Presentation
In this report, the authors present a rare case of germinoma developing in the medulla oblongata. A 31-year-old woman complained of intractable hiccups, hoarseness, and swallowing disturbance. [ncbi.nlm.nih.gov]
Clinical presentation depends on tumor location and may involve endocrine, hypothalamic, visual, and cognitive dysfunction. [jamanetwork.com]
Unlike chiasmatic gliomas, suprasellar germinomas characteristically present with a clinical triad of endocrine abnormalities, diabetes insipidus, and visual complaints. [karger.com]
The following tests may be used to investigate suspected germ cell tumors in your brain: Tumor markers are molecules that are present on the surface of tumor cells, but absent or present in smaller amounts on normal cells. [houstonmethodist.org]
Clinical presentation includes headache, nausea, vomiting, papilloedema, lethargy and somnolescence. Diagnosis of germinoma is important as treatment protocol differs when compared to the other histological subtypes. [scopemed.org]
Entire Body System
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Camping
One camp would argue that in the absence of evidence of dissemination outside the pineal region, that only this localized volume needs to be irradiated. [oncolink.org]
Our Children's Cancer Hospital provides opportunities for kids to be kids, through camps, field trips and special events. Learn more about our unique programs. [mdanderson.org]
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Epilepsy
ObservationAlonePerspective 513 Trigeminal Neuralgia 519 Surgical Perspective 527 Medical Management Perspective 535 55 Movement Disorder 541 DeepBrain Stimulation Perspective 549 Medical Perspective 559 58 Psychiatric and Pain Disorders 563 59 Intractable Epilepsies [books.google.es]
Phone: 617-636-8585 Fax #: 617-636-7587 Epilepsy neurosurgery, skull base surgery, pituitary surgery, neurovascular surgery, minimally invasive spine surgery, neurosurgical disorders in patients with achondroplasia, neurosurgical disorders in patients [tuftsmedicalcenter.org]
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Weight Gain
We report the case of a 9-year-old boy who presented with a 5-month history of fatigue, 16-pound weight gain, polydipsia, polyuria, visual complaints, and intermittent headache. [karger.com]
Respiratoric
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Hoarseness
A 31-year-old woman complained of intractable hiccups, hoarseness, and swallowing disturbance. [ncbi.nlm.nih.gov]
Headache PR, CMT, FB RT CR 8 months 11 Yasuhara [ 3 ] 27 F CN VIII, IX, X,XII paresis, ataxia, sleep apnea, numbness of limbs Biopsy, CMT, RT CR 6 months 12 Shuto [ 2 ] 28 M Loss of balance STR, CMT, FB WS RT CR 3 years 13 Nakatsuka [ 8 ] 31 F Hiccups, hoarseness [wjso.biomedcentral.com]
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Labored Breathing
Second, the patient could not lie down but sustained labored breathing. Given the patient’s history of prior radiotherapy, we abstained from treating this patient with another course of radiotherapy for fear of provoking brain stem edema. [wjso.biomedcentral.com]
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Sneezing
The medulla oblongata has nuclei, which regulate vomiting, swallowing, coughing and sneezing. Following the operation for germinoma, the patients almost always complained of dyspnea and dysphagia. [wjso.biomedcentral.com]
Gastrointestinal
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Hiccup
A 31-year-old woman complained of intractable hiccups, hoarseness, and swallowing disturbance. [ncbi.nlm.nih.gov]
Patients may often complain of headache, impaired vision, and hiccups among other symptoms. Reviewing the brain CT and MRI scans is very important for diagnosing brain stem germinomas. [wjso.biomedcentral.com]
Lower cranial nerves dysfunction, disturbance of breathing and cerebellar function, headache, nystagmus, sensory and motor disturbance, visual disturbance, and hiccups are the key symptoms reported.[ 3 9 ] From preoperative brain MRI of our patient, the [surgicalneurologyint.com]
Cardiovascular
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Vascular Disease
Fractionated Radiation Therapy Perspective 455 46 Arteriovenous Malformation 459 Surgery Perspective 473 Endovascular TherapyPerspective 479 49 CavernousMalformations and Other Vascular Diseases 491 Surgical Perspective 503 ObservationAlonePerspective [books.google.es]
Psychiatrical
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Fear
Given the patient’s history of prior radiotherapy, we abstained from treating this patient with another course of radiotherapy for fear of provoking brain stem edema. [wjso.biomedcentral.com]
Face, Head & Neck
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Facial Numbness
Case presentation Case 1 A 14-year-old male patient presented with right facial numbness and gait instability lasting 6 months. The neurological examination upon admission revealed right-sided deficits in cranial nerves V, VIII and IX. [wjso.biomedcentral.com]
Urogenital
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Polyuria
We report the case of a 9-year-old boy who presented with a 5-month history of fatigue, 16-pound weight gain, polydipsia, polyuria, visual complaints, and intermittent headache. [karger.com]
The differential diagnosis of polydipsia and polyuria should exclude diabetes mellitus and salt-losing nephropathy from end-stage renal disease. [n.neurology.org]
A 17-year-old boy presented with a history of headache for 8 months, progressive painless diminution of vision (right left) and polyuria for 6 months. The patient had remained short in stature and had failed to develop secondary sexual characters. [ijabmr.org]
A – D, MR images from 16-year-old boy who presented with a long-standing history of poor growth, delayed puberty, polydipsia, and polyuria. [ajnr.org]
The main symptoms of germinomas in this location are polydipsia, polyuria, visual impairment and other hypothalamic-pituitary dysfunctions, which include growth retardation and delayed puberty. [wjso.biomedcentral.com]
Neurologic
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Lethargy
Clinical presentation includes headache, nausea, vomiting, papilloedema, lethargy and somnolescence. Diagnosis of germinoma is important as treatment protocol differs when compared to the other histological subtypes. [scopemed.org]
A young man (22 years old) was presented with complaint of one year of headache, and recently vomiting, and in exam papilledema, lethargy, somnolence, diabetes insipidus. [mafiadoc.com]
In the pineal region, tumors may cause increased intracranial pressure by obstructing the cerebral aqueduct, producing headache, nausea, vomiting, and lethargy. [path.upmc.edu]
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Papilledema
Papilledema was detected on fundoscopy. [pediatricneurosciences.com]
[…] include: [16] HEENT Bulging soft spots ( fontanelles ) Eyes that are constantly looking down ( sunsetting sign ) Deficiency in upward-gaze Pupillary light-near dissociation (pupils respond to near stimuli but not light) Convergence-retraction nystagmus Papilledema [wikidoc.org]
A young man (22 years old) was presented with complaint of one year of headache, and recently vomiting, and in exam papilledema, lethargy, somnolence, diabetes insipidus. [mafiadoc.com]
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Trigeminal Neuralgia
Fractionated Radiation Therapy Perspective 455 46 Arteriovenous Malformation 459 Surgery Perspective 473 Endovascular TherapyPerspective 479 49 CavernousMalformations and Other Vascular Diseases 491 Surgical Perspective 503 ObservationAlonePerspective 513 Trigeminal [books.google.es]
Phone: 617-636-4500 Fax #: 617-636-7587 Neuro-oncology, Gamma Knife radiosurgery, meningiomas, pituitary tumors, gliomas, brain metastasis, trigeminal neuralgia View Full Profile Thomas R. [tuftsmedicalcenter.org]
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Neuralgia
Radiation Therapy Perspective 455 46 Arteriovenous Malformation 459 Surgery Perspective 473 Endovascular TherapyPerspective 479 49 CavernousMalformations and Other Vascular Diseases 491 Surgical Perspective 503 ObservationAlonePerspective 513 Trigeminal Neuralgia [books.google.es]
Phone: 617-636-4500 Fax #: 617-636-7587 Neuro-oncology, Gamma Knife radiosurgery, meningiomas, pituitary tumors, gliomas, brain metastasis, trigeminal neuralgia View Full Profile Thomas R. [tuftsmedicalcenter.org]
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Excitement
This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. [books.google.com]
"As a cancer survivor, I couldn't be more excited about that." Finding hope during pineal region germinoma treatment One day after baseball practice, Chase walked off the field with a sharp headache. It was unlike any pain he'd known before. [mdanderson.org]
Workup
Neurosarcoidosis, tuberculosis, and fungal infection show granulomatous response, and a detailed clinical workup is necessary to look for systemic involvement. [ijabmr.org]
The staging workup should include assays for AFP and human chorionic gonadotropin (HCG). AFP is elevated in almost all cases of endodermal sinus tumor and in many other patients with GCTs ( 12, 13 ). [radiologykey.com]
In the archives of 3 pathology departments, we found records of 7 patients with mediastinal GCTs who underwent mediastinal FNAB as part of the diagnostic workup. [thedoctorsdoctor.com]
Other Pathologies
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Granulomatous Tissue
Granulomatous tissue response in germinoma, a diagnostic pitfall in endoscopic biopsy. Neuropathology 2007;27:127-32. [ PUBMED ] 7. Lee D, Suh YL. [ijabmr.org]
Acta Neurochir 2002, 144: 1233-1237 [ PubMed ] 9) Mueller W, Schneider GH, Hoffmann KT, Zschenderlein R, von Deimling A: Granulomatous tissue response in germinoma, a diagnostic pitfall in endoscopic biopsy. [turkjpath.org]
Treatment
Therefore, we know that this treatment is highly effective. [oncolink.org]
We found that the β-HCG level declined significantly after treatment. Of the 40 cases examined, 37 had a β-HCG 0.1 mIU/mL before treatment and the level decreased to 0.1 post treatment. This result is consistent that of prior study [ 40 ]. [journals.plos.org]
Imaging studies and the analysis of your CSF will help your doctors to develop a treatment plan and to monitor your response to treatment. Blood tests can also be useful in diagnosing germ cell tumors. [houstonmethodist.org]
A variety of treatment modalities including radiotherapy, radiosurgery, surgical therapy and chemotherapy are also discussed. [books.google.com]
With proper evaluation and treatment of this disease, patients can have favorable prognoses. [wjso.biomedcentral.com]
Prognosis
BACKGROUND AND PURPOSE: Tumors of pineal cell origin have different prognosis and treatment than those of germ cell origin. The recent literature suggests that these tumors often look alike. [ncbi.nlm.nih.gov]
Accessed on December 2, 2015 Treatment and prognosis of pineal germinoma. Dr Henry Knipe et al. Radiopaedia 2015. . Accessed on December 2, 2015 Prognosis of pineal germinoma. Operative Neurosurgery 2015. . [wikidoc.org]
These types of tumors are surgically treated with chemotherapy and I or and the prognosis is good. [pure.udem.edu.mx]
[…] germ cell tumor (GCT) risk on the basis of the following11: Histologic type (seminomas have a better prognosis than nonseminomas) Localization of metastases (retroperitoneal and testicular portend better prognosis than mediastinal and intracranial) Initial [emedicine.medscape.com]
Etiology
Even in the United States, individuals with Asian/Pacific Islander ancestry have a two- to threefold higher risk of intracranial GCT compared with whites, suggesting that genetic factors may be more important than environmental factors in the etiology [uptodate.com]
The most common etiologies of spinal cord compression are lumbar disc herniation, spinal stenosis, and masses including primary and metastatic tumor. [bmcpediatr.biomedcentral.com]
The polydipsia and polyuria were thought to be of psychogenic etiology because there were serious psychosocial issues in the family though the urine specific gravity was clearly low. [n.neurology.org]
The etiology of extragonadal GCTs is unknown; in rare cases, they have been associated with Klinefelter syndrome [ 9 – 12 ]. [wjso.biomedcentral.com]
The etiology of primary prostate seminoma is unclear, although there are several possibilities: The origin of the urinary and reproductive systems is similar and the two are closely associated with each other. [spandidos-publications.com]
Epidemiology
This article focuses on the epidemiology, embryology, clinical presentation, means of diagnosis, treatment, and outcome of this rare neoplasm. [jamanetwork.com]
This publication takes advantage of the knowledge and experience of Japanese experts in pineal tumors, with emphasis on epidemiology and pathological diagnosis. [books.google.com]
[…] surgery and chemotherapy, no vascular invasion, no yolk sac or choriocarcinoma components Gross description Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or necrosis Choriocarcinoma Epidemiology [pathologyoutlines.com]
Accessed on December 1, 2015 Epidemiology of pineal germinoma. Operative Neurosurgery 2015. . Accessed on Dcember 2, 2015 10.0 10.1 Epidemiology of pineal germinoma. Dr Henry Knipe et al. Radiopaedia 2015. . [wikidoc.org]
EPIDEMIOLOGY In North America and Europe, intracranial GCTs represent 0.5 to 3 percent of pediatric central nervous system (CNS) tumors [ 1 ]. [uptodate.com]
Pathophysiology
It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. [books.google.com]
It refers to a tumor in the pineal gland that has a histology identical to two other tumors: dysgerminoma in the ovary and seminoma in the testis. [2] Pathophysiology Pathogenesis Pineal germinoma is a malignant neoplasm of the germinal tissue of the [wikidoc.org]
Pathophysiology Controversy remains regarding the origin of extragonadal germ cell tumors. These tumors can be found anywhere on the midline, particularly the retroperitoneum, the anterior mediastinum, the sacrococcyx, and the pineal gland. [emedicine.medscape.com]
Prevention
The child was treated with emergency decompression surgery and high-dose pulse steroid therapy to prevent secondary injury to the spinal cord. [bmcpediatr.biomedcentral.com]
Hospital for Sick Children Health A-Z Search a complete list of child health articles expand_more View All Drug A-Z Search a list of articles about medications expand_more View All Learning Hubs Browse a complete list of content groups Healthy Living & Prevention [aboutkidshealth.ca]
[…] sudden cardiac death - guidance (IPG603) Source: National Institute for Health and Care Excellence - NICE - 20 December 2017 Evidence-based recommendations on subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac [evidence.nhs.uk]
Tuba KURUOGLU,Mehmet Emin ONGER,Derya BAYIRLI TURAN,Enis KURUOGLU The Preventative Effect of α-Tocopherol on Spinal Epidural Fibrosis After Laminectomy in a Rat Model. [turkishneurosurgery.org.tr]
Radiation therapy : This treatment is important in controlling the local growth of the tumor and preventing the spread of the tumor. [danafarberbostonchildrens.org]