Presentation
Hepatorenal impairment was present and malaria parasites with ring form were seen on malaria prep in 18% of red blood cells. [ncbi.nlm.nih.gov]
Respiratoric
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Hyperpnea
A 4-mo old, 5 kg male was presented to a local hospital with acute vomiting, tachypnea, hyperpnea and intermittent agitation and lethargy. Shortly after a generalized tonic-clonic seizure he passed several tablets in his stool. [ncbi.nlm.nih.gov]
Course
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Severe Clinical Course
Risk factors that may be associated with a more severe clinical course include immunosuppression, splenectomy, and advanced age. [ncbi.nlm.nih.gov]
Gastrointestinal
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Overeating
In a patient treated in Manchester, a parasitaemia of 2.10 X 10(6) microliters (42 per cent) was virtually eliminated over eight hours by a 3.5 litre exchange blood transfusion. [ncbi.nlm.nih.gov]
Eyes
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Scotoma
Visual acuity was count fingers, and the patient noted a paracentral scotoma. Following transfusion, there was restoration of arteriolar flow as documented with fluorescein angiogram, and visual acuity returned to 20/20. [ncbi.nlm.nih.gov]
Neurologic
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Generalized Tonic-Clonic Seizure
Shortly after a generalized tonic-clonic seizure he passed several tablets in his stool. Salicylate (ASA) level was 85 mg/dL. [ncbi.nlm.nih.gov]
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Focal Neurologic Deficit
Four patients had seizures; three had focal neurologic deficits for more than 24 hours. Cerebral arteriography demonstrated vascular abnormalities, including irregularity, stenosis, and complete occlusion of vessels. [ncbi.nlm.nih.gov]
Workup
His laboratory workup revealed a markedly raised direct hyperbilirubinaemia and transaminases with prolonged prothrombin time. His serology was negative for HbsAg, HBc IgM, anti-HCV, HAV IgM, HEV IgM, and IgG. [ncbi.nlm.nih.gov]
X-Ray
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Bilateral Pulmonary Infiltrate
The patient was initially treated with chloroquine; however, she developed bilateral pulmonary infiltrates and premature labor, and her condition appeared to clinically deteriorate. [ncbi.nlm.nih.gov]
Serum
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Hypertriglyceridemia
In cases of profound, symptomatic hypertriglyceridemia due to lipid overdose, double-volume exchange transfusion should be considered, even in extremely preterm infants. [ncbi.nlm.nih.gov]
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Base Deficit
A significant improvement in post DVET IgG, IgA, IgM, C3 and base deficit was observed. No serious adverse effects occurred following DVET. [ncbi.nlm.nih.gov]
Microbiology
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Babesia Microti
A previously healthy, 58-year-old man was infected by Babesia microti, presumably through a tick bite. [ncbi.nlm.nih.gov]
Treatment
A comatose, 14-day-old boy was referred to our emergency department (ED) after an overdose of phenobarbital, which was used for the treatment of long-standing jaundice. Plasma phenobarbital concentration was 112.4 microg/ml before treatment. [ncbi.nlm.nih.gov]
Prognosis
The etiology was unidentified in 103 patients (16.8%), of whom 62 (60.1%) developed ABE and 9 (8.7%) had a poor prognosis. [ncbi.nlm.nih.gov]
This recommendation is based on the early studies by Field [ 34 ] that demonstrated a correlation between high levels of parasitemia and poor prognosis. [cid.oxfordjournals.org]
Etiology
The etiology was unidentified in 103 patients (16.8%), of whom 62 (60.1%) developed ABE and 9 (8.7%) had a poor prognosis. [ncbi.nlm.nih.gov]
Epidemiology
Commenda 12, 20122 Milan, Italy. [email protected] 3 Neonatal Intensive Care Unit, Department of Pediatrics and Child Neuropsychiatry, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy. [email protected] 4 Epidemiology [ncbi.nlm.nih.gov]
The Retrovirus Epidemiology Donor Study. N Engl J Med 1996; 334:1685-90. 29. Siegel JF, Rich MA, Brock WA. Association of sickle cell disease, priapism, exchange transfusion and neurological events: ASPEN syndrome. J Urol 1993; 150:1480-2. 30. [sickle.bwh.harvard.edu]
Pathophysiology
The proposed pathophysiology of these neurological events is related to cerebral ischemia after an acute increase in per cent total hemoglobin, concomitant decrease in per cent hemoglobin S and subsequent release of vasoactive substances during penile [ncbi.nlm.nih.gov]
Prevention
In terms of HbS decrease, stroke prevention, and iron overload prevention, this method showed comparable efficiency to erythrapheresis. [ncbi.nlm.nih.gov]
The target is usually to maintain a hemoglobin S level below 30% to prevent complications occurring.The commonest routine reason is to prevent a stroke occurring or re-occurring. [en.wikipedia.org]