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Extragonadal Germ Cell Tumor

Extragonadal Germ Cell Cancer


Presentation

  • Clinical presentation: A 36-year-old man who presented with left subclavial vein thrombosis was admitted to our hospital for specific cure. Computed tomographic scan of the chest showed a large anterior mediastinal mass.[mafiadoc.com]
  • Mixed [ edit ] Tumor ICD-O Peak Age (yr) Benign or malignant Histology Tumor marker Mixed 15–30 Malignant Depends on elements present Depends on elements present Mixed germ cell tumors occur in many forms.[en.wikipedia.org]
  • In the present study, patients with primary mediastinal GCTs had a worse prognosis than those with GCTs in other sites, and the mediastinal site was the only independent prognostic factor ( Table 3 ).[ncbi.nlm.nih.gov]
Precocious Puberty
  • "Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome". The Annals of Thoracic Surgery. 66 (2): 547–8. doi : 10.1016/S0003-4975(98)00504-9.[en.wikipedia.org]
Thrombosis
  • Clinical presentation: A 36-year-old man who presented with left subclavial vein thrombosis was admitted to our hospital for specific cure. Computed tomographic scan of the chest showed a large anterior mediastinal mass.[mafiadoc.com]
Suggestibility
  • Most authors (1,2) have suggested that these tumors originate from germ cells, although other theories of histogenesis have also been proposed (3).[mafiadoc.com]
  • Cause [ edit ] Some investigators suggest that this distribution arises as a consequence of abnormal migration of germ cells during embryogenesis.[en.wikipedia.org]
  • However, a recent study conducted in Germany suggests that the prognosis in children with primary mediastinal malignant GCTs improves with delayed resection after preoperative chemotherapy 10).[ncbi.nlm.nih.gov]

Treatment

  • Access to appropriate treatment has a large effect on outcome.[en.wikipedia.org]
  • Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy.[ncbi.nlm.nih.gov]
  • . : Treatment of disseminated germ cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N. Engl. J. Med., 316: 1435, 1987. Google Scholar Crossref Medline[journals.sagepub.com]
  • During the treatment, the alpha-fetoprotein level, was decreasing. Conclusion: Primary mediastinal Yolk sac neoplasm is a rare tumor.[mafiadoc.com]

Prognosis

  • AFP levels at the time of diagnosis were not correlated with prognosis ( Table 2 ).[ncbi.nlm.nih.gov]
  • Adjusting for these and other factors, survival was 60% higher for men treated in a cancer unit that treated the majority of these men, though the unit treated more men with the worst prognosis. [12] Choriocarcinoma of the testicles has the worst prognosis[en.wikipedia.org]
  • In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor. The single most important prognostic indicator is whether the tumor mass can be completely excised before or after chemotherapy.[mafiadoc.com]

Etiology

  • . : Testicular tumors - Epidemiologic, etiologic and pathologic features. Cancer, 32: 1186, 1973. Google Scholar Crossref Medline 8.[journals.sagepub.com]

Epidemiology

  • . : Testicular tumors - Epidemiologic, etiologic and pathologic features. Cancer, 32: 1186, 1973. Google Scholar Crossref Medline 8.[journals.sagepub.com]
Sex distribution
Age distribution

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