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Familial or Sporadic Hemiplegic Migraine


Presentation

  • As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules.[books.google.com]
  • Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables.[books.google.com]
  • It has been shown that 1.2.3.1 Familial hemiplegic migraine (FHM) very often presents with brainstem symptoms in addition to the typical aura symptoms, and that headache almost always occurs.[healthcentral.com]
  • Improve your interpretation of presenting symptoms with 39 new topics in the Differential Diagnosis section, and optimize patient care with 12 new tables in the Clinical Practice Guidelines section.[books.google.com]
  • He is well-published and has presented countless lectures and seminars around the world on headache, migraine, and other chronic disorders, and continues to be the principal investigator in numerous multi-center research studies. Dr.[books.google.com]
Developmental Delay
  • The section offers management reviews in headache, seizures, epilepsy, neurobehavioral disorders, school readiness, developmental delay and a range of other conditions.[books.google.com]
  • Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder characterized by recurrent episodes of hemiplegia and paroxysmal disturbances associated with persistent developmental delay and cognitive impairment.[blueprintgenetics.com]
Failure to Thrive
  • Fred Ferri’s popular "5 books in 1" format provides quick guidance on menorrhagia, Failure to Thrive (FTT), Cogan’s syndrome, and much more.[books.google.com]
Meningism
  • The final section, The Hospitalized Child, features chapters addressing current therapy issues for trauma, meningitis and encephalitis, injury to the preterm and term brains, status epilepticus and a host of other conditions associated with hospital care[books.google.com]
  • Ferri’s popular "5 books in 1" format provides quick guidance on short QT syndrome, microscopic polyangiitis, fungal meningitis, and much more. This medical reference makes the answers you need even easier to find - anytime, anywhere.[books.google.com]
  • […] or meningoencephalitis 9.1.1.3 Persistent headache attributed to past bacterial meningitis or meningoencephalitis 9.1.2 Headache attributed to viral meningitis or encephalitis 9.1.2.1 Headache attributed to viral meningitis 9.1.2.2 Headache attributed[curadeldolore.altervista.org]
  • Symptoms of FHM and SHM: Episodes of prolonged aura (up to several days or weeks) Hemiplegia (paralysis on one side of the body) Fever Meningismus (symptoms of meningitis without the actual illness and accompanying inflammation) Impaired consciousness[healthcentral.com]
  • Fever Symptoms of the condition “meningitis” without having the actual disease. - One will experience the identical symptoms of meningitis without really having the illness.[steadyhealth.com]
Cerebellar Sign
  • […] hemiplegic migraine and cerebellar signs.[nejm.org]
  • You can help by adding to it. ( August 2017 ) Diagnosis [ edit ] Diagnostic criteria require motor symptoms and at least one visual, sensory, or speech symptom, resembling basilar migraine. [4] They may also be associated with cerebellar signs. [5] Investigations[en.wikipedia.org]
  • It is well described that FHM1 can present with cerebellar signs, but parkinsonism has not previously been reported in FHM1 or EA2 even though parkinsonism has been described in SCA6.[karger.com]
  • A G301R Na /K   -ATPase mutation causes familial hemiplegic migraine type 2 with cerebellar signs. Neurogenetics. 2004;5:177–85. PubMed CrossRef Google Scholar 27. Dichgans M, Freilinger T, Eckstein G, et al.[link.springer.com]
Exertional Headache
  • Headache - The Basics _ Retinal Migraine - The Basics * _ Status Migrainous - The Basics _ Stroke - The Basics Tension-Type Headaches - The Basics Vestibular Migraine - The Basics Resources: Silberstein, Stephen D., Lipton, Richard B., Goadsby, Peter[healthcentral.com]
  • headaches, cough headaches, and headaches associated with sexual activity).[emedicine.medscape.com]

Workup

  • The workup should include the elimination of these and other disorders with similar symptoms.[pediatricneurologybriefs.com]
  • A complete exam, including family history and a full neurological workup, is required. What makes the diagnosis of hemiplegic migraine extremely challenging is that its symptoms are so similar to those of vascular disease, stroke or epilepsy.[diamondheadache.com]
  • Gastroenterologic evaluation and workup typically yield unremarkable results. [48] Abdominal migraine symptoms are usually relieved with sleep. Antiemetics may help in aborting an acute attack.[emedicine.medscape.com]

Treatment

  • An effective treatment for the severe and often prolonged aura symptoms is more warranted, but currently no such acute treatment is available.[ncbi.nlm.nih.gov]
  • The first chapter stresses the etiology and pathophysiology of childhood stroke as the basis for evaluations and treatment.[books.google.com]
  • Nausea and/or vomiting Phonophobia (increased sensitivity to sound) and/or photophobia (increased sensitivity to light) Treatment of FHM and SHM: Treatment of Hemiplegic Migraine can be challenging.[healthcentral.com]

Prognosis

  • The prognosis is generally good with complete recovery after the attacks. The frequency of the attacks tends to decrease with age, and the pattern becomes similar to migraine with aura.[thejournalofheadacheandpain.springeropen.com]

Etiology

  • The first chapter stresses the etiology and pathophysiology of childhood stroke as the basis for evaluations and treatment.[books.google.com]
  • The book is designed to supplement standard textbooks that provide detailed information on etiology, pathogenesis and therapeutic controversies in pediatric clinical neuroscience.[books.google.com]
  • .: Ophthalmoplegic migraine: diagnostic criteria, incidence of hospitalization and possible etiology. Acta Neurol. Scand. 1990; 81: 54-60. 33.[yadda.icm.edu.pl]
  • Additionally, gastroparesis, which occurs during migraine, has been implicated as an etiologic factor for cyclic vomiting and abdominal migraine. [51, 52, 53] A serum lactate level is helpful in these children to exclude mitochondrial disorders.[emedicine.medscape.com]

Epidemiology

  • Comments : Epidemiological studies have shown that sporadic cases occur with approximately the same prevalence as familial cases.[healthcentral.com]
  • Comments: Epidemiological studies have shown that sporadic cases occur with approximately the same prevalence as familial cases.[ichd-3.org]
  • .: An epidemiological survey of hemiplegic migraine. Cephalalgia 2002; 22: 361-375. 40.[yadda.icm.edu.pl]
  • You can help by adding to it. ( August 2017 ) Epidemiology [ edit ] Prevalence is estimated to be 0.005%. [7] The age of onset has been found to be under 15 years in 40% of cases while it is between 10 and 14 years in one third of the cases.[en.wikipedia.org]
  • Epidemiology of headache in Europe. European journal of neurology : the official journal of the European Federation of Neurological Societies, 13 (4), 333-45 PMID: 16643310 Image via Evgeny Atamanenko / Shutterstock.[brainblogger.com]
Sex distribution
Age distribution

Pathophysiology

  • The first chapter stresses the etiology and pathophysiology of childhood stroke as the basis for evaluations and treatment.[books.google.com]
  • @article{Russell2011SporadicAF, title {Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management}, author {Michael Bj{\o}rn Russell and A. H.[semanticscholar.org]
  • As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules.[books.google.com]
  • Pathophysiology of the migraine aura. The spreading depression theory. Brain. 1994;117(Pt 1):199–210. PubMed CrossRef Google Scholar 5. Olesen J, Larsen B, Lauritzen M.[link.springer.com]
  • More studies are needed to better understand the pathophysiologic role of these genes in comorbid depression, they added. "All hemiplegic migraine patients should be screened for depression," Terwindt said in an email.[medpagetoday.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.com]
  • Preventive: Given the severity of the symptoms and the contraindication of abortive medications, preventive regimens are considered especially important in the treatment of Hemiplegic Migraine.[healthcentral.com]
  • Flunarizine blocks voltage-gated Na( ) and Ca(2 ) currents in cultured rat cortical neurons: a possible locus of action in the prevention of migraine. Neurosci Lett. 2011;487:394–9. PubMed CrossRef Google Scholar 60.[link.springer.com]
  • Preventative Treatment : Prevention is especially important for those with Hemiplegic Migraine, because the symptoms are so severe and acute treatment options are limited.[migraineagain.com]

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