The condition of esophagitis, presents with the following signs and symptoms [7]:

• Swallowing becomes difficult and very painful
• Development of heartburn and regurgitation 
• Experiencing pain in chest during eating
• Food impaction, which occurs when food gets stuck in the esophagus during swallowing

• Weight Loss

  Can be associated with weight loss, heartburn, regurgitation (especially with lying flat), and aspiration pneumonias. Eosinophilia is thought to be due to a reactive process from stasis of esophageal contents. [online.epocrates.com]

  Symptoms can include difficult or painful swallowing, unintentional weight loss or food regurgitation. [ridgedalesurgerycenter.com]

  Symptoms can include difficult or painful swallowing, unintentional weight loss or food regurgitation. https://gastrohealth.com/wp-content/uploads/2017/06/logo.jpg 0 0 Gastro Health https://gastrohealth.com/wp-content/uploads/2017/06/logo.jpg Gastro Health [gastrohealth.com]

  Symptoms in children include: Problems feeding or eating Abdominal pain Vomiting Problems swallowing Food getting stuck in the esophagus Poor weight gain or weight loss, poor growth, and malnutrition Symptoms in adults include: Food getting stuck when [ucsfhealth.org]

  […] if needed — a five- or 10-pound weight loss can help. • Stop smoking. [kdhnews.com]

• Weakness

  Like Candida, this viral infection can develop in the esophagus when the body's immune system is weak. It is treatable with antiviral drugs. [webmd.com]

  They usually occur in people with a weak immune system. Esophagitis from infections is common in people who have HIV infection, use steroid medicines long-term, have had organ transplants, or have been treated with chemotherapy for cancer. [health.harvard.edu]

• Feeding Difficulties

  EoE is a chronic immune-mediated disorder of the esophagus, which may present as dysphagia, food impaction, heartburn, vomiting, abdominal pain, feeding difficulties, or failure to thrive. [pedsinreview.aappublications.org]

  In addition, young children with eosinophilic esophagitis may present with feeding difficulties. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. [dictionary.cambridge.org]

  Children can have feeding difficulties like difficulty advancing to age appropriate foods, coughing when they are trying to swallow solids or liquids. [childrensnational.org]

  Pain when swallowing, difficulty swallowing. Mouth sores. Abdominal pain. Babies or very young children who are unable to describe their symptoms may first show signs of having feeding difficulties. [ercare24.com]

• Pathologist

  These are later sent off to the pathologist to test for eosinophils. [healthline.com]

  The sample of the tissue obtained is then sent to a pathologist to view under a microscope and determine if you have Eosinophilic Esophagitis. At times, blood tests can show elevated levels of eosinophils, but this alone does not make the diagnosis. [gastrohealth.com]

  A pathologist will analyze the tissue samples under a high-powered microscope to see the small cell structures. If eosinophils are present in the sample, the pathologist will count how many are visible. [apfed.org]

  If EoE is suspected your physician will take biopsies from the lining of the esophagus to be examined by experienced pathologists to confirm the presence and quantity of eosinophils. [arizonadigestivehealth.com]

  The amount of inflammation and number of eosinophils present are then document by a Pathologist to help establish the diagnosis. [dhat.com]

• Anorexia

  Nausea and or vomiting Patients with esophagitis can have anorexia, nausea and vomiting. Nausea and or vomiting Patients with esophagitis can have anorexia, nausea and vomiting. [medicaljoyworks.com]

  In children, symptoms of EoE include abdominal pain, nausea, vomiting, anorexia and dysphagia. [clinicaladvisor.com]

  Atypical anorexia nervosa can be just as bad Neville H. Golden, MD and Philip S. [ccjm.org]

  […] related to esophagitis can also be found in other disorders and include: Heartburn: may be similar to chest pain in coronary artery disease Pain with swallowing (odynophagia) Difficulty swallowing (dysphagia) Nausea and/or vomiting Abdominal pain Cough Anorexia [verywellhealth.com]

  Regurgitation 237 (54.7) 173 (57.1) 0.53 Heartburn + Regurgitation 332 (76.7) 245 (78.4) 0.20 Atypical chest pain 139 (32.1) 103 (34.0) 0.59 Abdominal pain 115 (26.6) 67 (22.1) 0.17 Water brash 38 (8.8) 47 (15.5) 0.005 Nausea/vomiting 63 (14.5) 46 (15.2) 0.81 Anorexia [hindawi.com]

• Hoarseness

  Hoarseness of voice Irritation of vocal cords can cause hoarseness of voice. Hoarseness of voice Irritation of vocal cords can cause hoarseness of voice. Fever Patients with infective esophagitis can have fever. [medicaljoyworks.com]

  Symptoms may include: Cough Difficulty swallowing Painful swallowing Heartburn (acid reflux) Hoarseness Sore throat Treatment depends on the cause. [medlineplus.gov]

  Symptoms may include: Cough Difficulty swallowing Painful swallowing Heartburn (acid reflux) Hoarseness Sore throat Exams and Tests The doctor may perform the following tests: Esophageal manometry Esophagogastroduodenoscopy (EGD), removing a piece of [ufhealth.org]

• Non-Cardiac Chest Pain

  […] of Patients With Non-cardiac Chest Pain Using PillCam Eso - a Wireless Imaging Capsule of the Esophagus. [malacards.org]

  The PPI test has particularly been used in adults to differentiate cardiac from non-cardiac chest pain as well as GERD-related complaints of heartburn, chronic cough, and dyspepsia. [cancertherapyadvisor.com]

• Vomiting

  […] large amounts, often have forceful vomiting, have trouble breathing after vomiting or have vomit that is yellow or green, looks like coffee grounds, or contains blood Causes Esophagitis is generally categorized by the conditions that cause it. [mayoclinic.org]

  Nausea and or vomiting Patients with esophagitis can have anorexia, nausea and vomiting. Nausea and or vomiting Patients with esophagitis can have anorexia, nausea and vomiting. [medicaljoyworks.com]

  Excessive vomiting: The acid contained in vomit can irritate the esophagus, and excessive vomiting can lead to inflammation. Pills getting stuck: If a pill gets stuck in the esophagus, it can cause burning of the lining. [verywellhealth.com]

  EoE is characterized by eosinophilic inflammation of the esophagus causing gastrointestinal symptoms such as abdominal pain, vomiting, reflux, dysphagia, and food impactions. [ncbi.nlm.nih.gov]

  Irritation leading to esophagitis may be caused by any of the following: GERD, or gastroesophageal reflux disease Vomiting Surgery Medications such as aspirin and other anti-inflammatory drugs Taking a large pill with too little water or just before bedtime [webmd.com]

• Dysphagia

  The disease is characterized by esophageal symptoms, primarily dysphagia in adult patients, and esophageal eosinophilic infiltration. [ncbi.nlm.nih.gov]

  Symptoms The most common eosinophilic esophagitis symptoms are dysphagia (difficulty swallowing) mostly with solid food. [memorialhermann.org]

• Dysphagia

  The disease is characterized by esophageal symptoms, primarily dysphagia in adult patients, and esophageal eosinophilic infiltration. [ncbi.nlm.nih.gov]

  Symptoms The most common eosinophilic esophagitis symptoms are dysphagia (difficulty swallowing) mostly with solid food. [memorialhermann.org]

• Regurgitation

  Regurgitation is frequent when the patient is in supine position, bending forwards or wearing tight clothes after a heave meal. Regurgitation Regurgitation of acidic gastric contents occurs in reflux esophagitis. [medicaljoyworks.com]

  Primary esophagitis, caused by physical irritants, causes spasm and obstruction, with pain on swallowing or palpation, profuse salivation, regurgitation of slimy, blood-stained saliva and feed, and may lead to stricture formation. [medical-dictionary.thefreedictionary.com]

  Inflammation of the esophagus (the tube that carries food from the mouth to the stomach) ICD-9-CM Volume 2 Index entries containing back-references to 530.10 : Esophagitis (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (regurgitant [icd9data.com]

  Parents and some medical practitioners confuse vomiting with regurgitation, or use other terms for regurgitation (e.g., spitting up, spitting, or spilling). [cancertherapyadvisor.com]

  Patients with predominant symptoms of heartburn or acid regurgitation of at least one per month for the past 6 months in the absence of reflux oesophagitis were diagnosed as having NERD. [ncbi.nlm.nih.gov]

• Nausea

  Nausea and or vomiting Patients with esophagitis can have anorexia, nausea and vomiting. Nausea and or vomiting Patients with esophagitis can have anorexia, nausea and vomiting. [medicaljoyworks.com]

  It presents with failure to thrive, nausea, and vomiting in children and is a common reason for dysphagia and food impaction in adults. [ncbi.nlm.nih.gov]

  Abdominal pain, nausea, regurgitation, vomiting, trouble swallowing, food getting stuck, and heartburn are all possible symptoms of esophagitis. [nicklauschildrens.org]

  Eosinophilic gastroenteritis Patients often have GI symptoms not directly attributed to the esophagus such as abdominal pain, nausea, weight loss, GI bleeding, diarrhea, malabsorption, or protein-losing enteropathy. [online.epocrates.com]

  […] misdiagnosed as GORD (gastro oesophageal reflux disease), adult symptoms include problems with swallowing, bolus obstruction and chest pain related to swallowing, heartburn and regurgitation, while in children they can include reflux-related symptoms, nausea [pharmatimes.com]

• Chest Pain

  […] for evaluation of the chest pain. [healio.com]

  […] in your chest that lasts more than a few minutes Suspect you have food lodged in your esophagus Have a history of heart disease and experience chest pain Experience pain in your mouth or throat when you eat Have shortness of breath or chest pain that [mayoclinic.org]

  Chest pain Retrosternal or epigastric burning pain is characteristic of reflux esophagitis. Chest pain Retrosternal or epigastric burning pain is characteristic of reflux esophagitis. Water brash Water brash is the increased production of saliva. [medicaljoyworks.com]

  A 21-year-old man was admitted to our outpatient clinic with retrosternal chest pain, dysphagia, and odynophagia complaints, which occurred within 2 weeks after starting dexketoprofen trometamol. [ncbi.nlm.nih.gov]

  Symptoms of Reflux Esophagitis Difficulty swallowing (dysphagia) Painful swallowing (odynophagia) Chest pain Swallowed food becoming stuck in the esophagus Nausea Vomiting Abdominal pain Cough Decreased appetite Factors that can increase the risk for [waldorfendo.com]

• Retrosternal Chest Pain

  A 21-year-old man was admitted to our outpatient clinic with retrosternal chest pain, dysphagia, and odynophagia complaints, which occurred within 2 weeks after starting dexketoprofen trometamol. [ncbi.nlm.nih.gov]

  REFLUX ESOPHAGITIS The diagnosis of gastroesophageal reflux disease (GERD) is predominantly based on “troublesome” symptoms—when the classic symptoms of heartburn, retrosternal chest pain and dysphagia are no longer simply occasional physiologic issues [archivesofpathology.org]

• Osteoporosis

  Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 1995 ;333: 1437 - 1443 2. Siris E, Weinstein RS, Altman R, et al. [nejm.org]

  Pills that are most likely to cause esophagitis include: aspirin doxycycline iron supplements nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn) osteoporosis medications such as alendronate (Fosamax [health.harvard.edu]

  Most commonly, it occurs with some painkillers, antibiotics, drugs to treat potassium deficiency, and certain drugs for the treatment for osteoporosis. Infections Infectious esophagitis can occur in people who have weakened immune systems. [medicalnewstoday.com]

  The most likely culprits include antibiotics, some drugs that treat osteoporosis, medication to treat potassium deficiency, and some painkillers. [ercare24.com]

The following tests would be employed, for diagnosing the condition of esophagitis:

• Physical examination: A preliminary physical examination, which includes a question and answer session to understand the symptoms, is carried out.
• Barium X-ray: In this test, the individual is given solution of barium to drink, or is given a pill coated with barium. Barium evenly coats the esophageal lining, and the stomach, which makes it possible to clearly view the abnormalities inside the organs. An X-ray is conducted, which helps in analyzing the esophagus.
• Endoscopy: Endoscope is used for viewing the internal of the esophagus, to determine any unusual development. During this process, a sample of the tissue is also taken for biopsy. The sample is tested for viral agents, or presence of any abnormal cell development [8].

• Esophageal Motility Disorder

  This condition clinically presents as dysphagia, odynophagia, or an esophageal motility disorder. [51] Rubio et al first introduced LE in 2006 as a novel subset of chronic esophagitis. [52] Histologically, it is characterized by dense intraepithelial [emedicine.medscape.com]

  Some important differential diagnosis which must be considered is acute coronary syndrome with atypical chest pain, malignancy, peptic ulcer disease, rings and webs, pneumonia, pulmonary embolism, achalasia, and esophageal motility disorder. [ncbi.nlm.nih.gov]

The goal of treatment involves effective management of the symptoms, and treating the underlying disease conditions. Methods for treating esophagitis, depend on the cause of the condition. Following methods are employed to treat esophagitis:

• Reflux esophagitis is usually treated with over the counter medications that would help control gastrophageal reflux. If these do not work, then prescription strength medications, that include H2-receptor blockers, can be administered. When other modes of treatment fail to show any positive effect then surgery is the last resort [9].
• Eosinophilic esophagitis is treated with proton pump inhibitors, that would help reduce the allergic reactions [10]. Topical swallowed steroids can also be used, along with the 6–food elimination diet, in which individuals are asked to abstain from certain foods triggering allergies [11]. Surgical procedures, such as fundoplication may be employed, for correcting esophagitis.
• In the case of infectious esophagitis, antibiotics are administered to treat the causative agent. Various causative agents such as bacteria, virus, fungi and parasite can be effectively treated with medications.
• Drug-induced esophagitis is treated by avoiding medications, which cause damage, and irritation to the tissues of the esophagus. Administration of alternative drug, or taking liquid form of the same pill, can be considered. Individuals are also advised to stand, or sit for 30 minutes, after ingestion of the pill.

The prognosis of the condition is usually favorable, and patients usually respond to treatment. For individuals with compromised immunity, recovery period will be pretty long. However, if esophagitis has induced significant changes in the cells of the esophagus, then chances of developing cancer in the future increases [6].

In majority of the cases, back flow of the stomach acids into the esophagus, is the major cause of esophagitis. In addition, other factors such as infections, underlying disease conditions, allergies and medications, can also predispose an individual to develop the condition. The nature of the causative factor gives rise to a specific type of esophagitis.

Back flow of acidic contents of stomach into the esophagus, causes gastrophageal reflux to develop. This in turn, leads to inflammation of the esophagus, causing esophagitis. Certain medications, if not gulped with enough water, can cause its remnants to remain in the lining of the esophagus, irritating the tissues. Such a condition is termed as drug-induced esophagitis [2].

Esophagitis is a common occurrence amongst adults, children are seldom affected [3]. Reflux esophagitis and candida esophagitis are the most common forms of esophagitis. Symptoms of esophageal reflux occur in about 33 – 44% of population. Infectious esophagitis is majorly caused due to Herpes virus, and commonly occurs in those individuals with an underlying disease conditions, such as AIDS, lymphoma and leukemia [4].

The pathophysiology of esophagitis depends on the nature of the cause. However, the basic mechanism behind causation of inflammation of the esophagus, remains the same. Due to certain triggering factors, such as infection, drugs or gastrophageal reflux, irritation and damage to the tissues of the esophagus are caused. Such a phenomenon, favors the development of inflammation of the esophagus, which in turn, paves way for development of several unpleasant symptoms [5].

It is not always possible to prevent esophagitis. However, affected individuals can prevent its recurrence, by following those methods that have triggered previous bouts of esophagitis. It is necessary to avoid those medications, that can cause irritation in the esophageal lining. Also, avoiding direct contact with individuals, living with Herpes virus is also important.

Esophagitis is a painful condition, which can cause difficulty in swallowing of food in affected individuals. Some of the common forms of esophagitis include infectious esophagitis, eosinophilic esophagitis, pill esophagitis, reflux esophagitis and candida esophagitis. Of these, candida esophagitis is the most common form. Adults are more prone to develop the condition than children [1].

Definition: Esophagitis is a condition, wherein there is inflammation of esophagus, due to damage to its tissue by certain factors. Such a type of condition is more common amongst the adult population.

Cause: Gastropahgeal reflux, a condition characterized by back flow of the stomach contents to the esopahagus, is the most common cause of esopahgitis. In addition, certain types of drugs, allergic reactions, and infections can also lead to development of esophagitis.

Symptoms: Symptoms of esophagitis include difficulty and pain, while swallowing food, heartburn, chest pain, acid regurgitation and food impaction.

Diagnosis: Various tests will be required to diagnose the condition of esophagitis and also to determine development of future complications. Diagnosis is done through the barium X-ray test, and endoscopy. These procedures help in proper viewing of the internal features of esophagus, to look for the presence of abnormalities.

Treatment: The type of treatment employed, depends on the type of esophagitis that has set in. For reflux esophagitis, over the counter medication are prescribed for preventing gastrophageal reflux. In addition, prescription strength medications, containing H2-receptor blockers are administered. For infectious esophagitis, antibiotics are prescribed for treating the infections.

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