Symptoma

Familial Calcium Pyrophosphate Deposition

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease

A discussion of ANKH as the familial calcium pyrophosphate dihydrate deposition disease gene is presented. [ncbi.nlm.nih.gov]

Robert Terkeltaub, presents the state-of-the-art, clinically-focused coverage you need to manage these increasingly prevalent diseases. [books.google.com]

[…] as an acute polyarthritis. ( 12068153 ) Song JS...Park W 2002 47 Tumoural calcium pyrophosphate dihydrate crystal deposition disease presenting clinically as a malignant soft tissue mass diagnosed on fine needle aspiration biopsy. ( 12190291 ) Biankin [malacards.org]

A 58-year-old man presented to our outpatient clinic with acute right knee synovitis and an 11-month history of recurrent monoarthritis of both knees. The attacks were self-limiting and resolved in less than a week. [jrheum.org]

  • Tall Stature

    Bleasel JF, Bisagni-Faure A, Holderbaum D: Type procollagen gene (COL2A1 mutation in exon II associated with spon-dyloepiphyseal dysplasia, tall stature and osteoarthritis. J Rheumatol 1995, 22 :255–261. PubMed Google Scholar 46. [link.springer.com]

  • Soft Tissue Mass

    tissue mass diagnosed on fine needle aspiration biopsy. ( 12190291 ) Biankin S...Mawad S 2002 48 A very rare benign tumour in the parotid region: calcium pyrophosphate dihydrate crystal deposition disease. ( 11429081 ) Olin HB...Poulsen FW 2001 49 Tumoral [malacards.org]

  • Skin Rash

    Other adverse effects of colchicine include abdominal cramps, bone marrow suppression, axon-loss neuropathy, myopathy (especially in renal insufficiency), potential liver toxicity, arrhythmia, shock, and skin rash (uncommon). [clevelandclinicmeded.com]

  • Short Arm

    The CCAL2 locus has been mapped to the short arm of chromosome 5 and identified in families from the Alsace region of France and the United Kingdom. [ncbi.nlm.nih.gov]

    This paper documents CPPDD in an Argentinean kindred and French kindred presenting with a similar phenotype with linkage to the short arm of chromosome 5 markers. PubMed CrossRef Google Scholar 48. [link.springer.com]

    A study carried out in Europe in 1995 linked a familial form of the condition to chromosome 5p, 5 and further work carried out linked it more closely to 5p15, the short arm of chromosome 5. 6, 7 Another team has linked it to chromosome 8p as part of a [nature.com]

  • Brachydactyly

    : Familial spondy-loepiphyseal dysplasia tarda, brachydactyly, and precocious osteoarthritis associated with an arginine 75 cysteine muta-tion in the procollagen type II gene in a kindred of Chiloe Islanders: clinical, radiographic and pathologic findings [link.springer.com]

  • Neuropathic Arthropathy

    Neuropathic arthropathy (Charcot joint) is commonly associated with diabetes mellitus, tabes dorsalis, syringomyelia, and spinal cord injuries. True neuropathic arthropathy has impaired pain sensation including vibration and proprioception. [omagdigital.com]

    Severe joint degeneration : Neuropathic arthropathy is characterized by severe joint degeneration and disruption occurring in the course of neurologic disorders leading to joint denervation; the affected joint is often called a Charcot joint. [wikidoc.org]

  • Monoarthritis of the Knee

    A 58-year-old man presented to our outpatient clinic with acute right knee synovitis and an 11-month history of recurrent monoarthritis of both knees. The attacks were self-limiting and resolved in less than a week. [jrheum.org]

  • Long Arm

    The CCAL1 locus is located on the long arm of chromosome 8 and is associated with CPPD and severe osteoarthritis. [ncbi.nlm.nih.gov]

  • Myelopathy

    […] soft tissues (tophaceous pseudogout) May radiographically look like chondrosarcoma May be associated with cortical erosions (insertion of pectoralis major and gluteus maximus muscles) Intrathoracic sternoclavicular tophus has been reported Cervical myelopathy [orthopaedicsone.com]

    Fidler WK, Dewar CL, Fenton PV: Cervical Spine Pseudogout with Myelopathy and Charcot Joints. J Rheumatol 1996, 23 :1445–1448. PubMed Google Scholar 71. Rivera-Sanfeliz G, Wong W, Resnick D, et al. : Tophaceous Pseudogout. [link.springer.com]

    Septic arthritis typically involves a large joint such as the knee, 3 but can affect several joints and is accompanied by malaise, weight loss, fever, and swollen and/or warm joints. 3 Other conditions include neuropathies, radiculopathies, or myelopathies [aafp.org]

    […] patients with suspected CPPD. 14 Therefore, plain X-ray film has shown greater sensitivity than MRI in the diagnosis of CPP arthropathy of the knee. 24 CPP crystals may be deposited in both ligamentum flavum and posterior longitudinal ligament, leading to myelopathy [dovepress.com]

  • Radiculomyelopathy

    Williams C.J....Ryan L.M. 2003 39 The utility of alizarin red s staining in calcium pyrophosphate dihydrate crystal deposition disease. ( 12734902 ) Yamakawa K...Kikuchi M 2003 40 Calcium pyrophosphate dihydrate crystal deposition disease in cervical radiculomyelopathy [malacards.org]

Gout and Pseudogout Workup. Available online at . Accessed 6/20/2017. National Institute of Arthritis and Musculoskeletal and Skin Disease. 2016. Questions and Answers about Gout. Available online at . Accessed 6/20/2017. [labtestsonline.it]

(See Etiology, Presentation, and Workup .) Calcium pyrophosphate deposition disease. Radiograph of the knee showing chondrocalcinosis involving the meniscal cartilage, as well as evidence of osteoarthritis. Calcium pyrophosphate deposition disease. [emedicine.medscape.com]

Gout or hyperuricemia in an adolescent or child is rare but invariably a manifestation of an underlying metabolic or inherited enzyme deficiency warranting a workup for these diseases. Postmenopausal women. [clevelandclinicmeded.com]

  • Elevated Sedimentation Rate

    Occasionally, a gout attack triggers a systemic inflammatory response manifesting with fevers, leukocytosis, elevated sedimentation rates, and elevated C-reactive protein (CRP). Acute attacks can be precipitated by several factors. [clevelandclinicmeded.com]

Calcium pyrophosphate crystal deposition disease: diagnosis and treatment. Open Access Rheumatology : Research and Reviews. 2014;6:39-47. doi:10.2147/OARRR.S39039 MacMullan P, McCarthy G. [rarediseases.org]

Treatment of pseudogout attacks is with intra-articular corticosteroids or oral glucocorticoids, NSAIDs, or colchicine. [merckmanuals.com]

Treat your patients effectively using the latest information on drug treatments, from the recently-approved Uloric to Kristexx and Colcryst, which are still under review. [books.google.com]

It is also administered by injection as a treatment adjunct in cardiac arrest and in the treatment of hyperkalemia. calcium hydroxide an astringent compound used topically in solution or lotions. calcium lactate a calcium replenisher, administered orally [medical-dictionary.thefreedictionary.com]

The prognosis for individual attacks of acute calcium pyrophosphate arthritis is usually excellent. However, chronic arthritis can occur, and severe destructive arthropathy resembling neurogenic arthropathy (Charcot joints) occasionally occurs. [merckmanuals.com]

Prognosis of Pseudogout (Calcium pyrophosphate deposition disease) Prognosis is good for acute episodes of psuedogout, which usually improve over a period of 10 days or so. [myvmc.com]

Prognosis [ 2 ] Acute attacks usually resolve within ten days. [ 9 ] Some patients develop progressive joint damage with functional limitation. Prognosis will also be dependent on any underlying cause. [patient.info]

[…] synovial fluid leading to a synovitis Associated conditions hemochromatosis hyperparathyroidism hypomagnesemia can be seen in Gitelman and Bartter syndrome joint trauma, surgery, and severe medical illness these conditions can provoke an acute attack Prognosis [medbullets.com]

[…] treatment options are: Steroid injections: to treat severely swollen joints Oral steroids: to treat multiple swollen joints Nonsteroidal anti-inflammatory medications (NSAIDS): to ease the pain Colchicine: to treat attacks of CPPD arthritis Outlook (Prognosis [mountsinai.org]

Etiology Although the exact mechanism for the development of CPDD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. [emedicine.medscape.com]

Introduction Clinical definition a metabolic arthropathy due to deposition of calcium pyrophosphate dihydrate (CPP) in connective tissue Epidemiology risk factors radiographic CPP deposition increases with age Etiology CPP deposition in joints Pathogenesis [medbullets.com]

(Etiology) Formation of calcium pyrophosphate dihydrate salt crystals at the joints causes Pseudogout. [dovemed.com]

Etiology See Pathophysiology. Pathophysiology The exact physiologic dysfunction is not clear, but studies appear to implicate the chondrocyte and surrounding matrix as the responsible agents. [thehealthscience.com]

Etiology: The cause of CPPD crystal deposition disease is unknown. Formation of CPPD crystals in cartilage may be related to matrix changes or result from elevated levels of calcium or inorganic pyrophosphate. [rheumaknowledgy.com]

[…] crystal deposition disease: a rare diagnosis by fine-needle aspiration. ( 19688761 ) Kishore B...Khare V 2010 20 Calcium pyrophosphate dihydrate crystal deposition disease: sonographic findings. ( 19005616 ) Ciapetti A...Grassi W 2009 21 An update on the epidemiology [malacards.org]

Epidemiology Autosomal Dominant inheritance and sporadic cases III. Associated Conditions IV. [fpnotebook.com]

Epidemiology Frequency Estimates on the frequency of CPPD disease in the United States vary widely. Rates range from 4% to more than 25% of the population by age 80 years. [thehealthscience.com]

Calcium pyrophosphate dihydrate crystal deposition: Epidemiology, clinical features, diagnosis, and treatment. In: Terkeltaub R, ed. Gout and Other Crystal Deposition Arthropathies. Philadelphia, Penn: Elsevier; 2011:249-265. [the-rheumatologist.org]

Introduction Clinical definition a metabolic arthropathy due to deposition of calcium pyrophosphate dihydrate (CPP) in connective tissue Epidemiology risk factors radiographic CPP deposition increases with age Etiology CPP deposition in joints Pathogenesis [medbullets.com]

Etiology See Pathophysiology. Pathophysiology The exact physiologic dysfunction is not clear, but studies appear to implicate the chondrocyte and surrounding matrix as the responsible agents. [thehealthscience.com]

Am J Human Genet 1998, 63S :A-92. ort of two possible transcripts from chromosome 5, which are expressed in articular cartilage and might have a possible role in the pathophysiology of CPDDD Google Scholar 49. [link.springer.com]

Pathophysiology of Calcium Pyrophosphate Deposition Disease Calcium pyrophosphate deposition disease consists of the deposition of calcium pyrophosphate crystals into soft tissue. [boneandspine.com]

Pathophysiology of articular chondrocalcinosis—role of ANKH. Nat Rev Rheumatol. 2011;7:96-104. Terkeltaub R, Pritzker KPH. Pathogenesis and molecular genetics of calcium pyrophosphate dihydrate crystal deposition disease. In: Terkeltaub R, ed. [the-rheumatologist.org]

With coverage of the latest therapies, preventions, and imaging studies, along with access to the fully searchable text online at www.expertconsult.com, this comprehensive resource is ideal for any physician who diagnoses, treats, and manages gout and [books.google.com]

They act in vasospastic angina to relax and prevent coronary artery spasm. [medical-dictionary.thefreedictionary.com]

Experts do not know how to prevent these crystals. If CPPD is due to some other medical problem, treatment of that condition may sometimes prevent CPPD from getting worse. [rheumatology.org]

Prevention There is no known way to prevent this disorder. However, treating other problems that may cause CPPD arthritis may make the condition less severe. Regular follow-up visits may help prevent permanent damage of the affected joints. [mountsinai.org]

Prevention of Pseudogout is difficult or impossible, especially for high risk individuals. [dovemed.com]