Obstructive hydrocephalus is present. [18] MRI Brain MRI may be diagnostic of pineal germinoma. [wikidoc.org]

Clinical Presentation: Basal ganglia germinomas most commonly present with progressive hemiparesis. [ajnr.org]

Top Abstract Introduction Case Presentation Disscussion References A 68-year-old male presented with a tumor in the midline of the neck. The tumor was operated on and total thyroidectomy was performed. [turkjpath.org]

Although intracranial germinomas may present with synchronous midline lesions, development of metachronous testicular germ cell primaries seems to be extremely rare, and confirmed dissemination of intracranial GCT to the testes has never been reported [ncbi.nlm.nih.gov]

• Pain

  We report the case a 52-year-oLd male with left flank pain that radiated to external genitalia. Physical examintion showed a painLess and hard mass in the left flank; also a mass in left testicle. [pure.udem.edu.mx]

  RESEARCH REPORT Psychosocial factors related to postmastectomy pain syndrome among women with breast cancer: cross-sectional study Lanaban AR, Sorrosa R, Concha A. 2018-12-21 HTML PDF RECENT ARTICLES RESEARCH REPORTS Psychosocial factors related to postmastectomy [spmcpapers.com]

  491 Surgical Perspective 503 ObservationAlonePerspective 513 Trigeminal Neuralgia 519 Surgical Perspective 527 Medical Management Perspective 535 55 Movement Disorder 541 DeepBrain Stimulation Perspective 549 Medical Perspective 559 58 Psychiatric and Pain [books.google.es]

  They can include: A lump or mass Belly (abdominal) pain Chest pain Trouble breathing Trouble with eyesight Fever Pain in the lower spine Need to urinate often or trouble urinating Trouble with bowel movements (constipation) Increased thirst and urination [nationwidechildrens.org]

  Medical screening for red flags in the diagnosis and management of musculoskeletal spine pain. Pain Practice. 2007;7(1):53–71. View Article PubMed Google Scholar Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B. [bmcpediatr.biomedcentral.com]

• Swelling

  Some symptoms result from hydrocephalus (swelling of the brain). Fatigue, vomiting, headache, behavioral changes, difficulty with movements or vision changes may also occur. [nicklauschildrens.org]

  For tumors in the pineal gland region, children can have the following symptoms: Hydrocephalus (swelling of the brain) Headache Vomiting Fatigue Behavioral or cognitive changes Uncoordinated body movement (ataxia) Vision changes, including double vision [dana-farber.org]

  Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females. [bioportfolio.com]

  A possible sign is swelling of the abdomen but often, there are no symptoms in the early stage. Testicular — Testicular tumors often are detected at an early age because they become noticeable in the scrotum or cause pain. [ucsfbenioffchildrens.org]

• Fever

  2018 Tabada CF, Ladrero CX HTML PDF More infographics MORE ARTICLES CLINICAL IMAGES A 29-year-old male complaining about generalized, vague abdominal pain, gradual abdominal distension, post-prandial vomiting of previously eaten food, obstipation, and fever [spmcpapers.com]

  […] invasion of adjacent structures, hemorrhage or necrosis Choriocarcinoma Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic factors Poor prognosis Case reports 13 year old boy with shortness of breath, chest pain, fever [pathologyoutlines.com]

  Medicines and other treatments can be used for pain, fever, infection, and nausea and vomiting. With any cancer, how well a child is expected to recover (prognosis) varies. [nationwidechildrens.org]

  In general, though, childhood germ cell tumor symptoms can include: Lump in abdomen or lower back or testicle Pain in the abdomen Breast growth (for testicular germ cell tumors) In females, no period or unusual bleeding Fever Constipation Headaches Shortness [mdanderson.org]

  Fever occurred in 21 courses (81%), with an overall median duration of 3 days (range, 0–13). The number of HDC courses with episodes of clinically documented infections was 13 (50%). [nature.com]

• Asymptomatic

  An 8 year asymptomatic history after detection of abnormality on CT. Pediatr Neurosurg 2004;40:306-11. Oyama N, Terae S, Saitoh S, Sudoh A, Sawamura Y, Miyasaka K. Bilateral germinoma involving the basal ganglia and cerebral white matter. [medigraphic.com]

  An 8-Year Asymptomatic History after Detection of Abnormality on CT Takeda N. a · Fujita K. a · Katayama S. a · Uchihashi Y. a · Okamura Y. a · Nigami H. b · Hashimoto K. c · Kohmura E. d Author affiliations Departments of a Neurosurgery, b Pediatrics [karger.com]

  Other presenting signs and symptoms included an asymptomatic palpable mass (19%), abdominal distention (36%), and, less commonly, menstrual irregularities, malaise, nausea, vomiting, or vaginal bleeding ( 9, 19, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 [radiologykey.com]

  A 4-cm asymptomatic mass in the pouch of Douglas was observed, and the patient was diagnosed with ovarian mature cystic teratoma. [cancerindex.org]

  Also, if an intraspinal germinoma was suspected, MR imaging of the brain was considered to be necessary even in asymptomatic patients. References ↵ Curry WA, McKay CE, Richardson RL, et al. Klinefelter’s syndrome and mediastinal germ cell neoplasms. [ajnr.org]

• Lymphadenopathy

  Epidemiology Almost always males Sites Thymus Prognostic factors 5 year disease free survival is 50 - 65%; 10 year actuarial survival is 69% Good prognostic factors: age 35 years or less at diagnosis, no superior vena caval syndrome, no mediastinal lymphadenopathy [pathologyoutlines.com]

• Vomiting

  Clinical presentation includes headache, nausea, vomiting, papilloedema, lethargy and somnolescence. Diagnosis of germinoma is important as treatment protocol differs when compared to the other histological subtypes. [scopemed.org]

  Nausea and vomiting Some of the chemotherapy drugs used may make your child feel sick or vomit. We will give anti-sickness drugs at the same time to stop nausea and vomiting. These are usually very effective. Hair loss Temporary hair loss is common. [royalmarsden.nhs.uk]

  Fatigue, vomiting, headache, behavioral changes, difficulty with movements or vision changes may also occur. Other symptoms might include diabetes insipidus (thirst and passing a lot of urine), poor growth and early or late puberty. [nicklauschildrens.org]

• Nausea

  Clinical presentation includes headache, nausea, vomiting, papilloedema, lethargy and somnolescence. Diagnosis of germinoma is important as treatment protocol differs when compared to the other histological subtypes. [scopemed.org]

  Nausea and vomiting Some of the chemotherapy drugs used may make your child feel sick or vomit. We will give anti-sickness drugs at the same time to stop nausea and vomiting. These are usually very effective. Hair loss Temporary hair loss is common. [royalmarsden.nhs.uk]

  Symptoms Hydrocephalus commonly causes headaches and nausea or vomiting. Sometimes patients have difficulty looking up. Diagnosis Scans A magnetic resonance imaging (MRI) of the brain is the most important imaging study. [neurosurgery.ucla.edu]

• Abdominal Mass

  Although uncommon, teratomas should be considered in the differential diagnosis of extragonadal abdominal masses, particularly in young adults. [cancerindex.org]

  Br J Surg 1997 Jul;84(7):1022-5 Abstract quote BACKGROUND: Primary retroperitoneal germ cell tumours usually present as a large abdominal mass in young men. [thedoctorsdoctor.com]

• Diarrhea

  Nonhematologic grade III or IV toxicityincluded seven (38.8%) patients with mucositis and onepatient each with diarrhea, deep venous thrombosis, renalfailure, weight loss, and pulmonary toxicity.Treatment ResponseResponses according to radiologic evaluation [docslide.net]

• Aggressive Behavior

  behavior if not limited to mediastinum at diagnosis ( Cancer 1997;80:699, Pediatr Hematol Oncol 2012;29:633 ) Prognosis worse than gonadal germ cell tumors; 5 year disease free survival is 50 - 65% for seminomas, 20% for other subtypes Sarcomatous component [pathologyoutlines.com]

• Irritability

  […] germinoma is mainly from the obstructive hydrocephalus secondary to compression of the tectum of the midbrain and obstruction of the aqueduct. [15] Symptoms of pineal germinoma include: [16] Headaches Nausea Vomiting Seizures Hearing loss Sleepiness Irritability [wikidoc.org]

  Tumors in the pineal region of the brain can cause these symptoms: Increased fluid in the brain (hydrocephalus) Headache Vomiting Fatigue Feeling irritable Double vision Trouble looking up or focusing on close objects Coordination and balance issues Tumors [stjude.org]

  […] of adjacent structures, hemorrhage or necrosis Choriocarcinoma Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic factors Poor prognosis Case reports 13 year old boy with shortness of breath, chest pain, fever, irritable [pathologyoutlines.com]

• Cryptorchidism

  Specifically, males with cryptorchidism (failure of the testes to descend into the scrotal sac) have an increased risk to develop testicular germ cell tumors. Cryptorchidism can occur alone, however, and is also present in some genetic syndromes. [urmc.rochester.edu]

  Boys born with undescended testicles (cryptorchidism) are believed to have a higher risk of germ cell tumors in the testicles. What are the symptoms of germ cell tumors in a child? Symptoms can vary depending on the size and location of the tumor. [nationwidechildrens.org]

  Three patients withabdominal location had a history of cryptorchidism. Atpresentation 10 patients (55.5%) had elevated AFP and6 patients (33.3%) had elevated b-HCG levels.ToxicityToxicity was evaluated according to WHO standardcriteria [9]. [docslide.net]

Neurosarcoidosis, tuberculosis, and fungal infection show granulomatous response, and a detailed clinical workup is necessary to look for systemic involvement. [ijabmr.org]

The staging workup should include assays for AFP and human chorionic gonadotropin (HCG). AFP is elevated in almost all cases of endodermal sinus tumor and in many other patients with GCTs ( 12, 13 ). [radiologykey.com]

In the archives of 3 pathology departments, we found records of 7 patients with mediastinal GCTs who underwent mediastinal FNAB as part of the diagnostic workup. [thedoctorsdoctor.com]

“We decided to search for a better way of treatment and eventually came to this combination treatment.” [parkwaycancercentre.com]

The specific treatment will depend on the germinoma's location, size, and other characteristics. [danafarberbostonchildrens.org]

[ edit ] Treatment of M0 disease is somewhat controversial. [en.wikibooks.org]

Also the treatment of intracranial GCTs differs according to histological subtype. [sciforschenonline.org]

Patients received surgery, chemotherapy, radiotherapy, or a combination of treatment modalities as the primary treatment. [tmu.pure.elsevier.com]

Accessed on December 2, 2015 ↑ Treatment and prognosis of pineal germinoma. Dr Henry Knipe et al. Radiopaedia 2015. http://radiopaedia.org/articles/pineal-germinoma. Accessed on December 2, 2015 ↑ Prognosis of pineal germinoma. [wikidoc.org]

Prognosis With proper diagnosis and treatment the prognosis for Pineal Germinoma is quite good. The five-year survival rate with radiation is as high as 90%. [knowcancer.com]

These types of tumors are surgically treated with chemotherapy and I or and the prognosis is good. [pure.udem.edu.mx]

The prognosis is closely related to the histological subtype. Pure germinomas are highly radiosensitive, whereas NGGCTs are less sensitive to radiotherapy and they have a worse prognosis [17,18]. [sciforschenonline.org]

[…] germ cell tumor (GCT) risk on the basis of the following11: Histologic type (seminomas have a better prognosis than nonseminomas) Localization of metastases (retroperitoneal and testicular portend better prognosis than mediastinal and intracranial) Initial [emedicine.medscape.com]

Even in the United States, individuals with Asian/Pacific Islander ancestry have a two- to threefold higher risk of intracranial GCT compared with whites, suggesting that genetic factors may be more important than environmental factors in the etiology [uptodate.com]

The most common etiologies of spinal cord compression are lumbar disc herniation, spinal stenosis, and masses including primary and metastatic tumor. [bmcpediatr.biomedcentral.com]

The polydipsia and polyuria were thought to be of psychogenic etiology because there were serious psychosocial issues in the family though the urine specific gravity was clearly low. [n.neurology.org]

The etiology of extragonadal GCTs is unknown; in rare cases, they have been associated with Klinefelter syndrome [ 9 – 12 ]. [wjso.biomedcentral.com]

The etiology of primary prostate seminoma is unclear, although there are several possibilities: The origin of the urinary and reproductive systems is similar and the two are closely associated with each other. [spandidos-publications.com]

Accessed on December 1, 2015 ↑ Epidemiology of pineal germinoma. Operative Neurosurgery 2015. http://operativeneurosurgery.com/doku.php?id=pineal_germinoma. Accessed on Dcember 2, 2015 ↑ 10.0 10.1 Epidemiology of pineal germinoma. [wikidoc.org]

This article focuses on the epidemiology, embryology, clinical presentation, means of diagnosis, treatment, and outcome of this rare neoplasm. [jamanetwork.com]

This publication takes advantage of the knowledge and experience of Japanese experts in pineal tumors, with emphasis on epidemiology and pathological diagnosis. [books.google.com]

[…] surgery and chemotherapy, no vascular invasion, no yolk sac or choriocarcinoma components Gross description Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or necrosis Choriocarcinoma Epidemiology [pathologyoutlines.com]

This text is complete with detailed information concerning the epidemiology, pathology, oncological biology, clinical findings, radiology, and treatment options including surgical strategy, radiotherapy, and chemotherapy for this heterogeneous group of [books.google.de]

It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. [books.google.com]

It refers to a tumor in the pineal gland that has a histology identical to two other tumors: dysgerminoma in the ovary and seminoma in the testis. [2] Pathophysiology Pathogenesis Pineal germinoma is a malignant neoplasm of the germinal tissue of the [wikidoc.org]

Pathophysiology Controversy remains regarding the origin of extragonadal germ cell tumors. These tumors can be found anywhere on the midline, particularly the retroperitoneum, the anterior mediastinum, the sacrococcyx, and the pineal gland. [emedicine.medscape.com]

The child was treated with emergency decompression surgery and high-dose pulse steroid therapy to prevent secondary injury to the spinal cord. [bmcpediatr.biomedcentral.com]

The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects. [books.google.com]

[…] sudden cardiac death - guidance (IPG603) Source: National Institute for Health and Care Excellence - NICE - 20 December 2017 Evidence-based recommendations on subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac [evidence.nhs.uk]

Radiation therapy This treatment is important in controlling the local growth of the tumor and preventing the spread of the tumor. [childrenshospital.org]

Radiation therapy : This treatment is important in controlling the local growth of the tumor and preventing the spread of the tumor. [danafarberbostonchildrens.org]