Presentation
Genetic and hormonal influences largely determine hair thickness and the pattern of distribution; hair colour is genetically determined and depends on the amount of melanin present. [independentnurse.co.uk]
[…] factors such as androgenic drugs, and nonclassical congenital adrenal hyperplasia can also produce hirsutism. 12 In nonclassical congenital adrenal hyperplasia, which is typically caused by a deficiency of 21-hydroxylase, patients present with premature [mdedge.com]
Most of our hair follicles are present at birth, and we begin to lose follicles after age 40. [demoshealth.com]
These most commonly present with infertility, amenorrhoea, acne or hirsutism. [patient.info]
Rapid onset of hirsutism, virilization, or a palpable abdominal or pelvic mass all raise suspicion for an androgen-secreting tumor. 1 OTHER CAUSES Several other endocrinopathies can present with hirsutism but often have more distinctive presentations. [aafp.org]
Entire Body System
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Myxedema
[…] level Hyperprolactinemia Rare to present with isolated hirsutism Galactorrhea, amenorrhea, infertility Elevated prolactin level Thyroid dysfunction Rare to present with isolated hirsutism Hypothyroidism: fatigue, cold intolerance, dry skin, hair loss, myxedema [aafp.org]
Skin
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Hirsutism
In 4 patients great improvement of hirsutism was noted, but only after 6 months of therapy. In 4 patients there was some improvement, while 2 were resistant. [ncbi.nlm.nih.gov]
Turmeric Benefits for Hirsutism Turmeric is used to treat hirsutism, especially as a topical application. It is believed to work by softening and dissolving hair in areas where it is applied. [turmericforhealth.com]
Since starting my own website for hirsutism, The Hirsutism Hub, many girls have contacted me saying hormonal therapies did not work for their hormonal imbalance. [pcosdiva.com]
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Dry Skin
Side effects included reduced libido in 4 cases, mental depression in 3, dry skin and itching in 4 and transient nausea in one, but never necessitated cessation or interruption of treatment. [ncbi.nlm.nih.gov]
Sometimes turmeric pastes applied on the skin can cause a condition called contact dermatitis characterized by itching, rash, blisters, dry skin and pain. As a spice included in food, turmeric does not cause any side effects. [turmericforhealth.com]
It’s great for dry skin and the essential oil molecules are absorbed through the skin. You can also do this using a rollerball vial. [drannagarrett.com]
skin, headache, hepatotoxicity Typically used only after failure of other therapies C Eflornithine (Vaniqa) Apply topically twice daily Acne, erythema, burning FDA approval is only for use for unwanted facial hair C Table 3. [aafp.org]
Psychiatrical
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Decreased Libido
Side effects with finasteride have not been commonly reported but may include headache, depression and breast tenderness and decreased libido. [monash.edu]
One study found an 80-percent improvement in acne with flutamide 250mg/day. 6, 18 Side effects include breast tenderness, gastrointestinal upset, hot flashes, and decreased libido. [ncbi.nlm.nih.gov]
Workup
Further workup is guided by history and physical examination, and may include thyroid function tests, prolactin level, 17-hydroxyprogesterone level, and corticotropin stimulation test. Treatment includes hair removal and pharmacologic measures. [aafp.org]
Table 1 - Diagnostic Tests in the Hirsutism Workup [4] Fasting glucose-to-insulin ratio. A calculation of less than 4.5 suggests insulin resistance. 2-Hour glucose level after a 75-g glucose load. A measurement below 140 mg/dL is normal. [cushings-help.com]
Serum
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Hyperprolactinemia
PCOS can only be diagnosed after exclusion of some other diseases such as non-classical congenital adrenal hyperplasia (NCAH), idiopathic hyperandrogenemia, Cushing’s syndrome, hyperprolactinemia and acromegaly. [endocrine-abstracts.org]
These are signs that may present with the HAIR-AN syndrome or with another cause of excess androgens, such as idiopathic, ovarian, adrenal, or hyperprolactinemic hyperandrogenism. 21 Thyroid disease, hyperprolactinemia, acromegaly, Cushing syndrome, exogenous [mdedge.com]
These include acromegaly, Cushing syndrome, hyperprolactinemia, and thyroid dysfunction. 1 Evaluation Figure 2 provides a suggested approach to evaluating hirsutism. 1, 18 The medical history should include a medication and supplement review. [aafp.org]
[…] hypersensitivity to androgens.[2] Less common but potentially serious causes include Cushing's syndrome, congenital adrenal hyperplasia, adrenal or ovarian tumors, a luteoma (a pregnancy-related benign tumor), anorexia nervosa, hypothyroidism, porphyria, and hyperprolactinemia [cushings-help.com]
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Globulins Increased
Several changes in endocrine function took place during treatment: testosterone secretion rate diminished together with the urinary excretion of 17-KS and 17-KGS, while the serum concentration of testosterone binding globulin increased. [ncbi.nlm.nih.gov]
Several changes in endocrine function took place during treatment: testosterone secretion rate diminished together with the urinary excreetion of 17-KS and 17-KGS, while the serum concentration of testosterone binding globulin increased. [onlinelibrary.wiley.com]
Treatment
Side effects included reduced libido in 4 cases, mental depression in 3, dry skin and itching in 4 and transient nausea in one, but never necessitated cessation or interruption of treatment. [ncbi.nlm.nih.gov]
Two Treatment Three Treatment Four Treatment Five Treatment Six Go through the website and gain knowledge about fertility, infertility & IVF Treatment etc. [fertilityindia.com]
When used in combination with laser therapy for the treatment of facial hirsutism it enhances the efficacy of laser. Hair growth returns to pretreatment levels within 8 weeks of ceasing the treatment. [monash.edu]
Treatments for hirsutism Treatment for hirsutism usually involves techniques to remove the excess hair and treatment to help slow its growth or stop it coming back. [nhs.uk]
Prognosis
体重減少原因の検索： Unintentional weight loss: diagnosis and prognosis. The first pospective follow-up study from a secondary referral centre. [square.umin.ac.jp]
Etiology
Thus certain tests must be conducted to ascertain properly the etiology of hirsutism. However, there is no universal consensus regarding the least required tests for the differential diagnosis of hirsutism. [endocrine-abstracts.org]
Etiology Hair growth is influenced by a number of hormonal factors. Androgens, including testosterone, stimulate the hair follicle and affect the hair's size and pigmentation; to what extent depends on 5a-reductase activity. [cushings-help.com]
Etiologic diagnosis of hirsutism. [emedicine.medscape.com]
Hirsutism: implications, etiology, and management. Am J Obstet Gynecol. 1981;140(7):815–830. 6. Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961;21:1440–1447. 7. [aafp.org]
Epidemiology
Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society. Hum Reprod Update. 2012;18(2):146–70. PubMed CrossRef Google Scholar 14. [link.springer.com]
Epidemiology Polycystic ovaries on ultrasound are very common and can be seen in up to 33% of women of reproductive age. [ 1 ] However, the majority of women with polycystic ovaries do not have features of polycystic ovary syndrome (PCOS) and do not require [patient.info]
Several epidemiological studies have not validated this association. 38 For prescribing purposes, there exist several conditions that are considered contra-indications to the use of oral contraceptives. [ncbi.nlm.nih.gov]
Pathophysiology
Prevalence figures vary depending on diagnostic criteria used, but PCOS is thought to affect 5-15% of women of reproductive age. [ 2 ] Pathophysiology [ 1 ] The cause remains unclear but is likely to be multifactorial. [patient.info]
[…] long cycles over many months, beginning with an active phase (anagen) that is followed by a resting phase (telogen); during the telogen phase, the shaft separates from the follicle base and falls out.[4,5] Both the biology of normal hair growth and the pathophysiology [cushings-help.com]
Prevention
Calcium has been shown to improve menstrual regularity, magnesium improves insulin sensitivity, and vitamin D optimizes BMI, helping to prevent weight gain. [organicfacts.net]
Therefore, weight loss is a key component of therapeutic regimens intended to resolve symptoms and prevent complications. [cushings-help.com]
In order to prevent this problem, eat more spinach! The food you eat can help you to control your hair growth, so it's time to add these foods above to your diet. [hairfreelife.com]
How to prevent future hair regrowth? VIE Line Cosmetics by Natural Life Academy has developed ground breaking products to prevent unwanted facial and body hair regrowth. Experience the wisdom of earths most powerful plants and extracts. [naturallifeherbsandcosmetics.com]
Oral contraceptives are often combined with antiandrogens to improve their clinical effect and to prevent pregnancy, since accidental exposure of the male fetus to antiantrogens can harm fetal development. [obgyn.ucla.edu]