In the present case, we hereby report a 35-year-old male patient who presented with painless swelling over middle one third of face - left side since 8 months. [jdas.in]

The neoplasm sometimes presents with hyperparathyroidism, most of which cases are due to familial parathyroid tumours. [doi.org]

The swelling was present since 6 months which was of gradual onset. Swelling initially started small in size in the upper front gums which gradually progressed to the present size. [ijohsjournal.org]

The lesion presents with proptosis, exophthalmos, visual disturbances, nasal obstruction and facial asymmetry. [pagepress.org]

We present a case of POF in a 65-year-old male patient in the posterior maxillary gingiva, the clinical presentation of which differs from the usual presentation. Differential diagnosis and some interesting facts of POF are discussed. [jisponline.com]

• Asymptomatic

  Nonossifying fibroma is usually asymptomatic. When non ossifying fibromas are less than 2 cm they are referred to as fibrous cortical defects. [tumorsurgery.org]

  Treatment  Often difficult, not very satisfactory.  In the asymptomatic patient observation  Antibiotics  Sequestration of the cementum-like masses will occur slowly and followed by healing.  Saucerization or surgical excision 50. [slideshare.net]

  The majority of NOFs are asymptomatic. Larger lesions may be painful and potentially weaken the bone enough to predispose to pathological fracture. Multiple NOFs are associated with neurofibromatosis type 1 (NF1) and Jaffe-Campanacci syndrome. [radiopaedia.org]

  Mostly it is seen as an asymptomatic swelling predominantly in female patients and is rarely encountered in postmenopausal years. [sciepub.com]

  Patients usually have no symptoms (asymptomatic) unless they have fractured. Plain x-rays show the lesion. If the patient is asymptomatic and there is no deformity or fracture, the lesion can be conservatively managed/observed with x-rays. [massgeneral.org]

• Fracture

  If a pathologic fracture occurs, it is allowed to heal before surgical treatment because sometimes the lesion will disappear during fracture healing. Non-ossifying fibromas are virtually identical, but larger. [massgeneral.org]

  Surgery usually consists of a curettage and bone grafting. • Curettage and bone grafting is curative when required • In cases of the pathologic fractures consideration should be given to allowing the fracture to heal first then treating the nonossifying [tumorsurgery.org]

  If large (involving more than 50% of the diameter of the parent bone) then prophylactic curettage and bone grafting may be prudent to avoid a pathological fracture 1. [radiopaedia.org]

  […] or other stabilization techniques for frx prophylaxis and treatment Benign fibrous histiocytoma of bone Pathological fractures through non-ossifying fibromas. [wheelessonline.com]

  Fractures are more likely when the nonossifying fibroma is very large. At Children’s Hospital of Philadelphia (CHOP), our clinical experts perform a careful and complete medical workup and examination of your child. [chop.edu]

• Aggressive Behavior

  Discussion Juvenile aggressive ossifying fibroma is an uncommon benign lesion which is distinctly aggressive in behavior with a high tendency for recurrence and is usually seen affecting younger individuals with age less than 15 years. 1-3 Ninety percent [pagepress.org]

  Those that behave aggressively in a shorter duration could still be called aggressive-OF irrespective of the age at presentation, since aggressive behavior is not age related, as it could develop in both young and old patients. [njcponline.com]

  Conclusion The JPOF is a benign tumor with aggressive behavior that rarely affects the cranial bones; this is the first reported case within this localization causing neurological deficits. Total resection is the treatment of choice. [springerplus.springeropen.com]

  behavior, with high recurrence rate, particularly in partial and incomplete excisions, with complete removal being the gold standard treatment. [jiaomr.in]

  Despite the aggressive behavior, no metastasis has been reported. [21] Because of the aggressive nature of this entity and its high recurrence rate (30-50%), JOF should be treated like a locally aggressive neoplasm, very much like an ameloblastoma. [contempclindent.org]

At Children’s Hospital of Philadelphia (CHOP), our clinical experts perform a careful and complete medical workup and examination of your child. [chop.edu]

Treatment for the rare lung metastases involves chemotherapy and resection of the lung nodules. [massgeneral.org]

Most nonossifying fibromas require no treatment. They usually resolve on their own when your child’s bones stop growing. In some circumstances, treatment may be recommended to help stabilize the affected bone after a fracture. [chop.edu]

Up-to-date concepts of pathogenesis and disease management help you understand the diseases that affect oral and maxillofacial structures, formulate an accurate diagnosis, and institute proper treatment. [books.google.com]

Although the severity of pathology, no effective treatment exists. Therapy strategies include: (a) surgical treatment; (b) medical treatment. [reumatologiaclinica.org]

Treatment  Lesions exhibit only limited potential for progressive growth, more lesion require no additional treatment following biopsy.  Periodic observation 47. [slideshare.net]

[…] includes a brief description of each individual lesion or pathologic condition and the kind of pathologic process that it represents, followed by a discussion of its clinical and/or radiographic presentation, histopathologic features, and its treatment and prognosis [books.google.com]

[…] moderately increased activity can be seen during NOF "healing", corresponding to mild hyperemia and osteoblastic activity note that extensive uptake or hyperemia should prompt consideration of alternative diagnosis or a superimposed fracture 4 Treatment and prognosis [radiopaedia.org]

PROGNOSIS Biological Behavior • Benign tumor, indolent and not active nor aggressive. • The tumor may be large enough to place the bone at risk for fracture (probably greater than 50% of the diameter of the bone in both directions). • When the patient [tumorsurgery.org]

The prognosis is very good, and recurrence after removal of the tumor is rarely encountered [ 6, 15 ]. Liu [ 1 ] observed that the time of recurrence was always unpredictable, ranging from 6 months to 7 years after the operation. [omicsonline.org]

Prognosis is good, without any case of metastasis being reported. Declarations Authors’ contributions Study conception and design: CC, AS, MR. Acquisition of data: CC, MR, AS. Analysis and interpretation of data: CC, AP, AS. [springerplus.springeropen.com]

While the etiology of POF is unclear, inflammatory hyperplasia originating in the superficial PDL is considered to be one of the factors. [ijdr.in]

Etiology The etiology of osteofibrous dysplasia, as well as the cell of origin, remains to be established. [emedicine.medscape.com]

11p14.3 - 15.1 High levels of GDD1 protein expression in normal cardiac and skeletal muscle tissue as well as in growth plate chondrocytes and osteoblasts in bone suggests an important role for GDD1 in the development of the musculoskeletal systems Etiology [pathologyoutlines.com]

Etiology  Defective function of the osteoprotegerin/TNFRSF11A or B/RANKL/RANK pathway, a molecular regulator of osteoclastogenesis. 27. [slideshare.net]

[…] calcification, peripheral ossifying fibroma, calcifying fibroblastic granuloma, peripheral cementifying fibroma, peripheral fibroma with cementogenesis and peripheral cemento-ossifying fibroma. [1] Gracia de Marcos et al. (2010) [2] stated that the etiology [ijohsjournal.org]

Hence, reporting of similar cases should be encouraged to facilitate the better understanding of its varied epidemiological details and clinical presentation. FREE Publisher Full Text Early presentation in ameloblastic fibroma. [unboundmedicine.com]

Juvenile ossifying fibroma Rarely, ossifying fibroma is associated with syndromes: Hyperparathyroidism jaw tumor syndrome Familial gigantiform cementoma Gnathodiaphysial dysplasia Terminology Cemento-ossifying fibroma Cementifying fibroma Periodontoma Epidemiology [pathologyoutlines.com]

Epidemiology Osteofibrous dysplasia usually is diagnosed in children younger than 10 years, with a peak incidence in children aged 1-5 years. [emedicine.medscape.com]

Definition / general Benign fibro-osseous neoplasm Two general categories: Ossifying fibroma (discussed in this topic) Juvenile ossifying fibroma Usually requires surgical excision Terminology Cemento-ossifying fibroma Cementifying fibroma Periodontoma Pathophysiology [pathologyoutlines.com]

2014/25/2/220/135928 With the recent advancements in technology, our understanding of the pathophysiology of reactive and fibro osseous lesions has improved to a large extent. [ijdr.in]

Juvenile Paget Disease (Idiopathic Hyperphosphatasia)  Inherited as an autosomal recessive trait  Deformities in the long bones, kyphosis, acetabular protrusion and pathophysiologically by rapid turnover.  Long bone widening with pathologic fracture [slideshare.net]

This will reduce the stresses on the bone and prevent a fracture. The brace should be worn till the time you do an MRI and CT scan. Investigations to be done: MRI and CT scan. [icliniq.com]

Management of such case needs a multidisciplinary approach to prevent the recurrence along with regular long time follow-up. [ijdr.in]

In the present case, we decided to surgically excise the lesion along with peripheral ostectomy to prevent recurrence through Weber-Ferguson approach. [pagepress.org]

J Indian Soc Pedod Prevent Dent 2009; 27(1): 49-51. Poon CK, Kwan PC, Chao SY. Giant peripheral ossifying fibroma of the maxilla: report of a case. J Oral Maxillofac surg 1995;53: 695-8. [ojhas.org]

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. Am J Hum Genet. 2015 Dec 3. 97 (6):837-47. [Medline]. Anderson MJ, Townsend DR, Johnston JO, Bohay DR. Osteofibrous dysplasia in the newborn. Report of a case. [emedicine.medscape.com]