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2.1
Familial Hypospadias

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Presentation

Patients circumcised before the urethral defect was recognized comprised group 1, while those presenting without circumcision comprised group 2. [doi.org]

MATERIALS AND METHODS: In a single center study 63 unselected cases of severe hypospadias were studied for all presently known causes of hypospadias using clinical as well as molecular biological techniques. [ncbi.nlm.nih.gov]

Also, if chordee is present then this is corrected to allow the penis to straighten. [patient.info]

Treatment

1 HUANG Ying1 ZHANG Xiaozhong1 GUO Feng1 LIU Qiang1 WEI Hui1 WU Shaowen1 MEI Hua1(1Shenzhen Urological Hospital, Sun Yat-sen University of Medical Sciences, Shenzhen, Guangdong, 518001, China); The diagnosis and treatment of Klinefelter's syndrome (Report [en.cnki.com.cn]

Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. [books.google.com]

[…] and assisted reproductive technology to become pregnant; however, some treatments (such as intracytoplasmic sperm injection or ICSI) are more strongly associated with hypospadias, while other treatments (such as in vitro fertilization or IVF), are not [thinkgenetic.com]

Treatment If the hypospadias is mild, with the opening of the urethra just a little down from normal and with no bending of the penis, no treatment may be needed. However, in most cases an operation is required to correct the hypospadias. [patient.info]

[…] scrotum or perineum Position of the urethral meatus defines the type of hypospadia Penis is more likely to have associated ventral shortening and curvature with more proximal defects May be associated with family history of the disorder or infertility treatment [medbullets.com]

Prognosis

Prevention, and Complications Prognosis ranges widely depending on location and severity of anatomic abnormality surgical outcomes range, but as surgical technique and microsurgery improves, future prognosis is expected to increase significantly Prevention [medbullets.com]

Prognosis With adequate surgical repair, most males with simple hypospadias can lead normal lives with a penis that appears and functions in a normal manner. This includes fathering children. [medical-dictionary.thefreedictionary.com]

In experienced hands, complication rates for distal, midshaft, and proximal repairs are < 5%, 5% to 10%, and 15%, respectively [55]. 9 Prognosis Children with hypospadias have normal onset of puberty [62]. [asiaandro.com]

According to our experience, and many other authors, most of the congenital anomalies if detected and treated appropriately and soon enough, the future disabilities and prognosis will improve significantly. [scielo.br]

Prognosis With modern anesthetics, instruments, sutures, dressing materials, and antibiotics, hypospadias repair has become quite successful. Long-term studies on the outcomes of hypospadias using current practices are limited. [emedicine.com]

Etiology

In the majority of cases the underlying etiology remains unknown, which hampers further management based on the specific requirements associated with a specific etiology. [ncbi.nlm.nih.gov]

However, its etiology remains largely unknown. The authors investigated the contribution of genetic and environmental factors to familial aggregation of hypospadias. [semanticscholar.org]

The chromosomal etiology of congenital gonadal defects. Amer. J. Med., 30, 544 (1961). PubMed Google Scholar 8. Herbut, P. A.: Urethra. In: Urological Pathology, Kimpton, London 1952, p. 20. Google Scholar 9. [link.springer.com]

The etiology of hypospadias remains unknown and the incidence is doubling in western countries with no definable explanation. [books.google.com]

Epidemiology

DNK Source EPIDEMIOLOGY, Vol 21, N° 1, 2010, pages 109-113, 29 réf. [bdsp-ehesp.inist.fr]

Schnack2007FamilialAO, title={Familial aggregation of hypospadias: a cohort study.}, author={Tine H Schnack and Slobodan Zdravkovi'c and Charlotte Myrup and Tine Westergaard and Kaare Christensen and Jan Wohlfahrt and Mads Melbye}, journal={American journal of epidemiology [semanticscholar.org]

Schnack, Department of Epidemiology Research, Statens Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark. E-mail: [email protected] [journals.lww.com]

Abstract Epidemiological and genetic variables in hypospadias were analysed during the years 1978 to 1983 in a case control study of congenital malformations in the Emilia Romagna region of northern Italy. [doi.org]

Epidemiology 1997;8(5):537-544. Panamerican Health Organization Status of Malaria Programs in the Americas. Washington: PAHO, 1992. Secretaría de Medio Ambiente, Recursos Naturales y Pesca. [medigraphic.com]

Pathophysiology

[…] biochemistry of nutrition 180 Nutritional disorders and their management 200 Clinical biochemistry of the gastrointestinal tract 214 Assessment of hepatic function and investigation of jaundice 231 Acute and chronic liver disease 250 Glucose metabolism and the pathophysiology [books.google.de]

Pathophysiology Hypospadias is a congenital defect that is thought to occur embryologically during urethral development, between 8 and 20 weeks' gestation. [docgo.net]

Google Scholar 21 : The pathophysiology of hyperchloremic metabolic acidosis after urinary diversion through intestinal segments. Surgery 1985 ; 98 : 561. Google Scholar 22 : Continent urinary diversion: variations on the Mitrofanoff principle. J. [doi.org]

Prevention

Paediatr Perinat Epidemiol. 2007; 21: 210-218. http://www.ncbi.nlm.nih.gov/pubmed/19010807 Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, Rasmussen SA, and the National Birth Defects Prevention Study. [thinkgenetic.com]

0% Emergent - ED Care Needed - Preventable/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis [medicbind.com]

and Complications Prognosis ranges widely depending on location and severity of anatomic abnormality surgical outcomes range, but as surgical technique and microsurgery improves, future prognosis is expected to increase significantly Prevention none [medbullets.com]

Paulozzi National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724 USA Address correspondence to L.J. [web.archive.org]

He will be prescribed a medication to prevent bladder spasms during this time as well as an antibiotic to prevent infection. The most common complication of surgery is an urethrocutaneous fistula, or an opening between the urethra and penile skin. [texaschildrens.org]

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