Case Presentation: 60 year old African American man with history of HTN, HLD, and mitral valve regurgitation presented to the ER complaining of 2.5 weeks of progressively worsening right eye pain and swelling. [shmabstracts.com]

One year later he presented with an acute confusional episode that resolved over a two week period. [jneuro.com]

When lymphomas are present on the eye and nowhere else, they are treated with EBRT-external beam radiation therapy. [verywellhealth.com]

[…] of the disease often discloses little-to no atypicality in the lymphocytes present in the specimen. [mersi.com]

Nine patients (47%) presented with proptosis and five patients (26%) presented with an upper lid mass; three (15%) as conjunctival mass and two (11%) as lacrimal gland swelling [Table - 2]. [ijo.in]

DIAGNOSIS PCNSL should be suspected in any patient with posterior uveitis who has a negative workup for common causes of posterior uveitis. [retinatoday.com]

Clinical awareness of any atypical ocular presentations in NKTCL cases should necessitate thorough workup in order not to hinder an early discovery of disease relapse. References Armitage JO: The aggressive peripheral T-cell lymphomas. [cureus.com]

CSF dissemination is detected during staging workup in only 10–15% of cases (Grimm et al, 2007 ). [onlinelibrary.wiley.com]

Hence, all patients with ocular lymphoma should have a complete workup to rule out systemic lymphoma. " ________________________ Intra-ocular lymphoma: A rare malignant form of eye cancer. [lymphomation.org]

The following are treatment options for lymphoma of the eye. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. [cancer.ca]

He continues, "I hope that this treatment protocol would become the impetus for breaking down the poor prognosis of this disease." [u-tokyo.ac.jp]

Recurring tumors have worse prognosis compared to tumors that do not recur Response to treatment: Tumors that respond to treatment have better prognosis compared to tumors that do not respond to treatment Progression of the condition makes the outcome [dovemed.com]

The authors found that doxycycline treatment caused lymphoma to regress in both patients who did not test positive for the disease and those who did. [sciencedaily.com]

Depending on the size of the tumor, treatment can include complete excision, cryotherapy, injection of chemotherapy medicines, radiation, or treatment by intravenous chemotherapy. [willseye.org]

Among eye diseases, intraocular lymphoma has the worst survival prognosis. [u-tokyo.ac.jp]

Prognosis is less favourable. [radiopaedia.org]

Many people are diagnosed with eye lymphoma after it has already spread to the brain, which has a worse prognosis. It is important to remember that statistics on the survival rates for people with eye cancer are an estimate. [cancer.net]

The patient was admitted to our clinic for etiologic study and treatment. [ncbi.nlm.nih.gov]

Pathogenesis Etiology The eye itself is not the site of the lymphoma. There may be enlargement on the bulbar surface of the glans nictitans. One or both of the eyes may be affected. [vetstream.com]

The possible infective etiology may explain the probable increase in the incidence of orbital lymphomas (see below) 3. Typically patients are between 50 and 70 years of age, with no recognized gender predilection 6. [radiopaedia.org]

The differential diagnosis includes infectious, inflammatory, and other neoplastic processes.22 Infectious etiologies include endophthalmitis secondary to bacterial, viral, fungal, or parasitic infections.22 A vitreous sample is obtained and should be [archivesofpathology.org]

More rarely, an infectious etiology should also be considered. [djo.harvard.edu]

Epidemiology Neoplasia of the eye and orbit is uncommon in ferrets. Malignant lymphoma is the most common neoplasm in both the eye and the orbit. [vetstream.com]

"Epidemiology of primary CNS lymphoma". Journal of Neuro-Oncology. 43 (3): 199–201. doi : 10.1023/A:1006290032052. PMID 10563423. ^ Ahmed, S; Shahid, RK; Sison, CP; Fuchs, A; Mehrotra, B (February 2006). [en.wikipedia.org]

It provides a thorough review of conjunctival anatomy and physiology along with explanations of key findings, common clinical presentations, differential diagnoses, epidemiology, pathophysiology, risk factors, treatment and management options and prognosis [journal.opted.org]

PMID 28682481 Descriptive epidemiology of ophthalmic and ocular adnexal non-Hodgkin's lymphoma. Moslehi R, Coles FB, Schymura MJ Expert Rev Ophthalmol. 2011;6:175-180. [atlasgeneticsoncology.org]

Fisher SG, Fisher RI (2004) The epidemiology of non-Hodgkin's lymphoma. Oncogene 23: 6524-6534. Palackdharry CS (1994) The epidemiology of non-Hodgkin's lymphoma: Why the increased incidence? Oncology (Williston Park) 8: 67-73. [omicsonline.org]

A review of ocular lymphoma diagnosis, pathophysiology, and management is undertaken. Format: video Series: Moran Eye Center Grand Rounds Identifier: Moran_CORE_15769 Copyright statement: Copyright 2015. [morancore.utah.edu]

It provides a thorough review of conjunctival anatomy and physiology along with explanations of key findings, common clinical presentations, differential diagnoses, epidemiology, pathophysiology, risk factors, treatment and management options and prognosis [journal.opted.org]

Pathophysiology [ edit ] Recent studies [ by whom? ] have detected the presence of viral DNA in ocular lymphoma cells. This implies that pathogens play a role in ocular lymphoma. [en.wikipedia.org]

Pathophysiology of retinal lymphoma. Ocul Immunol Inflamm. 2009;17(4):227–237. 6. Char DH, Ljung BM, Deschênes J, Miller TR. Intraocular lymphoma: immunological and cytological analysis. Br J Ophthalmol. 1988;72(12):905–911. 7. [dovepress.com]

A pathophysiologic scenario involving chronic and sustained stimulation of the immune system leading to lymphoid transformation has emerged. [scienceopen.com]

This can help prevent cancer from spreading there or help destroy hidden cancer cells. [columbiaeye.org]

This finding shows that aggressive systemic chemotherapy and preventive radiotherapy could greatly improve the prognosis of the disease. "Intraocular malignant lymphoma, although a disease of the eye, is intractable and life-threatening. [u-tokyo.ac.jp]

Sometimes patients take a special antibiotic to prevent long-term involvement elsewhere in the body. Conjunctival Lymphoma Photos [willseye.org]

[…] at risk for getting eye lymphoma include those who: have rheumatoid arthritis or other autoimmune diseases have certain medical problems that affect their immune system have AIDS (acquired immunodeficiency syndrome) are taking certain medications to prevent [aao.org]

Radiation therapy may also be directed to the brain and spinal cord to help prevent the cancer from spreading there or to help destroy undetected cancer cells that could be there. Lauren R. Rosecan M.D., Ph.D., F.A.C.S. [sflhealthandwellness.com]