After 72 hours, she developed persistent non-bilious vomiting and presented to a district general hospital. [journals.lww.com]

It is characterized by the features of acute encephalopathy such as seizure, alteration of consciousness, and symmetric involvement of the bilateral thalamus on neuroimaging tests. [semanticscholar.org]

The disease progresses rapidly with symptoms that include cough, vomiting and diarrhea in combination with neurologic dysfunction, alteration of consciousness and seizures. [news-medical.net]

Her mother had been noted to have post-viral encephalitis and polyneuritis at the age of 19 with a residual foot-drop and was also found to be heterozygous for the same mutation. [journals.lww.com]