Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses. [books.google.com]

The term amyloid was reportedly coined by the famous 19th century pathologist Virchow who attributed its major constituent to carbohydrate accumulation [ 1 ]. [dermatology-s10.cdlib.org]

effusions& pain Myelopathy β 2 -microglobulin Amyloidosis, renal (ALys) Renal Visceral Lysozyme (LYZ) AApoAIIRenalApolipoprotein A II (APOA2) AApoCIIRenalApolipoprotein C II (APOC2) AApoCIIIRenalApolipoprotein C III (APOC3) Muckle-Wells syndrome Cold [neuromuscular.wustl.edu]

Typically, in both pedigrees, the onset of symptoms was around puberty, and pruritus usually began on the lower legs. [ncbi.nlm.nih.gov]

Ancillary Article Information DOI 10.1111/j.1600-0625.2010.01083.x Format Available Full text: HTML PDF Request Permissions Keywords apoptosis; gene expression; interleukin 31; oncostatin M; pruritus Publication History Issue online: 12 April 2010 Version [onlinelibrary.wiley.com]

Clinically-Relevant Mutations and Pathophysiology Disease: Primary cutaneous amyloidosis Description: A skin condition characterized by pruritus, skin scratching and by deposits of amyloid in the dermis. [guidetopharmacology.org]

Affiliated tissues include skin, and related phenotypes are scaling skin and pruritus Genetics Home Reference : 26 Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, [malacards.org]

[…] in pruritus, pigmentation or flattening of papules was labeled as 'no response'. [idoj.in]

In primary systemic amyloidosis, skin lesions typically occur on the: A. Upper back B. Pretibial area C. Tongue D. Eyelids E. No skin lesion 2. In secondary systemic amyloidosis, skin lesions typically occur on the: A. Upper back B. [woundsresearch.com]

Three family members had the characteristic skin lesion and also carried the gene for MEN 2a; two additional members carried the gene for MEN 2a, but did not manifest the observable skin changes associated with lichen amyloidosis. [annals.org]

Silverstein SR: Primary, systemic amyloidosis and the dermatologist: where classic skin lesions may provide the clue for early diagnosis, Dermatol Online J 11:5, 2005. [clinicalgate.com]

In lichen amyloidosis, PUVA has been reported to be effective in alleviating itch and flattening of skin lesions. [clinicaldermatology.eu]

The skin lesions were more pronounced on the lower legs (Figure 1A ), back and waist (Figure 1B, 1C ), and the larger hypopigmented lesions were seen mainly on the lower legs. [bmcdermatol.biomedcentral.com]

Abstract Familial primary localized cutaneous amyloidosis (FPLCA) is an autosomal dominant disorder associated with chronic itching and skin lichenification. [ncbi.nlm.nih.gov]

Tanaka's study [ 16 ] demonstrated that most changes of gene expression revealed alterations in epidermal differentiation and proliferation consistent with lichenification. [bmcdermatol.biomedcentral.com]

Wong reported the role of chronic friction in cutaneous amyloidosis. [1] Scratching has been known to produce traumatic and pressure changes such as excoriation, inflammation, pigmentation, and finally lichenification in the human skin. [idoj.in]

In both patients punch biopsies from the conchal bowl yielded a pauci-inflammatory specimen with orthohyperkeratosis and acanthosis (Fig. 4), as well as prominent follicular plugging (Fig. 5). [dermatology-s10.cdlib.org]