Acknowledgments We are grateful to Ari Frilander, BSc, Tuija Järvinen and Ilse Pyy, laboratory technicians, for skilled technical assistance. We thank Dr. Blas Frangione for the amyloid A and variant cystatin C antibodies, and Dr. [academic.oup.com]

Muscular weakness, dysphagia, and macroglossia are observed in some older AGel amyloidosis patients ( 2 ) and may reflect amyloid myopathy ( 33, 34 ). [academic.oup.com]

Muscular weakness, dysphagia, and macroglossia are observed in some older AGel amyloidosis patients ( 2 ) and may reflect amyloid myopathy ( 33, 34 ). [academic.oup.com]

A 58-yr-old man presented with involuntary facial twitching, progressive bilateral facial weakness, and tongue atrophy. His mother, maternal uncle, two sisters, and son suffered from the same symptoms. [ncbi.nlm.nih.gov]

67 An Elderly Woman with a Progressive Neuropathy 429 Case 68 A Young Woman with Difficulty Swallowing 433 Case 69 A Young Woman with Intermittent Weakness and a Positive Family History of Similar Problems 436 Case 70 A Woman with Muscle Weakness and Areflexia [books.google.com]

Aged patients may show severe bulbar signs, profound loss of vibratory sensitivity with areflexia, unsteady gait, and manual clumsiness ( 4 ). Autonomic dysfunction is mild ( 6 ). [academic.oup.com]

Kidney failure often dominates the clinical picture and a kidney transplant may effectively restore normal health for a long time. [ucl.ac.uk]

In some cases, the amyloid deposits will cause the kidneys to lose the ability to purify the blood, which can lead to kidney failure; also known as “renal” failure. These patients may need dialysis to replace the function of the kidneys. [amyloidosis.org]