It seems likely that the interaction of hemophilic joint damage and age-related arthropathy contributes to a combined effect in the adult patients previously reported. 14, 20 The present survey is limited mainly by the small numbers of patients presenting [haematologica.org]

It simply means that this specific mutation has not been found, although other mutations may be present. [clevelandheartlab.com]

The MTHFR A1298C variant is also associated with increased homocysteine and lowered plasma folate levels when present in combination with the C677T mutation. This test detects the above described mutations in Factor II gene. [ayassbioscience.com]

Footnotes ↵ 1 present address: Max McGee National Research Center for Juvenile Diabetes, Milwaukee, WI 53226 ↵ 2 present address: GeneInsight LLC, Madison, WI 53711 ↵ 3 present address: Waisman Center, University of Wisconsin-Madison, Madison, WI 53792 [clinchem.aaccjnls.org]

Poster presented at ISBT, Dubai, UAE, 2016 September. [molecular.roche.com]

• Chest Discomfort

  The American Heart Association published this list of warning signs: Chest discomfort. Most heart attacks involve discomfort in the center of the chest that lasts more than a few minutes, or that goes away and comes back. [hubpages.com]

• Exertional Chest Pain

  Sudden unexplained shortness of breath, which may worsen with exertion, chest pain (which often gets worse on taking deep breaths), and coughing (sometimes with blood) are suggestive of PE. [circ.ahajournals.org]

• Sweating

  Other signs may include breaking out in a cold sweat, nausea or lightheadedness For more information and some great references on this top, please read the article published by the American Heart Association. [hubpages.com]

Laboratory studies for factor II deficiency include coagulation studies and clotting factor assays (see Workup ). [emedicine.medscape.com]

[…] centres in Germany have been treated by the same medical teams using the same treatment protocols. [haematologica.org]

Also, non-hormonal treatments without thrombotic risk are available to lessen postmenopausal symptoms or to treat osteoporosis. [circ.ahajournals.org]

Appropriate diagnosis is critical in the process, to identify those individuals who require specific treatment. [newyorkfertilityservices.com]

Transforming testing & treatment together Giving you confidence in the performance of our systems and assays in your laboratory Our commitment to quality As pioneers of polymerase chain reaction (PCR) technology, we continue to demonstrate our commitment [molecular.roche.com]

Is there any treatment for Prothrombin Gene Mutation? No treatment to change genes is currently available. [melbournehaematology.com.au]

Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med 2016 ; 374 : 2209-21. （3iiiD） 8）Döhner H, et al. Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel. [jshem.or.jp]

[…] is characterized by reduced activity and normal antigen levels Epidemiology Rare; fewer than 100 cases have been reported Prevalence rate of approximately 1:2,000,000 in the general population Sites Mucocutaneous and soft tissue bleeding (see below) Etiology [pathologyoutlines.com]

Identification of inherited thrombophilias has increased our understanding of one potential etiology for venous thromboembolism (VTE) and of hypercoagulability in general. [womenshealthsection.com]

All studies conform to the multifactorial etiology of the disease. The risk of the thromboembolic disease increases in proportion to the number of risk factors [ 9 ]. [omicsonline.org]

[…] aspartic acid to glutamine substitution at position 552. [31] Two novel mutations in the prothrombin gene were delineated in association with compound heterozygous type 1/2 prothrombin deficiency. [32] Acquired factor II deficiency has several possible etiologies [emedicine.medscape.com]

Jadaon MM (2011) Epidemiology of Prothrombin G20210A Mutation in the Mediterranean Region. Mediterr J Hematol Infect Dis 3: e2011054. [omicsonline.org]

Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 3 :292–299. 15. Bernstein, CN, Blanchard, JF, Rawsthorne, P, et al. [nature.com]

[…] of prothrombin and is characterized by reduced prothrombin activity and antigen levels Dysprothrombinemia (type II deficiency) is the synthesis of dysfunctional prothrombin molecules and is characterized by reduced activity and normal antigen levels Epidemiology [pathologyoutlines.com]

"Epidemiology of factor V Leiden: clinical implications". Seminars in Thrombosis and Hemostasis. 24 (4): 367–79. doi : 10.1055/s-2007-996025. PMID 9763354. ^ Bertina RM, Koeleman BP, Koster T, et al. (May 1994). [en.wikipedia.org]

De Stefano V, Chiusolo P, Paciaroni K, Leone G: Epidemiology of factor V Leiden: Clinical implications. Semin Thromb Hemost 1998;24:367–379. [karger.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Venous thromboembolism (VTE) is a syndrome of deep vein thrombosis and its complication, pulmonary embolism. [mayomedicallaboratories.com]

"Thrombotic risk factors: basic pathophysiology". Crit Care Med. 38 (2 Suppl): S3–9. doi : 10.1097/CCM.0b013e3181c9cbd9. PMID 20083911. ^ a b c Poort SR, Rosendaal FR, Reitsma PH, Bertina RM (1996). [en.wikipedia.org]

Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment. Haemophilia. 2008 Nov. 14 (6):1159-63. [Medline]. Klincheva M, Vilarova EA, Angjusheva T, Milev I, Idoski E, Mitrev Z. [emedicine.medscape.com]

The pathophysiology is uncertain but is thought to involve thrombosis in the uteroplacental circulation, leading to infarction and placental insufficiency. [womenshealthsection.com]

This study is… Follow us on Twitter In the News: According to doctors, patients with atrial fibrillation, a common heart rhythm disorder, should take newer blood thinners to prevent stroke instead of warfarin: https://t.co/2vuN7cae8J Load More... [stoptheclot.org]

It can be caused by something preventing blood from circulating or clotting normally. [dailystrength.org]

ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March. [clotcare.com]

A vitamin K deficiency caused by antibiotics and intestinal disorders (that prevent absorption), can cause a temporary FII deficiency. Newborns may be born with a vitamin K deficiency. [hemophilia.ca]

After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Prothrombin is made chiefly by cells in the liver. [ghr.nlm.nih.gov]