Geschwind, Genetic prion disease: Experience of a rapidly progressive dementia center in the United States and a review of the literature, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2017, 174, 1, 36 Wiley Online Library 2 [onlinelibrary.wiley.com]

Progressive Dementia Progressive dementias become worse over time and patients eventually lose more of their abilities. Alzheimer's disease, Lewy body dementia, vascular dementia, and frontotemporal dementia are types of progressive dementia. [onhealth.com]

As the disease progresses, victims become unable to stand or eat, and eventually die between 6-12 months after the symptoms first appear. [theguardian.com]

pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0040264 11 behavioral abnormality 59 Very frequent (99-80%) 12 cognitive impairment 59 Very frequent (99-80%) Search GEO for disease gene expression data for Familial Alzheimer-Like Prion Disease. [malacards.org]

In people with the rarer vCJD, psychiatric symptoms may be more prominent in the beginning, with dementia — the loss of the ability to think, reason and remember — developing later in the illness. [mayoclinic.org]

impairment 59 Very frequent (99-80%) Search GEO for disease gene expression data for Familial Alzheimer-Like Prion Disease. [malacards.org]

As it is these lesions or abnormalities that are thought to cause the damage to brain cells and hence the cognitive impairment of dementia, their absence is important and reassuring.” [pbs.org]

2010 ) or mild cognitive impairment ( van Rossum et al., 2012 ; Blom et al., 2009 ). [alzforum.org]

These factors include: Age Genetics Smoking and alcohol use Atherosclerosis (hardening of arteries) High cholesterol Plasma homocysteine Diabetes Mild cognitive impairment Down syndrome Dementia Tests for Diagnosis Most often, dementia is diagnosed by [onhealth.com]

Hoozemans, Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology, Acta Neuropathologica Communications, 2016, 4, 1 CrossRef 6 Valerija Kovač, Iva Hafner-Bratkovič, Vladka Čurin Šerbec [onlinelibrary.wiley.com]