Presentation
Although dysphagia is known to be the first manifestation of bronchogenic carcinomas, such presentation in a case of a peripheral lung carcinoma has not been well described. [ncbi.nlm.nih.gov]
Entire Body System
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Collapse
CT scan of the brain demonstrated a lobulated mass lesion of the left frontal lobe with severe surrounding edema and collapse of the ipsilateral ventricular system [Figure - 3]. [neurologyindia.com]
Gastrointestinal
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Dysphagia
This case is reported with a review of the literature for cases with dysphagia secondary to a metastatic tumor in the esophagus. [ncbi.nlm.nih.gov]
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Odynophagia
Other than usual exhaustion from bleeding and parenteral feeding the patient had no other leading symptoms like dysphagia, odynophagia or substantial weight loss. [ijcasereportsandimages.com]
Symptoms and signs of oesophageal cancer which may cause a patient to present to a doctor include: Dysphagia Weight loss Loss of appetite Odynophagia Hoarseness Melaena Retrosternal pain Intractable hiccups Lymphadenopathy Differential diagnosis These [patient.info]
Liver, Gall & Pancreas
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Hepatosplenomegaly
By contrast, the multicentric type of CD (MCD) is associated with systemic symptoms, including hepatosplenomegaly, recurrent fevers, night sweats, and lymphadenopathy[ 2 ]. [wjgnet.com]
Workup
Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol, 6 (5), 112-20. Purim, O., Beny, A., Inbar, M., Shulman, K., Brenner, B., Dudnik, E., ... & Sarid, D. (2018). [oncolink.org]
"Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities". World Journal of Gastrointestinal Oncology. 6 (5): 112–20. doi : 10.4251/wjgo.v6.i5.112. PMC 4021327. PMID 24834141. [en.wikipedia.org]
X-Ray
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Posterior Mediastinal Mass
Large posterior mediastinal mass in a young woman. Pathologic diagnosis: localized hyaline-vascular-type Castleman disease (angiofollicular lymphoid hyperplasia). Arch Pathol Lab Med. 2001; 125 :964-967. [ PubMed ] [ DOI ] 13. [wjgnet.com]
Microbiology
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Human Herpesvirus 8
A variant of the multicentric form was later found to be associated with human herpesvirus 8 (HHV-8), which is the same virus found in Kaposi’s sarcoma. [wjgnet.com]
Treatment
Since treatment for recurrent breast cancer is generally palliative, systemic (chemo- and/or endocrine-) therapy in combination with radiotherapy is the first-line option for esophageal metastasis of breast cancer. [ncbi.nlm.nih.gov]
The background characteristics of esophageal cancer treatment are markedly different between Asian and Western countries, however. [books.google.com]
The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain. [keio.pure.elsevier.com]
Prognosis
Prognosis after treatment of recurrent disease is disappointing, and the prognosis is poor. Better early detection methods and effective systemic therapeutic plan for such rare cases are needed. [ghrnet.org]
Background: Brain metastases from esophageal carcinoma have historically been rare and associated with poor prognosis. With improvements in systemic disease control, the incidence of brain metastases is expected to rise. [oncologynurseadvisor.com]
The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain. [keio.pure.elsevier.com]
Lee, Annie LM Cheung, Yan-Ru Qin, Kwok Wah Chan, Wen Ning, Xin Yuan Guan and Stephanie Ma DOI: 10.1158/0008-5472.CAN-17-1411 Abstract Esophageal squamous cell carcinoma (ESCC) has a generally poor prognosis and molecular markers to improve early detection [cancerres.aacrjournals.org]
It seems that the clinical prognosis is usually disappointing regardless of whatever treatment is selected, and patients usually die within one year on an average from diagnosis with cardiac metastasis. [omicsonline.org]
Etiology
DISCUSSION CD is an uncommon benign lymphoproliferative disorder of unknown etiology that was first reported by Castleman et al[ 1 ] in 1956. [wjgnet.com]
These differ in etiology, precursor lesions, molecular properties, and epidemiology. While the incidence of EA has surpassed that of ESCC in the U.S., ESCCs represent 80 percent of esophageal cancer cases worldwide [5]. [austinpublishinggroup.com]
Epidemiology
"Epidemiology of Esophageal Cancer". Epidemiology of Chronic Disease: Global Perspectives. Burlington, MA: Jones & Bartlett Publishers. pp. 157–161. ISBN 978-0-7637-8047-0. Archived from the original on 2015-09-25. [en.wikipedia.org]
*SEER Surveillance, Epidemiology, and End Results [cancer.org]
These differ in etiology, precursor lesions, molecular properties, and epidemiology. While the incidence of EA has surpassed that of ESCC in the U.S., ESCCs represent 80 percent of esophageal cancer cases worldwide [5]. [austinpublishinggroup.com]
Epidemiology [ 1 ] Carcinoma of the oesophagus is a common, aggressive tumour. Several histological types are seen, almost all of which are epithelial in origin. [patient.info]
Didactic material will cover epidemiology, screening and diagnosis, staging, imaging, radiation therapy, systemic therapy, surgery, psychiatry, and patient support topics. [coursera.org]
Prevention
[…] co-stimulatory pathway can help promote T cell survival after activation PD-1/PD-L1: blocking this pathway can help prevent cancer-fighting T cells from becoming “exhausted,” and can restore the activity of already-exhausted T cells STAT3: activating [cancerresearch.org]
Although pharmaceutical agents for the prevention of acid secretion (histamine blockers, proton pump inhibitors) can be effective for the prevention of GERD symptoms, there is no proof that they decrease the incidence of Barrett's esophagus. [oncolink.org]
The immune system’s attack against foreign antigens is highly regulated by stimulatory and inhibitory mechanisms that evolved to prevent overly destructive immune responses to pathogen invasion. [austinpublishinggroup.com]
[ edit ] Prevention includes stopping smoking or chewing tobacco. [2] Overcoming addiction to areca chewing in Asia is another promising strategy for the prevention of esophageal squamous-cell carcinoma. [4] The risk can also be reduced by maintaining [en.wikipedia.org]
Prevention [ 15 ] Reducing risk factors (obesity, smoking and alcohol) should help. Earlier detection through screening and surveillance will improve survival rates. [patient.info]