Here, we present two cases of inherited form of RPC in siblings aged 4 and 7 years presented with a history of itchy raised lesions of 9 months and 3 years duration, respectively. [ijpd.in]

The familial variant of RPC is rare, affects one or more family members, presents at an early age and is usually triggered by simple trauma. [3] Three sisters aged 8, 11 and 13 years presented to us with multiple, shallow, well defined facial scars that [ijdvl.com]

A 30-year-old woman presented to the out-patient department with minimally itchy papules over the extremities since childhood. History of spontaneous remission and exacerbation was present. There was no history of oozing, vesiculation, or crusting. [e-ijd.org]

A 4 year old boy presented with history of itchy raised lesions on body of 2 years duration. Though parental consanguinity was not present, his elder brother had similar complaints. [pubfacts.com]

• Dentist

  This system helps physicians, medical students, dentists, nurses, pharmacists, and allied health professionals identify education deficits and learn new concepts. [knowledge.statpearls.com]

• Koebner Phenomenon

  phenomenon); scarring occurs with healing Differential diagnosis Kyrle's disease; perforating folliculitis; elastosis perforans serpiginosa; prurigo nodularis; Ferguson-Smith type of keratoacanthoma Therapy Tretinoin 0.025% cream; adapalene 0.1% gel; [link.springer.com]

  Koebners phenomenon was present in the child. Scarring was seen over the resolved lesions [Figure 1], [Figure 2] and [Figure 3]. Nails, hair, teeth, and mucosa were normal. Systemic examination was unremarkable. [e-ijd.org]

  Pruritus and the Koebner phenomenon were common, and histologically a micro-vasculopathy was noted in the dermis of all patients. We speculate that this disease is triggered by a cutaneous response to superficial trauma. [eurekamag.com]

  Different stages of evolution and regression were seen at the same time, the lesions were showing Koebner's phenomenon. [ijdvl.com]

  Pathophysiology The major abnormality in reactive perforating collagenosis is focal damage to collagen and the elimination of the disrupted collagen through the epidermis. [1] A frequent association with pruritus, the tendency to the Koebner phenomenon [emedicine.medscape.com]

• Gouty Tophus

  Tophus Pathology of Pseudoxanthoma Elasticum #dermatopathology Pathology of Elastosis Perforans Serpiginosa - 10 Important Facts Pathology of Gouty Tophus Pathology of Basaloid Follicular Hamartoma #dermatopathology Pathology of Papillary Eccrine Adenoma [pinterest.co.kr]

• Facial Scar

  In addition, the brother of a girl with RPC who claimed to be free of the dermatosis, had facial scars suggestive of RPC in the past. [ncbi.nlm.nih.gov]

  All our cases were females with facial involvement and presence of atrophic scarring. The scars varied in size and shape, some were round whereas others were linear in configuration. [ijdvl.com]

• Suggestibility

  History of parental consanguinity was present suggesting the possibility of autosomal recessive mode of inheritance in this familial case because none of the parents were affected with this disorder. [ijpd.in]

  In addition, the brother of a girl with RPC who claimed to be free of the dermatosis, had facial scars suggestive of RPC in the past. [ncbi.nlm.nih.gov]

  Kaiskou et al have suggested an infective etiology as they found improvement on oral clindamycin therapy in a patient. Treatment of the underlying associated disease improves the lesion and prognosis becomes better. [japi.org]

• Granulomatous Arthritis

  Familial granulomatous arthritis, iritis, and rash. J Pediatr intractable leg ulcers. [deepdyve.com]

[…] have been reported, including topical and systemic corticosteroids, retinoids, doxycycline, phototherapy and allopurinol. 4 There is little evidence supporting these treatments, and no controlled studies or treatment guidelines are available. [cmaj.ca]

The recurrent nature of lesions in familialRPC poses a treatment dilemma; a safe andeffective maintenance therapy is needed. [docslide.net]

No randomized controlled trials have evaluated the treatments for reactive perforating collagenosis, and all treatment suggestions are the result of case reports. [knowledge.statpearls.com]

Treatment was stopped because of difficulty with mobilityand attending the treatment centre. Because the patient wasgreatly distressed by the pruritus, acitretin 25 mg/day, orally,was started. [dokument.tips]

What treatment is available? Lesions are usually self-healing without any treatment but often recur. [dermnetnz.org]

In case of severe Reactive Perforating Collagenosis, the treatment may include the use of topical creams and moisturizers, phototherapy, and antihistamines for itching The prognosis of Reactive Perforating Collagenosis is frequently excellent, with or [dovemed.com]

In a series of 22 patients with acquired reactive perforating collagenosis, the mean patient age at presentation was 56 years. [2] Prognosis The lesions of reactive perforating collagenosis are intensely itchy, leaving some scarring after resolution. [emedicine.medscape.com]

Treatment of the underlying associated disease improves the lesion and prognosis becomes better. [japi.org]

Reactive perforating collagenosis is a rare, familial, nonpuritic skin disorder characterized by papules that grow in a diameter of 4 to 6mm and develop a central area of umbilication to which keratinous material is lodged. [1] [2] The etiology of reactive [ipfs.io]

The etiology of reactive perforating collagenosis is unknown. == See also == ... [encyclo.co.uk]

[2] Overview Reactive perforating collagenosis is a rare, familial, nonpuritic skin disorder characterized by papules that grow in a diameter of 4 to 6mm and develop a central area of umbilication to which keratinous material is lodged. [1] [2] The etiology [wikidoc.org]

Classification of these conditions often presents many nosological challenges, since underlying etiologies and pathogenetics are often not known. [howlingpixel.com]

The etiology of reactive perforating collagenosis is unknown. Source: Wikipedia MS-DRG Mapping DRG Group #606-607 - Minor skin disorders with MCC. DRG Group #606-607 - Minor skin disorders without MCC. [icd.codes]

[…] collagenosis, as follows [2] : Elimination of necrotic basophilic collagen bundles into a cup-shaped epidermal depression as seen in biopsy specimens Umbilicated papules or nodules with a central, adherent keratotic plug Onset of lesions after age 18 years Epidemiology [emedicine.medscape.com]

Epidemiology Reactive perforating collagenosis is a very rare inherited disease. Fewer than 50 cases have been reported in the literature since it was first described in 1967. [knowledge.statpearls.com]

Pathophysiology The major abnormality in reactive perforating collagenosis is focal damage to collagen and the elimination of the disrupted collagen through the epidermis. [1] A frequent association with pruritus, the tendency to the Koebner phenomenon [emedicine.medscape.com]

The common pathophysiological principle in these disorders is transepidermal elimination of dermal substances. [japi.org]

Pathophysiology There has been no specific genetic defect found. It has been reported that overexpression of TGF-beta3 and extracellular matrix proteins may be seen in patients with the acquired form of reactive perforating collagenosis. [knowledge.statpearls.com]

Your skinHolds body fluids in, preventing dehydrationKeeps harmful microbes out, preventing infectionsHelps you feel things like heat, cold, and painKeeps your body temperature evenMakes vitamin D when the sun shines on itAnything ... [codelay.com]

Currently, there are no specific methods or guidelines to prevent Reactive Perforating Collagenosis However, proper treatment and control of diabetes and other associated disorders can be ensured to help lower one’s risk for RPC If there is a family history [dovemed.com]

In our patient the t rauma was scratching secondary to pruritus, and the majority of the skin lesions healed when the patient was prevented from scratching and his diabetes mellitus was controlled. [docslide.com.br]

Three of the four patients (patients 2, 3and 4) had a significant improvement at 24 months withreduction in pruritus, prevention of new lesions developingand clearance of existing lesions. [myslide.es]