Dyspnœa and/or fatigue may even be present at rest. Discomfort is increased by any physical activity. 24. [slideshare.net]

Exertional dyspnea, fatigue, chest pains and syncope are the most common presenting complaints. Hemoptysis may also occur and may be of high volume 1. [radiopaedia.org]

Other symptoms that may be present include: Dizziness Fatigue Swelling around the ankles and feet Fainting Tightening feeling in the chest [aoporphan.com]

She reports that she has had increasing dyspnea on exertion and fatigue for the past 3 years, but it has gotten much worse in the last 2 months. [medbullets.com]

Some symptoms include chest pain, weakness, shortness of breath, and fatigue. The goal of treatment is control of the symptoms, although the disease usually develops into congestive heart failure. [mountsinai.org]

The male proband also had bilateral inguinal hernias and undescended testes. The same findings in two siblings suggest a genetic cause--either an autosomal recessive disorder or germline mosaicism in one parent for a dominant mutation. [ncbi.nlm.nih.gov]

The male proband also had bilateral inguinal hernias and undescended testes. The same findings in two siblings suggest a genetic cause–either an autosomal recessive disorder or germline mosaicism in one parent for a dominant mutation. [journals.lww.com]

On ExaminationEarly diastolic high pitched Graham-Steell murmur ofPRCaused by dilatation of the PV ring due to PAH S3 S4 gallop 27. [slideshare.net]

Steell murmur) may be apparent A murmur of tricuspid regurgitation can be present, and a right ventricular lift (heave) may be noted Jugular venous pulsations may be elevated in the presence of volume overload, right ventricular failure, or both; large [emedicine.medscape.com]

The siblings also shared several minor abnormalities: pectus carinatum, long fingers, proximally placed thumb, broad nasal bridge, and high-arched palate. The male proband also had bilateral inguinal hernias and undescended testes. [ncbi.nlm.nih.gov]

On Examination P 2 Loud with split Left Lower Parasternal impulse Bipedal Oedema 26. …contd. On ExaminationEarly diastolic high pitched Graham-Steell murmur ofPRCaused by dilatation of the PV ring due to PAH S3 S4 gallop 27. [slideshare.net]

The siblings also shared several minor abnormalities: pectus carinatum, long fingers, proximally placed thumb, broad nasal bridge, and high-arched palate. The male proband also had bilateral inguinal hernias and undescended testes. [ncbi.nlm.nih.gov]

Other neurological symptoms include various types of epileptic seizures and intellectual deficit; permanent cerebellar signs may be present in patients carrying a CACNA1A mutation [ 6 ]. [erj.ersjournals.com]

Cardiovascular Outcomes Data Managing Epilepsy: Parting Advice for Neurologists Type 2 Diabetes and Cardiovascular Disease: Risk Factors Managing Asthma With Biologic Therapy Selecting and Using a GLP-1 Agonist to Treat T2D Potential of Cannabidiol in Epileptic Encephalopathies [raredr.com]

Major findings involve three systems: pulmonary arterial hypertension, cardiac abnormalities including secundum-type atrial septal defect, and the hematopoietic system with intermittent neutropenia, lymphopenia, monocytosis, and anemia. [ncbi.nlm.nih.gov]

In addition, diuretics are associated with electrolyte changes including hyponatremia and hypokalemia and alkalosis. Electrolytes should be routinely monitored in patients with PAH who are using diuretics. [clevelandclinicmeded.com]