Presentation
In one of the two cases lichen amyloidosis of the auricular concha reported here, concomitant macular amyloidosis of the back was present. [dermatology-s10.cdlib.org]
Herrera, Ahmet Dogan Humana Press, ١٧/٠٨/٢٠١٥ - 542 من الصفحات The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. [books.google.com]
LCD type II (Meretoja syndrome) is a systemic disease presenting in young adulthood with cutaneous, nervous and corneal manifestations. Frequent recurrent erosions and impaired corneal sensation are often present by age 40 years. [healio.com]
Macroglossia with tooth indentation was present in second case. Hepatomegaly occurs in 50% of patients and splenomegaly in 10%. Hepatomegaly was present in our case 1. [odermatol.com]
Heat intolerance and telangiectases of the ears are often present early in the course of the disease. 11 The characteristic angiokeratomata develop after puberty and present as tiny red–black bilaterally symmetrical papules, 0.5–2 mm in diameter, with [basicmedicalkey.com]
Skin
- Papule
In 1983 four cases of smooth papules on the aural conchae were reported by Sanchez [ 4 ]. [dermatology-s10.cdlib.org]
Lichen amyloidosis is a cutaneous condition characterized by the appearance of occasionally itchy lichenoid papules, typically appearing bilaterally on the shins. [en.wikipedia.org]
Widespread and symmetrically distributed papules coalescing into plaques were prominent on the arms, thighs and legs. [clinicaldermatology.eu]
Haemorrhagic blisters may form following skin trauma such as pinching The most characteristic skin lesions consist of waxy papules, nodules, or plaques. [pcds.org.uk]
[…] in pruritus, pigmentation or flattening of papules was labeled as 'no response'. [idoj.in]
- Skin Lesion
In primary systemic amyloidosis, skin lesions typically occur on the: A. Upper back B. Pretibial area C. Tongue D. Eyelids E. No skin lesion 2. In secondary systemic amyloidosis, skin lesions typically occur on the: A. Upper back B. [woundsresearch.com]
Three family members had the characteristic skin lesion and also carried the gene for MEN 2a; two additional members carried the gene for MEN 2a, but did not manifest the observable skin changes associated with lichen amyloidosis. [annals.org]
Silverstein SR: Primary, systemic amyloidosis and the dermatologist: where classic skin lesions may provide the clue for early diagnosis, Dermatol Online J 11:5, 2005. [clinicalgate.com]
In lichen amyloidosis, PUVA has been reported to be effective in alleviating itch and flattening of skin lesions. [clinicaldermatology.eu]
The skin lesions were more pronounced on the lower legs (Figure 1A ), back and waist (Figure 1B, 1C ), and the larger hypopigmented lesions were seen mainly on the lower legs. [bmcdermatol.biomedcentral.com]
- Eruptions
Ensure that you’re up to speed with the hottest topics in dermatology, including drug eruptions from new medications, new therapeutics for melanoma, as well as viral infections, biologic agents, and newly described gene targets for treatment. [books.google.com]
Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. [malacards.org]
[…] cell histiocytosis may mimic eruptive xanthoma. 6 Eruptive xanthomata are associated with hypertriglyceridemia and most often occur in hyperchylomicronemic states. [basicmedicalkey.com]
Eruptive xanthomas are small papules that appear suddenly on the buttocks, hands, or extensor surfaces, sometimes accompanied by pruritus or tenderness. [bobbybukamd.com]
- Hyperkeratosis
However, hyperkeratosis and acanthosis were major epidermal findings for LA. Lymphohistiocytic infiltrates were common dermal changes for both variants of amyloidosis. [pigmentinternational.com]
The histological features which were present in all patients were mild hyperkeratosis, atrophy of the stratum malpighii, increased basal layer pigmentation, dermal pigmentary incontinence and dense condensed collagen in the papillary dermis. [cags.org.ae]
Verruciform xanthoma is an exophytic lesion characterized by massive but regular epidermal proliferation, parakeratosis, and hyperkeratosis ( Fig. 13.25 ). 32 Neutrophils, neutrophilic debris, and bacterial colonies may be evident in the parakeratotic [basicmedicalkey.com]
Histopathological features noted were epidermis showing hyperkeratosis and focal atrophy; dermis showing diffuse deposits of eosinophilic hyaline material extending into subcutaneous tissue ( Fig. 4 ). [odermatol.com]
There was mild hyperkeratosis of the epidermis in three (11.5%) specimens which showed moderate degree of acanthosis with broadening and elongation of the rete ridges. [e-ijd.org]
- Keratosis
Sub track Prevention and Management Genital wart Flat wart Periungual wart Actinic keratosis | Dermatology Conferences | Cosmetology Conferences | Plastic Surgery Conferences | Dermatology Meetings | Dermatologist Conferences 2019 Actinic keratosis is [clinicaldermatology.euroscicon.com]
actinic keratosis, porokeratosis of Mibelli, Bowen’s disease, and basal cell carcinoma. 4 These amyloid deposits do not have a known clinical significance. 3 There is no known documented case of progression of lichen amyloidosis or macular amyloidosis [woundsresearch.com]
Localized amyloid deposition can be found microscopically in the presence of a variety of cutaneous tumors, actinic keratosis and seborrheic dermatosis. This type of amyloidosis is nearly always subclinical and an incidental pathological finding. [healio.com]
Secondary localized cutaneous amyloidosis associated with actinic keratosis. J Invest Dermatol. 1973;61:293–9. PubMed Google Scholar 73. Speight EL, Milne DS, Lawrence CM. Secondary localized cutaneous amyloid in Bowen’s disease. [link.springer.com]
Uremic frost should be differentiated from eczema, postinflammatory desquamation, and retention keratosis. A history of severe azotemia as well as the presence of characteristic lesions help to make the diagnosis. [bobbybukamd.com]
Neurologic
- Confusion
The amassing of amyloid in the skin can happen as a skin constrained confusion. Cutaneous amyloidosis may likewise happen as foundational amyloidosis with an emphasis on essential restricted cutaneous amyloidosis. [clinicaldermatology.euroscicon.com]
Treatment
A comprehensive review of the literature on the treatment options for PCA showed no controlled trials available. However, case series indicated phototherapy (UVB, narrow band UVB, photochemotherapy) as the most successful treatment. [clinicaldermatology.eu]
What is the treatment of systemic amyloidosis? Nonspecific treatment Treatment is directed at maintaining the function of affected organs. For example, kidney failure can be treated with dialysis and congestive heart failure with diuretics. [dermnetnz.org]
Broaden your knowledge with updated information on serological diagnosis of pemphigus, TNF-I for hidradenitis suppurativa, the use of immunosuppressives for atopic dermatitis, excimer laser for the treatment of vitiligo and much more. [books.google.com]
Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment [clinicaltrials.gov]
Prognosis
Nodular amyloidosis is extremely rare, and there are notable differences in clinical presentation, prognosis, histology, and pathogenesis between this entity and the macular and lichenoid variants. [actasdermo.org]
Dialysis-related amyloidosis Pathophysiology Systemic Amyloidosis Organ-specific Amyloidosis Microscopic Pathology Causes Differentiating Amyloidosis from other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications and Prognosis [wikidoc.org]
Topics covered include classification/epidemiology, pathogenesis, clinical features (with classic images), diagnosis, prognosis and treatment. [dermatologyadvisor.com]
Prognosis depends upon the extent of involvement. Treatment of amyloidosis is aimed at reducing the supply of precursor proteins [ 1 ]. [odermatol.com]
Etiology
Herrera, Ahmet Dogan Humana Press, ١٧/٠٨/٢٠١٥ - 542 من الصفحات The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. [books.google.com]
Lack of clear-cut etiological factors makes it difficult to suggest a reasonable therapeutic modality. [e-ijd.org]
However, the etiology of amyloidosis remains unclear and population-based studies would prove to be of great benefit in evaluating the exact etiology of amyloidosis. [idoj.in]
It is proposed that ApoE might play an important part in the etiology of amyloidosis by functioning as a chaperone to promote the formation of amyloid filaments. [cags.org.ae]
Its etiology is unknown but chronic irritation to the skin has been proposed as an etiological factor. [4] The amyloid deposits in LA are mainly restricted to the upper dermis and arise because of focal epidermal damage with subsequent conversion of necrotic [ijdvl.com]
Epidemiology
Clinico-epidemiological study of macular amyloidosis from North India. Indian J Dermatol, 57(4), 269-74. Beccia, M., Biver, T., & Pardini, A. (2012). [recimundo.com]
The present study was an attempt to study the epidemiology of PLCA and the effectiveness of DMSO on the lesions. [idoj.in]
“The epidemiology of AL and AA amyloidosis”. Baillieres Clin Rheumatol. vol. 8. 1994. pp. 627-34. [dermatologyadvisor.com]
Epidemiology of primary cutaneous amyloidoses in southeast Asia. Clin Dermatol 1990;8:20-4. 13. Ollague W, Ollague J, Ferretti H. Epidemiology of primary cutaneous amyloidoses in South America. Clin Dermatol 1990;8:25-9. 14. [pigmentinternational.com]
Keywords: Epidemiology, macular amyloidosis, risk factors How to cite this article: Bandhlish A, Aggarwal A, Koranne RV. A clinico-epidemiological study of macular amyloidosis from North India. [e-ijd.org]
Pathophysiology
The genetic basis of FPLCA involves mutations in the OSMR and IL31RA genes but the disease pathophysiology is not fully understood. [ncbi.nlm.nih.gov]
Clinically-Relevant Mutations and Pathophysiology Disease: Primary cutaneous amyloidosis Description: A skin condition characterized by pruritus, skin scratching and by deposits of amyloid in the dermis. [guidetopharmacology.org]
Amyloidosis Main page Overview Historical Perspective Classification AL amyloidosis AA amyloidosis Heritable amyloidosis Age-related (senile) systemic amyloidosis Dialysis-related amyloidosis Pathophysiology Systemic Amyloidosis Organ-specific Amyloidosis [wikidoc.org]
Subtrack Ultraviolet Radiatioon Exposure Genetics and Mutations Diagnosis and Biopsy Pathophysiology Hyperpigmentation | Der matology Conferences | Cosmetology Conferences | Plastic Surgery Conferences | Dermatology Meetings | Dermatologist Conferences [clinicaldermatology.euroscicon.com]
Etiology Pathophysiology The amyloid deposits in macular amyloidosis are keratinocyte-derived. [infectiousdiseaseadvisor.com]
Prevention
Within this we support a broad spectrum of research with the objective of preventing disease and disability and of alleviating physical disability. [action.org.uk]
Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies v t e Urinary system · Pathology · Urologic disease / Uropathy ( N00-N39, 580-599 ) Abdominal Nephropathy / ( nephritis + nephrosis ) Glomerulopathy / glomerulitis [wikidoc.org]
Sub track Prevention and Management Genital wart Flat wart Periungual wart Actinic keratosis | Dermatology Conferences | Cosmetology Conferences | Plastic Surgery Conferences | Dermatology Meetings | Dermatologist Conferences 2019 Actinic keratosis is [clinicaldermatology.euroscicon.com]
The goal of treatment is to prevent secondary infection and to allow the lesions to heal on their own. [bobbybukamd.com]