Presentation
Plantes Medicinales et Phytotherapie 6(2): 137-148, 1972 Differentiation of some essential iols presenting a related constitution particularly by the analysis of their Ultraviolet, Infrared, Raman specters). V. [eurekamag.com]
SOME ADVANTAGES Key advantages of the present invention include the improved pharmacokinetics and pharmacodynamics of the compound of the present invention. [patents.google.com]
The structural formulae, serum concentrations, binding affinities to steroid receptors and serum binding globulins, and the relative potencies of the available estrogens and progestins are presented. [ncbi.nlm.nih.gov]
Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]
Entire Body System
- Infertility
Disruption of this essential function causes sperm to enter the epididymis diluted, rather than concentrated, resulting in infertility. [ncbi.nlm.nih.gov]
decreased body hair (e.g., loss of chest hair, female pattern of pubic hair distribution) Women: menstrual irregularities, enlargement of the breast and uterus, infertility, and increased cancer risk (e.g., endometrial cancer) Both sexes: palmar erythema [amboss.com]
To measure or monitor your estrogen levels; to detect an abnormal level or hormone imbalance as a cause of your signs and symptoms; to monitor treatment for infertility or symptoms of menopause; sometimes to test for fetal-placental status during early [labtestsonline.org]
The "Journal of Ethnopharmacology" notes that fennel has a long history of use as a treatment for lactation problems, infertility and pregnancy complications. [livewell.jillianmichaels.com]
High estrogen in men can cause: Enlarged breasts (gynecomastia) Poor erections Infertility [hormone.org]
- Anorexia
Those tests may be important if you have a health condition such as PCOS or have stopped menstruating because of excessive athletic training or anorexia nervosa. [webmd.com]
Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: Beyond leptin and ghrelin. Molecular and Cellular Endocrinology, CrossRef Google Scholar Suárez-Ortiz, Josué O. Cortés-Salazar, Felipe Malagón-Carrillo, Ariadna L. [doi.org]
Factors that can affect estrogen levels include: pregnancy, the end of pregnancy, and breastfeeding puberty menopause older age overweight and obesity extreme dieting or anorexia nervosa strenuous exercise or training the use of certain medications, including [medicalnewstoday.com]
Extreme exercise and anorexia can also cause a decrease in estrogen levels because women with low body fat may not be able to produce adequate amounts of estrogen. [livescience.com]
- Precocious Puberty
Increased levels of estradiol (E2) or estrone (E1) are seen in: Girls and Women: Early (precocious) puberty Tumors of the ovary or adrenal glands Boys and Men: Enlarged breasts (gynecomastia) Tumors of the testicles (testicular cancer) or adrenal glands [labtestsonline.org]
Estradiol or other hormone levels may be tested in the evaluation of precocious puberty in girls (the onset of signs of puberty before age seven), delayed puberty and in assisted reproductive technology (ART) to monitor ovarian follicle development in [healthywomen.org]
Gastrointestinal
- Diarrhea
[…] system acting as an antioxidant antibacterial effects antifungal activity anti-inflammatory properties anti-diabetic controlling dust mites Researchers found that ground fennel seeds in solution were effective against bacteria that cause indigestion, diarrhea [medicalnewstoday.com]
[…] or high triglyceride (cholesterol) levels that could lead to problems with your pancreas Vision loss caused by a blood clot in the eye Liver problems High blood pressure Severe allergic reaction Less Serious, Common Side Effects Muscle spasms Nausea Diarrhea [fda.gov]
Tell your doctor if any of these symptoms are severe or do not go away: headache upset stomach vomiting stomach cramps or bloating diarrhea appetite and weight changes changes in sex drive or ability nervousness brown or black skin patches acne swelling [medlineplus.gov]
Nausea appears to be the main side effect; other adverse effects include vomiting, anorexia, and diarrhea. 2. Excessive doses of estrogens inhibit the development of bones in young patients by accelerating epiphyseal closure [ 8, 19 ]. 3. [omicsonline.org]
Additionally, the newer CDK 4/6 inhibitors are associated with neutropenia, fatigue, anemia, QT prolongation, hepatobiliary toxicity, and diarrhea requiring frequent monitoring and dose adjustments. [tandfonline.com]
- Abdominal Bloating
Psychological Symptoms Anxiety Feeling overwhelmed or out of control Increased depressed mood Irritability Mood Swings Sense of feeling overwhelmed Sensitivity to rejection Social withdrawal Sudden sadness or tearfulness Physical Symptoms Abdominal bloating [womensmentalhealth.org]
Agents Natural (micronized) progesterone Fatigue Somnolence Synthetic progestins Edema Abdominal bloating Anxiety Irritability Depression Myalgia View/Print Table TABLE 3 Progestational Agents Active ingredient Brand name Formulation Strength Dosing [aafp.org]
- Loss of Appetite
[…] of appetite rash extreme tiredness, weakness, or lack of energy fever dark-colored urine light-colored stool Hormone replacement therapy may increase the risk of developing endometrial cancer and gallbladder disease. [medlineplus.gov]
Neurologic
- Headache
(including headaches with vision changes/lack of coordination, worsening of migraines, sudden/very severe headaches), slurred speech, weakness on one side of the body, sudden vision changes (such as partial/complete blindness).Your healthcare professionals [webmd.com]
If your estrogen is low throughout your cycle, it could lead to more headaches, but it's important to check with a doctor to make sure your headaches don't have another, potentially more serious cause. 10. [bustle.com]
Gallbladder disease or high triglyceride (cholesterol) levels that could lead to problems with your pancreas Vision loss caused by a blood clot in the eye Liver Problems High Blood Pressure Severe allergic reactions Less Serious, Common Side Effects Headaches [fda.gov]
Side effects include: bloating breast soreness headaches leg cramps indigestion nausea vaginal bleeding fluid retention, leading to swelling Some types of hormone therapy can also increase the risk of a stroke, blood clots, and uterine and breast cancer [medicalnewstoday.com]
- Agitation
The formazan crystals were dissolved in 200 μl DMSO and plates were further agitated on a plate shaker at 300–500 rpm for 10 minutes. [journals.plos.org]
Urogenital
- Amenorrhea
[…] in women with oligomenorrhea or secondary amenorrhea. [aafp.org]
Amenorrhea. Medscape Obstetrics & Gynecology. Available online at https://emedicine.medscape.com/article/252928-overview. Accessed on 07/07/18. Genzen, J. et. al. (2018 June, Updated). Amenorrhea. ARUP Consult. [labtestsonline.it]
Estrogens may be used to treat symptoms of conditions associated with estrogen deficiency such as amenorrhea and menopause. They may be used to suppress lactation and in men to treat androgen-dependent cancers such as prostate cancer. [drugs.com]
Your estrone and estradiol levels may also be tested if you’re experiencing: hot flashes night sweats insomnia frequently missed periods (amenorrhea) In some cases, your doctor may order a brain scan to check for any abnormalities that may be affecting [healthline.com]
Treatment
Tamoxifen is also a common chemotherapeutic treatment for ER-positive breast cancer. [cebp.aacrjournals.org]
Both the EE and EE/MT treatments were well tolerated. [ncbi.nlm.nih.gov]
However, there is not yet enough research to recommend these as effective treatments for PMDD. Herbal Remedies Herbal remedies may have some role in the treatment of premenstrual symptoms. [womensmentalhealth.org]
Prognosis
Consequently, estrogen mediated ER signaling plays a critical role in breast cancer diagnosis, prognosis, and treatment. Estrogen Receptors are ligand-triggered transcription factors. [ubir.buffalo.edu]
And the lifetime prognosis is bad. Life expectancy for people with schizophrenia is ten to 25 years shorter than for those in the general population. Death by suicide is 13 times more likely. [thecut.com]
View Article Google Scholar Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. [doi.org]
Etiology
Etiology Increased estrogen production (e.g., due to ovarian tumors, obesity) Excess estrogen supplementation (e.g., due to hormone replacement therapy) Increased metabolism and excretion of estrogens (e.g., due to chronic liver disease) Clinical features [amboss.com]
Premenstrual disorders: prevalence, etiology and impact. Journal of Reproductive Medicine ; 51(4 Suppl):339-347 Yonkers, K. A., & Casper, R. F. (2018, January 15). [womensmentalhealth.org]
The role of genetic factors in the etiology of temporomandibular disorders: a review. Cranio. 2016; 34 (1): 43-51. [ Links ] [scielo.edu.uy]
Etiology and treatment of hypogonadism in adolescents. Endocrinol Metab Clin North Am. 2009 Dec. 38(4):719-38. [Medline]. Murphy KG. Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis. [emedicine.medscape.com]
Epidemiology
[…] increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology [books.google.com]
In addition, the question of the risks from environmental estrogen mimics is a very difficult one, because the biological, epidemiological and exposure issues involved are all extremely complex. [scientificamerican.com]
Large-scale epidemiological studies have demonstrated that oestrogen replacement therapy leads to approximately 50 per cent reduction of cardiovascular disease in women taking hormones, compared with untreated women. [ncbi.nlm.nih.gov]
"The clinical practice of estradiol therapy has been nothing short of a roller coaster ride," lead study author Roksana Karim, PhD, MBBS, said in an interview at the Epidemiology and Prevention/Lifestyle and Cardiometabolic Health meeting sponsored by [medscape.com]
Epidemiology and pathogenesis of premenstrual syndrome and premenstrual dysphoric disorder (R. L. Barbieri & W. F. Crowley Jr., Eds.). [womensmentalhealth.org]
Pathophysiology
It is a truly integrated text using large numbers of real clinical cases to introduce the basic biochemistry, physiology and pathophysiology underlying endocrine disorders and also the principles of clinical diagnosis and treatment. [ncbi.nlm.nih.gov]
Coverage of pathophysiology and interventions for the pregnant woman, fetus, and newborn for selected abnormal events provides a solid understanding of physiologic adaptations and developmental physiology relating to major body systems and metabolic processes [books.google.com]
Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017;97(1):135–187. doi:10.1152/physrev.00033.2015 Gambacciani M, Levancini M. Management of postmenopausal osteoporosis and the prevention of fractures. [verywellhealth.com]
Gunson MJ, Arnett GW, Milam SB: Pathophysiology and pharmacologic control of osseous mandibular condylar resorption. J Oral Maxillofac Surg 2012; 70:1918-1934 [ Links ] 26. Gunson MJ, Arnett GW. [scielo.edu.uy]
Prevention
Some HRT products are also used to prevent weakening of bones (osteoporosis). Selective estrogen receptor modulators (SERMs) (raloxifene, bazedoxifene) are also used for preventing and treating osteoporosis and some symptoms of menopause. [canada.ca]
This product is not intended to diagnose, treat, cure, or prevent any disease. Legal Disclaimer This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. [amazon.com]
Both studies were concluded early when the research showed that hormone replacement did not help prevent heart disease and it increased risk for some medical problems. The FDA states that hormone therapy should not be taken to prevent heart disease. [hopkinsmedicine.org]