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Familial Papillary Thyroid Carcinoma with Papillary Renal Cell Carcinoma

Familial Papillary Thyroid Carcinoma with Papillary Renal Neoplasm


  • Multifocal papillary carcinoma is the most frequent presentation of familial nonmedullary thyroid carcinoma, and based on clinico-pathologic findings it is divided into 2 groups.[journals.lww.com]
  • CASE STUDY Initial Presentation A 49-year-old man with no significant past medical history presents with a painless mass in the anterior part of his neck.[jcomjournal.com]
  • FPTC generally presents at a younger age but presentation at almost the same age is an interesting finding. All sisters lived in different parts of world and were exposed to different environmental conditions.[journals.sfu.ca]
  • The exclusive PRCC histology and concurrent presentation in our cases hinted strongly at an etiological link.[annonc.oxfordjournals.org]
  • Evaluation serum calcitonin tumor marker histology amyloid (consisting of calcitonin) pentagastrin infusion hyperplasia present with high calcitonin level response following administration B-cell Malignant Lymphoma Introduction sequelae of Hashimoto's[medbullets.com]
  • […] aim to inhibit the growth of new blood vessels in the tumors, hence slowing growth and in some cases reducing the size of the tumors. [97] Side effects unfortunately are quite common with these treatments and include: [98] Gastrointestinal effects – nausea[en.wikipedia.org]


  • Since 2002, thyroid US has become an optional workup in health promotion programs at most hospitals in Korea, meaning that people can easily undergo US screenings at a cost of 30- 50, which has led to an abrupt increase in the detection and treatment[e-ultrasonography.org]


  • Treatment Options by Stage For information about the treatments listed below, see the Treatment Option Overview section.[cancer.gov]
  • : Treatment varies depending on the type of tumor.[uclahealth.org]
  • Staging determines what type of treatment you’ll receive. There are five types of standard treatment options. They are: Surgery: A surgeon may remove your tumor or the kidney, adrenal gland, and nearby lymph nodes.[healthline.com]
  • Endocrine surgeon Peter Angelos, MD, is an internationally respected authority on the treatment of endocrine cancers.[uchospitals.edu]
  • Determine the toxicity of this treatment in these patients. II. Determine the pharmacokinetic profile of this treatment in these patients. III. Determine the progression-free and overall survival of these patients. IV.[clinicaltrials.gov]


  • […] very poor prognosis Please rate topic.[medbullets.com]
  • Recurring tumors have worse prognosis compared to tumors that do not recur Response to treatment: Tumors that respond to treatment have better prognosis compared to tumors that do not respond to treatment If diagnosed early and treated promptly, the prognosis[dovemed.com]
  • Early detection is crucial for improving the prognosis but challenging because symptoms often appear late in the course of the disease.[amboss.com]
  • ) Often considered subtype of FTC with overall poorer prognosis Also known as oncocytic or oxyphilic carcinoma 2–3% of thyroid malignancies Usually in patients 60 years old Often radioresistant Medullary thyroid carcinoma (MTC) Neuroendocrine tumor arising[unboundmedicine.com]
  • Prognosis [ 3 ] This depends upon type and stage but most thyroid cancer has a good prognosis with 90% survival at 10 years, higher in young people without local or metastatic spread.[patient.info]


  • Pathophysiology The histopathology varies with the etiology and duration of the goiter.[ocw.tufts.edu]
  • In 2015, 765,547 patients living with thyroid cancer in the United States Etiology and Pathophysiology No established etiologic factors of pathogenesis; most cases arise spontaneously.[unboundmedicine.com]
  • Whereas the susceptibility gene for hereditary MTC, namely multiple endocrine neoplasia type 2 (MEN 2), is well defined, finding the genetic etiology for the familial nonmedullary thyroid carcinoma syndromes is proving arduous.[dx.doi.org]
  • Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer.[books.google.com]
  • Etiology Genetic factors: Ionizing radiation ; (particularly during childhood): mostly associated with papillary carcinoma References: [1] [3] [4] Classification Histological classification of thyroid tumors (according to WHO 2004) Thyroid cancer Thyroid[amboss.com]


  • Epidemiology References: [1] [2] Epidemiological data refers to the US, unless otherwise specified.[amboss.com]
  • Epidemiology Incidence: 14.5/100,000 per year in the United States Deaths: 0.5/100,000 per year in the United States In 2018, estimated 53,990 new cases and 2,060 deaths from thyroid cancer in the United States Predominant age: usually 40 years old Predominant[unboundmedicine.com]
  • The Canadian Cancer Society Epidemiology Statistics are also provided in an easy to use Web-based format. Examine the changing trends in thyroid cancer incidence by region, age, sex, or compare variables.[mythyroid.com]
  • Familial papillary renal cell tumors and subsequent cancers: a nationwide epidemiological study from Sweden. J Urol 2003 ; 169 : 1271 –1275. 2. Rabbani F, Reuter VE, Katz J, Russo P.[annonc.oxfordjournals.org]
  • Surveillance, Epidemiology, and End Results Program. SEER Stat Fact Sheets: thyroid cancer. Bethesda, MD: National Cancer Institute, 2016. 6. Jung KW, Won YJ, Oh CM, Kong HJ, Cho H, Lee DH, et al.[e-ultrasonography.org]
Sex distribution
Age distribution


  • Pathophysiology The histopathology varies with the etiology and duration of the goiter.[ocw.tufts.edu]
  • In 2015, 765,547 patients living with thyroid cancer in the United States Etiology and Pathophysiology No established etiologic factors of pathogenesis; most cases arise spontaneously.[unboundmedicine.com]
  • NMTC type 1 syndrome [10], and the telomere abnormalities and chromosome fragility might display in FPTC family [11]; Specifically, familial NMTC and its relationship with familial MNG are recognized as distinct clinical entities, and the molecular pathophysiology[journals.sfu.ca]
  • […] course. [10] While treatment with radioactive iodine has not been shown to raise the incidence of thyroid cancers, a meta-analysis demonstrated an increase in the risk of thyroid, kidney, and stomach cancer at diagnostic doses of greater than 1 Gy. [11] Pathophysiology[emedicine.medscape.com]
  • […] sickle cell disease. [23] The most significant disease affecting risk however is not genetically linked – patients with acquired cystic disease of the kidney requiring dialysis are 30 times more likely than the general population to develop RCC. [24] Pathophysiology[en.wikipedia.org]


  • Prevention: There is no known prevention. Awareness of risk (such as previous radiation therapy) can allow earlier diagnosis and treatment. Back to Thyroid Cancer[uclahealth.org]
  • Prevention Because most people with thyroid cancer have no known risk factor, it is not possible to completely prevent this disease. However, inherited cases of medullary thyroid cancer can be prevented and radiation to the neck is avoided.[medical-dictionary.thefreedictionary.com]
  • Screening and prevention of colorectal cancer Source: Finnish Medical Society Duodecim This article is freely available only to users in the UK.[evidence.nhs.uk]
  • Individuals with Attenuated FAP (AFAP) develop 10-100 colon polyps and have 70% lifetime risk to develop colorectal cancer without preventive removal of the colon. Other cancers and benign findings can be seen in both conditions.[mygenecounsel.com]
  • I hope that it will set an example for other expert groups to address nomenclature of various cancer types that have indolent behavior to prevent inappropriate and costly treatment.”[upmc.com]

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