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Familial Ossifying Fibroma

Multiple Ossifying Fibroma


Presentation

  • The neoplasm sometimes presents with hyperparathyroidism, most of which cases are due to familial parathyroid tumours.[doi.org]
  • The present report describes these two cases of familial and multiple ossifying fibromas.[ncbi.nlm.nih.gov]
  • […] contemporary overview of oral and maxillofacial pathology includes a brief description of each individual lesion or pathologic condition and the kind of pathologic process that it represents, followed by a discussion of its clinical and/or radiographic presentation[books.google.com]
  • In the present case, we hereby report a 35-year-old male patient who presented with painless swelling over middle one third of face - left side since 8 months.[jdas.in]
  • We present a case of POF in a 65-year-old male patient in the posterior maxillary gingiva, the clinical presentation of which differs from the usual presentation. Differential diagnosis and some interesting facts of POF are discussed.[jisponline.com]
Constitutional Symptom
  • She didn’t give any history of weight loss or any other constitutional symptoms.[benthamopen.com]
Sore Throat
  • He had been assessed in the ENT department 2 years previously with recurrent sore throats, mouth breaming, and snoring. Facial roentgenograph had shown an opaque right maxillary antrum.[healio.com]
Snoring
  • He had been assessed in the ENT department 2 years previously with recurrent sore throats, mouth breaming, and snoring. Facial roentgenograph had shown an opaque right maxillary antrum.[healio.com]
Rhinorrhea
  • Nasal congestion ana rhinorrhea persisted. Eighteen months later, rhinitis, hypertrophied inferior turbinates, and deviation of die nasal septum to die left were noted. He was offered a conservative operation.[healio.com]
Short Arm
  • To evaluate this hypothesis, we investigated amplification levels of other genes, one located on the long arm of chromosome 12, telomeric to MDM2 , ie, RASAL1 , and two located on the short arm of chromosome 12, ie, IPO8 and KLRG1 .[nature.com]
Xanthelasma
  • […] spongiotic gingival hyperplasia, oral lesions associated with cosmetic fillers, oropharyngeal carcinomas related to human papillomavirus (HPV), IgG4-related disease and mammary analogue secretory carcinomas, Globodontia, Lobodontia, Leishmaniasis, and Xanthelasma[books.google.com]

Workup

  • At Children’s Hospital of Philadelphia (CHOP), our clinical experts perform a careful and complete medical workup and examination of your child.[chop.edu]
Periostal Elevation
  • Longstanding lesions may show significant cortical destruction and periosteal elevation [ 18 Noffke CE. Juvenile ossifying fibroma of the mandible. An 8 year radiological follow-up.[benthamopen.com]
Human Papillomavirus
  • NEW cutting-edge content includes pathologies and conditions such as localized juvenile spongiotic gingival hyperplasia, oral lesions associated with cosmetic fillers, oropharyngeal carcinomas related to human papillomavirus (HPV), IgG4-related disease[books.google.com]

Treatment

  • Up-to-date concepts of pathogenesis and disease management help you understand the diseases that affect oral and maxillofacial structures, formulate an accurate diagnosis, and institute proper treatment.[books.google.com]
  • Treatment  Lesions exhibit only limited potential for progressive growth, more lesion require no additional treatment following biopsy.  Periodic observation 47.[slideshare.net]
  • Treatment for the rare lung metastases involves chemotherapy and resection of the lung nodules.[massgeneral.org]
  • , however, the defect may be supplemented with bone grafts or other stabilization techniques for frx prophylaxis and treatment Benign fibrous histiocytoma of bone Pathological fractures through non-ossifying fibromas.[wheelessonline.com]
  • Most nonossifying fibromas require no treatment. They usually resolve on their own when your child’s bones stop growing. In some circumstances, treatment may be recommended to help stabilize the affected bone after a fracture.[chop.edu]

Prognosis

  • […] includes a brief description of each individual lesion or pathologic condition and the kind of pathologic process that it represents, followed by a discussion of its clinical and/or radiographic presentation, histopathologic features, and its treatment and prognosis[books.google.com]
  • […] moderately increased activity can be seen during NOF "healing", corresponding to mild hyperemia and osteoblastic activity note that extensive uptake or hyperemia should prompt consideration of alternative diagnosis or a superimposed fracture 4 Treatment and prognosis[radiopaedia.org]
  • PROGNOSIS Biological Behavior • Benign tumor, indolent and not active nor aggressive. • The tumor may be large enough to place the bone at risk for fracture (probably greater than 50% of the diameter of the bone in both directions). • When the patient[tumorsurgery.org]
  • The prognosis is very good, and recurrence after removal of the tumor is rarely encountered [ 6, 15 ]. Liu [ 1 ] observed that the time of recurrence was always unpredictable, ranging from 6 months to 7 years after the operation.[omicsonline.org]
  • Prognosis is good, without any case of metastasis being reported. Declarations Authors’ contributions Study conception and design: CC, AS, MR. Acquisition of data: CC, MR, AS. Analysis and interpretation of data: CC, AP, AS.[springerplus.springeropen.com]

Etiology

  • While the etiology of POF is unclear, inflammatory hyperplasia originating in the superficial PDL is considered to be one of the factors.[ijdr.in]
  • Etiology The etiology of osteofibrous dysplasia, as well as the cell of origin, remains to be established.[emedicine.medscape.com]
  • Etiology  Defective function of the osteoprotegerin/TNFRSF11A or B/RANKL/RANK pathway, a molecular regulator of osteoclastogenesis. 27.[slideshare.net]
  • Cemento-ossifying fibroma (COF) is a nonneoplastic but locally destructive tumor of unknown etiology consisting of fibrous tissue and varying amounts of mineralized material. It is rarely described as a cause of ophthalmic symptoms and signs.[healio.com]
  • […] calcification, peripheral ossifying fibroma, calcifying fibroblastic granuloma, peripheral cementifying fibroma, peripheral fibroma with cementogenesis and peripheral cemento-ossifying fibroma. [1] Gracia de Marcos et al . (2010) [2] stated that the etiology[ijohsjournal.org]

Epidemiology

  • Hence, reporting of similar cases should be encouraged to facilitate the better understanding of its varied epidemiological details and clinical presentation. FREE Publisher Full Text Early presentation in ameloblastic fibroma.[unboundmedicine.com]
  • Epidemiology Osteofibrous dysplasia usually is diagnosed in children younger than 10 years, with a peak incidence in children aged 1-5 years.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Available from: With the recent advancements in technology, our understanding of the pathophysiology of reactive and fibro osseous lesions has improved to a large extent.[ijdr.in]
  • Juvenile Paget Disease (Idiopathic Hyperphosphatasia)  Inherited as an autosomal recessive trait  Deformities in the long bones, kyphosis, acetabular protrusion and pathophysiologically by rapid turnover.  Long bone widening with pathologic fracture[slideshare.net]

Prevention

  • This will reduce the stresses on the bone and prevent a fracture. The brace should be worn till the time you do an MRI and CT scan. Investigations to be done: MRI and CT scan.[icliniq.com]
  • Management of such case needs a multidisciplinary approach to prevent the recurrence along with regular long time follow-up.[ijdr.in]
  • In the present case, we decided to surgically excise the lesion along with peripheral ostectomy to prevent recurrence through Weber-Ferguson approach.[pagepress.org]
  • J Indian Soc Pedod Prevent Dent 2009; 27(1): 49-51. Poon CK, Kwan PC, Chao SY. Giant peripheral ossifying fibroma of the maxilla: report of a case. J Oral Maxillofac surg 1995;53: 695-8.[ojhas.org]
  • To prevent recurrence, complete removal of the lesion and gingival curettage is ensured followed by oral hygiene maintenance instructions to the patient.[jisponline.com]

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