Factor VIII Antibody Staining Protocol for Immunohistochemistry Description: Factor VIII is a glycoprotein present in human plasma. Factor VIII related antigen has been reported present in human endothelial cells. [ihcworld.com]

We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. [ncbi.nlm.nih.gov]

Whereas ELISAs are suitable for large-scale rapid screening to detect possible FVIII inhibitors, they cannot quantify an inhibitor, if present. [academic.oup.com]

Written for a multidisciplinary audience, this revision presents current data on antithrombotic therapy including warfarins and heparin, delivers practical techniques for diagnosing and treating bleeding and clotting disorders, and includes all topics [books.google.com]

After 1 hr incubation in the presence of the A2 domain epitope-targeting MAb, 1D4, the residual fVIII activity was 3% and the ETP was similar whether or not fVIII or rfVIIa alone were present but was higher when both were present (83% of fVIII control [journals.plos.org]

• Polyradiculoneuropathy

  Abstract A 66-year-old man with a 45-month course of chronic inflammatory polyradiculoneuropathy developed a coagulopathy due to an antibody to factor VIII. [ncbi.nlm.nih.gov]

  Ayyar, Joseph Melo, Kurt Kloss First published September 1, 1983, DOI: https://doi.org/10.1212/WNL.33.9.1224 Abstract A 66-year-old man with a 45-month course of chronic inflammatory polyradiculoneuropathy developed a coagulopathy due to an antibody to [neurology.org]

• Hepatocellular Carcinoma

  Inhibitory Effect Of Antisense Vascular Endothelial Growth Factor Rna On The Profile Of Hepatocellular Carcinoma Cell Line In Vitro And In Vivo. Wu Y, Chen W, Guo M, He Q, Hu Y. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4827-36. Ecollection 2014. [bosterbio.com]

[…] irreversible hemoarthropathy. 3,4 Standard treatment for hemophilia A includes regular prophylaxis and episodic treatment with recombinant or plasma-derived factor VIII. [nejm.org]

The key findings are as follows: 1) Sub-optimal compliance with targeted inhibitor screening following FVIII treatment was seen in non-severe HA in London haemophilia centres. 2) A national survey of AHA demonstrated heterogeneity in the management of [qmro.qmul.ac.uk]

Those studies are expected to have a significant impact on the optimization of treatments for patients with inhibitor as well as for patients with thrombophilia. [ncbi.nlm.nih.gov]

Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. N Engl J Med. 1993 ; 328 : 453 – 459. 19.. [academic.oup.com]

New assays for monitoring haemophilia treatment. Haemophilia 14 (suppl. 3), 83–92 (2008). 30. Shetty, S., Bhave, M. & Ghosh, K. Acquired hemophilia A: diagnosis, aetiology, clinical spectrum and treatment options. Autoimmun. [nature.com]

Although most inhibitors reported in the literature were at high titers (mean: 67.7 Bethesda Units/ml), their prognosis was good, as they disappeared in most cases after suspension of the involved drug or after immunosuppressive therapy (complete remission [ncbi.nlm.nih.gov]

Anti-factor VIII IgA as a potential marker of poor prognosis in acquired hemophilia A: results from the GTH-AH 01/2010 Study. Blood. 2016 Feb 24. [Medline]. [emedicine.medscape.com]

Bleeding Assessment Tools: Limits and Advantages for the Diagnosis and Prognosis of Inherited Bleeding Disorders. Semin Thromb Hemost. 2016 Jul. 42 (5):463-70. Gill JC, Castaman G, Windyga J, Kouides P, Ragni M, Leebeek FW, et al. [labtestsonline.it]

Therefore, in addition to playing a role in cancer metastasis and prognosis, [49] they might enforce communication between cancer cells and platelets. [journals.lww.com]

This practical text covers disorders of thrombosis and hemostasis in a logical and sequential manner: etiology, pathophysiology, clinical and laboratory diagnosis, and management. [books.google.com]

An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant. Case Rep Hematol. 2013. 2013:521785. [Medline]. Collins PW. [emedicine.medscape.com]

However, further studies are needed to better elucidate the epidemiology, natural history, clinical relevance, and optimal treatment of drug-associated factor VIII autoantibodies. [ncbi.nlm.nih.gov]

Factor VIII inhibitors in patients with haemophilia A: epidemiology of inhibitor development and induction of immune tolerance for factor VIII. Semin Thromb Haemost 1995; 21: 382–9. 5 Scharrer I, Neutzling O. [miamibeachcondo.us]

Epidemiology United States statistics The incidence of acquired hemophilia A has been estimated to be 0.2-1.0 case per 1 million persons per year, but this figure may underestimate the true incidence of the disorder, given the difficulty in making the [emedicine.medscape.com]

Epidemiology of cancer-associated venous thrombosis. Blood 2013; 122:1712–1723. 4. Khorana AA, Francis CW, Culakova E, et al. Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. [journals.lww.com]

This practical text covers disorders of thrombosis and hemostasis in a logical and sequential manner: etiology, pathophysiology, clinical and laboratory diagnosis, and management. [books.google.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Factor VIII inhibitors are IgG antibodies directed against coagulation FVIII that typically result in development of potentially [mayomedicallaboratories.com]

A proper knowledge of its pathophysiology and of the predisposing risk factors may allow to implement strategies of prevention. [journals.lww.com]

Acquired factor VIII inhibitors: pathophysiology and treatment. Hematology Am Soc Hematol Educ Program. 2006. 432-7. [Medline]. Franchini M. Acquired hemophilia A. Hematology. 2006 Apr. 11(2):119-25. [Medline]. Green D, Blanc J, Foiles N. [emedicine.medscape.com]

Abstract Recombinant activated factor VII (rFVIIa) was used before and after inguinal hernioplasty to prevent bleeding in a patient with hemophilia A complicated by a high-potency antifactor VIII inhibitor. rFVIIa (75 micrograms/kg) was given before and [ncbi.nlm.nih.gov]

Hillyer has been awarded many million dollars in research funding from the National Institutes of Health, the Centers for Disease Control and Prevention and other agencies. [books.google.com]

A recent survey explored the spectrum of practice for VTE prevention in patients with acute leukemia. [journals.lww.com]

Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med 2007 ;357: 535 - 544 7. Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. Guidelines for the management of hemophilia. [nejm.org]