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Familial Papillary or Follicular Thyroid Carcinoma

FNMTC


Presentation

  • Presentation is usually with a solitary palpable thyroid mass.[radiopaedia.org]
  • CASE STUDY Initial Presentation A 49-year-old man with no significant past medical history presents with a painless mass in the anterior part of his neck.[jcomjournal.com]
  • Clinical presentation  It can present as multinodular or solitary nodular goitre.  The diagnosis is confirmed after an ultrasound scan reveals features of malignancy like microcalcifications  Metastasis in flat bones: when a patient with a thyroid[slideshare.net]
  • Multifocal papillary carcinoma is the most frequent presentation of familial nonmedullary thyroid carcinoma, and based on clinico-pathologic findings it is divided into 2 groups.[journals.lww.com]
  • Evaluation serum calcitonin tumor marker histology amyloid (consisting of calcitonin) pentagastrin infusion hyperplasia present with high calcitonin level response following administration B-cell Malignant Lymphoma Introduction sequelae of Hashimoto's[medbullets.com]
Supraclavicular Fat Pads
  • At follow-up, 2 months after surgery, physical examination revealed facial plethora, supraclavicular fat pads, gynecomastia, hepatomegaly, and edema of the extremities.[karger.com]
Leg Edema
  • Three weeks after the surgery, blood sugar levels improved, the leg edema disappeared, and the patient lost 7 kg in weight.[karger.com]
Macrocephaly
  • PTEN Gene (Source: SyndromesPedia ) Cowden syndrome (CS) is associated with: An increased risk to develop cancer of the breast, endometrium (the inner lining of the uterus), thyroid, kidney, colon and skin (melanoma); Macrocephaly: a larger than average[mygenecounsel.com]
Retinal Pigmentation
  • Patients may have extraintestinal manifestations that include osteomas, dental abnormalities, epidermal cysts, desmoids tumors, congenital hypertrophy of the retinal pigment epithelium (CHRPE), hepatoblastoma, medulloblastoma, and thyroid cancers.[shifrinmd.com]
  • pigment epithelium (CHRPE); Tumors of the skull and jaw bone.[mygenecounsel.com]
Suggestibility
  • In summary, our data suggest the roles of RTFC in thyroid carcinogenesis. Copyright 2016 Elsevier Inc. All rights reserved. KEYWORDS: C14orf93; Exome sequencing; RTFC; Thyroid cancer[ncbi.nlm.nih.gov]
  • Suggested Citation: Espinosa, A., J. Gilbert. 2018. Molecular Profiling of Thyroid Cancer. My Cancer Genome (Updated March 16).[mycancergenome.org]
  • Aggressive papillary thyroid cancer variants are potentially suggested by mutations of the TERT promoter, p53 or PI3kinase.[thyroidcancer.com]
  • Imaging Ultrasound Thyroid scintigraphy Indications : Thyroid nodule with TSH level Evaluation of ectopic thyroid tissue or retrosternal goiter Findings : decreased tracer uptake suggests a malignant non-functioning ( cold ) nodule.[amboss.com]
  • […] recognised in recent years. 4-6 There has been increasing awareness that this may constitute a distinct disease subgroup rather than chance occurrence, as reflected by the review of case series by Loh. 7 Familial papillary microcarcinoma has also been suggested[jmg.bmj.com]

Workup

  • The workup revealed a nodular thyroid gland with a follicular lesion on fine-needle aspiration.[karger.com]
  • Treatment for all PTC patients with a positive family history, regardless of variant, should entail a workup and evaluation including FNA of subcentimeter nodules, screening at a younger age, and earlier surgical intervention.[omicsonline.org]
  • Five percent of the population can have thyroid nodules, and the majority will be benign. [6] Appropriate workup includes an ultrasound of the neck, followed by lab studies.[en.wikipedia.org]

Treatment

  • Treatment In most hospitals, a team of specialists called a multidisciplinary team will advise on the best treatment for you. Treatment has a very high chance of curing papillary thyroid and follicular thyroid cancer.[makesensecampaign.eu]
  • Your doctor will tell you if any of these treatments is an option for you.[nyp.org]
  • TreatmentTreatment of primary:  Total thyroidectomy is always preferred  Treatment of the metastasis:  After total thyroidectomy a whole body scan is done to look for metastasis in the bone.[slideshare.net]
  • The main treatments are: surgery – to remove part or all of the thyroid radioactive iodine treatment – you swallow a radioactive substance that travels through your blood and kills the cancer cells external radiotherapy – a machine is used to direct beams[nhs.uk]
  • Sources of such radiation include certain medical treatments and radiation fallout from power plant accidents or nuclear weapons. Having had head or neck radiation treatments in childhood is a risk factor for thyroid cancer.[mcancer.org]

Prognosis

  • […] very poor prognosis Please rate topic.[medbullets.com]
  • As with any malignancy, staging of disease is an important part of management to inform treatment planning and prognosis.[radiopaedia.org]
  • […] concentrate 131 I. 51, 52 and 53 Prognosis in Children.[oncohemakey.com]
  • Early detection is crucial for improving the prognosis but challenging because symptoms often appear late in the course of the disease.[amboss.com]
  • Prognosis for patients with thyroid cancer The prognosis for patients with thyroid cancer depends on many factors including: The tumour type; The age of the patient and gender; The local and regional tumour extent at the time of diagnosis; Spread of the[thyroid.com.au]

Etiology

  • Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • Whereas the susceptibility gene for hereditary MTC, namely multiple endocrine neoplasia type 2 (MEN 2), is well defined, finding the genetic etiology for the familial nonmedullary thyroid carcinoma syndromes is proving arduous.[academic.oup.com]
  • Etiology Genetic factors: Ionizing radiation ; (particularly during childhood): mostly associated with papillary carcinoma References: [1] [3] [4] Classification Histological classification of thyroid tumors (according to WHO 2004) Thyroid cancer Thyroid[amboss.com]

Epidemiology

  • Epidemiology References: [1] [2] Epidemiological data refers to the US, unless otherwise specified.[amboss.com]
  • Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surg 2006;135:451-7. Bonora E, Tallini G, Romeo G.[journals.sfu.ca]
  • [ edit ] According to Surveillance, Epidemiology, and End Results (SEER), the incidence of papillary cancer has increased from 4.8 to 14.9 per 100,000 from 1975 to 2012.[en.wikipedia.org]
  • The form of thyroid cancer that is increasing in incidence is papillary cancer of the thyroid, as illustrated in Ann Epidemiol 2000 Jan;10(1):24-30 Primary malignancies of the thyroid: epidemiologic analysis of the Florida Cancer Data System registry[mythyroid.com]
  • "Thyroid cancer epidemiology in England and Wales: time trends and geographical distribution" . Br J Cancer . 67 (2): 330–40. doi : 10.1038/bjc.1993.61 . PMC 1968194 . PMID 8431362 .[en.wikipedia.org]
Sex distribution
Age distribution

Prevention

  • Sciences and College of Life Sciences, Nankai University, Tianjin 300071, China. 2 Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention[ncbi.nlm.nih.gov]
  • Prevention Doctors aren't sure what causes most cases of thyroid cancer, so there's no way to prevent thyroid cancer in people who have an average risk of the disease.[mayoclinic.org]
  • References Thyroid Cancer Prevention & Detection. Available at: Accessed January 26, 2015. Back to the Head & Neck Cancers Special Report[targetedonc.com]
  • Individuals with Attenuated FAP (AFAP) develop 10-100 colon polyps and have 70% lifetime risk to develop colorectal cancer without preventive removal of the colon. Other cancers and benign findings can be seen in both conditions.[mygenecounsel.com]
  • Q: Can thyroid cancer be prevented? A: Most people with thyroid cancer have no known risk factors; therefore, it is not possible to prevent most cases of this disease.[cancerschmancer.org]

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