Presentation
Esophageal tuberculosis secondary to tuberculous mediastinal lymphadenopathy is a very unusual presentation of adult tuberculosis. We report a patient presenting with fever of unknown origin and dysphagia. [ncbi.nlm.nih.gov]
Esophageal tuberculosis presenting with hematemesis. [wjgnet.com]
Immune System
- Mediastinal Lymphadenopathy
We report a patient with dysphagia who proved to have esophageal narrowing, mediastinal lymphadenopathy, and intramural pseudodiverticulosis. [ncbi.nlm.nih.gov]
Bloomberg TJ, Dow CJ: Contemporary mediastinal tuberculosis. Thorax 35 :392–396, 1980 PubMed Google Scholar 11. Amorosa JK, Smith PR, Cohen JR, Ramsey C, Lyons HA: Tuberculous mediastinal lymphadenopathy in the adult. [link.springer.com]
- Cervical Lymphadenopathy
The remaining two cases had a past history of tuberculosis; one presented with cervical lymphadenopathy and one mediastinal lymphadenopathy. [ncbi.nlm.nih.gov]
After antituberculous chemotherapy for six months, the mediastinal and cervical lymphadenopathy were reduced in size and the esophageal ulceration almost disappeared. [jstage.jst.go.jp]
Entire Body System
- Pseudotumor
Radiological abnormalities seen in barium swallow examination were extrinsic compression, traction diverticula, strictures, sinus/fistulous tracts, kinking and pseudotumor mass of esophagus in decreasing order of frequency. [ncbi.nlm.nih.gov]
Primary tuberculosis of esophagus: Pseudotumoral presentation. Am J Gastroenterol 1984; 79 :839–841. 17. Anand, BS, Schneider, FE, El-Zaatari, FA, et al. [nature.com]
[…] the differential diagnosis of esophageal cancer, esophageal other benign: esophageal papilloma esophageal hemangioma, neurofibroma esophagus and esophageal adenocarcinoma, esophageal granular cell tumor and esophageal myoblasts and other inflammatory pseudotumor [cancerlive.net]
Sometimes due to massive hyperplasia, there can be false tumor-like mass (pseudotumor) formation into the esophageal lumen, resulting in luminal narrowing; and (3) Granular esophageal tuberculosis (least common): occurs in the severe systemic disease [wjgnet.com]
[…] into a massive mass, mainly in a large number of tuberculous granulation tissue and fibrous tissue hyperplasia, was the size Ranging from the deep and intramuscular mucosa, mucosal integrity, hyperplasia tissue can sometimes be pseudo-tumor-like mass (pseudotumor [healthfrom.com]
- Intermittent Fever
Review of systems revealed no dyspnea, orthopnea, productive cough or intermittent fever with night sweats. She claimed to have no melena, hematochezia, heartburn, ingestion of caustic agents, or recent change in bowel habits. [academic.oup.com]
She had no nausea, melena, productive cough, intermittent fever with night sweats or weight loss. No family history was reported. Physical examination and standard laboratory test results were normal. Tuberculosis skin test is positive. [omicsonline.org]
A 29-year-old male, chronic alcoholic was referred to us with history of cough following intake of food, purulent (earlier mucoid) expectoration and intermittent fever since one month. [lungindia.com]
- Fever of Unknown Origin
We report a patient presenting with fever of unknown origin and dysphagia. Barium swallow demonstrated esophageal displacement, mucosal ulceration and perforation with a fistulous tract into the mediastinum. [ncbi.nlm.nih.gov]
- Progressive Dementia
—78-year-old woman with rapid progressive dementia and myoclonus. [ajronline.org]
- Localized Edema
Endoscopic examination of the more characteristic of the mirror seen: esophageal mucosa is shallow in rat rodent ulcers, the base was gray, with exudate, local edema. esophageal mucosa can have a number of yellow ridge-like granulation tissue, the so-called [healthfrom.com]
Gastrointestinal
- Dysphagia
The unusual cause and the interesting clinical course of dysphagia are described. [ncbi.nlm.nih.gov]
Interesting case of spontaneously resolved dysphagia in a young female due to complicated esophageal tuberculosis. [pagepress.org]
This report describes a patient with a 2‐wk history of epigastric pain and dysphagia, and a mid‐esophageal ulceration resulting from infection with Mycobacterium tuberculosis. [jhu.pure.elsevier.com]
Tuberculosis presenting as dysphagia: Clinical, endoscopic, radiological and endosonographic features. Endosc Ultrasound 2013;2:92-5. 2. Rana SS, Bhasin DK, Sharma V, et al. Dysphagia as the first manifestation of tuberculosis. [eusjournal.com]
- Progressive Dysphagia
Patients usually present with progressive dysphagia or odynophagia. We report a patient with hematemesis that was later attributed to the erosion of tuberculous subcarinal lymph nodes into the esophagus. [ncbi.nlm.nih.gov]
Here, we present a case of primary esophageal tuberculosis with non-progressive dysphagia for 4 months in a 41-year-old female. [omicsonline.org]
[…] in dysphagia, non-progressive dysphagia, and food traits have nothing to do, the course is often short, anti-tuberculosis drug treatment effective; esophageal cancer caused by Dysuria and chest pain was progressive increase, often in a short period of [healthfrom.com]
LOCALIZED Tuberculosis of oesophagus : a rare condition A 40 year-old man was admitted with progressive dysphagia and epigastric and retro-sternal pain without irradiation. [orion-group.net]
- Gagging
Risk factors Children – tendency to put Oesophageal strictures, carcinoma Psychosis Loss of consciousness – seizures, alcohol, deep sleep C/F Choking/gagging at time of ingestion Pain/discomfort Dysphagia/odynophagia Drooling of [de.slideshare.net]
Neurologic
- Myoclonus
—78-year-old woman with rapid progressive dementia and myoclonus. [ajronline.org]
Workup
Here, we report a case of isolated colonic tuberculosis where the initial diagnostic workup was suggestive of Crohn's disease. [gastrointestinalatlas.com]
X-Ray
- Right Pleural Effusion
The examination performed at that time revealed a right pleural effusion that resolved spontaneously over six months of follow-up, with no etiological diagnosis made. [ncbi.nlm.nih.gov]
Paradoxical response to antituberculous medication for tuberculous pleural effusion in a 29-year-old man. Magnified frontal chest radiograph, obtained a month after detection of right pleural effusion, shows that the pleural fluid has disappeared. [auntminnie.com]
Skin Test
- PPD Skin Test Positive
[…] tuberculin test (PPD skin test) positive, serum tuberculosis antibody positive. (5) X-ray barium angiography: esophageal tuberculosis esophageal cavity with filling defects and ulcers, or mucosal lesions were altered, the wall slightly stiff, mediastinal [healthfrom.com]
- Skin Test Positive
[…] tuberculin test (PPD skin test) positive, serum tuberculosis antibody positive. (5) X-ray barium angiography: esophageal tuberculosis esophageal cavity with filling defects and ulcers, or mucosal lesions were altered, the wall slightly stiff, mediastinal [healthfrom.com]
Microbiology
- Acid-Fast Bacilli in the Sputum
Sputum became positive for acid-fast bacilli (AFB) and sputum culture was reported to be positive for Mycobacterium tuberculosis. [sjkdt.org]
Colonoscopy
- Multiple Ulcerations
Radiologic and endoscopic examinations revealed a stenotic lesion with reddish mucosa and multiple ulcers in the middle esophagus. There was no associated lesion outside the esophagus. [ncbi.nlm.nih.gov]
In this video multiple ulcers of the ascending colon and cecum are observed with the retroflexed maneuver that was performed from the cecum all the way to the rectum using a adult colonoscope. [gastrointestinalatlas.com]
Esophageal peptic ulcer Esophageal peptic ulcer occurred in the lower esophageal, the patient has esophageal hiatus hernia and gastroesophageal reflux, esophageal barium angiography can be seen when the shadow is mostly single, sometimes multiple, round [healthfrom.com]
Other Pathologies
- Lymphocytic Infiltrate
Histologic examination demonstrating bundles of smooth muscle separated by fibrous septa with scattered perivascular lymphocytic infiltrates. lymphocytic infiltrates (figure 4, 100 x). [hon.ch]
Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. [wjgnet.com]
EUS guided biopsy which revealed epitheloid granulomas with lymphocytic infiltrate suggestive of tuberculosis. Polymerase chain reaction of the tissue was highly specific for mycobacterium tuberculosis. [ispub.com]
The histological examination for biopsy one revealed heavy lymphocytic infiltrate and polymorphonuclear cells, with ulceration, without lesions of malignancy. [ncbi.nlm.nih.gov]
Pleura
- Pleural Exudate
Diagnostic thoracocentesis revealed a turbid pleural exudates with pH = 7.38, glucose = 72 mg/dL, total protein = 4.3 mg/dL, total cells = 2200/mm 3, consisting of 80% lymphocytes and 20% polymorphonuclear cells and lactate dehydrogenase = 724 U/L. [wjgnet.com]
Treatment
Interventions used included endoscopy, EUS, EUS-FNA (fine needle aspiration) followed by antituberculosis treatment. The main outcome measurements were symptoms, endoscopic features, EUS features, pathological yield, and response to treatment. [ncbi.nlm.nih.gov]
Treatment Summary of treatment of esophageal tuberculosis Department of Oncology Surgery Department of Oncology Surgery Department of Oncology Surgery Treatment: Surgical treatment of drug treatment supportive treatment Treatment cycle: 9 months Cure [healthfrom.com]
Esophageal TB treatment is usually effective with antituberculous agent. [omicsonline.org]
Prognosis
The majority of cases is treated in an effective way with the typical tuberculostatic regimen for pulmonary TB, although the diagnosis and treatment delay worsens the prognosis [ 8 ]. [omicsonline.org]
[…] gastronomy (rare) 1 complication of acute radiation-induced esophagitis infective etiology affecting the esophagus 3,4 esophageal tuberculosis esophageal syphilis esophageal histoplasmosis esophageal actinomycosis esophageal candidiasis Treatment and prognosis [radiopaedia.org]
Ollé Goig JE, Sandy R (2003) Prognosis of mono-and polydrug resistant pulmonary tubercolosis in the city of Santa Cruz, Bolivia. Arch Bronconeumol 39:382–386 PubMed CrossRef Google Scholar 13. [link.springer.com]
Fistula can be closed with self-expanding metal stents or by surgical explorationwith a muscle flap. [2], [6] However, even with appropriate procedural intervention, prognosis is poor if the mediastinum is involved. [jacpjournal.org]
Hematemesis most often is due to arterioesophageal fistula with grave prognosis. In this patient upper gastrointestinal bleeding was due to ulceration in the mid-esophagus due to erosion of tuberculous subcarinal lymph nodes. [wjgnet.com]
Etiology
While the findings were non-conclusive for esophageal tuberculosis, characteristic lesions of tuberculosis in lungs or spine were suggestive of tuberculous etiology. [ncbi.nlm.nih.gov]
Pathology Etiology BOF can be either congenital or acquired, with the latter including: esophageal cancer : can complicate 5-15% of cases 2 percutaneous endoscopic gastronomy (rare) 1 complication of acute radiation-induced esophagitis infective etiology [radiopaedia.org]
Jain et al. reviewed 2176 patients with over 6-week dysphagia and found only 12 confirmed cases of tuberculosis as etiology of the symptom [9]. [scielo.br]
Epidemiology
Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations. [asmscience.org]
According to past medical history, it could be reactivation of TB but it need an epidemiologic antecedent (contacts). However, i think that my second diagnosis take more interest because TB increase the risk for cancer. [blog.myesr.org]
Epidemiology of Tuberculosis. In: UpToDate, Lerner SP (Ed), UpToDate, Waltham, MA. Oeltmann JE, Kammerer JS, Pevzner ES, Moonan PK. Tuberculosis and substance abuse in the United States, 1997-2006. [verywell.com]
Epidemiology of extra-pulmonary tuberculosis in the United States: high rates persist in the post-HIV era. Int J Tuberc Lung Dis 2014;18:1516-1521. 8. Mou Y, Zeng H, Wang QM, et al. [e-ce.org]
[…] tuberculosis is a specific product of Mycobacterium tuberculosis, is to identify whether the human body infected with Mycobacterium tuberculosis and the body's response to Mycobacterium tuberculosis infection of a biological agent, widely used in tuberculosis epidemiological [healthfrom.com]
Pathophysiology
Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations. [asmscience.org]
Pathophysiology Abdominal tuberculosis Primary Secondary 10 Abdominal TB results from ingestion of milk or food infected with Mycobacterium bovis, has become very rare these days. Mycobacterium tuberculosis is the pathogen in most of the 20 cases [slideshare.net]
The pathophysiology is related to the inflammation that occurs when the recovered immune system targets either live microorganisms or antigens from dead microorganisms 3 – 7. [f1000research.com]
Is phrenic nerve palsy part of the pathophysiological mechanism in strangulation and hanging?". Am J Forensic Med Pathol. 31 : 100–2. doi : 10.1097/PAF.0b013e3181c297e1. PMID 19935388. ^ Cooper, Angus. [en.wikipedia.org]
Prevention
[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
Chest radiography can also be used as a screening tool for prevention. In high-prevalence countries, an x-ray exam is recommended by WHO/UNAIDS before starting isoniazid preventive therapy for HIV-related TB. [auntminnie.com]
It accounts for 0.3% of all reported GI TB cases. [11] This is probably because of stratified squamous epithelium and peristalsis of the esophagus that prevents stasis of infected mucus if any. [ijtonline.in]
Prevention Prevention of esophageal tuberculosis Improve the body immunity and to avoid contact with tuberculosis patients, is an important measure to prevent esophageal tuberculosis, for open tuberculosis patients, to avoid ingestion of Mycobacterium [healthfrom.com]
Organ transplants: To prevent the body from rejecting a transplanted organ (heart, kidney, or liver), people typically take life-long immunosuppressant medications. [verywell.com]