Case presentation A 3-year-old boy presented for evaluation of multiple facial nodules that had been present for six months. After their initial appearance, the lesions sporadically fluctuated in size but never resolved completely. [escholarship.org]

Lesions may be present for weeks or months and tend to follow a chronic course. [accessmedicine.mhmedical.com]

[…] with a history of a red-brown well-circumscribed lesion present on the face for a long duration. [dermatologyadvisor.com]

• Cat Scratch

  Cultures for mycobacteria and cat scratch disease serologies were negative. Antibiotic therapy was ineffective; the lesion healed spontaneously with a mean duration of 11 months. [ncbi.nlm.nih.gov]

• Plethora

  J Cutan Aesthet Surg 2011;4:156-7 Sir, Despite evaluation of a plethora of modalities, treatment of Granuloma Faciale (GF) remains disappointing. [jcasonline.com]

• Loss of Appetite

  Common side-effects mentioned in the summary of product characteristics (SPC) include nausea and loss of appetite. [medicaljournals.se]

• Facial Skin Lesion

  skin lesions whose course is chronic and slowly progressive. 3 Diagnosis is based on clinical features, histopathology and, more recently, dermatoscopy. 1 Multiple modalities of medical and surgical treatment have been suggested, but none has proved [ncbi.nlm.nih.gov]

• Skin Ulcer

  There was no skin ulceration. No photosensitivity, fever or joint pain was present. Past and personal history was unremarkable. Figure 1: Before treatment - single, grey-brown nodule with prominent follicular orifices over left cheek. [jcasonline.com]

• Night Sweats

  The patient was otherwise systemically well, with no fevers, night sweats, fatigue, weight loss, or symptoms of infection. [karger.com]

• Facial Edema

  Among these, there were 68% (27/40) cases of orofacial granulomatosis and 43% (3/7) cases of solid facial edema. [53] In an unpublished study conducted in our department, 10 (52.6%) of 19 cases of clinically diagnosed granulomatous cheilitis showed granulomas [ijdpdd.com]

• Facial Burn

  A mucosal variant of the skin lesion granuloma faciale. Burns BV, Roberts PF, De Carpentier J, Zarod AP. Department of Otolaryngology, North Manchester General Hospital, Manchester. [thedoctorsdoctor.com]

Such a reaction should prompt referral to an allergist or rheumatologist for allergy and autoimmune workup. Major complications. More significant complications include migration of the filler, granuloma formation, and infection. 3 Migration. [aao.org]

• Afipia Felis

  We recorded clinical details about the nodule and its duration, ultrasound study pattern, cultures for bacteria and mycobacteria, and Bartonella henselae and Afipia felis antibody testing. [ncbi.nlm.nih.gov]

  Ultrasound studies have shown that the lesions are solid and cultures for bacteria and mycobacteria, and antibody tests for Bartonella henselae and Afipia felis are negative [ 4 ]. [escholarship.org]

• Bartonella Henselae

  Bartonella henselae titers and the Coccidioidomycosis immitis immunodiffusion test were negative; a Tuberculin Skin Test was non-reactive. [escholarship.org]

  We recorded clinical details about the nodule and its duration, ultrasound study pattern, cultures for bacteria and mycobacteria, and Bartonella henselae and Afipia felis antibody testing. [ncbi.nlm.nih.gov]

• Granulomatous Tissue

  tissue L92.9 (abnormal) (excessive) ICD-10-CM Codes Adjacent To L92.9 L91 Hypertrophic disorders of skin L91.0 Hypertrophic scar L91.8 Other hypertrophic disorders of the skin L91.9 Hypertrophic disorder of the skin, unspecified L92 Granulomatous disorders [icd10data.com]

Treatment Options Treatment options are summarized in Table I. Table I. Treatment options for granuloma faciale. [dermatologyadvisor.com]

Treatment Options Treatment options are summarized in Table I. Table I. [psychiatryadvisor.com]

The treatments were performed with 5 mm minimally overlapping spots at 8.0 J/cm 2 for the first treatment and 8.5 J/cm 2 for the second treatment. No anesthesia was needed and there was no significant postoperative discomfort. [jamanetwork.com]

This case supports previous reports of successful treatment of GF with topical tacrolimus. Keywords: Granuloma faciale, tacrolimus, treatment How to cite this article: Gupta L, Naik H, Kumar NM, Kar HK. [jcasonline.com]

The patients were reviewed according to demographics, location, treatment, and prognosis. Follow-up was obtained through a questionnaire sent to each referring physician. [mdedge.com]

Granuloma faciale (GF) is an uncommon cutaneous disease of uncertain etiology that predominantly affects the face. Extrafacial lesions are rare. [mayoclinic.pure.elsevier.com]

Etiology and Pathophysiology Etiology and pathogenesis are not clearly defined, but several hypotheses exist. Some cases are idiopathic. [unboundmedicine.com]

[…] and Pathogenesis The etiology of granuloma faciale is unknown. [plasticsurgerykey.com]

Etiology is unknown. Early cases of granuloma faciale were reported as “eosinophilic granuloma” of the skin. [accessmedicine.mhmedical.com]

Epidemiology Primarily a disease of middle-aged white men with rare reports of GF in Japanese, blacks, and children Incidence/Prevalence Rare; precise incidence and prevalence are unknown. [unboundmedicine.com]

OBJECTIVES: To improve our epidemiological, clinical and pathological knowledge on IFAG, to search for an infectious aetiology, and to assess therapeutic recommendations. [ncbi.nlm.nih.gov]

Epidemiology Early cases of granuloma faciale were reported as “eosinophilic granuloma” of the skin. [plasticsurgerykey.com]

Case Overview granuloma faciale Member Rated 0 Patient case no. 1546 Date added 16 April 2003 Patient details Age --Undetermined-- Localisation Head / face / cheek Primary Lesions Plaque / erythematous Pathophysiology reactive conditions / eosinophilic [dermquest.com]

Etiology and Pathophysiology Etiology and pathogenesis are not clearly defined, but several hypotheses exist. Some cases are idiopathic. [unboundmedicine.com]

Regarding the pathophysiology, our study rules out a primary infectious disease, and allows considering IFAG either as a granulomatous process appearing around an embryological residue or as a manifestation to include in the spectrum of granulomatous [ncbi.nlm.nih.gov]

Pathophysiology The skin is the primary organ system that is affected. [emedicine.medscape.com]

How can Granuloma Faciale be Prevented? Currently, there are no known methods to prevent Granuloma Faciale occurrence. However, some of the risk factors may be recognized and controlled. [dovemed.com]

The characteristic appearance and location of the lesions in the absence of adenopathy and constitutional symptoms should make the clinical diagnosis straightforward and prevent unnecessary interventions. [escholarship.org]

We take the utmost care to prevent poor voice outcomes. [voicedoctorla.com]

Counselling the patient and adopting preventative measures such appropriate filler choice and prevention of infection should be part of every case of dermal filler injections. [aestheticsjournal.com]