The familial occurrence of axonal and slowly progressive polyneuropathy led us to consider these patients as candidates for TTR molecular analysis. We found a missense mutation causing Ile68Leu TTR substitution in both. [ncbi.nlm.nih.gov]

Materials and methods 56 years old man presented with a 5 -year history of progressive polyneuropathy. His symptoms started with numbness and paresthesia in the feet followed by weakness. Three years after similar symptoms spread into his hands. [ojrd.biomedcentral.com]

Manifestations of TTR‐related FAP predominantly include a length‐dependent progressive polyneuropathy, myocardiopathy and ocular involvement. Early liver transplantation and tafamidis are currently available to treat these patients. [els.net]

A chronic immune mediated neuropathy (chronic inflammatory demyelinating polyradiculoneuropathy - CIDP), may result in relapsing or progressive polyneuropathy. This usually results in an asymmetric weakness and sensory loss. [dartmouth.edu]

Rapidly progressive polyneuropathy resembling GBS but without raised protein or slowed NCVs can occur in alcoholics. Subacute combined degeneration of the spinal cord (SACD) : Vitamin B12 deficiency leads to SACD. [neuroweb.us]

[…] night, urgency, stress incontinence, retention, hesitancy Sexual dysfunction: erectile dysfunction, vaginal dryness, decreased libido Gastrointestinal dysfunction: intermittent diarrhea, constipation, nausea, vomiting, full-ness after eating little, loss [my.clevelandclinic.org]

Difficulty digesting food, such as feeling full after a few bites of food, loss of appetite, diarrhea, constipation, abdominal bloating, nausea, vomiting, difficulty swallowing and heartburn, all due to changes in digestive function. [mayoclinic.org]

Autonomic features can be quite severe (paralytic ileus, acute abdomen, impotence or postural hypotension). Symptoms of polyneuropathy should prompt dose reduction. Permanent absent ankle jerks is commonly noted in asymptomatic patients. [neuroweb.us]

Mees lines and sole hyperkeratosis develop. CBC reveals anemia with basophilic stippling. Thallium polyneuropathy: High doses of thallium (rodenticide) cause shock due to gastroenteritis and dehydration. [neuroweb.us]

Neurological examination revealed mild proximal muscle weakness and polyneuropathy too. Her 69-year-old sister (patient 2) also showed PEO, parkinsonism and polyneuropathy. [jstage.jst.go.jp]

Polymyositis usually appears in people 30-60 years old and presents as insidious onset of symmetrical, proximal muscle weakness, occasionally accompanied by muscle soreness. [dartmouth.edu]

[…] without peripheral neuropathy. [intechopen.com]

Diagnosis of the Patient with Suspected Peripheral Neuropathy Figure 1. Approach to the patient with peripheral neuropathy. [aafp.org]

Peripheral Neuropathy & Neuropathic Pain: Into The Light. tfm Publishing Limited. p. 17. ISBN 9781910079027. Retrieved 3 August 2016. External links [ edit ] [en.wikipedia.org]

Foot drop (foot can't be picked up or held horizontal) Progressive deformity of leg ("inverted champagne bottle") or foot (abnormally high arched feet, flat feet, hammer toes) Decreased sensation or numbness in the foot or leg Awkward gait and balance [peripheralneuropathycenter.uchicago.edu]

drop) curled toes (known as hammer toes) loss of lower leg muscle, which leads to skinny calves numbness or burning sensation in the feet or hands “slapping” when walking (feet hit the floor hard when walking) weakness of the hips, legs, or feet leg [hnf-cure.org]

Patients can also suffer from high arched feet, hammer toes, foot drop, foot deformities, and scoliosis. These symptoms are a result of severe muscular weakness and atrophy. [en.wikipedia.org]

Foot drop (foot can’t be picked up or held horizontal) Progressive deformity of leg (“inverted champagne bottle”) or foot (abnormally high arched feet, flat feet, hammer toes) Decreased sensation or numbness in the foot or leg Awkward gait and balance [foundationforpn.org]

A bilateral foot drop may result in a steppage gait in which the patient must lift the knees very high in order to clear the toes. Proximal weakness results in an inability to squat or to rise unassisted from a chair. [aafp.org]