We present a rare case of autosomal dominant benign familial myxoma occurring in three generations of the family operated successfully at our institute. [link.springer.com]

ATRIAL MYXOMA PRESENTING AS STROKE. [journalijar.com]

Abstract Familial atrial myxomas may present as a component of the Carney complex, an autosomal dominant multiple neoplasia and lentiginosis syndrome. [ncbi.nlm.nih.gov]

Atrial myxomas presented at earlier age successively and in more aggressive form in these three generations. [medworm.com]

• Fatigue

  The tumor is characterized by palpitations, disseminated neuritis, nausea, weight loss, fatigue, dyspnea, fever, and occasional sudden loss of consciousness. It is treated by surgical removal of the tumor. [medical-dictionary.thefreedictionary.com]

  Clinical presentation depends on the size, mobility and location of tumor, ranging from nonspecific and/or constitutional symptoms to sudden cardiac death, and includes dyspnea, hemoptisis, syncope, fatigue, fever, cutaneous rash, increases in venous [orpha.net]

  Constitutional disturbances, such as fatigue, fever, erythematous rash, arthralgia, myalgia, and weight loss, and laboratory abnormalities, such as anemia and elevations in the erythrocyte sedimentation rate and the serum C-reactive protein and globulin [histopathology-india.net]

  Symptoms of right-sided heart failure Patients experience fatigue and peripheral edema. Abdominal distension due to ascites is rare; however, it is more common in slowly growing right-sided tumors. [odlarmed.com]

   The classic clinical presentation of a myxoma is intracardiac obstruction with congestive heart failure (67%);  Signs of embolization (29%); systemic or constitutional symptoms of fever (19%); weight loss or fatigue (17%);  Immunologic manifestations [slideshare.net]

• Arthralgia

  Prognosis Excellent after excision. atrial myxoma Cardiology The most common 1º cardiac neoplasm, age of onset 25-55 Clinical Symptoms may be obstructive–right-sided congestion—most are right-sided, ± ascites, constitutional–fever, fatigue, arthralgias [medical-dictionary.thefreedictionary.com]

  Other less frequent complaints include Raynaud’s phenomenon, arthralgias, myalgias, erythematous rash, clubbing of the digits. 18.  Possible etiologies of such varied complaints and symptoms include - tumor embolization with secondary myalgias arthralgias [slideshare.net]

  Fever, weight loss, arthralgia, myalgia, Raynaud phenomenon, rash, and clubbing may occur. Cardiac findings include new-onset congestive heart failure, chest pain, and dyspnea that improves when supine. [rheumaknowledgy.com]

  In this report, our patient denied fever, arthralgias, and anemia but complained of weight loss (2 kg in two months) as the only constitutional sign. [jmedicalcasereports.biomedcentral.com]

  Constitutional disturbances, such as fatigue, fever, erythematous rash, arthralgia, myalgia, and weight loss, and laboratory abnormalities, such as anemia and elevations in the erythrocyte sedimentation rate and the serum C-reactive protein and globulin [histopathology-india.net]

• Flaccid Paralysis

  Our patient is a 27-year-old man with X-linked agammaglobulinemia (XLA) first diagnosed when he presented at 11 months of age in the summer of 1989 with acute-onset bilateral flaccid paralysis and sensory loss in his lower extremities subsequent to varicella [medworm.com]

Much has changed in recent years when it comes to TIA risk stratification, workup and antiplatelet therapy. [capriles-urgencias.com]

[…] regurgitaiton • Tricuspid stenosis • Tricuspid regurgitation • Pulmonary hypertension • Endocarditis • Vasculitis • Left atrial thrombus • Pulmonary embolism • Cerebrovascular accidents • Collagen-vascular disease • Carcinoid heart disease • Ebstein’s anomaly WORKUP [encyclopedia.lubopitko-bg.com]

Lab workup showed deranged PT/INR and severe factor 7 deficiencies. [apicareonline.com]

This era was followed by improved environmental factors which operate to produce methods of medical treatment, introduction congenital cardiac malformations. [books.google.com]

Treatment for familial atrial myxoma depends on many factors such as how large the tumor is and its location in the body. [diseaseinfosearch.org]

According to new datasets, smaller tracts can be equally effective in the treatment and might offer the possibility to reduce bleeding, length of hospital stay, postoperative pain as well as overall ... [medworm.com]

A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. [leehealth.org]

Treatment Treatments Although atrial myxomas are not cancerous, complications are common. If untreated, it can lead to an embolism (tumor cells breaking off and traveling with the bloodstream). [nhcs.com.sg]

Prognosis Excellent after excision. atrial myxoma Cardiology The most common 1º cardiac neoplasm, age of onset 25-55 Clinical Symptoms may be obstructive–right-sided congestion—most are right-sided, ± ascites, constitutional–fever, fatigue, arthralgias [medical-dictionary.thefreedictionary.com]

Prognosis of Atrial Myxoma Although atrial myxomas have the potential to embolise and to grow elsewhere, they are not believed to be able to spread to other sites. [myvmc.com]

His daughters were at his bedside and his prognosis was bleak. A massive stroke on Monday left Nixon paralyzed on the right side, unable to speak and partially blind. [latimes.com]

Prognosis [ edit ] An embolized fragment of an atrial myxoma in the iliac bifurcation. Although a myxoma is not cancer, complications are common. [en.wikipedia.org]

A 30-year-single-center experience in atrial myxomas: from presentation to treatment and prognosis. Thorac Cardiovasc Surg. 2013 Sep;61(6):530-6. 2. Amano J. Cardiac Myxoma: Its Origin and Tumor Characteristics. [degruyter.com]

Their etiology is not precisely century with the first clinical recognition of known, so we have included chapters that dis symptoms and patterns for diagnosis of car cuss many aspects of congenital cardiac mal diovascular diseases. [books.google.com]

Etiology Sporadic – 90%. Familial – 10%. May form part of Carney's complex (Carney's, LAMB, NAME syndrome) or non-syndromic familial cardiac myxomas 10,11. Pathophysiology Originate from the endocardium. [pie.med.utoronto.ca]

Raynaud phenomenon ETIOLOGY • Most cases (90%) of atrial myxomas are sporadic with no known cause. In the remaining 10% of cases a familial pattern occurs having an autosomal dominant transmission. [encyclopedia.lubopitko-bg.com]

Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. [emedicine.medscape.com]

Causes Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. Familial atrial myxomas have an autosomal dominant transmission. Carney syndrome is genetically heterogenous and is caused by a defect in more than one gene. [odlarmed.com]

Myxomas have been demonstrated to produce numerous growth factors and cytokines, including vascular endothelial growth factor, resulting in angiogenesis and tumor growth and an increased expression of the inflammatory cytokine, interleukin-6. [6, 7, 8] Epidemiology [thehealthscience.com]

EPIDEMIOLOGY & DEMOGRAPHICS • Atrial myxomas account for 50% of all primary tumors of the heart. • Approximately 75% of myxomas arise from the left atrium in close relationship to the fossa ovalis. [encyclopedia.lubopitko-bg.com]

Epidemiology Cardiac myxomas can occur across all age groups, however, they occur with the greatest frequency amongst between the third and sixth decades of life. [atlasgeneticsoncology.org]

[…] mutation was found in exon 2 in the causative gene of Carney complex, protein kinase A regulatory subunit 1 alpha ( PRKAR1A ). [10] At present, there does not appear to be an association between cardiac myxomas and herpes simplex types 1 and 2. [11] Epidemiology [emedicine.medscape.com]

Pathophysiology Myxomas account for 40-50% of primary cardiac tumors. Approximately 90% are solitary and pedunculated, and 75-85% occur in the left atrial cavity. Up to 25% of cases are found in the right atrium. Most cases are sporadic. [thehealthscience.com]

Pathophysiology Originate from the endocardium. Composed of embryonic multipotential mesenchymal cells that persist during cardiac septation which can differentiate into angioblasts, fibroblasts, cartilage and myoblasts. [pie.med.utoronto.ca]

Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) revels novel mutations and clues for pathophysiology [revespcardiol.org]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]

This may require emergency surgery to prevent sudden death. The tumor must be surgically removed and some patients may need their mitral valve replaced as well. [nhcs.com.sg]

This may require emergency surgery to prevent sudden death. Cardiac tumor - myxoma; Heart tumor - myxoma Lenihan DJ, Yusuf SW, Shah A. Tumors affecting the cardiovascular system. [medlineplus.gov]