Clinical description FP is an asymptomatic condition that presents through blood tests as unexpectedly high plasma potassium levels, after storage at or below room temperature. [orpha.net]

The present mapping work confirms this relationship, and the comparison of temperature effects shows that different thermotropic variants can be due to mutations of what is almost certainly the same gene. [bloodjournal.org]

Of note, both patients presented as blood donors, and increased cold-induced potassium leak was demonstrated. [ash.confex.com]

OMIM : 57 'Familial pseudohyperkalemia' (PSHK) is a term that was coined to describe conditions in which a patient presents with pseudohyperkalemia as a result of a temperature-based abnormality in the transport of potassium (K) and sodium (Na) across [malacards.org]

However, pseudohyperkalaemia is a common laboratory artefact and, if unrecognised, may lead to a dilemma. 1 2 Workup for falsely elevated potassium levels may lead to delay in treatment and waste of resources. [hkmj.org]

The clinical necessity of routine potassium testing in healthy normal individuals without renal dysfunction or symptoms of hyperkalemia or hypokalemia needs to be discussed and addressed in each laboratory and clinical practice, since workup algorithms [jalm.aaccjnls.org]

Furthermore, the authors suggest that if the above workup is inconclusive for cause, a renal biopsy should be performed. [renalfellow.blogspot.com]

Management and treatment No treatment is required. [orpha.net]

Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. [books.google.com]

Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. [books.google.ro]

Prognosis The prognosis for patients is excellent. Most patients remain asymptomatic. The documents contained in this web site are presented for information purposes only. [orpha.net]

WBC RBCs in which the margin appears indented, purportedly due to splenic removal of a Heinz body Treatment and Prognosis of G6PD deficiency -preventing the common manifestations of hemolytic anemia and neonatal jaundice -avoidance of fava bean consumption [quizlet.com]

The classification is useful in the sense that there was a statistically significant correlation between IgA subclass and renal survival (with subclass I having the best prognosis and subclass V having the worst prognosis). [renalfellow.blogspot.com]

Etiology All families identified so far have mutations in the ABCB6 gene (2q36), leading to an inherited abnormality in the movement of ions across the red cell membrane, such that when the red cells are cooled they lose potassium into the plasma. [orpha.net]

Rule out etiologies of reactive thrombocytosis. If etiology is identified, then treat underlying disease or remove inciting process. Your patient may have pseudohyperkalemia on serum basic metabolic panel as high as 9 milliequivalents/liter (mEq/L). [clinicaladvisor.com]

Renal etiologies of hypokalemiaExcess mineralocorticoid states Secondary hyperaldosteronism - Diuretics, GI fluid losses Source Undetermined 65. [slideshare.net]

Summary Epidemiology The prevalence is unknown. Less than 15 kindreds have been reported in the literature so far (the majority being from the United Kingdom). [orpha.net]

The involvement of cation leaks in the storage lesion of red blood cells JF Flatt, WM Bawazir, LJ Bruce Frontiers in physiology 5, 214, 2014 64 2014 Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients S Khositseth [scholar.google.com]

Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. [books.google.com]

Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. [books.google.ro]

The primary defect is in the anion transporter, band 3 (see section on "Pathophysiology"). [cancertherapyadvisor.com]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.ro]