clostridial infections.G6PD deficiency. 16. [slideshare.net]

There is a wide range of measured values for K of RBCs that fall into two groupings. (1) Values reported from micropipette-based studies are in the range of 300-500 mN/m ( Evans,1973 ; Waugh and Evans,1979 ). (2) Recently, measurements based on dynamic [intechopen.com]

An increase in scleral icterus and a darker urine color is commonly seen in children with nonspecific viral infections. Even when patients have no detectable jaundice, there is usually laboratory evidence of ongoing hemolysis. [oncohemakey.com]

Forget BG, Chang JG, Coupal E, et al.. Molecular genetics of the human β-spectrin gene. Trans Assoc Am Physicians 1988 ; 101: 149 –54. 31. Winkelmann JC, Chang J-G, Tse WT, Scarpa AL, Marchesi VT, Forget BG.. [nejm.org]

In: Handin RI, Lux SE, Stossel TP (eds) Blood: Principles and Practice of Hematology Lippincott: Philadelphia 1995 pp 1701–1818 3 Gallagher PG, Forget BG, Lux SE. Disorders of the erythrocyte membrane. [nature.com]

(Reprinted with permission from Gallagher PG, Tse WT, Forget BG. Clinical and molecular aspects of disorders of the erythrocyte membrane skeleton. Semin Perinatol 1990;14:352.) FIGURE 27.4. [oncohemakey.com]

Membranes 437 Ion Movements in Skeletal Muscle in Relation to the Activation 449 Excitable Tissues The Heart 469 Ion Transport through LigandGated Channels 491 Biogenesis Membrane Localization and Regulation 498 [books.google.com]

Deficiency of protein 4.2 in erythrocytes from a patient with a Coombs negative hemolytic anemia: evidence for a role of protein 4.2 in stabilizing ankyrin on the membrane. J Clin Invest 1988 ; 81: 893 –901. 13. [nejm.org]

abnormalities involving deletions or translocations of the ankyrin-1 gene locus on chromosome 8p. [oncohemakey.com]