Case presentation A 3-year-old boy presented for evaluation of multiple facial nodules that had been present for six months. After their initial appearance, the lesions sporadically fluctuated in size but never resolved completely. [escholarship.org]

[…] with a history of a red-brown well-circumscribed lesion present on the face for a long duration. [psychiatryadvisor.com]

Lesions may be present for weeks or months and tend to follow a chronic course. [accessmedicine.mhmedical.com]

• Cervical Lymphadenopathy

  No cervical lymphadenopathy was identified. The patient underwent excision of the well-circumscribed mass via a right laryngotomy approach (figure 2). [drrandytate.com]

  There was no pre-auricular or cervical lymphadenopathy. The remainder of his examination was normal. Figure 3 An ultrasound showed that the lesions were homogenous, hypoechoic and solid. [escholarship.org]

• Cat Scratch

  Cultures for mycobacteria and cat scratch disease serologies were negative. Antibiotic therapy was ineffective; the lesion healed spontaneously with a mean duration of 11 months. [ncbi.nlm.nih.gov]

• Plethora

  J Cutan Aesthet Surg 2011;4:156-7 Sir, Despite evaluation of a plethora of modalities, treatment of Granuloma Faciale (GF) remains disappointing. [jcasonline.com]

• Saddle Nose

  (Int J Dermatol 2020;59:e29) 47 year old woman with multiple facial plaques, epistaxis and saddle nose (Br J Dermatol 2018;178:e395) 54 year old man with multiple plaques and nodules on the forehead (Clin Exp Dermatol 2017;42:799) 63 year old woman with [pathologyoutlines.com]

• Umbilical Plaque

  The biopsy from the infra-umbilical plaque revealed fibrin deposition in the vessel wall [Figure 5], in addition to the above histopathological features. [ijdvl.com]

• Loss of Appetite

  Common side-effects mentioned in the summary of product characteristics (SPC) include nausea and loss of appetite. [medicaljournals.se]

• Conjunctival Hyperemia

  As a major difference, conjunctival hyperemia, blepharoconjonctivitis, or keratitis-like ocular manifestations are typical for rosacea and very rarely seen with IFAG. 1 Oral antibiotic regimens like oral clarithromycin or erythromycin fasten the healing [nature.com]

• Facial Skin Lesion

  Abstract The granuloma faciale is a rare and benign skin disease of unknown etiology, characterized by chronic leukocitoclastic vasculitis. It is characterized by skin lesions predominantly facial whose course is chronic and slowly progressive. [ncbi.nlm.nih.gov]

  It is characterized by skin lesions predominantly facial whose course is chronic and slowly progressive. The diagnosis is based on clinical features, histopathology and, more recently, in dermoscopy. [scielo.br]

• Skin Ulcer

  There was no skin ulceration. No photosensitivity, fever or joint pain was present. Past and personal history was unremarkable. Figure 1: Before treatment - single, grey-brown nodule with prominent follicular orifices over left cheek. [jcasonline.com]

• Night Sweats

  The patient was otherwise systemically well, with no fevers, night sweats, fatigue, weight loss, or symptoms of infection. [karger.com]

• Facial Edema

  It shows perivascular and perifollicular lymphocytic infiltrates with giant cells and dermal edema. [55] Facial aseptic granuloma presents as an asymptomatic erythematous nodule over the cheeks in children. [ijdpdd.com]

• Facial Burn

  A mucosal variant of the skin lesion granuloma faciale. Burns BV, Roberts PF, De Carpentier J, Zarod AP. Department of Otolaryngology, North Manchester General Hospital, Manchester. [thedoctorsdoctor.com]

Such a reaction should prompt referral to an allergist or rheumatologist for allergy and autoimmune workup. Major complications. More significant complications include migration of the filler, granuloma formation, and infection. 3 Migration. [aao.org]

• Afipia Felis

  We recorded clinical details about the nodule and its duration, ultrasound study pattern, cultures for bacteria and mycobacteria, and Bartonella henselae and Afipia felis antibody testing. [ncbi.nlm.nih.gov]

  Ultrasound studies have shown that the lesions are solid and cultures for bacteria and mycobacteria, and antibody tests for Bartonella henselae and Afipia felis are negative [ 4 ]. [escholarship.org]

• Bartonella Henselae

  Bartonella henselae titers and the Coccidioidomycosis immitis immunodiffusion test were negative; a Tuberculin Skin Test was non-reactive. [escholarship.org]

  We recorded clinical details about the nodule and its duration, ultrasound study pattern, cultures for bacteria and mycobacteria, and Bartonella henselae and Afipia felis antibody testing. [ncbi.nlm.nih.gov]

• Fibrinoid Necrosis

  Two specimens showed fibrinoid necrosis. Concentric fibrosis around small blood vessels was demonstrated in 5 patients. [ncbi.nlm.nih.gov]

  necrosis of small vessels is variable Perivascular fibrosis with clefting between collagen bundles results in storiform fibrosis Fibrosing vasculitis pattern also observed in erythema elevatum diutinum (Am J Clin Pathol 2016;145:401) Microscopic (histologic [pathologyoutlines.com]

  There was no true fibrinoid necrosis or leukocytoclasis. Small aggregates of foamy histiocytes were noted within the superficial dermis. The distribution of inflammatory changes was in keeping with GF. [karger.com]

  The type of necrosis is also used as a clue, for example, caseation necrosis in LMDF and fibrinoid necrosis in sarcoidosis, but this is a more difficult and less reproducible differentiating feature. [ijdpdd.com]

• Granulomatous Tissue

  ICD-10-CM Codes › L00-L99 Diseases of the skin and subcutaneous tissue › L80-L99 Other disorders of the skin and subcutaneous tissue › L92- Granulomatous disorders of skin and subcutaneous tissue › Granulomatous disorder of the skin and subcutaneous tissue [icd10data.com]

Treatment Options Treatment options are summarized in Table I. Table I. Treatment options for granuloma faciale. [dermatologyadvisor.com]

Treatment Options Treatment options are summarized in Table I. Table I. [psychiatryadvisor.com]

The treatments were performed with 5 mm minimally overlapping spots at 8.0 J/cm 2 for the first treatment and 8.5 J/cm 2 for the second treatment. No anesthesia was needed and there was no significant postoperative discomfort. [jamanetwork.com]

Granuloma faciale is resistant to many treatments and prone to relapse. [termedia.pl]

The patients were reviewed according to demographics, location, treatment, and prognosis. Follow-up was obtained through a questionnaire sent to each referring physician. [mdedge.com]

Granuloma faciale (GF) is an uncommon cutaneous disease of uncertain etiology that predominantly affects the face. Extrafacial lesions are rare. [mayoclinic.pure.elsevier.com]

[…] and Pathogenesis The etiology of granuloma faciale is unknown. [plasticsurgerykey.com]

Etiology and Pathophysiology Etiology and pathogenesis are not clearly defined, but several hypotheses exist. Some cases are idiopathic. [unboundmedicine.com]

Etiology is unknown. Early cases of granuloma faciale were reported as “eosinophilic granuloma” of the skin. [accessmedicine.mhmedical.com]

Epidemiology Primarily a disease of middle-aged white men with rare reports of GF in Japanese, blacks, and children Incidence/Prevalence Rare; precise incidence and prevalence are unknown. [unboundmedicine.com]

OBJECTIVES: To improve our epidemiological, clinical and pathological knowledge on IFAG, to search for an infectious aetiology, and to assess therapeutic recommendations. [ncbi.nlm.nih.gov]

Epidemiology Early cases of granuloma faciale were reported as “eosinophilic granuloma” of the skin. [plasticsurgerykey.com]

Etiology and Pathophysiology Etiology and pathogenesis are not clearly defined, but several hypotheses exist. Some cases are idiopathic. [unboundmedicine.com]

Regarding the pathophysiology, our study rules out a primary infectious disease, and allows considering IFAG either as a granulomatous process appearing around an embryological residue or as a manifestation to include in the spectrum of granulomatous [ncbi.nlm.nih.gov]

Case Overview granuloma faciale Member Rated 0 Patient case no. 1546 Date added 16 April 2003 Patient details Age --Undetermined-- Localisation Head / face / cheek Primary Lesions Plaque / erythematous Pathophysiology reactive conditions / eosinophilic [dermquest.com]

[…] vasculitis: leukocytoclasia with perivascular and often storiform fibrosis ICD coding ICD-10: L92.2 - Granuloma faciale (eosinophilic granuloma of skin) Sites Face - forehead, cheeks and nose - most common Extrafacial - trunk or extremities - not uncommon Pathophysiology [pathologyoutlines.com]

We take the utmost care to prevent poor voice outcomes. [voicedoctorla.com]

Counselling the patient and adopting preventative measures such appropriate filler choice and prevention of infection should be part of every case of dermal filler injections. [aestheticsjournal.com]

How can Granuloma Faciale be Prevented? Currently, there are no known methods to prevent Granuloma Faciale occurrence. However, some of the risk factors may be recognized and controlled. [dovemed.com]

There is no known preventive for granuloma inguinale, although it is rare where sanitary living conditions prevail. The drainage from lesions may be infectious and handwashing and basic cleanliness are required. [medical-dictionary.thefreedictionary.com]