SOME ADVANTAGES Key advantages of the present invention include the improved pharmacokinetics and pharmacodynamics of the compound of the present invention. [patents.google.com]

Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]

The structural formulae, serum concentrations, binding affinities to steroid receptors and serum binding globulins, and the relative potencies of the available estrogens and progestins are presented. [doi.org]

• Precocious Puberty

  Increased levels of estradiol (E2) or estrone (E1) are seen in: Girls and Women: Early (precocious) puberty Tumors of the ovary or adrenal glands Boys and Men: Enlarged breasts (gynecomastia) Tumors of the testicles (testicular cancer) or adrenal glands [labtestsonline.org]

  Estradiol or other hormone levels may be tested in the evaluation of precocious puberty in girls (the onset of signs of puberty before age seven), delayed puberty and in assisted reproductive technology (ART) to monitor ovarian follicle development in [healthywomen.org]

• No Pubic Hair

  At the annual Pediatric Academic Society meeting in May in San Francisco, they presented a report that described how a preschool-age girl, and then her kindergarten-age brother, mysteriously began growing pubic hair. [nytimes.com]

  (e.g., loss of chest hair, female pattern of pubic hair distribution) Women: menstrual irregularities, enlargement of the breast and uterus, infertility, and increased cancer risk (e.g., endometrial cancer) Both sexes: palmar erythema, spider telangiectasias [amboss.com]

  Stimulate the development of: vagina uterus uterine tubes secondary sex characteristics return to main menu Stimulation:estrogen- stromal development ductal growth in the breast growth spurt/closing of the epiphyses of long bones (puberty) axillary & pubic [pharmacology2000.com]

  In females, it helps develop and maintain both the reproductive system and female characteristics, such as breasts and pubic hair. [medicalnewstoday.com]

  Pubic hair, the hair under your arms, and the development of your breasts are all thanks to estrogen. [chicagoobgyn.com]

• Cryptorchidism

  I also looked at the incidences of cryptorchidism and hypospadias, birth defects that are representative of possible effects from in utero exposure to excessive estrogens. [scientificamerican.com]

Tamoxifen is also a common chemotherapeutic treatment for ER-positive breast cancer. [cebp.aacrjournals.org]

Both the EE and EE/MT treatments were well tolerated. [ncbi.nlm.nih.gov]

However, there is not yet enough research to recommend these as effective treatments for PMDD. Herbal Remedies Herbal remedies may have some role in the treatment of premenstrual symptoms. [womensmentalhealth.org]

Consequently, estrogen mediated ER signaling plays a critical role in breast cancer diagnosis, prognosis, and treatment. Estrogen Receptors are ligand-triggered transcription factors. [ubir.buffalo.edu]

And the lifetime prognosis is bad. Life expectancy for people with schizophrenia is ten to 25 years shorter than for those in the general population. Death by suicide is 13 times more likely. [thecut.com]

Etiology Increased estrogen production (e.g., due to ovarian tumors, obesity) Excess estrogen supplementation (e.g., due to hormone replacement therapy) Increased metabolism and excretion of estrogens (e.g., due to chronic liver disease) Clinical features [amboss.com]

Premenstrual disorders: prevalence, etiology and impact. Journal of Reproductive Medicine ; 51(4 Suppl):339-347 Yonkers, K. A., & Casper, R. F. (2018, January 15). [womensmentalhealth.org]

Etiology and treatment of hypogonadism in adolescents. Endocrinol Metab Clin North Am. 2009 Dec. 38(4):719-38. [Medline]. Murphy KG. Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis. [emedicine.medscape.com]

Because of the diverse etiology of these diseases, the comprehension of the mechanism underlying estrogen beneficial action is puzzling. [nature.com]

In addition, the question of the risks from environmental estrogen mimics is a very difficult one, because the biological, epidemiological and exposure issues involved are all extremely complex. [scientificamerican.com]

[…] increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology [books.google.com]

Large-scale epidemiological studies have demonstrated that oestrogen replacement therapy leads to approximately 50 per cent reduction of cardiovascular disease in women taking hormones, compared with untreated women. [ncbi.nlm.nih.gov]

"The clinical practice of estradiol therapy has been nothing short of a roller coaster ride," lead study author Roksana Karim, PhD, MBBS, said in an interview at the Epidemiology and Prevention/Lifestyle and Cardiometabolic Health meeting sponsored by [medscape.com]

Epidemiology and pathogenesis of premenstrual syndrome and premenstrual dysphoric disorder (R. L. Barbieri & W. F. Crowley Jr., Eds.). [womensmentalhealth.org]

There is increasing evidence that in both men and women extraglandular production of C(18) steroids from C(19) precursors is important in normal physiology as well as in pathophysiologic states. [ncbi.nlm.nih.gov]

Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017;97(1):135–187. doi:10.1152/physrev.00033.2015 Gambacciani M, Levancini M. Management of postmenopausal osteoporosis and the prevention of fractures. [verywellhealth.com]

This issue is even more complex if we consider that hormone positively affects other pathophysiologic processes, such as osteoporosis, atherosclerosis and stroke. [nature.com]

Some HRT products are also used to prevent weakening of bones (osteoporosis). Selective estrogen receptor modulators (SERMs) (raloxifene, bazedoxifene) are also used for preventing and treating osteoporosis and some symptoms of menopause. [canada.ca]

This product is not intended to diagnose, treat, cure, or prevent any disease. Legal Disclaimer This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. [amazon.com]

Both studies were concluded early when the research showed that hormone replacement did not help prevent heart disease and it increased risk for some medical problems. The FDA states that hormone therapy should not be taken to prevent heart disease. [hopkinsmedicine.org]