Presentation
Plantes Medicinales et Phytotherapie 6(2): 137-148, 1972 Differentiation of some essential iols presenting a related constitution particularly by the analysis of their Ultraviolet, Infrared, Raman specters). V. [eurekamag.com]
SOME ADVANTAGES Key advantages of the present invention include the improved pharmacokinetics and pharmacodynamics of the compound of the present invention. [patents.google.com]
The structural formulae, serum concentrations, binding affinities to steroid receptors and serum binding globulins, and the relative potencies of the available estrogens and progestins are presented. [ncbi.nlm.nih.gov]
Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]
Entire Body System
- Infertility
Disruption of this essential function causes sperm to enter the epididymis diluted, rather than concentrated, resulting in infertility. [ncbi.nlm.nih.gov]
decreased body hair (e.g., loss of chest hair, female pattern of pubic hair distribution) Women: menstrual irregularities, enlargement of the breast and uterus, infertility, and increased cancer risk (e.g., endometrial cancer) Both sexes: palmar erythema [amboss.com]
To measure or monitor your estrogen levels; to detect an abnormal level or hormone imbalance as a cause of your signs and symptoms; to monitor treatment for infertility or symptoms of menopause; sometimes to test for fetal-placental status during early [labtestsonline.org]
The "Journal of Ethnopharmacology" notes that fennel has a long history of use as a treatment for lactation problems, infertility and pregnancy complications. [livewell.jillianmichaels.com]
High estrogen in men can cause: Enlarged breasts (gynecomastia) Poor erections Infertility [hormone.org]
- Weight Gain
Potential Side Effects Bloating of stomach; breast pain; increased breast size; nausea; swelling of feet and lower legs; weight gain. Special Instructions Apply patches to clean, dry skin of lower stomach area. [arthritis.org]
Regular exercise is a must for women experiencing fatigue, weight gain and hot flashes related to menopause. 30 minutes of walking five days a week is recommended. [wsfpa.com]
Many of these toxins are known to cause weight gain, which serves to fuel the production of more estrogen from our own fat cells. Ironically, you might experience the very same symptoms if you are estrogen deficient. [fi.bab.la]
However, low levels can result in weight gain and cardiovascular disease. Estriol Levels of estriol rise during pregnancy, as it helps the uterus grow and prepares the body for delivery. Estriol levels peak just before birth. [medicalnewstoday.com]
gain, injection site reactions, swelling due to increased fluid retention and difficulty breathing. [playhealthy.drugfree.org]
- Fatigue
This condition, characterized by the body’s inability to produce this important hormone, can cause many symptoms, including: loss of libido drop in sperm production erectile dysfunction (ED) fatigue Estrogen in men Estrogen, primarily thought of as a [healthline.com]
Physical side effects associated with Anti-Estrogen use include: increased risk of blood clots, abdominal pain, joint pain, muscle pain, headaches, nausea, hot flashes, fatigue, high blood pressure, intestinal problems acne, bladder problems, rapid weight [playhealthy.drugfree.org]
Medical illnesses such as chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome and migraine disorder can have features that overlap with PMDD. [womensmentalhealth.org]
[…] problems, among others: Weight gain, mainly in your waist, hips, and thighs Menstrual problems, such as light or heavy bleeding Worsening of premenstrual syndrome Fibrocystic breasts (non-cancerous breast lumps) Fibroids (noncancerous tumors) in the uterus Fatigue [hormone.org]
High levels can result in bloating, breast tenderness, heavy bleeding Low levels can result in hot flashes, night sweats, palpitations, headaches, insomnia, fatigue, bone loss, vaginal dryness Lack of progesterone can cause periods to become irregular [menopause.org]
- Swelling
Get medical help right away if you experience: sudden shortness of breath, chest/jaw/left arm pain, unusual sweating, confusion, coughing up blood, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, tingling/weakness/numbness in the arms [webmd.com]
Potential Side Effects Bloating of stomach; breast pain; increased breast size; nausea; swelling of feet and lower legs; weight gain. Special Instructions Apply patches to clean, dry skin of lower stomach area. [arthritis.org]
Side effects include: bloating breast soreness headaches leg cramps indigestion nausea vaginal bleeding fluid retention, leading to swelling Some types of hormone therapy can also increase the risk of a stroke, blood clots, and uterine and breast cancer [medicalnewstoday.com]
Anti-Estrogen use include: increased risk of blood clots, abdominal pain, joint pain, muscle pain, headaches, nausea, hot flashes, fatigue, high blood pressure, intestinal problems acne, bladder problems, rapid weight gain, injection site reactions, swelling [playhealthy.drugfree.org]
- Precocious Puberty
Increased levels of estradiol (E2) or estrone (E1) are seen in: Girls and Women: Early (precocious) puberty Tumors of the ovary or adrenal glands Boys and Men: Enlarged breasts (gynecomastia) Tumors of the testicles (testicular cancer) or adrenal glands [labtestsonline.org]
Estradiol or other hormone levels may be tested in the evaluation of precocious puberty in girls (the onset of signs of puberty before age seven), delayed puberty and in assisted reproductive technology (ART) to monitor ovarian follicle development in [healthywomen.org]
Gastrointestinal
- Abdominal Bloating
Psychological Symptoms Anxiety Feeling overwhelmed or out of control Increased depressed mood Irritability Mood Swings Sense of feeling overwhelmed Sensitivity to rejection Social withdrawal Sudden sadness or tearfulness Physical Symptoms Abdominal bloating [womensmentalhealth.org]
Agents Natural (micronized) progesterone Fatigue Somnolence Synthetic progestins Edema Abdominal bloating Anxiety Irritability Depression Myalgia View/Print Table TABLE 3 Progestational Agents Active ingredient Brand name Formulation Strength Dosing [aafp.org]
Cardiovascular
- Heart Disease
Women who participated in the WHI showed an increased risk for breast cancer, coronary heart disease (including nonfatal heart attacks), stroke, blood clots and gall bladder disease. [my.clevelandclinic.org]
Both studies were concluded early when the research showed that hormone replacement did not help prevent heart disease and it increased risk for some medical problems. The FDA states that hormone therapy should not be taken to prevent heart disease. [hopkinsmedicine.org]
Taken all together, the positive effect of estrogen on the prevention of heart disease is significant in premenopausal women. In menopause, when the protective effect of estrogen is gone, there is a steady increase in heart disease in women. [verywellhealth.com]
Estrogen and heart disease Estrogen deficiency increases the risk of heart disease. Lack of estrogen is an impetus to atherosclerosis. [news-medical.net]
Skin
- Night Sweats
It can also do so indirectly, in the form of hot flashes and night sweats, which can drain your energy and undermine your desire for sex as a result. These effects are discussed in detail in the “Causes of Sexual Problems” section of this program. [menopause.org]
Vitamins Useful to Menopausal Women 400 IU vitamin E may help hot flashes and night sweats. Vitamin C helps the absorption of vitamin E. B vitamins may help menopausal symptoms. [wsfpa.com]
Hormone therapy for women is considered one of the most effective treatments for bothersome hot flashes and night sweats, Dr. Lindsay Shirreff previously told Global News. [globalnews.ca]
Use in Canada HRT products containing estrogens and/or progestogens are used to treat menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. Some HRT products are also used to prevent weakening of bones (osteoporosis). [canada.ca]
Symptoms of low estrogen include: Menstrual periods that are less frequent or that stop Hot flashes (suddenly feeling very warm) and/or night sweats Trouble sleeping Dryness and thinning of the vagina Low sexual desire Mood swings Dry skin Some women [hormone.org]
- Dry Skin
Special Instructions Apply patches to clean, dry skin of lower stomach area. Take tablets at the same time each day with a glass of water. Be Aware Women who have not had a hysterectomy should take estrogen with progesterone. [arthritis.org]
Symptoms of low estrogen include: Menstrual periods that are less frequent or that stop Hot flashes (suddenly feeling very warm) and/or night sweats Trouble sleeping Dryness and thinning of the vagina Low sexual desire Mood swings Dry skin Some women [hormone.org]
skin Some of these effects are common during menopause. [medicalnewstoday.com]
Urogenital
- Amenorrhea
[…] in women with oligomenorrhea or secondary amenorrhea. [aafp.org]
Amenorrhea. Medscape Obstetrics & Gynecology. Available online at https://emedicine.medscape.com/article/252928-overview. Accessed on 07/07/18. Genzen, J. et. al. (2018 June, Updated). Amenorrhea. ARUP Consult. [labtestsonline.it]
Estrogens may be used to treat symptoms of conditions associated with estrogen deficiency such as amenorrhea and menopause. They may be used to suppress lactation and in men to treat androgen-dependent cancers such as prostate cancer. [drugs.com]
Your estrone and estradiol levels may also be tested if you’re experiencing: hot flashes night sweats insomnia frequently missed periods (amenorrhea) In some cases, your doctor may order a brain scan to check for any abnormalities that may be affecting [healthline.com]
Neurologic
- Headache
(including headaches with vision changes/lack of coordination, worsening of migraines, sudden/very severe headaches), slurred speech, weakness on one side of the body, sudden vision changes (such as partial/complete blindness).Your healthcare professionals [webmd.com]
If your estrogen is low throughout your cycle, it could lead to more headaches, but it's important to check with a doctor to make sure your headaches don't have another, potentially more serious cause. 10. [bustle.com]
Gallbladder disease or high triglyceride (cholesterol) levels that could lead to problems with your pancreas Vision loss caused by a blood clot in the eye Liver Problems High Blood Pressure Severe allergic reactions Less Serious, Common Side Effects Headaches [fda.gov]
Side effects include: bloating breast soreness headaches leg cramps indigestion nausea vaginal bleeding fluid retention, leading to swelling Some types of hormone therapy can also increase the risk of a stroke, blood clots, and uterine and breast cancer [medicalnewstoday.com]
- Irritability
Medical illnesses such as chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome and migraine disorder can have features that overlap with PMDD. [womensmentalhealth.org]
As with all herbal supplements, this product may cause GI irritation for select users. [amazon.com]
They may cause allergic reactions, skin irritation or neurotoxic manifestations. [web.archive.org]
In fact, tinctures or teas made from fennel seeds can be used to treat stomach muscle spasms caused by irritable bowel syndrome, ulcerative colitis, Crohn’s disease, and other conditions affecting the gastrointestinal system. [medicalnewstoday.com]
- Lethargy
Psychological side effects associated with Anti-Estrogen use include: insomnia, depression, anxiety, lethargy, and mood swings. A major concern with Anti-Estrogens has to do with the lowering of estrogen levels in the body. [playhealthy.drugfree.org]
[…] tenderness and swelling Fibrocystic breast lumps A slump in libido (sex drive) Irregular menstrual cycle (as well as heavy periods or no periods) Increased premenstrual syndrome Mood swings Anxiety Headaches Weight gain Hair loss Cold hands and feet Lethargy [naturalcycles.com]
[…] patients. 2 Psychological Symptoms Anger Anxiety Depression Irritability Sense of feeling overwhelmed Sensitivity to rejection Social withdrawal Physical Symptoms Abdominal bloating Appetite disturbance (usually increased) Breast tenderness Headaches Lethargy [womensmentalhealth.org]
[…] emergency room after a period of disorganized behavior, not having eaten or washed for weeks, often speaking incoherently, and presenting with what the DSM 5 calls “positive” symptoms — hallucinations, delusions — as well as some “negative” ones, such as lethargy [thecut.com]
- Burning Sensation
Improvement in symptoms as assessed by participants Proportion of women showing cure or improvement (mild symptoms) in most bothersome symptoms relating to atrophy such as dryness, dyspareunia, itching, burning sensation and discomfort at end point (immediately [cochranelibrary.com]
Treatment
Tamoxifen is also a common chemotherapeutic treatment for ER-positive breast cancer. [cebp.aacrjournals.org]
Both the EE and EE/MT treatments were well tolerated. [ncbi.nlm.nih.gov]
However, there is not yet enough research to recommend these as effective treatments for PMDD. Herbal Remedies Herbal remedies may have some role in the treatment of premenstrual symptoms. [womensmentalhealth.org]
Prognosis
Consequently, estrogen mediated ER signaling plays a critical role in breast cancer diagnosis, prognosis, and treatment. Estrogen Receptors are ligand-triggered transcription factors. [ubir.buffalo.edu]
And the lifetime prognosis is bad. Life expectancy for people with schizophrenia is ten to 25 years shorter than for those in the general population. Death by suicide is 13 times more likely. [thecut.com]
View Article Google Scholar Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. [doi.org]
Etiology
Etiology Increased estrogen production (e.g., due to ovarian tumors, obesity) Excess estrogen supplementation (e.g., due to hormone replacement therapy) Increased metabolism and excretion of estrogens (e.g., due to chronic liver disease) Clinical features [amboss.com]
Premenstrual disorders: prevalence, etiology and impact. Journal of Reproductive Medicine ; 51(4 Suppl):339-347 Yonkers, K. A., & Casper, R. F. (2018, January 15). [womensmentalhealth.org]
The role of genetic factors in the etiology of temporomandibular disorders: a review. Cranio. 2016; 34 (1): 43-51. [ Links ] [scielo.edu.uy]
Etiology and treatment of hypogonadism in adolescents. Endocrinol Metab Clin North Am. 2009 Dec. 38(4):719-38. [Medline]. Murphy KG. Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis. [emedicine.medscape.com]
Epidemiology
[…] increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology [books.google.com]
In addition, the question of the risks from environmental estrogen mimics is a very difficult one, because the biological, epidemiological and exposure issues involved are all extremely complex. [scientificamerican.com]
Large-scale epidemiological studies have demonstrated that oestrogen replacement therapy leads to approximately 50 per cent reduction of cardiovascular disease in women taking hormones, compared with untreated women. [ncbi.nlm.nih.gov]
"The clinical practice of estradiol therapy has been nothing short of a roller coaster ride," lead study author Roksana Karim, PhD, MBBS, said in an interview at the Epidemiology and Prevention/Lifestyle and Cardiometabolic Health meeting sponsored by [medscape.com]
Epidemiology and pathogenesis of premenstrual syndrome and premenstrual dysphoric disorder (R. L. Barbieri & W. F. Crowley Jr., Eds.). [womensmentalhealth.org]
Pathophysiology
It is a truly integrated text using large numbers of real clinical cases to introduce the basic biochemistry, physiology and pathophysiology underlying endocrine disorders and also the principles of clinical diagnosis and treatment. [ncbi.nlm.nih.gov]
Coverage of pathophysiology and interventions for the pregnant woman, fetus, and newborn for selected abnormal events provides a solid understanding of physiologic adaptations and developmental physiology relating to major body systems and metabolic processes [books.google.com]
Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017;97(1):135–187. doi:10.1152/physrev.00033.2015 Gambacciani M, Levancini M. Management of postmenopausal osteoporosis and the prevention of fractures. [verywellhealth.com]
Gunson MJ, Arnett GW, Milam SB: Pathophysiology and pharmacologic control of osseous mandibular condylar resorption. J Oral Maxillofac Surg 2012; 70:1918-1934 [ Links ] 26. Gunson MJ, Arnett GW. [scielo.edu.uy]
Prevention
Some HRT products are also used to prevent weakening of bones (osteoporosis). Selective estrogen receptor modulators (SERMs) (raloxifene, bazedoxifene) are also used for preventing and treating osteoporosis and some symptoms of menopause. [canada.ca]
This product is not intended to diagnose, treat, cure, or prevent any disease. Legal Disclaimer This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. [amazon.com]
Both studies were concluded early when the research showed that hormone replacement did not help prevent heart disease and it increased risk for some medical problems. The FDA states that hormone therapy should not be taken to prevent heart disease. [hopkinsmedicine.org]