FH-II may present either as an aldosterone-producing adenoma (APA; see this term), bilateral adrenal hyperaldosteronism (BAH), or both. Fatigue, and muscle weakness are reported. [orpha.net]

ANP (natriuresis & diuresis) (note NO escape from hypokalemia) Primary aldosterone secreting adrenal adenomas will present with eosinophilic inclusions knwon as ------------. [quizlet.com]

Weakness may be present from hypokalaemia. Headaches and lethargy may also be present. [patient.info]

Familial hyperaldosteronism 1 Familial hyperaldosteronism type I FH1 FH I FH type 1 Glucocorticoid-remediable aldosteronism Glucocorticoid sensitive hypertension Glucocorticoid-suppressible hyperaldosteronism GRA GSH Any medical or genetic information present [uniprot.org]

• Fatigue

  Fatigue, and muscle weakness are reported. Complications due to hypertension, chronic increase of aldosterone secretion accompanied with sodium retention and hypokalemia (found in approximately 25% of patients) may occur. [orpha.net]

• Long Arm

  […] to date is a family with seven affected members from Queensland, Australia, which was previously described in detail. 13 Linkage between FH-II in this family and the CYP11B2/CYP11B1 locus on chromosome 8 was not found. 13 14 Furthermore, the entire long [jmg.bmj.com]

• Headache

  Headaches and lethargy may also be present. Case finding - looking for primary hyperaldosteronism Establish whether the patient's blood pressure is under control and whether the treatment of their blood pressure been difficult. [patient.info]

Management and treatment FH-II does not respond to glucocorticoid treatment. Adrenalectomy is performed in case of APA, and medical therapy with aldosterone antagonists in case of BAH. [orpha.net]

Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.com]

Prognosis With treatment prognosis is good. The cardiovascular morbidity of FH-II patients is increased compared to patients with essential hypertension. The documents contained in this web site are presented for information purposes only. [orpha.net]

Prognosis With treatment prognosis is good. The cardiovascular morbidity of FH-II patients is increased compared to patients with essential hypertension. Last updated: 6/1/2014 [rarediseases.info.nih.gov]

Covers new developments in epidemiology, pathophysiology, immunology, clinical findings, laboratory testing, invasive and non-invasive testing, risk stratification, clinical decision-making, prognosis, and management. [books.google.com]

Etiology The exact etiopathogenetic mechanism is unknown. Linkage analysis has shown an association with the chromosomal region 7p22 but no causal gene has been found to date. [orpha.net]

Covers new developments in epidemiology, pathophysiology, immunology, clinical findings, laboratory testing, invasive and non-invasive testing, risk stratification, clinical decision-making, prognosis, and management. [books.google.com]

Summary Epidemiology PA is the most common form of secondary hypertension and is found in 10% of cases. However, familial forms are rare and represent 5% of adult PA cases. [orpha.net]

Epidemiology PA is the most common form of secondary hypertension and is found in 10% of cases. However, familial forms are rare and represent 5% of adult PA cases. [rarediseases.info.nih.gov]

Covers new developments in epidemiology, pathophysiology, immunology, clinical findings, laboratory testing, invasive and non-invasive testing, risk stratification, clinical decision-making, prognosis, and management. [books.google.com]

Treatable - 0% Emergent - ED Care Needed - Preventable/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary [medicbind.com]

[…] other genotypes (G151R, T158A, I157S, and Y152C), (1) FH-III patients with G151E have shown milder phenotype, and (2) G151E-harboring cells were found to have rapid lethality due to much larger sodium conductance of the encoded channel (Kir3.4), which prevents [karger.com]

An enzyme exists in mineralocorticoid target tissues to prevent overstimulation by glucocorticoids and this enzyme, 11-beta hydroxysteroid dehydrogenase type II, catalyzes the deactivation of glucocorticoids to 11-dehydro metabolites. [wikivividly.com]