In case of severe and/or resistant hypertension, additional antihypertensive medication is required. Prognosis With treatment prognosis is good. [orpha.net]

FH-III has a wide phenotypic variability from spironolactone-responsive hyperaldosteronism to massive adrenal hypertrophy with drug-resistant hypertension. [karger.com]

Patients with hypertension and hypokalaemia or resistant hypertension should be screened. If the ratio is 800 then patients should be investigated with further imaging to locate the source. [patient.info]

Fatigue, and muscle weakness are reported. Complications due to hypertension, chronic increase of aldosterone secretion accompanied with sodium retention and hypokalemia (found in approximately 25% of patients) may occur. [orpha.net]

[…] responses of hormonally regulated tissues. 23 24 PMS2 encodes a protein involved in DNA mismatch repair that is associated with hereditary non-polyposis colorectal cancer type 4, and Turcot syndrome with glioblastoma, and has been localised to 7p22 by FISH [jmg.bmj.com]

arm of chromosome 8 was excluded from harbouring the disease locus. 13 Other loci harbouring potential candidate genes were also excluded, including that of the angiotensin II receptor type 1 gene. 15 For the purposes of the present study, we screened [jmg.bmj.com]

Discussion FH-II is an inherited, non-glucocorticoid remediable form of hyperaldosteronism that was relatively recently recognised as a distinct entity. 5 12 The present study reports the identification of a locus for this condition on the short arm of [jmg.bmj.com]

All DNA samples, including the newly collected ones, were then used for examination of linkage between the disease and loci that produced suggestive lod scores in the genome wide search (see below). [jmg.bmj.com]

It was found that the concentrations of sodium and potassium ions on the two sides of the membrane are interdependent, suggesting that the same carrier transports both ions. [wikivividly.com]

Headaches and lethargy may also be present. Case finding - looking for primary hyperaldosteronism Establish whether the patient's blood pressure is under control and whether the treatment of their blood pressure been difficult. [patient.info]

The role of ARMC5 in human cell cultures from nodules of primary macronodular adrenocortical hyperplasia (PMAH). Mol Cell Endocrinol (e-pub ahead of print 1 July 2017; doi: 10.1016/j.mce.2017.06.027. 13. [nature.com]

Primary aldosteronism occurs most commonly from the fourth decade onwards 3 and may be the result of an adrenal adenoma or bilateral adrenocortical hyperplasia. 4 5 Patients with familial hyperaldosteronism (FH) are usually detected at a younger age than [jmg.bmj.com]