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Familial Mitral Valve Prolapse

Familial Autosomal Dominant Mitral Valve Prolapse


Presentation

  • Ventricular arrhythmias were present in five of the eight families and sudden cardiac death occurred in six patients.[ncbi.nlm.nih.gov]
  • After replication, two identical sister chromatids are present. At the end of mitosis or meiosis, the two sisters separate and move to opposite poles before the cell splits.[books.google.com]
  • […] syndrome, and rarely may be due to rheumatic carditis, a connective tissue disorder such as Marfan syndrome, or ruptured chorda tendinea ("flail mitral leaflet"). mitral valve prolapse A condition of the mitral valve known as the floppy valve syndrome and present[medical-dictionary.thefreedictionary.com]
  • Her 44-year-old brother presented a similar phenotype with LVNC associated with anterior mitral valve leaflet prolapse causing severe mitral regurgitation ( Panel D ; Supplementary data online, Videos S5 and S6 ).[academic.oup.com]
Diastolic Murmur
  • Clinical variables used in the present investigation included age, sex, body mass index (BMI), and the presence of a murmur on auscultation (defined as systolic murmur 3 in any location and any diastolic murmur).[circ.ahajournals.org]
High Arched Palate

Workup

Left Axis Deviation
  • axis deviation ) · QT ( Short QT syndrome ) · T ( T wave alternans ) · ST ( Osborn wave, ST elevation, ST depression ) Cardiomegaly Ventricular hypertrophy ( Left, Right / Cor pulmonale ) · Atrial enlargement ( Left, Right ) Other Cardiac fibrosis ·[dictionnaire.sensagent.leparisien.fr]
Right Axis Deviation
  • axis deviation, Left axis deviation ) · QT ( Short QT syndrome ) · T ( T wave alternans ) · ST ( Osborn wave, ST elevation, ST depression ) Cardiomegaly Ventricular hypertrophy ( Left, Right / Cor pulmonale ) · Atrial enlargement ( Left, Right ) Other[dictionnaire.sensagent.leparisien.fr]
ST Elevation
  • […] arrest Sudden cardiac death · Asystole · Pulseless electrical activity · Sinoatrial arrest Other/ungrouped hexaxial reference system ( Right axis deviation, Left axis deviation ) · QT ( Short QT syndrome ) · T ( T wave alternans ) · ST ( Osborn wave, ST[dictionnaire.sensagent.leparisien.fr]
Torsades De Pointes
  • de pointes · Catecholaminergic polymorphic · Accelerated idioventricular rhythm Premature contraction Atrial · Ventricular Pre-excitation syndrome Wolff-Parkinson-White · Lown-Ganong-Levine Flutter/ fibrillation Atrial flutter · Ventricular flutter ·[dictionnaire.sensagent.leparisien.fr]
T Wave Alternans
  • wave alternans ) · ST ( Osborn wave, ST elevation, ST depression ) Cardiomegaly Ventricular hypertrophy ( Left, Right / Cor pulmonale ) · Atrial enlargement ( Left, Right ) Other Cardiac fibrosis · Heart failure ( Cardiac asthma ) · Rheumatic fever heart[dictionnaire.sensagent.leparisien.fr]

Treatment

  • Treatment - Mitral valve prolapse- familial- X-linked Treatment depends on the nature and severity of associated symptoms. For example, heart failure requires digoxin, diuretics, a sodium-restricted diet and, in acute cases, oxygen.[checkorphan.org]
  • You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.[rarediseases.info.nih.gov]
  • […] you believe that you are suffering from any of the symptoms of Mitral Valve Prolapse, Familial, Autosomal Dominant it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment[medigest.uk]
  • Treatment Persons who experience certain types of an irregular heartbeat with MVP should be treated. Propranolol (Inderal) or other beta blockers or digoxin (Lanoxin) are often helpful.[medical-dictionary.thefreedictionary.com]

Prognosis

  • High Blood Pressure: Home Testing o Home Blood Pressure Tests o Home Blood Pressure Monitors o Home Heart Tests * Heart Health: Home Testing: o Heart Rate Monitors o Irregular Heartbeat Detection o Heart Electrocardiogram (ECG) o Home Cholesterol Tests Prognosis[checkorphan.org]
  • Prognosis MVP is usually not a serious condition. However, dangerous, untreated irregular heartbeats may rarely cause sudden death. These persons should be carefully monitored.[medical-dictionary.thefreedictionary.com]
  • Nevertheless, it is found in all age groups Please find comprehensive information on Mitral Valve Prolapse (MVP) regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and[dovemed.com]

Etiology

  • We address both issues in the context of a recent article published in the Journal , which explored the results of mitral valve repair in degenerative disease according to etiologic classification - Barlow's disease or fibroelastic deficiency.[mitralvalverepair.org]
  • Etiology Pathophysiology The most common underlying pathology in the case of mitral valve prolapse is myxomatous degeneration. Mitral valve prolapse sets into motion a vicious cycle of events.[amboss.com]
  • MVP is the most common cause of mitral regurgitation requiring surgical repair, however, very little is known about its etiology. MVP has a strong genetic background with significant heterogeneity.[cordis.europa.eu]
  • Despite a clear heritable component, the genetic etiology leading to non-syndromic MVP has remained elusive.[cgm.massgeneral.org]
  • Etiologic heterogeneity and cardiac findings. Am J Dis Child. 1991 Jan. 145(1):90-3. [Medline]. Terechtchenko L, Doronina SA, Pochinok EM, Riftine A.[emedicine.medscape.com]

Epidemiology

  • His epidemiological research has focused on 4 inter-related areas: a. the epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic[books.google.ro]
  • Epidemiological substudy:z The underlying cause of organic MR often is unknown, but a familial basis for mitral valve prolapse has been suggested.[open.rsyd.dk]
  • Epidemiology References: [1] Epidemiological data refers to the US, unless otherwise specified. Etiology Pathophysiology The most common underlying pathology in the case of mitral valve prolapse is myxomatous degeneration.[amboss.com]
  • (D.L.); the Divisions of Cardiology and Clinical Epidemiology, Beth Israel Deaconess Medical Center, Boston (D.L.); and the Divisions of Cardiology (D.L., E.J.B.) and Epidemiology and Preventive Medicine (D.L., M.G.L., J.C.E., E.J.B.), Boston University[nejm.org]
  • Epidemiological approaches to heart disease: the Framingham study. Am J Public Health Nations Health . 1951 ; 41 :279–281. Crossref Medline Google Scholar 34. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP .[circ.ahajournals.org]
Sex distribution
Age distribution

Pathophysiology

  • Physician-scientist with focus on heart failure leading research and training program developing novel insights into pathophysiology of cardiovascular disease and innovative strategies to prevent and treat advanced heart failure.[books.google.ro]
  • Etiology Pathophysiology The most common underlying pathology in the case of mitral valve prolapse is myxomatous degeneration. Mitral valve prolapse sets into motion a vicious cycle of events.[amboss.com]
  • Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation. 2014;129(21):2158–... Otto CM, Bonow RO, eds.[5minuteconsult.com]
  • Carpentier’s functional classification of mitral regurgitation - From “Valvular heart disease: Secondary mitral regurgitation: pathophysiology, diagnosis, and treatment Heart 2011;97:12 1012-1023” Signs and symptoms The classic auscultatory finding is[wikiecho.org]

Prevention

  • Prevention - Mitral valve prolapse- familial- X-linked Not supplied.[checkorphan.org]
  • Recognition of a positive history of disease in a family will allow genetic testing and precise diagnosis, leading to the ability to presymptomatically screen at-risk members of a family and allow screening and prevention strategies to be implemented.[books.google.com]
  • Prevention of infective endocarditis Individuals with MVP are at higher risk of bacterial infection of the heart, called infective endocarditis.[dictionnaire.sensagent.leparisien.fr]
  • These defects could be prevented by the introduction of the normal copy of the human DCHS1 gene but not the mutated version.[hms.harvard.edu]

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