SOME ADVANTAGES Key advantages of the present invention include the improved pharmacokinetics and pharmacodynamics of the compound of the present invention. [patents.google.com]

Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]

US5663431A ( en ) 1997-09-02 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present CN1118460C ( en ) 2003-08-20 Pyrimidine derivatives as 5HT2C-receptor antagonists CA2449874C [google.la]

"THE MATERIAL PRESENTED HERE ONLY ENHANCES CLASSROOM TEACHING AND IN NO WAY SHOULD BE CONSTRUED AS REPLACING IT. [people.vcu.edu]

• Precocious Puberty

  Increased levels of estradiol (E2) or estrone (E1) are seen in: Girls and Women: Early (precocious) puberty Tumors of the ovary or adrenal glands Boys and Men: Enlarged breasts (gynecomastia) Tumors of the testicles (testicular cancer) or adrenal glands [labtestsonline.org]

  Estradiol or other hormone levels may be tested in the evaluation of precocious puberty in girls (the onset of signs of puberty before age seven), delayed puberty and in assisted reproductive technology (ART) to monitor ovarian follicle development in [healthywomen.org]

• Leg Cramp

  Side effects include: bloating breast soreness headaches leg cramps indigestion nausea vaginal bleeding fluid retention, leading to swelling Some types of hormone therapy can also increase the risk of a stroke, blood clots, and uterine and breast cancer [medicalnewstoday.com]

Tamoxifen is also a common chemotherapeutic treatment for ER-positive breast cancer. [cebp.aacrjournals.org]

The current Canadian product information for HRT products warns about the risk of ovarian cancer during treatment, especially after 5 years of treatment or more. [canada.ca]

Several studies show beneficial effects of estrogen treatment in women with anxiety and depressive symptoms. Recent data indicate that the estrogen receptor (ER) beta appears to be a major mediator of estrogenic effects in depression and anxiety. [ncbi.nlm.nih.gov]

Consequently, estrogen mediated ER signaling plays a critical role in breast cancer diagnosis, prognosis, and treatment. Estrogen Receptors are ligand-triggered transcription factors. [ubir.buffalo.edu]

And the lifetime prognosis is bad. Life expectancy for people with schizophrenia is ten to 25 years shorter than for those in the general population. Death by suicide is 13 times more likely. [thecut.com]

View Article Google Scholar Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. [doi.org]

Premenstrual disorders: prevalence, etiology and impact. Journal of Reproductive Medicine ; 51(4 Suppl):339-347 Yonkers, K. A., & Casper, R. F. (2018, January 15). [womensmentalhealth.org]

Etiology Menopause Ovarian insufficiency: idiopathic or secondary to an underlying conditions (e.g., Turner syndrome, polycystic ovary syndrome) Congenital aromatase deficiency ( aromatase androgens and estrogen) Hyperprolactinemia (e.g., in pituitary [amboss.com]

Etiology and treatment of hypogonadism in adolescents. Endocrinol Metab Clin North Am. 2009 Dec. 38(4):719-38. [Medline]. Murphy KG. Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis. [emedicine.medscape.com]

Exploring the relationship between negative urgency and dysregulated eating: Etiologic associations and the role of negative affect. Journal of Abnormal Psychology, 122, 433 – 444. doi: 10.1037/a0031250 Google Scholar Crossref Medline Racine, S. [doi.org]

[…] increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology [books.google.com]

Large-scale epidemiological studies have demonstrated that oestrogen replacement therapy leads to approximately 50 per cent reduction of cardiovascular disease in women taking hormones, compared with untreated women. [ncbi.nlm.nih.gov]

In addition, the question of the risks from environmental estrogen mimics is a very difficult one, because the biological, epidemiological and exposure issues involved are all extremely complex. [scientificamerican.com]

"The clinical practice of estradiol therapy has been nothing short of a roller coaster ride," lead study author Roksana Karim, PhD, MBBS, said in an interview at the Epidemiology and Prevention/Lifestyle and Cardiometabolic Health meeting sponsored by [medscape.com]

Past epidemiological evidence, however, does worry Dr. Cooper, because some chemical exposures have been associated with early puberty. [nytimes.com]

There is increasing evidence that in both men and women extraglandular production of C(18) steroids from C(19) precursors is important in normal physiology as well as in pathophysiologic states. [ncbi.nlm.nih.gov]

Coverage of pathophysiology and interventions for the pregnant woman, fetus, and newborn for selected abnormal events provides a solid understanding of physiologic adaptations and developmental physiology relating to major body systems and metabolic processes [books.google.com]

Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017;97(1):135–187. doi:10.1152/physrev.00033.2015 Gambacciani M, Levancini M. Management of postmenopausal osteoporosis and the prevention of fractures. [verywellhealth.com]

Jean-François Arnal, Marie-Cécile Valéra, Bernard Payrastre, Francoise Lenfant and Pierre Gourdy, Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models, Thrombosis Research, 130, (S7), (2012). I.J. [doi.org]

Some HRT products are also used to prevent weakening of bones (osteoporosis). Selective estrogen receptor modulators (SERMs) (raloxifene, bazedoxifene) are also used for preventing and treating osteoporosis and some symptoms of menopause. [canada.ca]

Besides being natural body products, estrogens may be administered to i) treat or prevent osteoporosis and ii) in birth control in combination with progesterones We will have more chance to study the birth control aspect when we move to progestins. [people.vcu.edu]