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Esophageal Tuberculosis


Presentation

  • Esophageal tuberculosis secondary to tuberculous mediastinal lymphadenopathy is a very unusual presentation of adult tuberculosis. We report a patient presenting with fever of unknown origin and dysphagia.[ncbi.nlm.nih.gov]
Cervical Lymphadenopathy
  • The remaining two cases had a past history of tuberculosis; one presented with cervical lymphadenopathy and one mediastinal lymphadenopathy.[ncbi.nlm.nih.gov]
  • After antituberculous chemotherapy for six months, the mediastinal and cervical lymphadenopathy were reduced in size and the esophageal ulceration almost disappeared.[jstage.jst.go.jp]
Pseudotumor
  • Radiological abnormalities seen in barium swallow examination were extrinsic compression, traction diverticula, strictures, sinus/fistulous tracts, kinking and pseudotumor mass of esophagus in decreasing order of frequency.[ncbi.nlm.nih.gov]
  • Primary tuberculosis of esophagus: Pseudotumoral presentation . Am J Gastroenterol 1984; 79 :839–841. 17. Anand, BS , Schneider, FE , El-Zaatari, FA , et al.[nature.com]
  • Sometimes due to massive hyperplasia, there can be false tumor-like mass (pseudotumor) formation into the esophageal lumen, resulting in luminal narrowing; and (3) Granular esophageal tuberculosis (least common): occurs in the severe systemic disease[wjgnet.com]
  • […] the differential diagnosis of esophageal cancer, esophageal other benign: esophageal papilloma esophageal hemangioma, neurofibroma esophagus and esophageal adenocarcinoma, esophageal granular cell tumor and esophageal myoblasts and other inflammatory pseudotumor[cancerlive.net]
  • […] into a massive mass, mainly in a large number of tuberculous granulation tissue and fibrous tissue hyperplasia, was the size Ranging from the deep and intramuscular mucosa, mucosal integrity, hyperplasia tissue can sometimes be pseudo-tumor-like mass (pseudotumor[healthfrom.com]
Fever of Unknown Origin
  • We report a patient presenting with fever of unknown origin and dysphagia. Barium swallow demonstrated esophageal displacement, mucosal ulceration and perforation with a fistulous tract into the mediastinum.[ncbi.nlm.nih.gov]
Whipple Disease
  • MAC infection is also called pseudo-Whipple disease because of the diffuse mucosal fold thickening in the jejunum and histiocytic aggregates infected with MAC that stain positive with periodic acid–Schiff testing.[emedicine.medscape.com]
Progressive Dementia
  • .—78-year-old woman with rapid progressive dementia and myoclonus.[ajronline.org]
Localized Edema
  • Endoscopic examination of the more characteristic of the mirror seen: esophageal mucosa is shallow in rat rodent ulcers, the base was gray, with exudate, local edema. esophageal mucosa can have a number of yellow ridge-like granulation tissue, the so-called[healthfrom.com]
Gagging
  • .  Risk factors  Children – tendency to put  Oesophageal strictures, carcinoma  Psychosis  Loss of consciousness – seizures, alcohol, deep sleep  C/F  Choking/gagging at time of ingestion  Pain/discomfort  Dysphagia/odynophagia  Drooling of[de.slideshare.net]

Workup

  • Here, we report a case of isolated colonic tuberculosis where the initial diagnostic workup was suggestive of Crohn's disease.[gastrointestinalatlas.com]
PPD Skin Test Positive
  • skin test) positive, serum tuberculosis antibody positive. (5) X-ray barium angiography: esophageal tuberculosis esophageal cavity with filling defects and ulcers, or mucosal lesions were altered, the wall slightly stiff, mediastinal lymph node tuberculosis[healthfrom.com]
Acid-Fast Bacilli in the Sputum
  • Sputum became positive for acid-fast bacilli (AFB) and sputum culture was reported to be positive for Mycobacterium tuberculosis.[sjkdt.org]

Treatment

  • Interventions used included endoscopy, EUS, EUS-FNA (fine needle aspiration) followed by antituberculosis treatment. The main outcome measurements were symptoms, endoscopic features, EUS features, pathological yield, and response to treatment.[ncbi.nlm.nih.gov]
  • Treatment Summary of treatment of esophageal tuberculosis Department of Oncology Surgery Department of Oncology Surgery Department of Oncology Surgery Treatment: Surgical treatment of drug treatment supportive treatment Treatment cycle: 9 months Cure[healthfrom.com]

Prognosis

  • The majority of cases is treated in an effective way with the typical tuberculostatic regimen for pulmonary TB, although the diagnosis and treatment delay worsens the prognosis [ 8 ].[omicsonline.org]
  • […] gastronomy (rare) 1 complication of acute radiation-induced esophagitis infective etiology affecting the esophagus 3,4 esophageal tuberculosis esophageal syphilis esophageal histoplasmosis esophageal actinomycosis esophageal candidiasis Treatment and prognosis[radiopaedia.org]
  • Hematemesis most often is due to arterioesophageal fistula with grave prognosis. In this patient upper gastrointestinal bleeding was due to ulceration in the mid-esophagus due to erosion of tuberculous subcarinal lymph nodes.[wjgnet.com]
  • (B) prognosis Esophageal tuberculosis, such as early detection, early diagnosis and early treatment, the prognosis is good.[healthfrom.com]
  • Ollé Goig JE, Sandy R (2003) Prognosis of mono-and polydrug resistant pulmonary tubercolosis in the city of Santa Cruz, Bolivia. Arch Bronconeumol 39:382–386 PubMed CrossRef Google Scholar 13.[link.springer.com]

Etiology

  • A positive T-spot (R) TB assay result, together with the bronchoscopic detection of a small exophytic lesion at the right main bronchus depicting caseating epitheloid cell granulomas, provided evidence for a tuberculous etiology of the esophageal tumor[ncbi.nlm.nih.gov]
  • Jain et al. reviewed 2176 patients with over 6-week dysphagia and found only 12 confirmed cases of tuberculosis as etiology of the symptom [9].[scielo.br]
  • Our aim is to study tuberculosis as an etiological factor in the causation of dysphagia, the role of cytology and histopathology in establishing its diagnosis, and the outcome of antitubercular treatment in these patients.[nature.com]

Epidemiology

  • Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations.[asmscience.org]
  • Epidemiology of Tuberculosis. In: UpToDate, Lerner SP (Ed), UpToDate, Waltham, MA. Oeltmann JE, Kammerer JS, Pevzner ES, Moonan PK. Tuberculosis and substance abuse in the United States, 1997-2006.[verywell.com]
  • According to past medical history, it could be reactivation of TB but it need an epidemiologic antecedent (contacts). However, i think that my second diagnosis take more interest because TB increase the risk for cancer.[blog.myesr.org]
  • […] tuberculosis is a specific product of Mycobacterium tuberculosis, is to identify whether the human body infected with Mycobacterium tuberculosis and the body's response to Mycobacterium tuberculosis infection of a biological agent, widely used in tuberculosis epidemiological[healthfrom.com]
  • Epidemiology of extra-pulmonary tuberculosis in the United States: high rates persist in the post-HIV era. Int J Tuberc Lung Dis 2014;18:1516-1521. 8. Mou Y, Zeng H, Wang QM, et al.[e-ce.org]
Sex distribution
Age distribution

Pathophysiology

  • Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations.[asmscience.org]
  • Pathophysiology Abdominal tuberculosis Primary Secondary  10 Abdominal TB results from ingestion of milk or food infected with Mycobacterium bovis, has become very rare these days.  Mycobacterium tuberculosis is the pathogen in most of the 20 cases[slideshare.net]
  • The pathophysiology is related to the inflammation that occurs when the recovered immune system targets either live microorganisms or antigens from dead microorganisms 3 – 7.[f1000research.com]
  • Is phrenic nerve palsy part of the pathophysiological mechanism in strangulation and hanging?". Am J Forensic Med Pathol . 31 : 100–2. doi : 10.1097/PAF.0b013e3181c297e1 . PMID 19935388 . Cooper, Angus.[en.wikipedia.org]

Prevention

  • It accounts for 0.3% of all reported GI TB cases. [11] This is probably because of stratified squamous epithelium and peristalsis of the esophagus that prevents stasis of infected mucus if any.[ijtonline.in]
  • Prevention Prevention of esophageal tuberculosis Improve the body immunity and to avoid contact with tuberculosis patients, is an important measure to prevent esophageal tuberculosis, for open tuberculosis patients, to avoid ingestion of Mycobacterium[healthfrom.com]
  • […] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.[nccn.org]
  • Chest radiography can also be used as a screening tool for prevention. In high-prevalence countries, an x-ray exam is recommended by WHO/UNAIDS before starting isoniazid preventive therapy for HIV-related TB.[auntminnie.com]
  • In this way bacteriological infection on account of the stomach contents can be prevented.[capsinternational.com]

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